PLX166871

GSE97619: Differentiation of Inflammation-responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

The goals of this study are to generate inflammation-sensitive astrocytes from human induced pluripotent stem cells. We examine the transcriptomic inflammatory signature of generated astrocytes following Il1Beta exposure.; Primary human cerebellar astrocytes, human induced pluripotent stem cells (hiPSC)-derived neural precursor cells (NPCs) and hiPSC-derived astrocytes were treated with Il1beta and compared to vehicle treated controls.; Results: hiPSC-derived can be differentiated to astrocytes that are inflammation sensitive. SOURCE: Galina Erikson (gerikson@salk.edu) - Salk Institute

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