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Sequencing-based assays page 109
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GSE150996: Neutrophil gene expression in adult-onset Still's disease
Adult-onset Stills disease (AOSD) is a rare autoinflammatory disease, characterized by fever, rash, ...
GSE146378: Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier
The goal of this study is to study endothelial cell Il1r1 signaling in EAE (multiple scleroris) SOUR...
GSE151706: Epidermis Kif3a knockout transcriptome reveals genes involved in skin barrier homeostasis
In order to address Kif3a role in skin barrier, we performed RNA-seq on 8 week old animals and addre...
GSE135584: Cytosolic Proteostatic Adaptation to Mitochondrial Stress Causes Progressive Muscle Wasting
Purpose: Muscle wasting (or atrophy) occurs in primary neuromuscular diseases and during aging, with...
GSE146887: Transcriptomic Characterization of Human Choroidal Neovascular Membranes Identifies Calprotectin as a Novel Biomarker for Patients with Age-related Macular Degeneration
Although genome-wide association studies, animal models, and cell culture systems have yielded impor...
GSE149884: The transcriptome of a murine model of melanoma initiation and progression unravels molecular signatures of phenotype switch and novel independent prognostic factors for melanoma patients
Despite advances in therapeutics, metastatic melanoma is still associated with a poor prognosis. The...
GSE147906: Anatomical locations of CD8+ memory T cells determine distinct mechanisms of reactivation I
Global profiling to investigate the consequence of the lack of TAP-1 on hematopoetic cell or non-hem...
GSE135648: An ontogenetic switch in the positive and negative selection of B cells [IgHEL]
Developing B cells can differentiate into a variety of different subsets, but the mechanisms that de...
GSE146402: Characterization of an Enzalutamide Resistant Primary Prostate Cancer Xenograft Derived from a Patient of West African Ancestry
Here we report the establishment and characterization of a Prostate Cancer Patient Derived Explant (...
GSE146845: Gender specific transcription regulation in the prefrontal cortex following social defeat stress
Major depressive disorder (MDD) affects ~20% of the world population and is characterized by strong ...
GSE147478: SWI/SNF complex mutations promote thyroid tumor progression and resistance to redifferentiation therapy (RNA-seq, Fig3)
Recurrent mutations in genes encoding subunits of the SWI/SNF chromatin remodeling complex occur com...
GSE146425: Tcf1 and Lef1 regulate follicular helper T cell function eliciated by vaccination [RNA-Seq]
The goal of this study is to determine the impact of Tcf1 and Lef1 deficiency on T follicular helper...
GSE154798: Hispidulin attenuates cardiac hypertrophy by improving mitochondrial dysfunction
Purpose:RNA-Seq analysis was performed on mouse hearts with or without hispidulin treatment 4 weeks ...
GSE151631: RNA sequencing of corneas from two keratoconus patient groups identifies potential biomarkers and decreased NRF2-antioxidant responses
Purpose: The goals of this study are to identify differentially expressed genes between keratoconus ...
GSE146472: Adolescent Social Isolation Reprograms the Medial Amygdala: Transcriptome and Sex Differences in Reward
Adolescence is a sensitive window for reward- and stress-associated behavior. Although stress during...
GSE154172: Heat shock protein gp96 induces Foxp3 expression in Regulatory T Cells via interaction with TLRs for treatment of Auto-immune Diseases [Foxp3Cre Myd88fl/fl]
Upregulate and stabilize Foxp3 expression in Treg are essential for manipulating Treg cell function ...
GSE146495: T cell transcriptomes in the course of allogeneic hematopoietic stem cell transplantation
RNA seq data of pooled T cells isolated from skin and blood at multiple time points before and after...
GSE149897: Negative feedback control of neuronal activity by microglia
Microglia, the brain resident macrophages, play a key role in the regulation of brain function by re...
GSE147327: Single-cell RNA sequencing of wildtype and miR-146a deficient T cells from mice treated with anti-PD-1 therapy
We observed increased severity of immune related adverse events (irAEs) to anti-PD-1 therapy as well...
