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Learn MoreThe purpose of this study was to perform an unbiased RNA expression profile in platelets from HIV subjects under ART and healthy controls to identify a gene signature for the HIV hyperactive phenotype.; Methods: Rna-Sequencing was performed in leukocyte-depleted platelet RNA from 6 HIV subjects and 3 healthy controls. qRTPCR validation was performed to validate our candidate transcripts.; Results: Across the 9 platelet samples, there was an average of 28.3 million mapped reads per sample with an average unique mapping rate of 91.6 %. Using a cut-off of normalized counts 1 across the 9 samples, we found 11988 expressed transcripts.; Conclusions: Our study represents a detailed analysis of platelet transcriptome generated by RNA-seq technology in HIV patients under ART. Further experiments identified the mechanism of our transcript target in mediating platelet activity and platelet cell effector function. SOURCE: Jeffrey,Stuart,Berger (jeffrey.berger@nyumc.org) - 707 NYU Langone Medical Center
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