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Sequencing-based assays page 110
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GSE139684: Transcriptional profiling of astrocytes in the prefrontal cortex, hippocampus, accumbens nucleus and caudate putamen of a Aldh1l1-TRAP (JD130) mouse line after chronic social defeat stress
Psychiatric disorders, especially major depressive disorder, are prominent cause of disability world...
GSE154234: Analysis of mRNA expression between irradiated and non-irradiated keloid-derived primary cells.
This study aims to compare mRNA expression between irradiated and non-irradiated keloid-derived prim...
GSE150028: Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice [Striatum (CPu)]
Background: The schizophrenia associated gene, BRD1, encodes an epigenetic regulator which chromatin...
GSE153447: Transciptomic analysis of human aortic smooth muscle cells (HASMCs) with BAF60a overexpression
We used NGS-derived transcriptome profiling (RNA-seq) to compare the transcriptional difference betw...
GSE147666: Identification of genes showing an age related expression in iNKT1, 2, and 17 cells of BALB/c thymus
In this study we applied RNA high-throughput seqencing to compare the global gene expression of youn...
GSE154259: Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling [single-cell RNA-seq]
We performed Smart-seq2 scRNAseq on 156 pancreatic tuft cells . We also profiled FACS sorted EpCAM+;...
GSE137515: Genetic screen for neuropathic pain study in importin alpha3 knock out mice
Here we show that importin alpha () 3 (KPNA4) controls pain responsiveness in peripheral sensory ne...
GSE146978: Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation (2)
In this study we examine the outcomes of p16INK4a activation in the adult epidermis. We found that p...
GSE150250: Gonadal white adipose tissue gene expression changes in response to adipose-specific Med19 knockout
We report the gene expression changes in the gWAT tissue of adipose-specific Med19 knockout mice SOU...
GSE147544: RNA sequencing of motor neurons derived from induced pluripotent stem cells of ALS patients with the M337V mutation in TARDBP
Sequencing of human iPS-derived motor neurons from fibroblasts of Amyotrophic lateral sclerosis pati...
GSE147596: Paired immunoglobulin-like receptors mediate innate memory to non-self MHC molecules
Abstract: Immunological memory specific to previously encountered antigens is a cardinal feature of ...
GSE154266: Bulk RNA-sequencing analysis of isogenic murine Kras/p53 (KP) Brg1 wildtype cells versus Brg1 knockout (KPB) cells
The goals of this experiment is to identify transcriptomic changes upon loss of Brg1 in lung adenoca...
GSE147613: Paeonia lactiflora extract suppresses cisplatin-induced muscle wasting via donwnregulations of muscle-specific E3 ubiquitin ligases
Cisplatin is a broad-spectrum anti-cancer drugs used in diverse types of cancer, however, muscle was...
GSE146487: Transcriptional profiling of endothelial cells lacking Tgfbr2
Tgfbr2 controls signal transduction after binding activated Tgfb1. Inactivation of this receptor in ...
GSE137414: RNA sequencing of pancres tissue of WT and IL23 expression mice (KSR23)
The goal of this study is to check if elevated level of IL-23 and/or its downstream cytokines affect...
GSE146959: RNA-sequencing of C3H/10T1/2 mesenchymal stem cells expressing H2B mutant histones
Purpose of study is to assess changes in gene expression profiles of mesenchymal stem cell upon expr...
GSE149924: Skeletal muscle aging and pathways regulated by 15-PGDH inhibition
To identify signalling pathways and genes regulated by 15-PGDH inhibition by SW033291 SOURCE: Dr.Hel...
GSE150300: Changes of gene expression patterns of human cancer cell lines responding to Interferon-gamma
We report the differences of gene expression pattern of 4 different human cancer cell lines respondi...
GSE147767: RNA sequencing of NT control cells, Traf3 KO, and Traf3/p100 double KO cells
Loss of Traf3 caused a dramatic induction of innate immune response genes. Antigen presentation, int...
GSE137337: Epigenetic regulator function through mouse gastrulation
Development of a multicellular organism uses the same genetic code to generate a broad diversity of ...
