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Sequencing-based assays page 56
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GSE103327: Transcriptome profiling of HepG2 cells upon treatment of the menin-MLL inhibitor MI-503 or DMSO
Hepatocellular carcinoma (HCC) accounts for the majority of malignant liver tumors and results in ma...
GSE119470: Animal model of acute-on-chronic alcoholic liver injury
Background and aims: We aimed to study the pathogenesis of AH in an animal model of acute-on-chronic...
GSE107159: Role of myelin-derived antigens in pain: a female connection
Intrasciatic injections of the MBP84-104-WT (wild type) peptide, MBP84-104-SCR (scramble) peptide an...
GSE106445: Transcriptome analysis of satellite cells with a genetic deletion of HDAC4 to identify the gene modulated by HDAC4
NGS technology was used for high-throughput profiling of the transcriptome by comparing satellite ce...
GSE101732: RNA-sequencing of Mbd3-null and control haematopoietic stem cell and lymphoid progenitor cell populations
To determine the role of Mbd3/NuRD in lymphopoiesis, gene expression in purified populations of Mbd3...
GSE57433: Human Nonsense-Mediated RNA Decay Initiates Widely by Endonucleolysis and Targets snoRNA Host Genes
Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (...
GSE102992: Transcriptomic response to 24-hour food deprivation in four hypothalamic nuclei in Snord116 deletion mice
Mice with a congenital Snord116 deletion model aspects of the Prader-Willi Syndrome. In this study,...
GSE102158: Lnc-31 acts as a molecular scaffold to control the Rock1 mRNA translation
Cytoplasmic long non coding RNAs have been shown to act at many different levels to control post-tra...
GSE103355: RNA sequencing of lung tissue from Fra-2 transgenic mouse (Fra-2tg) and wild-type littermates
Fra-2tg mice develop spontaneous lung fibrosis. We carried out this sequencing with tissue from youn...
GSE93034: A protective function of IL-22BP in acute liver injury
Acute liver injury is a critical life-threatening event. Common causes are infections, intoxication,...
GSE99888: Singlecell transcriptomic analysis of mouse CA1 inhibitory neurons
We studied the transcriptomes of mouse CA1 inhibitory cells. Novel clustering methods identified ...
GSE106226: Multi-axial self-organisation properties of mouse embryonic stem cells into gastruloids [individual]
Gastruloids, small aggregates of murine Embryonic Stem (ES) cells stimulated to undergo gastrulation...
GSE102118: Genomic signatures of platinum re-sensitization in ovarian cancer [RNA-Seq]
Epigenetic changes, particularly DNA methylation aberrations have been implicated in acquired resist...
GSE103069: Comparing expression in livers of 1-month vs 6-month old mice
To look for age-related changes in the liver, we used RNAseq gene expression analysis to characteriz...
GSE94133: BET-Bromodomain Inhibitors Engage The Host Immune System And Regulate Expression Of The Immune Checkpoint Ligand PD-L1 [EuMyc_RNA-seq]
BET inhibitors (BETi) target bromodomain-containing proteins and are currently being evaluated as an...
GSE100277: Next-generation sequencing measuring mRNA expression in nave T cells isolated from Mettl3 KO and WT mice
Nave T cells were obtained by StemCell CD4+ T cell isolation kit of spleen from Mettl3 KO and WT mic...
GSE110046: Impaired TNFa-driven dendritic cell activation limits LPS-induced protection from asthma in infants.
We found that approximately 200 genes were differentially expressed between CD11b+ lung-migratory de...
GSE101838: Rlim-independent XCI in female embryonic stem cells in vitro
The transcriptomes of differentiated and undifferentiated E14 (male), Pgk12.1 (female; WT) and Pgk12...
GSE102171: Concomitant Loss of Smad4 and Activation of Wnt Signaling Triggers Enterocyte De-differentiation and Adenoma Formation
In the current work, we add to the understanding of differentiated-cell-derived tumorigenesis by dem...
GSE105223: Exacerbating role of angiopoietin-2 in cardiac hypoxia and inflammation after myocardial infarction
To unveil the role of Angiopoietin-2 in regulating vascular remodeling after myocardial infarction S...
