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Sequencing-based assays page 17
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GSE85329: Olfactory sensory neuron-specific IGF1R knockout in mice results in increased smell perception, insulin resistance and adiposity
Olfaction is fundamental for survival but there is little known about the connection between smell p...
GSE102630: Dietary effect on mouse intestinal Bmi1 stem cells
Dietary effect on mouse intestinal Bmi1 stem cells SOURCE: Wenge Li (wenge.li@einstein.yu.edu) - Aug...
GSE117551: Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition[thyroid]
This study assessed tumor suppressor roles of CREBBP in SCLC and other neuroendocrine tumors. Geneti...
GSE101596: Transcriptome analysis of fasted mouse livers
We report application of RNA-seq to quantify gene expression changes in fasted mouse livers compared...
GSE90958: ncRNA transcription-induced changes in nuclear architecture directs with high precision enhancer-promoter interaction
It is now well established that transcriptional enhancers dictate with high precision lineage-speci...
GSE104064: RNAseq data on HDAC Class IIa inhibitor (CHDI-00390576) dosed Q175 mice.
WT and Q175 heterozygous (het) mice treated orally twice a day with vehicle (10% HPCD), and Q175 mic...
GSE106389: RNAseq anaysis of ventral striatum cholinergic cells of p11 cKO mice
Purpose: To identify gene expression changes in cholinergic neurons of the ventral striatum of p11 c...
GSE156777: Next Generation Sequencing Facilitates Quantitative Analysis of Control and rhCYGB treated liver transcriptomes [TAA]
Purpose: The goal of this study is to investigate the effect of recombinant human Cytoglobin (rhCYGB...
GSE110018: PU.1 represses and activates gene expression in early T cells by redirection of transcription factor ensembles [RNA-Seq]
Transcription factors normally regulate gene expression through their action at sites where they bin...
GSE102639: RNA seq_A375 gSMARCB1 + A549 etoposide, Aurora kinases inhibitors treated
To study the senescence gene signatures in the cells, which were genetic SMARCB1 depleted or treate...
GSE132969: Vitamin C dependent KDM6 demethylation specifies a functional chromatin state for endothelial-to-hematopoietic transition [RNA-Seq]
Hematopoietic stem/progenitor cells (HSPCs) are generated from hemogenic endothelial cells (HECs) th...
GSE95293: KDM4 inhibition targets breast cancer stem cells [RNA-Seq]
We treated breast cancer stemm cells (BCSC) with a KDM4 inhibitor SOURCE: Eric Metzger Uniklinik-Fre...
GSE92323: Requirements for different Tcf1 isoforms in T cell development
Comparison of transcriptome between control, Tcf1 long isoform (p45)-deficient, complete Tcf1-defici...
GSE101510: IRF4 modulates CD8 T cell sensitivity to IL-2 family cytokines
The purpose of this study is to identify expression differences between wild type CD8 T cells vs IRF...
GSE85360: The histone 3 lysine 4 methyltransferase Setd1b is a maternal effect gene required for the oogenic gene expression program
Germ cell development involves major reprogramming of the epigenome to prime the zygote for totipote...
GSE92293: RNA-seq in neutrophils from Juvenile Idiopathic Arthritis
In this study, we explored transcriptional complexity in human neutrophils from juvenile idiopathis ...
GSE89482: Gene Expression in Cx3cr1-GFP+ Cells in PS2APP Alzheimer's Disease mice
This project defines the microglial gene expression profile in a transgenic mouse model of Alzheimer...
GSE101904: A quantitative chemotherapy genetic interaction map identifies new factors associated with PARP inhibitor resistance
The goal of this study was to understand the gene expression changes in MCF10A cells with GPBP1 knoc...
GSE93313: Expression Analysis of 2D, 3D Quiescent, and 3D Activated Pancreatic Stellate Cells
This study used Illumina single-end RNA-sequencing to examine gene expression differences between 2 ...
GSE106390: Next Generation Sequencing Analysis of B16F10.9 melanoma cells untreated or treated with IFN-gamma
We compare gene expression in B16F10.9 melanoma cells untreated or treated with IFN-gamma SOURCE: Ar...