GSE154854: Single cell RNAseq analysis of organotypic brain slice microglia
Single cell RNA sequencing analysis was performed on microglia isolated from brain slices (timepoin...
GSE154092: A combination of growth factors and cytokines alter mouse fetal liver and placental gene expression profiles.
This study investigated the effects of preimplantation exposure to combined Growth factors and cytok...
GSE139421: Investigating Global Changes in Gene Expression in a Murine Model of Cherubism
Purpose: To identify the mechanistic changes that lead to impaired osteogenesis and spontaneous oste...
GSE146401: High throughput RNA sequencing of hepatocellular carcinoma and pre tumor samples from Tdg fl/-; UBC-cre/ERT2+ mice livers and their age/sex matched Tdg fl/fl controls livers
We isolated whole livers from male TDG knockout livers (4-month post tamoxifen injection) and HCC, a...
GSE147469: RNA Seqeuncing of Adult Tissue after Maternal Diet Manipulation
We report differnces to gene expression in the Dorsal Striatum, Ventral Striatum, Ventral Tegmental ...
GSE151312: Effect of XCT790 on Human Aortic Valve (AV) Endothelial Cells (ECs) from Patients with Healthy Tricuspid, Calcified Tricuspid, or Calcified Bicuspid Avs
RNA-seq on human primary AV ECs from patients with healthy tricuspid, calcified tricuspid, or calcif...
GSE146387: Stabilizing heterochromatin by ZKSCAN3 safeguards hMSCs from senescence
Zinc finger protein with KRAB and SCAN domain 3 (ZKSCAN3), a transcriptional repressor, involves in ...
GSE147496: RNA-seq of primary mouse B cell progenitor populations after activation with LPS
Naive resting B-cells were purified from bone marrow from C57BL/6 mice using flow cytometry sorting....
GSE153521: Integrative profiling of early host chromatin accessibility responses in human neutrophils with sensitive pathogen detection [RNA-seq]
ATAC-seq and RNA-seq of primary human neutrophils challenged with multiple pathogen mimicking ligand...
GSE135649: An ontogenetic switch in the positive and negative selection of B cells [B cell subsets]
Developing B cells can differentiate into a variety of different subsets, but the mechanisms that de...
GSE137321: c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program [RNA-seq]
The transcription factor c-Maf is an essential regulator of group 3 ILC homeostasis and effector pla...
GSE146912: Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury
Background: The kidney glomerulus is a specialized capillary bed that is involved in urine productio...
GSE137869: Caloric restriction reprograms the single-cell transcriptional landscape of Rattus norvegicus aging
To obtain the first aging and CR cell atlas, we systematically analyzed 168,703 cells across 6 kinds...
GSE149947: Gene expression classifiers identify bacterial and viral etiologies of acute respiratory illness in Sri Lanka.
Previously developed gene expression signatures had high predictive accuracy at distinguishing viral...
GSE135703: Characterizing adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq: Validation in the adult mouse and translational implications for the adult human cochlea
Characterizing adult cochlear supporting cell transcriptional diversity using scRNA-Seq; Hearing los...
GSE148292: Effects of BMPER, CXCL10 and HOXA9 on neovascularization during early-growth stage of primary high-grade glioma
Neovascularization is required in high-grade glioma (HGG). The objective of this study was to explor...
GSE148347: High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays
Stem-cell-derived epithelial organoids are routinely used for the biological and biomedical modellin...
GSE150243: Differential gene expression of neutrophils that lack lymphotoxin beta receptor identifies a metabolic gene signature
Isolating Neutrophils from mouse blood, we employed bulk RNAseq and DE gene expression analysis to d...
GSE150069 (mouse): Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline
Translation of NRF1/NRF2-mediated liver tissue biomarkers to an in vitro assay using an advanced mic...
GSE146371: Analysis of Transcriptome in hematopoietic stem cells after radiation injury with treatment of EGF or saline
Purpose: This study is designed to understand whether Epidermal Growth Factor treatment alters the t...