GSE111855: Learning the cis sequence elements that determine AP-1 monomer specificity (RNA-seq data sets)
Regulation of gene expression is mediated by combinations of DNA binding transcription factors that ...
GSE102182: Developmental stage specific chromosome architecture in human erythroid cells (RNA-seq)
Chromatin structure is tightly intertwined with transcription regulation. Here we compared the chrom...
GSE102309: Transcriptome of neutrophils deficient in cxcr4 and arntl
Our study aims to analyze time-dependent changes in neutrophil phenotype SOURCE: Manuel,J,Gomez (mjg...
GSE105267: Expression data of endothelium and hematopoietic cluster cells in the wild type and Steel mutant E11.5 AGM and vitelline and umbilical arteries
Kit ligand (Kitl, aka SCF) is a pivotal cytokine in fetal liver and bone marrow hematopoiesis. Its r...
GSE106810: LINE-2 transposable elements are a source of functional human microRNAs and target sites
Transposable elements (TEs) are dynamically expressed at high levels in multiple human tissues, but ...
GSE108184: c-Maf-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont
Both microbial and host genetic factors contribute to the pathogenesis of autoimmune disease. Accumu...
GSE100898: Cry2 is critical for circadian regulation of myogenic differentiation by Bclaf1-mediated mRNA stabilization of cyclin D1 and Tmem176b
Circadian rhythms regulate cell proliferation and differentiation; however, little is known about th...
GSE101915: Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia [Mouse RNA-Seq]
Determination of the molecular properties of genetically targeted cell types has led to fundamental ...
GSE106362: PTEN loss in the fallopian tube induces hyperplasia and ovarian tumor formation
The goals of this study are to compare mouse oviductal transcriptome profiling (RNA-seq) of PTEN-dep...
GSE103070: Transcriptome profile of wildtype and Ret homozygote null mouse guts at E10.5 ,E12.5 and E14.5
Total mRNA seq was perfomed on widtype and Ret null mouse embryonic gut at 3 stages of devlopment- E...
GSE94132: Effect of Praziquantel on the Differential Expression of Mouse Hepatic Genes and Parasite ATP Binding Cassette Transporter Gene Family Members During Schistosoma mansoni Infection
Schistosomiasis is a disease caused by parasitic worms that significantly impacts on the lives of ap...
GSE101108: Transcriptomic and genomic profiling of early-stage ovarian carcinomas associated with histotype and overall survival [RNA-Seq]
Ovarian cancer is the most lethal gynecological malignancy in the western world. Despite recent effo...
GSE96586: Murine Norovirus Infection Initiates Interferon and TNF Signaling with Significant Alteration of Lipid and Cell Cycle Homeostasis
Murine norovirus (MNV) is genetically similar to human norovirus (HuNoV), and offers both an efficie...
GSE103353: The mRNA alteration in HT22 cells induced by the overexpression of long noncoding RNA AK046375
We overexpressed the lncRNA-AK046375 by lentivirus in HT22 cells, which were immortalized from the m...
GSE123669: Immature low-density neutrophils exhibit metabolic flexibility that facilitates breast cancer liver metastasis
Neutrophils play a key role in the control of metastatic progression. Neutrophils are phenotypically...
GSE109906: RNAseq of cortex of 6-month old APPPS1 and APPPS1;Apoe-/- mice
One of the hallmarks of Alzheimers disease is the presence of extracellular diffuse and fibrillar pl...
GSE100634: Transcription factor Foxo1 is essential for IL-9 induction in T helper cells
Interleukin 9 (IL-9) producing helper T (Th9) cells play a crucial role in allergic inflammation, au...
GSE105164: Wnt inhibition confers hESCs a unique transcriptional state compatible with differentiation, but not with derivation
Human embryonic stem cells (hESCs) hold great value for future clinical applications. However, stand...
GSE100471: Defining the early steps of cardiovascularlineage segregation by single cell RNA-seq
Mouse heart development arises fromMesp1 expressing cardiovascular progenitors that are specified at...