GSE94315: Higher levels of heteroplasmy at OriL control mtDNA copy number, glucose metabolism and lifespan in mice
Higher levels of the 12A heteroplasmy control mitochondrial function and metabolic pathway, conseque...
GSE86021 (mouse): Crenolanib in combination with azacitidine abrogates stromal protection and survival of leukemia-initiating cells in FLT3-ITD+ AML
Effectively targeting leukemia-initiating cells (LIC) in FLT3-internal-tandem-duplication (ITD)-muta...
GSE105068: Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (lungs)
Here we compare gene expression profiles between lungs taken from a Wild type mouse to lungs from a ...
GSE101016: Dynamic regulation of T Follicular Regulatory (Tfr) cell responses by IL-2 during influenza infection
We found that approximately 2,000 genes were differentially expressed between conventional Treg and ...
GSE100941: Cerebellar granule cell replenishment postinjury by adaptive reprogramming of Nestin+ progenitors
We report the application of RNA-sequencing for high-throughput profiling of gene expression in Nest...
GSE95626: MLL4 establishes super-enhancers and broad H3K4me3 for tumor-suppressive function
Clusters of enhancers called super-enhancers are associated with gene activation. Broad trimethyl hi...
GSE102113: Acetylation of cytidine in messenger RNA
Generation of the "epitranscriptome through post-transcriptional ribonucleoside modification embeds ...
GSE93974: Kdm2b regulates somatic reprogramming through variant PRC1 complex dependent function [RNA-seq]
Polycomb repressive complex 1 (PRC1) plays essential roles in cell fate determination. Recent studie...
GSE124936: Genomic Resolution of DLX-orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons
DLX transcription factors (TFs) are master regulators of the developing vertebrate brain, driving fo...
GSE107149: DNA methylation state is associated with the formation of loops and links in hematopoietic stem cells [RNA-seq]
We present the high resolution HiC study of genome folding in primary hematopoietic stem and progeni...
GSE94372: downregulation of DDX5 and DDX17
RNAseq : MCF-7 cells were transfected with siRNA targeting both DDX5 and DDX17 RNA helicases, and to...
GSE101558: Genome expression analysis of Lung Progenitors matured in the presence of constitutively active or pharmacologically inhibited Glycogen Synthase Kinase 3
In 3D cultures of hPSC-derived lung progenitors withdrawal of the GSK3 inhibitor, CHIR99021, induces...
GSE94144: Selective inhibition of EZH2 by a small molecule inhibitor regulates microglia gene expression essential for inflammation
Impressive studies have been well documented that Enhancer of zeste homolog 2 (EZH2) could have a ro...
GSE106468: RNA-seq profiles of WT and Qk-KO corpus callosum and oligodendrocytes
This study is to analyze the transcriptomic profiles of Plp-CreERT2;QKLoxP/LoxP (Qk-KO) and Plp-CreE...
GSE100269: LEC-induced gene expression changes in melanoma cells
RNA sequencing to analyze the gene expression changes in the WM852 and Bowes melanoma cells upon the...
GSE90655: Clonal conversion of B-lymphoid leukemia reveals cross-lineage transfer of malignant states.
Even though leukemia is considered as confined to one specific hematopoietic cell type, cases of acu...
GSE100316: RNA-seq analysis of mTOR{delta}APC and WT lung and spleen APC subsets
Purified CD11b+, Alveolar macrophage and HDM induced inflammatory DCs from WT and mTOR{delta} APC mi...
GSE102185: Effect of FGF13 depletion on the H460 cell line
The purpose of our study was to explore the relevance of the FGF13 protein in a NSCLC cell line SOUR...
GSE103307: Role of FGFR1 in neuronal devlopment
Purpose: The goal was to study the effects of nFGFR1 on neuronal progenitor cells, by analyzing diff...
GSE90466: CHD7 controls cerebellar development via Reelin
Mutation of the gene encoding the ATP-dependent chromatin remodeler CHD7 causes CHARGE syndrome. The...
GSE94353: Hepatocyte maturation
We report the maintenance of mature metabolic function and their induction in primary and hepatic ce...
