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Talk to our team for accessPluto has a large database of published data, available to explore, conduct your own analysis, and view QC reports.
Talk to our team for accessStore large, raw sequencing data files and transform them into biologically-meaningful results in your browser. Gain critical QC information, quantify targets within and across data sets, and run best-in-class computational biology analyses specific to each assay type.
We evaluate the effects of chronic administration of antipsychotic haloperidol versus placebo in mal...
Recent reports have proposed a new paradigm for obtaining mature somatic cell types from fibroblasts...
Chromosomal rearrangements of the Mixed Lineage Leukemia (MLL) gene result in fusion proteins which ...
To identify FUS regulated genes and its dependency of snRNP70, the gene expression profiles in neuro...
We have generated expression profiles of induced pluripotent stem cells (iPSCs) and iPSC-derived neu...
Although membrane-anchored PD-L1 has been well-studied for its engagement with PD-1 on T cells to ev...
We discovered that two mitotic regulators, BuGZ and Bub3, involved in splicing regulation during int...
The enhancer landscape is dramatically restructured as nave preimplantation epiblasts transition to ...
We used RNA-seq to examine the effect of Myc activation on U2OS cells transcriptome. We also examine...
We found that -arrestin 1 -/- mice were more sensitive to hypoxia-induced pulmonary arterial hyperte...
The generation of induced pluripotent stem cells (iPSCs) and the direct conversion approach provide ...
The advent of Next Generation Sequencing has allowed transcriptomes to be profiled with unprecedente...
-77-/- mice exhibited late embryonic lethality, anemia, and a constellation of phenotypes. -77 confe...
Our data provide a comprehensive list of transcriptomics alterations and warrant holistic approach i...
5-methylcytosine (5mC) regulates multiple cellular processes and is faithfully maintained following ...
MUC1 kidney disease mouse model generated by knock-in of the human mutated MUC1-fs gene. The mice we...
Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, a...
We studied the effect of knocking down SUZ12 on the responsiveness of IFNg target genes SOURCE: Rod ...
Primary mouse embryonic fibroblasts (MEFs) from wt and MK2/3 KO mice were treated with 20M etoposide...
Target competition (ceRNA crosstalk) within miRNA-regulated gene networks has been proposed to influ...
The use of the hormonal contraceptive DMPA has been associated with a moderate increase in sexually ...
It is well known that both recipient cells and donor nuclei demonstrate a mitotic advantage as obser...
The most immature progenitors in the murine thymus are early T lineage progenitors (ETP). These cell...
Single cell suspension of hippocampus was generated and single cell mRNAseq libraries were prepared ...
Purpose: The goals of this study are to establish a roadmap of XCI and compare the transcriptomes of...
Transcription factors related to the insect sex determination gene Doublesex (DMRT proteins) control...
Turnover and exchange of nucleosomal histones and their variants, a process long believed to be stat...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and highly lethal lung disease with un...
Expression levels of the RNA-binding protein Quaking (QKI) are low in monocytes of early, human athe...
We have found that BCL6 is a component of the conserved stress response program regulated by HSF1. B...
Single cell transcriptomics has emerged as a powerful approach to dissecting phenotypic heterogeneit...
Obesity is linked to the development of metabolic disorders. Expansion of white adipose tissue (WAT)...
This Study sought to understand the differential gene expression profile of Pkd2 mutant mice kidneys...
The MYC transcription factor is an unstable protein and its turnover is controlled by the ubiquitin ...
NR4A nuclear receptors are known tumor suppressors of acute myeloid leukemia and are essential regul...
Single-cell transcriptomics requires a method that is sensitive, accurate, and reproducible. Here, w...
RNA-Seq data of micoglia isolated from brains of indicated mouse types. SOURCE: Ido Amit (ido.amit@...
Human embryonic stem cells (hESCs) have the unique property of immortality, ability to infinitely se...
Splicing of precursor mRNA (pre-mRNA) is an important regulatory step in gene expression. Recent evi...
Direct lineage reprogramming represents a remarkable conversion of cellular and transcriptome states...
We have sequenced wildtype and mutant heart, liver, lung, and hindlimb from E14.5 embryos of the mut...
RNA-seq analysis of LPS stimulated bone marrow-derived macrophages, derived from heterozygous Il19-t...
Purpose: The goals of this study are to assess the transcriptional networks governed by the transcr...
We compare GW9662 (PPARg antagonist) treated CD4+ T cells under Th2 coculture conditions with vehicl...
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory ...
Purpose: This study was carried out to determine the consequences of the Rfx2-/- genotype on spermat...
We found that EGR1 stimulates the expression of EZH2, which in turn inhibited the expression of EGR1...
E2A is an essential regulator of early B-cell development. Here we demonstrated that E2A together wi...
Comparison of the TP53 wild-type myeloma cell line AMO1 with the CRISPR/Cas9 engineered AMO1 cell li...
Insulin action in adipocytes affects whole-body insulin sensitivity. Studies of adipose-specific Glu...