GSE102729: RNA sequencing (RNA-SEQ) of Human endothelial cells (HUVEC) in LFS, sFRP2OE, and WT conditioned media
Purpose: To understand molecular and cellular effects of secreted sFRP2 to endothelial cells; Method...
GSE104044: System-wide Dissection of the Transcriptional Response to RUNX1 During Hematopoietic Specification [RNA-seq]
The specification of hematopoietic cells in the developing embryo occurs in specific stages and is r...
GSE123674: Axl targeting in experimental unilateral ureteral obstruction
We investigated if Axl receptor tyrosine kinase was up-regulated in unilateral ureteral obstruction ...
GSE100981: Mesenchymal Igf2 is a major regulator of pancreatic growth and function
The genetic mechanisms that determine the size of the adult pancreas are not fully understood. Here ...
GSE101905: Transient and permanent reconfiguration of chromatin and transcription factor occupancy drive reprogramming
Somatic cell reprogramming into pluripotent stem cells (iPSC) through the forced expression of defin...
GSE102335: Microglia innatly develop within cerebral organoids
Here we report that human organoid-grown microglia have transcriptional identity similar to that of ...
GSE97399: Transcriptional profiling of quiescent muscle stem cells in vivo
Many stem cell populations exist in a quiescent state in vivo, exiting quiescence and entering the c...
GSE103203: Endometrial epithelial cell transcriptome response to co-culture with adipose stromal cells
The role of obesity in endometrial cancer development is tested by co-culturing adipose stromal cell...
GSE107915: Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma
Thymic lymphomas were dissected from Cic adult knockout mice or wildtype mice transplanted with Cic ...
GSE94990: A Reciprocal Regulatory Loop Between TAZ/YAP and G protein Gs Regulates Schwann Cell Proliferation and Differentiation
Schwann cell (SC) myelination in the peripheral nervous system is essential for motor function, and ...
GSE120647: Glioblastoma multiforme cancer stem cells from different patients exhibit consistent gene expression changes following Hes3 RNA interference
Cancer cells are plastic, switching between signaling pathways to regulate growth under different co...
GSE104458: Metformin induces chromosome reorganization and changes in gene expression in normal human fibroblasts
We report the effects of metformin treatment on the transcriptome of normal human dermal fibroblasts...
GSE103383: RNA Seq analysis of pancreatic beta cell transcriptome during dedifferentiation
We report RNA Seq analysis using Illumina nextSeq500 of human beta cells EndoC-BH1 treated with FGF2...
GSE102215: RNA-Seq in neutrophils from Antiphospholipid Syndrome
Antiphospholipid antibodies are a leading cause of thrombosis. To further elucidate the role of neut...
GSE105160 (mouse): RNASeq of mouse, human, and non-human primate primary dermal fibroblasts to poly(I:C) transfection
Here, we performed RNA-Seq on mRNA isolated from primary dermal fibroblasts of human, mice and multi...
GSE70068: RNA-Seq analysis of human neutrophils isolated by different protocols (Polymorphprep and negative selection) and incubated with and without in vitro cytokine stimulation
We report gene expression in human neutrophils isolated by two methods: Polymorphprep (~95% purity) ...
GSE101657: Gene expression changes in ketogenic and high-fat diets
The ketone body -hydroxybutyrate (BHB) is produced during dietary restriction, fasting, and exercise...
GSE102728: IgG immunocomplexes sensitize human monocytes for inflammatory hyperactivity via transcriptomic and epigenetic reprogramming in autoimmune disease
Prevalence of circulating immunocomplexes (ICs) strongly correlates with systemic autoimmune disorde...
GSE122780: Identification of distinct murine brown adipocyte lineages
We identify distinct murine brown adipocytes lineages using bioinformatics analysis of gene expressi...
GSE107391: Integrated Genetic and Proteomic Analysis Identifies PLK1 as a Candidate Therapeutic Target for SETD2-Deficient Clear Cell Renal Cell Carcinoma
We systematically analyzed the alterations in histone epigenetic marks (H3K36me3 and H4K16ac), mRNA ...
GSE101292: Allele-specific expression profiling of imprinted genes in mouse isogenic pluripotent tissues and cell lines
Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in...
