PLX215397

GSE98133: Determination of Lsd1 function in C2C12 myoblast cells by global transcriptome analysis

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

First, we aimed to identify genes whose transcript levels change at the onset of myogenic versus adipogenic differentiation of muscle precursors. We therefore compared RNA-seq results obtained from C2C12 cells differentiated for 1 day in myogenic and adipogenic medium. Out of these genes, we wanted to determine those whose expression was affected by altered Lsd1 levels. To this end, we performed RNA-seq in C2C12 cells upon LSD1 overexpression and Lsd1 knock-down in adipogenic medium and compared them to corresponding control cells. SOURCE: Roland Schuele (roland.schuele@uniklinik-freiburg.de) - Schuele Zentrale Klinische Forschung