GSE103390: Transcriptomic analysis of brainstem samples from mutants with Hoxa5 postnatal inactivation versus controls at postnatal day 21
After inactivation of Hoxa5 at postnatal days (P)1-P4, we established RNA-seq profiling with RNA ext...
GSE86903 (mouse): Comparative principles of DNA methylation reprogramming during human and mouse in vitro primordial germ cell specification [Mouse and Human RNA-seq and BS-seq]
Primordial germ cell (PGC) development is characterized by global epigenetic remodeling, which reset...
GSE117547: Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition[SCLC]
This study assessed tumor suppressor roles of CREBBP in SCLC and other neuroendocrine tumors. Geneti...
GSE109922: Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis
Genetic studies have identified recurrent somatic mutations in Acute Myeloid Leukemia (AML) patients...
GSE94142: Genome wide maps of H3K4me3, H3K27me3 and H3K27ac in Brachyury mutants and RNA-seq data of Brachyury mutants
The transcription factor BRACHYURY is the founding member of the T-box family of proteins. A conserv...
GSE119631: Characterization of the dynamics of lamin A and lamin B LADs in HepG2 cells: impact of cyclosporin A
Purpose: to qualify and quantify the rearrangement of interactions of nuclear lamins A/C and B with ...
GSE109195: Comparing the Transcriptomes of Marf1-genetrap (GT) oocytes with those microinjected with mRNAs for wild type MARF1 (GTWT) or D272-mutated MARF1 (GTD272) by RNA-Seq Analysis
The goal of this study is to reveal the globle effect of supplementation with either wild type MARF1...
GSE96050: ZFP36 RNA binding proteins restrain T-cell activation kinetics and anti-viral immunity [RNA-seq]
Dynamic post-transcriptional control of RNA expression by RNA-binding proteins (RBPs) is critical du...
GSE92965: Cardiac microvascular endothelail cells of EC-KLF2 and/or KLF4 knockout mice at day 6 post-tamoxifen
Maintenance of vascular integrity in the adult animal is needed for survival and critically dependen...
GSE85353 (mouse): DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance [RNA]
Background: Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by a...
GSE107199: Next Generation Sequencing for Quantitative Transcriptomic Profiling of TLR3, TLR7 and TLR8 Activation in Neurons
The goal of this study is to compare gene expression of mouse cultured cortical and hippocampal neur...
GSE103664: The Estrogen Receptor (ER) has stage- and cell type-specific roles in the mammary epithelium with distinct requirements for activation function-1 and -2
We provide evidence that luminal responder cells express low level ER required for cell expansion du...
GSE102812: RNA-seq of FSHD and control immortalised myoblasts
FSHD and control immortalised myoblasts show repression of Pax7 target genes SOURCE: Christopher,Raj...
GSE96961: Environmental enrichment prevents transcriptional disturbances induced by alpha-Synuclein overexpression
Using a mouse model overexpressing human SNCA and profiling the hippocampal transcriptome, we assess...
GSE112823: The gene expression profiles of antigen-primed wildtype and Ddit3-/- CD8 Pmel T cells
T cell undergoes ER stress during regular priming which may lead to T cell dysfunction in cancer. ER...
GSE84589: Cis-regulatory landscape of four cell types of the retina
The retina is composed of ~50 cell-types with specific functions for the process of vision. Identifi...
GSE93359: Transcriptome analysis of p16/p21-dependent monocytic myeloid-derived suppressor cells accumulation.
p16 and p21 act as tumor suppressors through induction of cellular senescence. However, senescence-...
GSE94768: Comparison of Wild type and Pofut1-deleted skeletal muscle in young and old mice
Pofut1 is an essential gene that glycosylates proteins containing EGF-like repeats, including Notch ...
GSE101540: RNA-seq of cancer cell lines treated with T-025
4 cancer cell lines were treated with T-025 for 6 hours; T-025 is a novel small molecule inhibitor o...
GSE99353: Frontal cortex transcriptomic analysis of a TDP-43 Q331K knock-in mouse
Here we analyse transcriptome profiles within the frontal cortex between wild type, heterozygous and...