GSE146478: The anti-fibrosis effect of iguratimod on skin tissues of systemic sclerosis patients
To evaluate the possibility of iguratimod working on SSc patients in clinical practice, we collected...
GSE150284: CoolMPS for robust sequencing of single-nuclear RNAs captured by droplet-based method
Massively-parallel single-cell and single-nucleus RNA sequencing (scRNA-seq, snRNA-seq) requires ext...
GSE151967: The Histone Methyltransferase Setd2 Modulates Oxidative Stress to Attenuates Colonic Inammation and Tumorigenesis [RNA-Seq]
Inflammatory bowel disease (IBD) is a complex and relapsing inflammatory disease, and patients with ...
GSE154182: Deletion of the gene encoding the N-methyl-D Aspartate Receptor GluN1 subunit in Schwann cells causes ultrastructural changes in Remak bundles and hypersensitivity in pain processing
Mouse DRGs (n=3 per genotype) were isolated from a novel mouse model with conditional deletion of ...
GSE147493: Transcriptome analysis in a unique cohort of untreated primary tumors collected from diagnostic prostate needle biopsies (PNBX) of localized (M0) and metastatic (M1) cases
PNBX were collected from 99 patients treated in the VA Greater Los Angeles (GLA-VA) Healthcare Syste...
GSE147423: Transcriptomic analysis of day 1 (D1) differentiating WT and HDAC11-deficient mouse myoblasts
To get insight into the transcriptomic changes caused by HDAC11 loss at early myogenic differentiati...
GSE153480: Single cell RNA-seq of neonatal heart regeneration
The adult mammalian heart has limited capacity for regeneration following injury, whereas the neonat...
GSE150267: Sensory neurons expressing calcitonin gene-related peptide regulate adaptive thermogenesis and diet-induced obesity
We report role of CGRP+ neurons in the regulation of themogenesis on High fat diet in adipose tissue...
GSE108115: UTX and 53BP1 co-regulate genetic programs for neural differentiation of human embryonic stem cells [RNA-seq]
UTX is a histone H3 lysine 27 demethylase required for development. However, the mechanisms underlyi...
GSE154254: Genetic deletion of microRNA biogenesis in muscle cells reveals a hierarchical non- clustered network that controls focal adhesion signaling during muscle regeneration
Objective: Decreased muscle mass is a major contributor to age-related morbidity, and strategies to ...
GSE137504: Genome-wide expression analysis of murine sciatic nerve of young and old mice
The regenerative capacity of peripheral nerves declines during aging, contributing to the developmen...
GSE147564: Single-nucleus RNA sequencing of intermediates during human primed and nave reprogramming.
We report single-nucleus RNA time-course profiling of intermediate populations of reprogramming of h...
GSE146784: T cells and Dendritic cells from MC38 tumors treated with anti-PD-1 or anti-PD-1 plus D18
We treated mice bearing MC38 tumors with anti-PD-1 antibody (twice each week) or D18 (once one week)...
GSE150069 (human): Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline
Translation of NRF1/NRF2-mediated liver tissue biomarkers to an in vitro assay using an advanced mic...
GSE146482: Next-generation sequencing reveals differential responses to acute versus long-term exposures to graphene oxide in human lung BEAS-2B cells
Numerous studies have addressed the biological impact of graphene-based materials including graphene...
GSE154258: Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling [bulk RNA-seq]
We performed bulk RNA-seq on pancreatic and intestinal tuft cells, bone marrow derived macrophages w...
GSE144999: Determining transcriptome changes in whole spinal cord of GarsC201R/+ adult mice [17-burgess-001]
To determine transcriptome changes in adult spinal cord induced by the GarsC201R mutation.; How muta...
GSE149965: RNA-seq of FACS-enriched mammary subpopulations (basal, luminal progenitor, mature luminal) from WT and ID4 knockout mice
The goal of this study was to determine the genes regulated by ID4 in mammary epithelial subpopulati...