In developing male germ cells, prospermatogonia, two Piwi proteins, MILI and MIWI2, use piRNA guides...
Lamins are components of the peripheral nuclear lamina and interact with heterochromatic genomic reg...
We investigated parent-of-origin and allele-specific expression effects on obesity and hepatic gene ...
Data accompaning to van Gurp et al. Development 2019. single-cell sequencing of the developing mouse...
The global impact of DNA methylation on alternative splicing is largely unknown. Using a genome-wide...
To study the development and function of natural-arising T regulatory (nTreg) cells, we developed a ...
Gan mice express Wnt1, Ptgs2, and Ptges, which develop inflammation-associated gastric tumors (Oshim...
Characterize the spatiotemporal dynamics of gene expression in neurons in developing olfactory bulb ...
Microglia and macrophages are immune cells that differ in the inflammatory response to immune challe...
In many mouse models of skin cancer, only a few tumors typically form although many cells competent ...
Purpose: A) compare the gene expression in whole DRG and in large diameter DRG neurons of mice expos...
Studies from global loss-of-function mutants suggest that alternative NF-kB downstream of NF-kB indu...
The ZFP36L3 protein is a rodent-specific, placenta- and yolk sac-specific member of the tristetrapro...
We profile 36,199 single-cell transcriptomes at multiple timepoints throughout a highly efficient ch...
Disruptions of protein homeostasis in the endoplasmic reticulum (ER) elicit activation of the unfold...
CT26 tumors were implanted subcutaneously into syngeneic BALB/C mice and allowed to grow for 15-25 d...
Transposable elements (TEs) comprise a substantial proportion of primate genomes. Because of the pot...
In order to investigate how transcription factor dose impacts B-lymphocyte development, we generated...
single cell polyA+ and total RNA-seq data was generated for NGP, SK-N-BE-2C and SHSY5Y-MYCN-TR cells...
Global DNA demethylation occurs in vivo in the early embryo and primordial germ cells, and in vitro ...
The goal of this study is to compare the transcriptome of the 2 MVT1 subpopulations in order to iden...
We characterized the gene expression differences in mDA neurons from all PD (Parkinson's disease) ca...
Purpose: To use RNA-Seq analysis of endothelial cell in various Notch1 alllels in order to determine...
To better understand molecular mechanisms of human pancreatic development associated with GATA6 hapl...
The DNA-binding protein, Ikaros, functions as a potent tumor suppressor and hematopoietic regulator....
We report the effects of 1,25(OH)2D3 treatment on the mRNA expression in human muscle cells SOURCE: ...
Alternative Cleavage and Polyadenylation (APA) plays a crucial role in the regulation of gene expres...
We report global RNA expression profiles in whole heart ventricle tissue from postnatal day 2 mice t...
To define ncRNA expression in hypoxic endothelial cells, we applied pro-angiogenic hypoxia to cultur...
Our study reveals that ischemic stroke can influence the expression of LncRNAs and mRNAs in the peri...
We previously utilized interval-specific congenic lines derived from C57BL/6J (B6) and DBA/2J (D2) ...
Somatic differentiation requires induction of lineage specific genes to fulfill specialized tissue f...
High uniform fluid shear stress (FSS) is atheroprotective and preserves the endothelial phenotype an...
RNA-seq were performed with six samples, WT KH2 ESCs treated with or without PD0325901 for 48 hours ...
The transcriptional coactivator Yap promotes proliferation and inhibits apoptosis, suggesting that Y...
Lysophosphatidic acid receptor 1 (LPA1) is a phospholipid which has been linked to adult hippocampal...
We previously showed that STAT3 regulates myoblast differentiation in cell culture models, yet its r...
We performed RNA-sequencing on erythropoietic cells cultured in normoxia or hypoxia at days 3,7, and...
Purpose: The goal of this study is to compare downstream genes of Sema6D signaling in LPS plus IFNg ...
Promiscuous gene expression (pGE) of numerous self-antigens in thymic epithelial cells (TEC) enables...
Aged mdx mice were treated with 2.5x105 cardiosphere-derived cells (CDCs) or 2.0x109 exosomes intrav...
Granulopoietic differentiation of myeloid progenitor cells derived from control iPSCs was performed...
Ten-Eleven-Translocation-2 (Tet2) is a DNA methylcytosine dioxygenase that functions as a tumor supp...
Synthetic DNA-binding proteins have found broad application in gene therapies and as tools for inter...
The molecular clock is a transcriptional oscillator present in brain and peripheral cells that coord...
We ovexpressed human alpha synuclein alone or together with Nurr1 in mouse primary midbrain cultures...
Background & Aims: Perturbations in pancreatic ductal bicarbonate secretion often result in chronic ...
Identification of temporal changes in gene expression in macrophages isolated from the site of nerve...
Background: To determine differentially expressed and spliced RNA transcripts in chronic lymphocytic...
Maternal stress, anxiety, and depression increase the risk of psychiatric disorders in the progeny. ...