GSE93031: Defects in dosage compensation impact global gene regulation in the mouse trophoblast
X chromosome inactivation (XCI) is critical for the development of the extraembryonic tissue as well...
GSE93339: Transcriptome analysis of wild-type and Yap-deficient embryonic lungs by RNA-Seq
We extracted total RNA from wild-type and Yap-f/f;Shh-Cre/+ embryonic lung 12.5 dpc, and perform RNA...
GSE93381: Gene expression profiling (RNA-seq with partial depletion of rRNA) of livers of hypophysectomized male mice treated with a single pulse of growth hormone (GH)
We investigated the effects of a single pulse of growth hormone on the transcriptional activation of...
GSE94159: Gene expression changes after blockade of Frizzled7 in murine intestinal organoids
RNA was isolated from intestinal primary mouse organoids at 6h and 24h after treatment with dFz7-21 ...
GSE99989: Epidermal Wnt signaling regulates transcriptome heterogeneity and proliferative fate in neighboring cells
We performed single-cell mRNA-Seq on wild-type mouse keratinocytes co-cultured with keratinocytes in...
GSE94659: Next Generation Sequencing Facilitates Quantitative Analysis of Ern1f/f and Ern1f/fLyz2-Cre macrophage Transcriptomes
Purpose: IRE1 are indicated to play important role in LPS-induced macrophage activation. The goals o...
GSE94843: RNA-sequencing of murine norovirus (MNV) infection and loxoribine (Lox) stimulation in RAW264.7 macrophages
This study aimed to generate a comprehensive analysis of changes in the transcriptome following MNV ...
GSE124233: The non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice
FAM46C has been proved to be a RNA polyadenylation polymerase. Fam46c KO resulted in male infertilit...
GSE101991: Retinoic acid regulation of bone marrow-derived LCs
This study investigates the impact of retinoic acid on Langerhans cell gene expression SOURCE: Chang...
GSE94011: E3 SUMO ligase PIAS3 fine-tunes dorsoventral patterning and visual response of cones in the mouse retina but is not essential for photoreceptor cell fate specification
Differentiation of distinct neurons in the developing retina is controlled by combinatorial action o...
GSE95141: RNA sequencing of striatum tissue from naive Csnk1e knockout mice and wild-type mice
RNA sequencing of striatum tissue from naive Csnk1e knockout mice and wild-type mice SOURCE: Lisa Go...
GSE92723: Transcriptome analysis for KDM6A mutated urothelial bladder carcinoma and EZH2 inhibitor treated KDM6A mutated urothelial bladder carcinoma
Purpose: The goals of this study are to compare 1. The transcription profile in KDM6A wildtype and ...
GSE107419: Comprehensive mapping of transcriptional networks specifying lactogenic differentiation of murine mammary epithelial stem like cells
Purpose: Understanding of gene transcriptional networks specifying murine mammary epithelial cells ...
GSE102138: Transcriptional profiling identifies differential expression of long non-coding RNAs in Jo-1 associated and inclusion body myositis
Myositis is characterised by muscle inflammation and weakness. Although generally thought to be driv...
GSE96650: Next Generation Sequencing of Wild Type and LXR-Ser196 phosphorylation deficient Murine Hepatic Transcriptomes on a Chow diet
Liver X Receptors (LXR and ) are ligand-activated transcription factors that play a key role in the ...
GSE83471: Hierarchical RNA processing is rate limiting for mitochondrial ribosome assembly
In animals the organization of the compact mitochondrial genome and lack of introns have necessitate...
GSE98947: Cell surface polysaccharides of Bifidobacterium induce functional regulatory T cells
To characterize the effect of CSGG in dendritic cell phenotypic changes, we performed gene expressio...
GSE107407: Transcriptome of ESCs upon MLL1 inhibition/deletion
This study describes the transcriptome profiling of: 1) Mll1fl/fl mESCs in LIF/Serum medium as contr...
GSE92999: Co-clinical analysis of a genetically-engineered mouse model and human prostate cancer reveals significance of NKX3.1 expression for response to 5-reductase inhibition (Mouse Finasteride Prostate RNASeq)
Analysis of transcriptome from 12 month old finasteride (and vehicle) treated mouse prostatic tissue...
