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Talk to our team for accessPluto has a large database of published data, available to explore, conduct your own analysis, and view QC reports.
Talk to our team for accessStore large, raw sequencing data files and transform them into biologically-meaningful results in your browser. Gain critical QC information, quantify targets within and across data sets, and run best-in-class computational biology analyses specific to each assay type.
Purpose: The goals of this study are to use hepatic transcriptome profiling (RNA-seq) to examine th...
Innate defense regulator (IDR) peptide-1002 is a synthetic host defense peptide derivative with stro...
T cell exhaustion is a progressive loss of effector function and memory potential due to persistent ...
Women suffer chronic pain more frequently than men. It is not clear whether this is due to differenc...
To determine the functions of Spi-C in innate immune responses, we investigated the overall gene exp...
Specialized tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that migrat...
Id proteins have been shown to promote the differentiation of conventional and T cells, and to supp...
Alzheimers disease (AD) and Frontotemporal dementia (FTD) are the two most common forms of dementia ...
AXL is activated by its ligand GAS6 and is expressed in triple-negative breast cancer cells. We repo...
We used RNA-sequencing to profile gene expression differences between Tregs from skin and LNs of Fox...
We identify c-Maf as an essential factor regulating adoption of RORgamma t+ and T follicular regulat...
Throughout HIV-1 replication cycle, a complex interplay of host-pathogen interactions takes place in...
DES is a synthetic estrogen that is associated with adverse effects on reproductive organs. Our grou...
We report here the RNA-seq data of proliferating IMR90 cells and etoposide-induced senescent cells w...
To examine whether the competition between hMTR4 with ALYREF is important for the specific exosome r...
Several recent studies have suggested that genes that are longer than 100 kb are more likely to be m...
The Notch pathway plays a critical role in regulating the proliferation and differentiation of endot...
RNA was isolated from control and Mettl3 cKO mouse testes using the TRIzol (Invitrogen) reagent by f...
Analysis of transcriptome changes in human umbilical vein cells (HUVEC) and mesenchymal stem cells (...
Cellular reprogramming converts differentiated cells into induced pluripotent stem cells (iPSCs). Ho...
Gene expression profiling by high-throughput sequencing reveals qualitative and quantitative changes...
Polycomb repressive complexes 1 and 2 (PRC1/2) act to limit transcriptional activity at gene promote...
Tfam inactivation by Nkx2.5Cre caused embryonic lethal myocardial hypoplasia. Tfam inactivation was ...
Normal brain aging is marked by a cognitive decline, spurred by changes in cellular metabolism and h...
The goal of the experiment was to determine the role of the polycomb repressive complex 2 in the ner...
Expulsion of parasitic gastrointestinal nematodes requires diverse effector mechanisms coordinated b...
Purpose: Due to its high metastatic proclivity, pancreatic ductal adenocarcinoma (PDAC) is one of th...
The three-dimensional organization of chromosomes is tightly related to their biological function. B...
Polycomb-group proteins are key regulators of the transcriptional programs that maintain stem cell i...
To gain a global view of translational inhibition by microRNA (miRNA), we isolated polysomes from wi...
There are currently no effective targeted therapies for KRAS mutant cancers. Therapeutic strategies ...
To search for CLOCK-controlled genes in human keratinocytes, we introduced siRNAs against CLOCK and ...
The reprogramming of fibroblasts into pluripotent stem cells by Oct4, Sox2, Myc and Klf4 represents ...
The discovery that TDP-43 mutations cause familial ALS and that many patients display pathological T...
mRNA transcriptional comparison between two pieces of tissue from three SBxVEC-Cre+ animals and thre...
Epigenetic regulation is based upon a network of complexes that modulate the chromatin character and...
T cells exhibit an intensified STING response, which leads to the expression of a distinct set of ge...
We identified novel recurrent genetic lesions in T-PLL affecting genes involved in JAK/STAT signalin...
Enhancer activation is a critical step for gene activation. Here we report a novel epigenetic crosst...
Using RNA-seq, we have reported that signaling crosstalk among IFN- and LPS is integrated at the lev...
Phenotypic and functional changes seen in the aged adaptive immune system are primarily driven by ag...
To investigate the role of motor neuron autophagy in ALS, we generated mice in which the critical au...
In this Study, we used RNA-targeting Cas9 (RCas9) to reverse characteristic Myotonic Dystrophy (DM1)...
T follicular helper (Tfh) cells are a subset of CD4+ T cells that promote antibody production during...
Antibody affinity maturation occurs in germinal centres (GC) where B cells cycle between the light z...
The JNK pathway has been implicated in breast cancer, both from human tumor sequencing studies and f...
Purpose: The outer blood-retina barrier is established through the coordinated terminal maturation o...
We developed TARGET-seq, a single-cell genotyping and RNA-seq method, which allows accurate detectio...
Microsatellite expansions often occur in non-coding regions of the genome. In this study, we test th...
Global transcriptional silencing is a highly conserved evolutionary event central to the transition ...