GSE107806: RNA-sequencing of human peripheral blood mononuclear cells (PB MNCs) and induced neural progenitor cells derived from PB MNCs
We have successfully generated human induced neural progenitor cells (iNPCs) from peripheral blood m...
GSE146524: Impact of liver-specific deletion of Dhcr24 gene on tissue gene expression
Genetic loss of the enzyme 3-hydroxysterol-24 reductase (DHCR24) results in Desmosterolosis (MIM #60...
GSE154964: Transcriptome map of cancerous and para-cancerous tissues in patients with liver hepatocellular carcinoma
To validate CXCL12 and IL7R expression between cancerous and paracancerous, five cancer and five par...
GSE150851: Transcriptomic changes of sigmoidal gut biopsies in psoriasis patients and healthy subjects
This study aims to understand the systemic component of psoriasis pathogenesis since psoriasis patie...
GSE146982: GPD1 enhances the anti-cancer effects of metformin by synergistically increasing total cellular glycerol-3-phosphate
GPD1 overexpression enhances the anti-cancer effect of metformin through synergistic inhibition of m...
GSE78957: Association with Aurora-A controls N-MYC-dependent promoter escape and pause release of RNA polymerase II during the cell cycle
MYC proteins bind globally to active promoters and promote transcriptional elongation by RNA polymer...
GSE151638: Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
WT or Zeb2 cKO (cardiomyocyte-specific) mice received a myocardial infarction. After 14 days, the bo...
GSE145656: Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell based in vitro disease-modelling: Convergence of schizophrenia and autism-related cellular phenotypes
Background: De novo mutations (DNMs) have been implicated in the etiology of schizophrenia, a chroni...
GSE146101: STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology
The signal transducer and activator of transcription 3 (STAT3) signalling pathway is activated throu...
GSE147400: Knocking out non-muscle myosin II in retinal ganglion cells promotes long-distance optic nerve regeneration II
In addition to altered gene expression, pathological cytoskeletal dynamics in the axon are another k...
GSE154988: Properties of PD1+ B cells in Rheumatoid Arthritis (RA) Patients
We study a new pathogenic, glycolytic PD1+ B cell population in sites of inflammation of patients wi...
GSE117699: p38 SAPK and SKIIP induced changes in alternative splicing patterns upon osmostress
Alternative splicing is a crucial mechanism for gene regulation that is modulated in response to a w...
GSE146962: O-linked -N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1
Using RNA sequencing we compared the transcriptome change between control and OGT knockout heart sam...
GSE150871: Scar-free healing and axon regeneration after spinal cord injury in neonatal mice is orchestrated by microglia
By utilizing single-cell analysis at different times after P2 injury(0, 3, and 5 dpi), we discovered...
GSE137899: Gene expression profiling of tankyrase-inhibited mouse articular chondrocytes
Osteoarthritis (OA) is a prevalent degenerative disease, which involves progressive and irreversible...
GSE146812: Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction
Clonal hematopoiesis of indeterminate potential is prevalent in elderly individuals and associated w...
GSE149991: Exposure to mites sensitizes intestinal stem cell maintenance, splenic marginal zone B cell homeostasis, and heart development to Notch dosage and cooperativity [RNA-seq]
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of...
GSE154199: RNA sequencing of KAT5 mutant patient-derived fibroblasts
KAT5 encodes an essential lysine acetyltransferase previously called TIP60 involved in gene expressi...
GSE147026: Transcriptome analyses in aortic dissection and normal human aorta
To identify the m6A methylome in the aorta of patients with acute aortic dissection. MeRIP-seq and R...
GSE140890: Parallel scRNA-seq and genetic recording reveals lineage decisions in early mouse embryogenesis
How cell fate is specified at early stages of development is a fundamental question in biology. We a...
GSE135866: Cytotoxic therapy-induced effects on both hematopoietic and marrow stromal cells promotes therapy-related myeloid neoplasms
Therapy-related myeloid neoplasms (t-MNs) comprise therapy-related acute myeloid leukemia (t-AML) a...