GSE93416: Expression Profiling of MEFs and SKOM induced reprogramming cells after modulation of Cell cycle and Dnmt1 expression
To generate association of DNA methylation level and gene expression profile, we applied RNA-sequenc...
GSE94671: The BLUEPRINT Murine Lymphocyte Epigenome Reference Resource [RNA-seq]
This data release is part of the EU BLUEPRINT reference epignome project (http://www.blueprint-epige...
GSE102642: Gene expression of ectoplacental cones of early post-implantation embryos (6.5 days post-coitus) from control and obese dams
We used a low-input strand specific total RNA library preparation kit to obtain transcriptomes from ...
GSE144709: Effect of C3a treatment over cell death of pancreatic islets ex vivo
RNAseq of islets from WT mice treated in vehicle or palmitate conditions, wit or without recombinant...
GSE90531: Deletion of Histone Deacetylase 3 in Adult Beta Cells Improves Glucose Tolerance via Increased Insulin Secretion
Objective: Histone deacetylases are epigenetic regulators known to control gene transcription in var...
GSE102792: Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy
Cardiac-restricted deletion of myocardin-related transcription factors (MRTFs) in adult mice leads t...
GSE127469: Single cell RNA-seq identifies cell diversity in embryonic salivary glands [Single cell RNA-seq]
Our single-cell and bulk transcriptome analyses revealed striking molecular heterogeneity in the mes...
GSE104018: RNAseq of T-ALL upon long non coding rna purturbation
T cell leukemia cell lines transciptome changes upon long non coding RNA knockdown by CRISPR and ASO...
GSE102817: Transcriptome analysis of splenic monocytes from Foxp3DTR and WT mice post-MI versus sham operated animals
Objective: To study the impact of endogenous CD4+ Foxp3+ T-cells on splenic monocyte differentiation...
GSE112318: The long noncoding RNA lnc-ob1 facilitates bone formation by upregulating Osterix in osteoblasts
Long noncoding RNAs (lncRNAs) have emerged as integral regulators of physiology and disease, but spe...
GSE102808: Analyzing differential gene expression pattern upon BRUCE knockdown in full medium and starvation conditions
BRUCE was identified as a novel positive regulator of autophagy. By analyzing changes in mRNA levels...
GSE142581: DELTA1/NOTCH2-mediated signaling regulates muscle stem cell self-renewal
How satellite cells and their progenitors balance differentiation and self-renewal to achieve sustai...
GSE103173: The transcription factor Bhlhe40 is a switch of inflammatory versus anti-inflammatory Th1 cell fate determination
Type 1 T helper (Th1) cells play a critical role in host defense against intracellular pathogens and...
GSE103200: Comparing gene expression in livers of 1-month vs 6-month old mice following DEN treatment
To look for age-related changes in the liver that take place during DNA damage resolution, we used R...
GSE104906: ERR coordinates a transcriptional program of mitochondrial and renal reabsorptive functions implicated in kidney disease[RNA-seq]
Here we show that estrogen-related receptor (ERR) is an essential transcriptional coordinator of bo...
GSE83144: Alteration in microRNA-25 Balance Causes Heart and Kidney Impairment
Contradictorily, both up- and downregulation of miR-25 can reverse heart failure. Importantly, these...
GSE97993: Transitory accumulation of myeloid-derived suppressor cells in neonates is critical for maintenance of homeostasis
Myeloid-derived suppressor cells (MDSC) are potent negative regulators of immune responses at many p...
GSE92625: PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not nave ESCs
We generated deletion of core components of PRC2 in human embryonic stem cells, (H1, H1-EZH1-/-, H1-...
GSE99709: RNA-Sequencing of Stat3 silenced oligodendrocyte progenitor cells.
We examine the role of Stat3 in oligodendrocyte progenitor cells and determine that direct binding o...
GSE96774: Replication defective viral products exploit a cellular pro-survival mechanism to establish persistent infections
Replication defective viral genomes (DVGs) generated during virus replication are the primary trigge...