PLX098577

GSE99537: Modulation of Macrophage Subpopulation Response in Radiation-Treated Gliomas Circumvents Tumor Recurrence

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

Thorough examination of tumor associated macrophage/microglia have shed light into their pro-tumorigenic functions in glioblastoma multiforme (GBM) development and progression. However, the dynamic evolution of these two ontogenically distinct macrophage subpopulation in the course of therapeutic response and recurrence is unknown. We employed multiple mouse models of GBM to show that infiltrating bone marrow derived macrophages (BMDM) and brain resident microglia (MG) content and phenotype are altered post radiotherapy. We identified IR specific and stage-dependent shared and distinct BMDM and MG signatures, and demonstrated that only dual targeting of these populations using CSF-1R inhibition combined with IR led to a sustained overall survival. Our findings establish that plasticity underlie macrophage evolution in the irradiated tumor microenvironment, and reveals the therapeutic potential of their targeting to enhance the efficacy of standard of care treatment in GBM. SOURCE: Robert,L,Bowman (bowmanr@mskcc.org) - Joyce Lab MSKCC