GSE113878: transcriptional response to endothelial cell-specific inactivation of Tspan12 in the mature retina
Blood-retina barrier (BRB) formation and retinal angiogenesis depend on beta-catenin signaling induc...
GSE106805: DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice
Lung CD4+ T cell responses may determine outcomes in pediatric pnuemonia. We therefore sought to def...
GSE140380: Transcriptional differences between skin from patients with atopic dermatitis and control skin obtained from the healthy margins of Mohs surgery patients
Purpose: To determine the transcriptional differences between skin from patients with atopic dermati...
GSE101585: Aberrant expression profile of lncRNA and mRNA in dilated cardiomyopathy by RNA-sequence
We aimed to identify aberrantly expressed lncRNA and mRNA expression profiles of dilated cardiomyopa...
GSE106514: Single-cell analysis reveals heterogeneity of high endothelial venules and different regulation of genes controlling lymphocyte entry to lymph nodes
High endothelial venules (HEVs) are specialized blood vessels allowing recirculation of nave lymphoc...
GSE122346: The epigenetic regulator ATF7 controls adipocyte differentiation and thermogenic gene program
The adipocytes functions as a central organ in the regulation of metabolic homeostasis. Factors whic...
GSE101968: Obstructed defecation an enteric neuropathy? An exploratory study of patient samples
The aim of this experimental study is to elucidate alterations of the autonomous enteric nervous sys...
GSE100408: Probing the Roles of SUMOylation in Cancer Cell Biology Using a Selective SAE inhibitor
Small ubiquitin-like modifier (SUMO) family proteins regulate target protein functions by post-trans...
GSE101730: The histone methyltransferase G9a is required for silencing of helper lineage genes in CD8+ T cells
During a binary cell fate decision, a progeny silences the gene expression program associated with t...
GSE101921: Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization
In addition to mediating sister chromatid cohesion, cohesin plays a central role in DNA looping and ...
GSE103566: Transcriptional coactivator PGC-1 contains a novel CBP80-binding motif that orchestrates efficient target gene expression
This RNA-seq dataset was generated to identify genes whose transcription relies on the CBP80-binding...
GSE104973: Comparison of RNA-seq and Microarray Platforms for Splice Event Detection using a Cross-Platform Algorithm [RNA-Seq]
In this study, we compare the performance of RNA-seq (Illumina HiSeq) and junction arrays (Affymetri...
GSE119443: RNA-seq of WT, Tet1-/-, Tet2-/-, Tet1-/-:Tet2-/- (DKO), and Tet1-/-:Tet2-/-:Tet3-/- (TKO) murine embryonic stem cells following six days of LIF withdrawal.
The goal of this study was to identify transcriptional differences between varying combinations of T...
GSE123972: RNA-seq analysis of hepatocellular carcinoma plasma
Hepatocellular carcinoma (HCC) is currently the third leading cause of death worldwide and the most ...
GSE101972: RNA-seq analysis of the role of HBO1 (KAT7/MYST2) in the ovarian cancer cell line UWB1.289.
Analysis of change in transcriptosome after stable lentiviral HBO1 knockdown in UWB1.289 ovarian can...
GSE108787: Temporal dynamic reorganization of 3D chromatin in hormone-induced breast cancer and endocrine resistance
To establish a data-driven learning model of the temporal dynamics and 3D chromatin reorganization, ...
GSE140389: Effectof high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice
We examined theeffectof chronic high fat diet (HFD) on amyloid deposition and cognition of 12-months...
GSE94386: RNA editing is the essential function of ADAR1 and, in the absence of MDA5, is dispensable for normal adult homeostasis [mmPCR-seq]
Adenosine-to-Inosine (A-to-I) editing of dsRNA by ADAR proteins is a pervasive feature of the epitra...
GSE144841: 4EHP and GIGYF1/2 induce translation-coupled messenger RNA decay
Although canonical mRNA degradation is generally recognized to be translation dependent, our underst...
GSE101480: Targeted inhibition of STAT/TET1 axis as a potent therapeutic strategy for acute myeloid leukemia
Effective therapy of acute myeloid leukemia (AML) remains an unmet need. DNA methylcytosine dioxygen...