GSE150019: Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Neutrophils TGFbeta)
Purpose: we aimed at providing the phenotypic profile of G-MDSCs based on their prognostic significa...
GSE150350: TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
The PIWI protein MIWI2 and its associated PIWI-interacting RNAs (piRNAs) instruct DNA methylation of...
GSE154316: Comparison of wild type and Tmem184b mutant adult DRG
The goal of this study was to evaluate gene expression that is dependent upon Tmem184b expression. O...
GSE145525: Acute perturbation strategies in interrogating RNA Polymerase II elongation factor function in gene expression
The regulation of gene expression catalyzed by RNA Polymerase II (Pol II) requires a host of accesso...
GSE137457: The Mediator subunit MED23 regulates inflammatory responses and liver fibrosis
Liver fibrosis, often associated with cirrhosis and hepatocellular carcinomas, is characterized by h...
GSE147001: Cytosolic dsRNA-induced gene expression in mouse RAW24.7 macrophages and FIP200 knockout RAW cells
Our preliminary data showed that FIP200 is essential for dsRNA-induced interferon production. To cor...
GSE147395: Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans
T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. Ho...
GSE144125: Lack of TREM2 differentially affects the phenotype and transcriptome of mice expressing human APOE3 and APOE4
We aim to investigate the interaction between two of the major genetic risk factors for AD: inherita...
GSE147498: Long-term expansion with germline potential of human primordial germ cell-like cells in vitro [RNA-seq]
Human germ cells perpetuate human genetic and epigenetic information. However, the underlying mechan...
GSE154354: Evaluating developmental effects of Tmem184b in dorsal root ganglia
We evaluated transcriptomic signatures at critical timepoints of sensory differentiation in wild typ...
GSE111896: Single-cell transcriptomic analysis of tissue resident memory T cells in human lung cancer [ 10x genomics]
High numbers of tissue-resident memory T (TRM) cells have been associated with better clinical outco...
GSE141194: Protein arginine methyltransferase 5 promotes cholesterol biosynthesis mediated Th17 responses and autoimmunity [Th17]
Protein Arginine Methyltransferase (PRMT) 5 catalyzes symmetric dimethylation of arginine, a post-tr...
GSE138756: SPC+ KP vs SPC+ KPG1 tumours
Glucose transporters are the first and rate-limiting step for cellular glucose usage, which is often...
GSE150041: RNA sequencing study using Prox1-eGFP mice to investigate the role of lymphatic vasculature in chronic cardiac dysfunction
The goal of the study is to examine the transcriptional changes in different cell populations isolat...
GSE147376: RNA-seq analysis of pulmonary arterial smooth muscle cells(PASMCs)stimulated with BMP9/10
Inactivation of BMP9/10 in mice leads to attenuated contractility of smooth muscle cells and decreas...
GSE145546: Next Generation Sequencing Facilitates Quantitative Analysis of Taurine Promoted Transcriptomes
Purpose: Taurine promotes the activation of plasmacytoid dendritic cells. The goals of this study ar...
GSE108496: In vitro modeling of human germ cell development using pluripotent stem cells
In this study, we developed a feeder-, serum-, and animal product-free culture condition, and succes...
GSE147474: Transcriptome analysis of the facial processes in Rspo2, WNT9b and Rspo2;Wnt9b double mutant mice
Purpose: To determine transcriptome profile of the facial processes of Wnt9b, Rspo2 and double gene ...
GSE147465: Transcriptomic analysis of tumor infiltrating CD8+ T cells during PDAC progression
CD8+ T cells are master effectors of anti-tumor immunity and their presence at tumor sites correlate...
GSE145569: Smooth muscle cell-derived vascular progenitor cells promote arterial remodeling and fibrosis through loss of Klf4 activity and spontaneous differentiation into myofibroblasts
Resident vascular adventitial progenitor cells express the stem cell marker, Sca1 (AdvSca1 cells). U...
GSE141191: Transcriptomic profiling of small intestinal crypts upon MEX3A deletion
The effort to better understand intestinal stem cell (ISC) identity and regulation remains a challen...
