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Talk to our team for accessStore large, raw sequencing data files and transform them into biologically-meaningful results in your browser. Gain critical QC information, quantify targets within and across data sets, and run best-in-class computational biology analyses specific to each assay type.
The COMPASS family catalyzes histone H3 lysine 4 (H3K4) methylation and its members are essential fo...
The DNA-binding protein REST forms complexes with histone deacetylases (HDACs) to repress neuronal g...
PolyA-selected RNA isolated from livers of adult male and female mice with a combined loss of EZH1 a...
The Ribo-seq analysis demonstrated that eIF1A is predominantly essential for translation of genes wi...
Needle biopsies were performed to obtain liver samples from patients for clinical purposes from pati...
Aims: Hypertension poses a significant challenge to vasculature homeostasis and stands as the most c...
RNA subcellular localization often correlates with its function and regulation. For many long noncod...
Recent studies have shown that non-enzymatic function of CD73 play a key role in tumor progression, ...
In recent years, highly detailed characterization of adult bone marrow (BM) myeloid progenitors has ...
Background: Though Illumina has largely dominated the RNA-Seq field, the simultaneous availability o...
Activation of identity determining transcription factors (TFs), or core regulatory TFs, is governed ...
Since we found an upregulation of the long non coding RNA MALAT1 in Multiple Sclerosis (MS) patients...
RNAseq was performed on sciatic nerves from controls and Krox20 mutants to elucidate the role of Kro...
We examined the transcriptional profiles of macrophages that reside in the islets of Langerhans of N...
Somatic mutations in ARID1A, a SWI/SNF chromatin remodeling gene, are prevalent in human malignancie...
Background; Glioblastomas are the most common and lethal primary brain tumors. Microglia, the reside...
Single-cell RNA-seq: We used single-cell RNAseq to investigate the maturation of astrocytes within h...
This study is to analyze the transcriptomic profiles of 6 weeks 0.2% cuprizone treated Cx3cr1-CreER;...
Of the thousands of long non-coding RNAs expressed in embryonic stem (ES) cells, few have known role...
Purpose: Transcriptomic analysis of ADAM17 cKO mice, a mouse model of atopic dermatitis.; Methods: S...
Spermatogenesis generates mature male gametes and is critical for the proper transmission of genetic...
Objective: To assess the development of neuronal subtypes and the emergence of evoked electrical act...
Human embryonic stem cells (hESC) can be differentiated towards progeny resembling trophoblast upon ...
Considering m6A modification in mRNA was reported to be important in many biology processes, like ce...
We analyze gene expression data of human organoid developmet SOURCE: Orly Reiner (orly.reiner@weizma...
microRNA (miRNA)-mediated gene silencing is commonly deregulated in a wide variety of diseases. Ther...
Direct lineage conversion offers a new strategy for tissue regeneration and disease modeling. Despit...
Purpose: A1CF is an RNA binding protein that has not been extensively studied on a transcriptome-wid...
The goal of this study is to compare the transcriptome profiling (RNA-seq) of two CD25 regulatory T ...
We have found that PRMT5 methylates BCL6 and is needed for its full transcriptional repressor activi...
In order to asses differences between expression profiles of postnatal and adult mice, RNA-sequencin...
Stress-response gene activity replaces cardiomyocyte lineage-specific program in a transcriptionally...
Here we show that synthesis of the mitochondrial phospholipid cardiolipin is an indispensable driver...
Histone H3 lysine 27 to methionine mutations (H3K27M) resulting in aberrant chromatin regulation are...
Molecular mechanism of long-term memory has been extensively studied in the context of hippocampus-d...
The MALT1 paracaspase plays an essential role in Activated B-cell like Diffuse Large B-cell Lymphoma...
N6-Methyladenosine (m6A) and N6,2-O-dimethyladenosine (m6Am) are abundant mRNA modifications that re...
This experiment was conducted to identify mRNA transcripts alteration in muscle from skeletal muscle...
The loss of primary auditory neurons (PANs) leads to permanent hearing impairment since they are inc...
To investigate the effect of Smchd1 ablation on de novo X chromosome inactivation (XCI), we derived ...
We report the application of RNA sequencing to determine the transcriptional response of primary bon...
Purpose: A1CF is an RNA binding protein that has not been extensively studied on a transcriptome-wid...
The purpose of this study is to understand the effects of adrenergic signaling on the transcriptome ...
Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain b...
RNA sequencing was used to evaluate genes regulated in C3H10T1/2 cells by the Smo agonist purmorpham...
Characterisation of the splenic light zone germinal center B cells in mice carrying WT endogenous mo...
Mature B cells leave the bone marrow as nave B cells and migrate to the secondary lymphoid organs w...
RNAseq of germinal center B cells with different Blimp-1-GFP reporter level. Sorted germinal center ...
