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PLX040313
GSE96552: Genome-wide profiling of somato-dendritic mRNA distribution in the hippocampus in RNG105/caprin1 conditional knockout (cKO) mice
- Organsim mouse
- Type RNASEQ
- Target gene
- Project ARCHS4
Background: mRNA localization and translation in neuronal dendrites are the basis for long-term synaptic plasticity and memory formation. RNA granules, membrane-less macromolecular assemblies in which dendritic mRNAs are recruited, are thought to contribute to these processes. RNG105/caprin1 is an RNA granule assembly factor involved in mRNA transport.; Results: Genome-wide profiling of mRNA distribution in distinct hippocampal layers revealed dendritically and somatically enriched mRNAs, and demonstrated marked reduction in the differential somato-dendritic localization of the mRNAs in RNG105 cKO mice.; Conclusion: RNG105 is an essential factor for the localization of many, but particularly for specific mRNAs localized to dendrites. SOURCE: Rie Ohashi (ohashi@nibb.ac.jp) - National Institute for Basic Biology
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