GSE108278: Transcriptional profiling of growing and senescent WT and IL-1R-depleted IMR90 cells
Senescent cells no longer divide, but remain metabolically active and secrete an array of cytokines,...
GSE140823: Loss of androgen signaling in mesenchymal SHH responsive cells diminishes prostate development, growth, and regeneration
Prostate embryonic development, pubertal and adult growth, maintenance, and regeneration are regulat...
GSE146424: The minor spliceosome is required for limb growth but not patterning
Diseases caused by mutations in components of the minor spliceosome frequently result in primordial ...
GSE147556: RNA-seq on MCF10A-YAP cells (overexpressed constrictively activated YAP in MCF10A cells) transduced with sgRNAs vectors targeting TRAM2 gene
We performed a CRISPR-based functional genetic screen targeting TEAD4 binding motif located within ...
GSE148349 (mouse): Transient in vivo base editing with no detectable RNA- and DNA off-target mutations
RNA-programmable deaminases, known as base editors (BEs), enable precise single base conversions on ...
GSE153091: Genome-wide maps of gene expression in mouse Inguinal white adipose tissue
Using high throughput sequencing we report gene expression changes in mouse inguinal adipocytes from...
GSE147794: Human Regulatory T cells from Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood
Single-cell RNA and TCR sequencing data from sorted Tregs in umbilical cord blood and adult peripher...
GSE140205: RNASeq of gene expressions in humanized APOE Male and Female aging Mice
Late onset Alzheimers disease (LOAD) is a progressive neurodegenerative disease with four well-estab...
GSE150853: Large-scale analysis of human and mouse RNA-seq datasets to identify undiscovered male reproductive tract-specific genes (mouse)
The development of a safe and effective, reversible, non-hormonal contraceptive method for men has b...
GSE145772: Memory of cell divisions directs the continuous process of primitive hematopoietic lineage commitment
Hematopoietic stem cells (HSCs) exist in a dormant state, and progressively lose regenerative potenc...
GSE145804: -Synuclein Translocates To The Nucleus To Activate Retinoic Acid- Dependent Gene Transcription
-Synuclein (-Syn) is a protein implicated in the pathogenesis of Parkinsons disease (PD). It is prim...
GSE138839: Effects of a male meiotic driver on male and female transcriptomes in the house mouse
We investigated effects of the t haplotype in house mice, an autosomal male meiotic driver, on genom...
GSE150266: Use of mice defective in interferon signaling to distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease
The type 1 interferon (IFN) response is part of the innate immune response and best known for its ro...
GSE153012: GPR35 mediates lysophosphatidic acid-signaling in bone marrow-derived macrophages at the transcriptional level
Purpose: Our previous experiments showed that LPA activated inhibitory G-protein signaling in human ...
GSE151674: Analysis of lung transcriptomic changes following inhibition of LTR-signalling in cigarette smoke exposed mice
How LTR-signalling drives chronic tissue damage particularly in the lung, which mechanisms regulate ...
GSE151742: Expression of the neuronal tRNA n-Tr20 regulates synaptic transmission and seizure susceptibility
Loss of the nuclear-encoded brain-specific arginine UCU tRNA, n-Tr20, gene increases seizure thresho...
GSE146548: Inhibiting YAP1 in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte-like cells
Despite advances in surgical care and chemotherapeutic regimens, the five-year survival rate for Sta...
GSE145860: RNA_Sequencing Facilitates Quantitative Analysis of macrophages transcriptomes from Wild Type and miR_7 deficiency mice Transcriptomes
Purpose: The goals of this study are to analyze the differential gene expression of miR_7 deficienc...
GSE145803: Transcriptional comparison of in vitro and in vivo generated human dendritic cells
Classical dendritic cells (cDCs) are rare sentinel cells specialized in the regulation of adaptive i...
GSE153154: Characterization of mature Tregs in the thymus
Using Foxp3.RFP Rag.GFP reporter mice,; mature Tregs in the thymus were characterized by performing ...