The goal of this study was to identify and analyze differential gene expression between normal liver...
Collagen type XI alpha 1 (COL11A1) is identified as one of the most upregulated genes in cisplatin-r...
Serine-threonine kinase receptor-associated protein (STRAP) is upregulated in breast, colorectal and...
We profiled retinal progenitor cells by integrating next generation sequencing methods and interroga...
We examined the the effects of cognitive training on behavior, synaptic physiology, and gene express...
RNAseq of murine CD11b+ CD103+ DCs and CD11b+ CX3CR1+ Mononuclear Phagocyes SOURCE: Irina LeonardiLA...
Purpose: BCR-ABL-positive acute lymphoid leukemia (ALL) has a dire prognosis. Despite improved disea...
In this study, female DO mice were administered zileuton or vehicle i.g. daily for seven days, and a...
Tumor-stromal communication within the microenvironment contributes to initiation of metastasis and ...
Gene expression profiling was performed to characterise transcriptional programs associated with res...
The chromatin regulator ATRX is inactivated in large subsets of adult and pediatric glioma. Whether...
Female C57BL/6J mice hemizygous for the 5XFAD transgene (MMRRC Stock No #34848-JAX) were bred to ma...
The enzymes of the poly-ADP-ribose polymerase (PARP) super-family control many relevant cellular pro...
In metazoans, the fertilized embryo is transcriptionally mostly silent for a few cell divisions, unt...
Abstarct:Mutations in the endoplasmic reticulum (ER) Ca2+ sensor stromal interaction molecule 1 (STI...
Medicinal cannabis has garnered worldwide attention in recent years but has been hampered by the psy...
rRNA-depleted RNA isolated from livers of control male and female mice and from male mice with hepat...
The early events that signal renal dysfunction in presymptomatic heart failure are unclear. To evalu...
Chromosome conformation capture technologies have revealed important insights into genome folding. Y...
We report here the broad transcriptomic program regulated by BACH2 transcription factor. We used a...
Methylated mammalian promoters are transcriptionally silenced even in the presence of all the factor...
There is an ongoing debate whether sex hormones impact risk of HIV transmission. This study evaluate...
Using RNA-Seq, we examined the transcriptome profiles of human iPSC-derived macrophage (IPSDM) with ...
We purified two populations of human jejunal enteroendocrine cells (GLP1+ and GLP1-) by FACS and ide...
We differentiated WT, LMO2KO or TAL1 KO mouse ES cell lines into Flk-1+ haemangioblasts and/or Tie2...
Reprogramming resident glia into functional and subtype-specific neurons in vivo by delivering repro...
Although dendritic cells (DCs) are among the human cell population best equipped for cell-intrinsic ...
Alternative splicing contributes to gene expression dynamics in many tissues, yet its role in audito...
It remains unclear how epigenetic modulators impact the tumorigenic potential of Myc. Here we show t...
Sensory neurons were extracted from the dorsal root or trigeminal ganglia of AdvGFP transgenic mice ...
In the germline stem cell lineage, proliferating gonial cells switch from mitotic proliferation to m...
Uromodulin (UMOD) is a secreted glycoprotein exclusively expressed by the cells lining the thick asc...
Gut-draining mesenteric lymph nodes (mLNs) play a key role in peripheral tolerance towards food and ...
Low and disturbed blood flow drives the progression of arterial diseases including atherosclerosis a...
Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal porti...
Stabilin-1/CLEVER-1 is a multidomain protein present in lymphatic and vascular endothelial cells and...
RNA-Seq profiling of Burkitt Lymphoma cell line (BL2) with B-cell activating factor (BAFF) for 24 hr...
Vascular extracellular matrix (ECM) stiffening is a risk factor for aortic and coronary artery disea...
T cell factor 1 (Tcf1, encoded by Tcf7) promotes the central memory CD8+ T cell (TCM) differentiatio...
Rett Syndrome (RTT) is a severe, neurodevelopmental disorder primarily affecting girls, characterize...
Pseudouridylation (pseudouridine) is the most abundant and widespread type of RNA epigenetic modific...
To investigate the role of ADAR1 in gastric carcinogenesis, RNA sequencing and small RNA sequencing ...
While years of investigation have elucidated many aspects of embryonic stem cell (ESC) regulation, t...
Circular RNAs (circRNAs) have recently emerged as a large class of novel non-coding RNA species. How...
The hematopoietic stem cell (HSC) compartment consists of a small pool of cells capable of replenish...
The most common form of senile dementia, Alzheimers disease (AD), is characterized by A plaques and...
RNA-Seq was performed on the mouse keratinocyte cultures with Sbsn knockeddown to study the role of ...
Genes and pathways that allow cells to cope with oncogene-induced stress represent selective cancer ...
We characterize histone H2A.Z binding and RNA expression in the hippocampus of young (2.5 months) an...
Differential expression patterns of total mRNA in traditionally expanded T cells (vehicle) compared ...