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We report the single-cell transcriptomic profiles of Bmi1-GFP+ and Prox1-GFP+ cells in comparison to...
The circadian clock dynamically rewires promoter-enhancer loops in tissues to drive robust daily rhy...
KMT2C is a key regulator of ER activity whose loss allows for hormone independent proliferation in M...
Loss of function mutations of the histone acetyltransferase CREBBP have recently been described at h...
In order to determine the full breath of C5aR and TLR crosstalk in human DC, RNA sequencing analysis...
In the present study, we demonstrate that NOD2 receptor triggering by muramyl dipeptide converts blo...
Dietary effect on mouse intestinal Lgr5 stem cells SOURCE: Wenge Li (wenge.li@einstein.yu.edu) - Aug...
This experiment was designed to look for in vitro IL-3 gene signature in donor blood at two differen...
The primary aim of this study was to characterize the transcriptomic changes between the acute and c...
Neocortical hyperexcitability is a prominent feature of inherited and sporadic amyotrophic lateral s...
we conducted gene expression profile analysis by using WT and Ezh2-deficient bone marrow-derived mac...
In hESCs, Wnt3/-catenin activity is low and Activin/SMAD signaling ensures NANOG expression to susta...
We have developed highly potent synthetic activators of the vertebrate immune system that specifical...
Purpose: Study the temporal effect of OHT on gene expression in MCF7 cells using mRNA-seq.; Methods:...
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transpor...
Background: Metformin, one of the first-line medication for the treatment of type 2 diabetes and ges...
Epigenetic regulation is based upon a network of complexes that modulate the chromatin character and...
Pro-opiomelanocortin (POMC)- and agouti-related peptide (AgRP)-expressing neurons of the arcuate nuc...
The investigation aims to profile the molecular dynamics of Rituximab treatment in cells. Specifica...
Disruption of Ski/Smad4 license Th17 differentiation. TGF-b-Ski-Smad4-RORgt-Th17 axis SOURCE: Yisong...
We used deep sequencing to probe the transcriptome, the methylome and the chromatin landscape of cul...
The overall study (Quinn et al. Cell Reports, 2018) aimed to understand why CD8 virtual memory T (TV...
Age/autoimmune-associated B cells (ABCs) are a T-bet dependent B cell subset, which accumulates prem...
Gametes are highly specialised cells that can give rise to the next generation through their ability...
We collected single or duplicate samples at the various time points, generated single cell suspensio...
In this study, we analyzed the transcriptome profiles of mouse sciatic nerves after developmental (P...
The mechanism for sex determination in mammalian germ cells remains unclear. Here, we reconstitute t...
Generation of preclinical models which recapitulate at best the extreme intra-tumoral heterogeneity ...
We analyzed the transcriptome of the C57BL/6J mouse hypothalamus, hippocampus, neocortex, and cerebe...
In murine models, we find that oncogenic BRAF paradoxically suppresses stem cell renewal and instead...
The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzhei...
Human papilloma virus (HPV)-driven cutaneous squamous cell carcinoma (cSCC) is the most common cance...
Obesity is a chronic organismal stress that disrupts multiple systemic and tissue-specific functions...
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity ar...
Spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality, with an incidenc...
Relatively little is known about how the identity of early neuronal stem cells changes before and af...
Polycomb repressive complex-2 (PRC2) is a group of proteins that play important role during developm...
Metabolic production of acetyl-CoA has been linked to histone acetylation and gene regulation, howev...
Rational: Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the ...
Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed protein kinase...
The mechanisms that activate some genes while silencing others are critical to ensure precision in l...
Purpose: To identify alterations induced by developmental exposure to tributyltin at different stage...
Although microglial have an essential role in host defense in the brain, the abnormal activation of ...
Despite increasing evidence to indicate that long non-coding RNAs (lncRNAs) are novel regulators of ...
Camphor white oil (CWO) application was found to induce regression of papillomas in a mouse chemical...
CD8 T cells that respond to PD-1 blockade (during the early stage of infection) have enriched CD28 c...
Rational: Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the ...
We identify a new phase of functional compensation following acute liver injury that occurs prior to...
Haploinsufficiency and aneuploidy are two phenomena, where alteration of gene dosage causes severe c...
RNA-Seq splicing data from the corneal endothelia of FECD patients and controls reveal hundreds of d...
We performed RNAseq analysis to determine the effect of ClpP-deletion on cumulus cells global gene e...