GSE146731 (mouse): Histone H3.3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis
Histone H3.3 glycine 34 to arginine/valine (H3.3G34R/V) mutations occur in deadly hemispheric high-g...
GSE148356: bulk mRNA sequencing of splenic Red Pulp Fibroblasts (RPF) and lymph node Fibroblastic Reticular Cells (FRC)
bulk mRNA sequencing was used to compare the fibroblastic nature of RPF and FRC transcriptomes, and ...
GSE148510: RNA-sequencing of Wild-type and Bmal1 KO M1 macrophages
The goal of this study was to determine role of the circadian regulator Bmal1 in metabolic regulatio...
GSE154216: Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development (RNA-seq)
We investigated the role of Paired Box 9 in regulating the transcription of mRNAs required for human...
GSE135710: Single-cell RNA-seq of B cell polustion in breast cancer patients
Re-education of immune cells in tumor microenvironment is required for optimal treatment outcome. Th...
GSE147366: RNA sequencing of HAP1 WT and MED13 KO clones
Purpose: The aim of the experiment was to eludicate differentialy expressed genes (DEGs) upon treatm...
GSE146747: Regulation of Ag-activated B cells by Nur77/Nr4a1
We identify differentially expressed inducible genes in activated B cells harvested from mice lackin...
GSE147778: Protein Kinase / suppresses liver cancer by repressing autophagy and oxidative phosphorylation in hepatocytes [RD]
Oxidative stress plays a critical role in liver tissue damage and in hepatocellular carcinoma (HCC) ...
GSE148849: Gene Expression Analysis of the response to ACC inhibition
BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by h...
GSE145284: The omentum of obese girls harbors small adipocytes and browning transcrips
Severe obesity (SO) affects about 6% of youth in US, augmenting the risks for cardiovascular disease...
GSE135667: Col6a1-/- Mouse Lung
Collagen 6 (COL6) is known for its role in a spectrum of congenital muscular dystrophies, which are ...
GSE146470: The lipid handling capacity of subcutaneous fat is programmed by mTORC2 during development
Obesity causes type 2 diabetes, cardiovascular diseases, NAFLD, and cancer, but all fat is not equal...
GSE147339: Inflammasome Signaling and Impaired Vascular Health in Psoriasis
De-identified RNA sequencing of whole blood in psoriasis and control participants SOURCE: Michael,Se...
GSE154211: RNA-Seq analysis of HCV-related HCC and NBNC-HCC tumor and non-tumor part gene analysis
We performed RNA-seq analysisfor 2 HCV-HCC and 3 NBNC-HCC tumor and non-tumor regions, total for 10 ...
GSE149887: Differential gene expression in mouse myeloid cells
Among hematopoietic cells, osteoclasts (Oc) and immature dendritic cells (Dc) are closely related my...
GSE147608: Transcription profiling of monocytes from patients with active and inactive systemic juvenile idiopathic arthritis.
Systemic juvenile idiopathic arthritis (SJIA) confers high risk for macrophage activation syndrome (...
GSE147368: Functional characterization of the novel GWAS-identified GP2 coding variant
In a meta-analysis of three GWASs in the Japanese population, we identified a novel locus at 16p12.3...
GSE138753: CC10+ KP vs CC10+ KPG1 tumours
Glucose transporters are the first and rate-limiting step for cellular glucose usage, which is often...
GSE137347 (mouse): The transcriptomic landscape of MAIT cell development in the thymus (NN41 RNAseq data set)
We report the transcriptomic landscape of MAIT cell development by examining thymic immature stage 1...
GSE147743: RNA stability measurements in RBMS1 knockdown cells and control cells
In order to identify RBMS1-dependent changes in RNA stability, RBMS1 levels in SW480 breast cancer c...
GSE145347: Single Cell RNA sequencing of MAFB +/+ and -/- cells at the pancreatic progenitor and beta-like stages
Pancreatic Beta-cells are essential for regulating blood glucose levels. Much of our knowledge relat...