GSE101467: Gene expression in control and DOCK8 CRISPR KHYG1 NK cells
Mutations in the DOCK8 gene cause an autosomal recessive form of hyper-immunoglobulin E syndrome, ch...
GSE103095: Comparison of 7 small cell lung cancer PDX models, cultured ex vivo, for response to LSD1 inhibitor RG6016/ORY1001
The goal of this study was to understand how the LSD1 inhibitor RG6016/ORY1001 leads to selective ef...
GSE106966: Genome-wide Sequencing Facilitates Quantitative Analysis of Wild Type and CRAF-/- cells
We utilized C-Raf-knockout cell model and carried out RNA-seq analysis of the global transcriptomes ...
GSE100526: TLR4 deficiency reduces inflammatory signaling by reprogramming macrophage lipid metabolism
Chronic inflammation is a hallmark of obesity and is linked to the development of numerous diseases....
GSE99389: Transcriptome analysis of CD4+ T cells infected with Ebolavirus
Evaluating the transcriptome profiles of CD4+ T cells that were cultured with mock, LPS, or recombin...
GSE110092: Shroom3-Fyn interaction determines nephrin phosphorylation and Albuminuria in allografts
Glomerular RNA-sequencing: Shroom3 knockdown adult mice vs controls SOURCE: Weijia Zhang (weijia.zha...
GSE113546: Transcriptomic analysis reveals a statin-induced core molecular signature in human iPSC-CMs
Statins prevent cardiovascular disease via their salutary function as inhibitors of cholesterol bios...
GSE102247: Autosomal dominant retinitis pigmentosa rhodopsin mutation Q344X drives specific alterations in gene transcription
The goal of the study was to identify transcriptional modifications in retinal tissues from mouse mo...
GSE96096: Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB
The serpinopathies are human pathologies caused by mutations that promote polymerisation and intrace...
GSE96960: Alloantigen-specific regulatory T cells generated in presence of vitaminC display enhanced stability of Foxp3 expression and promote skin allograft acceptance
Regulatory T cells (Tregs) are critical for the maintenance of immune homeostasis and selftolerance,...
GSE102772: Transcriptome characterization of murine ventricular cardiomyocytes
We generated a comprehensive RNAseq data set of wildtype murine ventricular cardiomyocytes . Moreove...
GSE110144: T cells activated in the presence or absence of TLR agonists
We report the gene expression differences between OT-1 T cells activated alone or in the presence of...
GSE103086: CONTROL OF GROWTH AND GUT MATURATION BY HoxD GENES AND THE ASSOCIATED LncRNA Haglr
In this work we have analyzed the transcriptomic profiles of E9 mouse embryos. We show that Hoxd1 an...
GSE101413: Tracking transcriptional changes in a species-specific manner during experimental hepatoblastoma progression in vivo
Hepatoblastoma is a primitive liver cancer occurring mainly in infants with defined molecular altera...
GSE97452: Synthetic lethal interactions and convergent biological effects underlie the mutual exclusivity of MDS-associated spliceosomal gene mutations
RNA splicing factor mutations constitute the most common class of alterations in myelodysplastic syn...
GSE103114: ZIKV infection of monocytes activates inflammasome pathways
The objective of this assay was to determine the effect of ZIKV on host cellular pathways SOURCE: Su...
GSE101700: Differential expression of genes in Fezf2KO mouse retina and control retina
To analyze roles of transcription factor Fezf2 in retinal development, knockout mouse of Fezf2 was g...
GSE102227: RNA-seq profiling of thymic epithelial cells from Mcl1 knockout and wildtype mice
T cell differentiation is governed by interactions with thymic epithelial cells (TECs) and defects i...
GSE102751: Transcriptomic analysis of IPF lung-associated and normal peripheral blood T cells
Lung explant derived T cells were sorted from mechanically dissociated IPF lung explants and compare...
GSE104288: Comprehensive Analysis of Gene Expression Patterns in Friedreichs Ataxia Fibroblasts by RNA Sequencing Reveals Altered Levels of Protein Synthesis Factors and Solute Carriers
Friedreichs ataxia (FRDA) is an autosomal recessive neurodegenerative disease usually caused by larg...