Background Breakthroughs in HIV treatment, especially antiretroviral therapy (ART), have massively r...
The protein encoded by the NRG1 gene is a membrane glycoprotein that mediates cell-cell signaling an...
RNA-seq analysis of Tas2r143-expressing cells in the trachea and stomach of adult Tas2r143-reporter ...
We identified long noncoding RNAs (lncRNAs) expressed in macrophages and characterized one lncRNA, d...
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it i...
Objectives: The collagen VI related muscular dystrophies (COL6-RD), Ullrich congenital muscular dys...
Mutations mimicking growth factor-induced proliferation and motility characterize some aggressive su...
Ribonucleoprotein immunoprecipitation followed by mass spectrometry and RNA-Seq was used to investig...
We performed a time-course experiment to determine the temporal transcriptional changes that occur i...
The significance of cardiac stem cell (CSC) populations for cardiac regeneration remains disputed. H...
Epigenetic regulation of chromatin states is thought to control the self-renewal and differentiation...
We performed single cell RNA-seq on the cell somas of mouse neurons and astrocytes. The transcriptom...
Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome a...
The circadian clock and rhythmic food intake are both important regulators of rhythmic gene expressi...
We report the application of transcriptome sequencing for investigating of the hsa-miR-371a-5p and h...
We experimented how well various supervised machine learning methods such as decision tree, partial ...
A family of vertebrate-specific microRNAs called the ESCC microRNAs regulates proliferation and diff...
The goals of this study are to compare gene expression profiles of Uhrf1 WT and KO germinal center B...
The experiment was performed to verify wether knockdown of AS1 in combination with TNFa treatment af...
Using Cdh5-Cre and Sm22-Cre transgenes to characterize the impact of disruption of the angiotensin I...
We found the impaired renal function accompanied with severe cardiac dysfunction in mice co-treated ...
The Polycomb repressive complexes PRC1 and PRC2 play an essential role in cell fate decisions, embry...
Despite the widespread use of glucocorticoids (GCs) for treating inflammatory conditions, the underl...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a dismal prognosis. Currently, ...
Metabolically-targeted therapies hold the promise of offering an effective and less toxic treatment ...
Long noncoding RNAs (lncRNAs) serve an essential role in regulating immunological functions. However...
The goals of this study are to define the putatitve impacts of FXRalpha deficiency in testicular phy...
The antitumor activity of bromodomain inhibitors (BETi) has been demonstrated across numerous types ...
Single-cell RNA-seq of mitotically enriched cells in the medial ganglionic eminence (Dlx6 negative),...
Homeostatic scaling allows neurons to maintain stable activity patterns by globally altering their s...
The aim of this study is to evaluate the effect of Autoimmune regulator (Aire) gene disruption in a ...
The lymphoid branch of the immune defense is composed of innate and adaptive immune cells. Using mul...
Corticotropin-releasing factor (CRF) and its type 1 receptor (CRFR1) play an important role in the b...
While recent clinical studies demonstrate the promise of cancer immunotherapy, a barrier for broaden...
Nephron number is a major determinant of long-term renal function. We hypothesized a link between ep...
There is some emerging evidence that members of the Schlafen (SLFN) family of proteins mediate anti...
Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are incompletely ...
We analyze the difference between ETX-side1 cells and ETX-side2 cells. Side1 cells are associated wi...
We use RNA-sequencing to measure global transcription in LH timed endometrial biopsies of 10 women a...
DC subsets of the murine healthy heart consisted of IRF8-dependent conventional (c)DC1, IRF4-depend...
Mammary glands were collected from 8 pregnant (12.5 day) mice and 8 adult (10 week old) female mice....
The molecular mechanisms underlying folding of mammalian chromosomes remain poorly understood. The t...
Herein, we report viral interferon regulatory factor 3 (vIRF3) as a pro-angiogenic factor together w...
We have found that the signal-dependent chromatin modulator Histone Deacetylase 7 interacts with and...
Heart failure (HF) is a major health and economic burden in developed countries. It has been propose...
PRMT5 is the major type II protein arginine methyltransferase catalyzing the symmetric dimethylation...
Exposure to hypoxia requires adaptive mechanisms for survival. During acute hypoxia, Na,K-ATPase end...
Microglia are fundamentally important immune cells within the central nervous system (CNS) that resp...
Single-cell RNA-seq to profile a developmental time course of interneuron development, measuring the...