Systemic sclerosis (SSc) is a complex multi-system autoimmune disease characterized by immune dysreg...
We report the first genome-wide landscape of H3K9me2 ChIP-seq profile in mouse oocytes. We also perf...
In this study: (1) We have mapped the genome wide binding distribution and enrichment of Rinf/CXXC5 ...
Mammals have evolved neurophysiologic reflexes such as coughing and scratching to expel invading pat...
Although cohesin and CTCF are major determinants of interphase 3D genome organisation, their impact ...
The association between type 2 DM (T2DM) and susceptibility to tuberculosis (TB) is well recognized....
Circular RNAs (circRNAs) are a new class of endogenous and regulatory non-coding RNAs, but their exp...
Cell suspensions were prepared from lungs dissociated from bleomycin treated mice and control mice. ...
The molecular requirements that guide the differentiation of monocytes into macrophages or monocyte-...
T follicular helper (Tfh) cells, which reside in the B cell follicles and help Ig class switching, e...
Resistance to the first approved BCL-2 inhibitor venetoclax is emerging in lymphoid malignancies. Th...
We found that PRMT5 deletion or inhibition impairs homologous recombination (HR) DNA repair, leading...
We have ectopically expressed four V5-tagged mouse homeobox genes in mouse embryonic fibroblasts wit...
We developed and report on a novel new technique to reprogramm fobroblasts from two non-permissive m...
Difference in RNA content of different cell types introduces bias to gene expression deconvolution m...
IL-7 regulates homeostatic mechanisms that maintain the overall size of the T cell pool throughout l...
FoxA transcription factors are critical for liver development through their pioneering activity, whi...
Neural stem cells (NSCs) contribute to plasticity and repair of the adult brain. Niches harboring NS...
Background:African American men (AAM) are at higher risk of being diagnosed with prostate cancer (PC...
We Investigate the persistence of negative impacts on sperm parameters for more than one generation ...
We found that genetic deletion of Lis1 (also known as Pafah1b1) in mouse liver led to increased lipi...
In crown group tetrapods, individual digits are homologized in relation to a pentadactyl ground plan...
Here we investigated whether sterile triggers of inflammation induce trained immunity and thereby in...
PTK2 was knocked down by doxycycline-dependent expression of small hairpin RNA against PTK2 in Breas...
Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein (FMRP), a tra...
We have performed RNA sequencing analysis of brain tissue and blood from the MJD84.2 mouse model for...
Although cohesin and CTCF are major determinants of interphase 3D genome organisation, their impact ...
We identified RNF123 (KPC1) ubiquitin E3 ligase is involved in glioblastoma progression through NF-k...
The goal of this study was to determine whether depletion and repopulation of microglia in adult and...
The Mediator complex regulates gene transcription by linking basal transcriptional machinery with DN...
Here, we describe an approach to enrich newly transcribed RNAs from primary mouse neurons using 4-th...
EMT in cancer has been associated with tumour stemness, metastasis and resistance to therapy. It has...
Innate lymphoid cells (ILCs) are important for mucosal immunity. The intestine harbors all ILC subse...
Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implica...
Circular RNAs (circRNAs) represent a class of covalently closed RNAs, derived from a non-canonical s...
Innate lymphoid cells (ILCs) are considered to be the innate counterparts of adaptive T lymphocytes ...
The recurrent chromosome 16 inversion in acute myeloid leukemia generates a fusion gene between CBFB...
The Myc/Max heterodimer has crucial roles in normal cellular processes such as cell proliferation, m...
BCR-ABL1-targeting tyrosine kinase inhibitors (TKIs) have revolutionized treatment of Philadelphia c...
To determine the effects of glioma-conditioned medium on global gene expression in ECs. SOURCE: Yi F...
PKCb-null (Prkcb-/-) mice are severely immunodeficient. Here we show that mice whose B cells lack PK...
We are interested in whether fibroblasts (CD45-CD31-Epcam-PDPN+PDGFRA+) cells exhibit unique transcr...
The mouse X-inactivation center (Xic) locus represents a powerful model for understanding the links ...
Definitive hematopoietic cells arise from hemogenic endothelium during mid-gestation, indicating a d...
Here we analyse transcriptome profiles within the frontal cortex between wild type, heterozygous and...
We report the application of RNA-seq for high-throughput profiling of transcriptom in male and femal...
Termination is a ubiquitous phase in every transcription cycle but is incompletely understood and a ...
Gastrointestinal infections caused by enteric yersiniae can become persistent and complicated by rel...
Dazl (deleted in azoospermia like) is a member of the DAZ family of germ cell-restricted RNA binding...
Downregulation of EZH2 Leads to Cellular Senescence with Features of SASP SOURCE: John Sedivy Brown ...
Lamins, the major structural proteins within the nuclear lamina, are crucial for the functionality o...
We wished to investigate differential effects of stimulation with immune complex on colonic macropha...