GSE137398: Single-cell profiles of retinal neurons differing in resilience to injury reveal neuroprotective genes - Time course of transcriptomic changes in single retinal ganglion cells following optic nerve crush
Neuronal types in the central nervous system differ dramatically in their resilience to injury or in...
GSE148411: RNA sequencing data of microglia isolated from brains of WT, Hexb-tdTomato, Hexb-CreERT2 and Hexb-KO mice. [Hexb-KO]
RNA sequencing of FACS sorted microglia isolated from brain tissue of WT, Hexb-tdTomato, Hexb-CreERT...
GSE150238: An allosteric/intrinsic mechanism supports termination of snRNA transcription.
Termination of protein-coding gene transcription by RNA polymerase II (Pol II) depends on endonucleo...
GSE140779: A mammalian Wnt5aRor2Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis
Alveolar formation increases the surface area for gas-exchange and is key to the physiological funct...
GSE135841: Epigenetic priming by Dppa2/4 in pluripotency facilitates multi-lineage commitment
Epigenetic priming factors establish a permissive epigenetic landscape which is not required until a...
GSE146915: RNA-seq from lung E18.5
The impact of Mll3 removal on lung development was evaluated by mRNA profiling of three lung samples...
GSE150020: Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Epigenetic treatments)
Purpose: we aimed at providing the phenotypic profile of G-MDSCs based on their prognostic significa...
GSE151648: Transcriptomics of Human Liver Ischemia and Reperfusion Injury
For orthotopic liver transplants, ischemia-reperfusion injury (IRI) is known to compromise allograft...
GSE135819: GDE3 regulates oligodendrocyte precursor proliferation via release of soluble CNTFR
Oligodendrocyte development is tightly controlled by extrinsic signals; however, mechanisms that mod...
GSE147346: mRNA sequencing of stem cell-derived beta cells before and after transplantation in mice
A drastic transition at birth, from constant maternal nutrient supply in utero to intermittent postn...
GSE140822: Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map
While the cerebral cortex is organized into six excitatory neuronal layers, it is unclear whether gl...
GSE146452: Reduced Type I Interferon response signature detected in dendritic cells from prediabetic NOD mice compared to C57BL/6.g7 and Rag KO [stimulated samples]
Investigating type I interferon in prediabetic stage of DCs from NOD mice compared to C57BL/6.g7 and...
GSE154918: RNAseq analysis of blood from sepsis patients and healthy controls
Gene expression changes in the blood was studied by RNAseq; Results: Strong differences between pati...
GSE147404: Gene expression in human embryonic stem cells (hESCs) upon the differentiation to neural lineages by timed delivery of retinoic acid
We report gene-expression profiling of hESCs differentiating to neuronal lineages upon the treatment...
GSE149888: RNA-sequencing of adipose-derived stem cells in 0 or direct-current electric field
The circRNA, lncRNA, miRNA, and mRNA levels of both the direct-current electric field and control gr...
GSE147990: SFR KO mice germinal center B cell RNA sequencing
WT-AID-GFP+ and SFR KO-AID-GFP+ mice were immunized with NP(18)OVA+ alum, on Day 9, germinal center ...
GSE151666: RNA sequencing of pre-treatment primary cervical cancer
Investigate the transcriptomic differences between HPV-positive and HPV-negative primary cervical tu...
GSE146403: Loss of the nuclear protein RTF2 enhances influenza replication
While hundreds of genes are induced by Type I interferons, their roles in restricting the influenza ...
GSE145051: Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
We report reproductive tract extracellular vesicles (EVs) transmit information regarding stress in t...
GSE146780: Enforced Expression of NUP98-HOXA10hd Fusion Gene in Multipotent Progenitors Support Long-term Hematopoiesis in primary mice [MPP]
Allogenic hematopoietic stem cell (HSC) transplantation is widely used for treatment of blood disord...
GSE152138: Immunomodulation of Intracranial Melanoma in Response to Blood-Tumor Barrier Opening with Focused Ultrasound - Bulk RNA seq
Activating microbubbles (MBs) with focused ultrasound (FUS) for blood-brain (BBB) and blood-tumor ba...
GSE151675: Activation of the myeloid checkpoint inhibitor LILRB3 (ILT5) elicits profound immununomodulation
Purpose:To investigate the potential immunomodulatory function of a new panel of LILRB3-specific mon...
GSE140869: Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection [VIII]
By CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that CB...
GSE151796: Comparison of two human organoid models of lung and intestinal inflammation reveals Toll-like receptor signalling activation and monocyte recruitment.
OBJECTIVES: The activation of immune responses in mucosal tissues is a key factor for the developmen...
GSE146474: Sin3A mutant pancreatic islets
Sin3A null islet cells compared with wild type SOURCE: Ken Lau (ken.s.lau@vanderbilt.edu) - Vanderb...
GSE151827: Non-CG methylation and multiple epigenetic layers associate child abuse with immune and small GTPase dysregulation
Early-life adversity (ELA) is a major predictor of psychopathology, and is thought to increase lifet...
GSE151897: RHEUMATOID ARTHRITIS SYNOVIAL MICROENVIRONMENT INDUCES METABOLIC AND FUNCTIONAL ADAPTATIONS IN DENDRITIC CELLS
Rheumatoid Arthritis (RA) is a chronic autoimmune disease which causes degradation of cartilage and ...
GSE146953: Transcriptome profiling of human peritoneal mesothelial cells grown in static and stretching conditions
RNA-Seq was used to characterize the changes induced by mechanical stretching on the gene expression...
GSE138771: Loss of microRNA-21 in K-Ras-driven mouse models of pancreatic cancer
The microenvironment of pancreatic cancer adenocarcinoma (PDAC) is highly desmoplastic with distinct...
GSE147929: Myocardial Infarction accelerates breast cancer progression via innate immune reprogramming (RNA-seq: sham vs LAD ligation)
Breast cancer patients have increased risk of myocardial infarction (MI), but whether these events i...
GSE109786: An investigation of the effect of anti-apoptosis mutations on human pluripotent stem cells transcriptome when apoptosis stress was applied
We performed RNA-sequencing on hPSCs treated with mitosis poison nocodazol (NOC) or MCL1 inhibitor A...
GSE150003: ATR inhibition potentiates ionizing radiation-induced innate immunity via sensing cytosolic RNA
Radiotherapy, widely used for cancer treatment for decades, is revitalizing through its ability to i...
GSE151813: RNA-Seq Analysis of mouse lung cancer cell lines derived from KP mice and Reprogrammed somatic cells
We report the gene expression profile of three murine lung cancer cell lines, and also comparing the...
GSE151926: Genome-wide transcriptional regulation of the long non-coding RNA steroid receptor RNA activator in human erythroblasts
We report a novel function of the lncRNA SRA in regulation of global gene expression through direct ...
GSE140773: The Toxoplasma gondii virulence factor ROP16 acts in cis and trans and suppresses T cell responses [CEP_invivo_Ai6_1dpi]
The ability of Toxoplasma gondii to inject the rhoptry kinase ROP16 into host cells results in the a...
GSE154936: Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR/Cas9 screening and transcriptomics
The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, wi...
GSE149890: Nascent RNA-seq of human AID-NeonGreen-Tpr tagged DLD-1 cells after loss of Tpr nucleoporin
We used SLAM-seq approach to define a contribution of RNA synthesis into RNA abundance changes after...
GSE137329: Loss of Maenli lncRNA expression causes engrailed-1 dependent congenital limb malformations [RNA-seq]
Long non-coding RNAs (lncRNAs) can be important components in gene regulatory networks1, but we are ...
GSE146954: Transcriptome profiling of WT and Cav-1- mouse peritoneal mesothelial cells grown in static and stretching conditions
RNA-Seq was used to characterize the changes induced by mechanical stretching on the gene expression...
GSE150027: Ethanol exposure drives colon location-specific cell composition changes in a normal colon crypt 3D organoid model
Here, we used bulk RNA-seq data derived from healthy colon organoids (un)exposed to ethanol. Through...