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Sequencing-based assays page 74
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GSE119265: Early onset preeclampsia (EOPE) in a model for early stage human placental trophoblast
Early onset preeclampsia (EOPE) affects about 0.4% of pregnancies and is characterized by impaired t...
GSE109165: Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/-catenin pathway
Regulator of G protein signaling z1 (RGSz1), a member of the RGS family of proteins, is present in s...
GSE121560: Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia (RNA-seq of KLF6 KO)
Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increase...
GSE118167: RNA-sequencing of human retinal pigment epithelum
We assessed the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells diffe...
GSE119044: MC-LR induced ncRNA and mRNAs changes in mouse testis
We have builded a network including mRNA, miRNA, piRNA, lncRNA and circRNA after exposure to MC-LR f...
GSE118713: Epigenetic reprogramming at estrogen-receptor binding sites alters the 3D chromatin landscape in endocrine resistant breast cancer [RNA-seq]
Endocrine therapy resistance invariably develops in estrogen receptor positive (ER+) breast cancer, ...
GSE109237: Promotion of myoblast differentiation by Fkbp5 via isomerization of Cdk4.
The molecular chaperons FK506-binding proteins (Fkbps) comprise one of three families of peptidyl pr...
GSE121519: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid.
In comparison with exosomal mRNAs in CSF from four patients with amyotrophic lateral sclerosis, 543 ...
GSE118898: The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells
Identification of Nanog targets by transcriptomic changes of Nanog induction and depletion, identifi...
GSE109238: Next Generation Sequencing Analysis of lung and spleen tissue transcriptomes from Wild Type KrasLA2 and miR-301a-/- Kras mice
Purpose: we used next generation sequencing to analyze gene expression profiles of lung and spleen t...
GSE118185: Differential expression in wild-type and mutant neurofibroma and MPNST cell lines
Using RNA-seq we characterized gene expression changes occuring upon knockout of EZH2, EZH1, EZH1+EZ...
GSE120784: Effect of IL-1b on primary human skin-relevant cells
Analyses of IL-1b-induced transcriptome in various skin-relevant cell types (keratinocytes, dermal f...
GSE121632: Gene expression analysis of a panel of human fibroblasts that generate an aligned (anisotropic) vs non-aligned extracellular matrix
A panel of human fibroblasts derived from patient samples (vulval, oral, cervical and breast carcino...
GSE118748: Improved expansion, functionality and tumor targeting of adoptively transferred T cells with kinetically engineered IL-2
The adoptive transfer of cancer-specific T cells in combination with high dose interleukin-2 (IL-2) ...
GSE120128: RNA-sequencing of innate lymphoid cells that were sorted from mouse skin
Purpose: Transcriptomic analysis of skin innate lymphoid cells; Methods: Innate lymphoid cells were ...
GSE120746: a-synuclein accumulation in an iPSC derived model of early onset sporadic Parkinsons Disease reveals novel drug targets
iPSC derived dopaminergic neuron cultures sequenced from different patient lines. SOURCE: Samuel,A,S...
GSE118841: Description of NRF2-dependent transcriptome in non-small cell lung cancer cell lines with KEAP1 mutations
We report NRF2-dependent changes in the transcriptome of A549, H460 and H2023 cell lines. SOURCE: Ho...
GSE118731: A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture
Vascular endothelial cells (ECs) derived from the central nervous system (CNS) variably lose their u...
GSE119487: m6A-seq profiling in WT, WtapKO and Mettl3KO mESCs
By m6A-seq, we examined the m6A pattern on Xist, which immediately after the A-repeat region. The ce...
GSE111143: RNA-Seq of CD8+ T cells during LCMV infection [WT infection]
T cell receptor (TCR) stimulation of nave CD8+ T cells initiates reprogramming of cis-regulatory lan...
GSE118698: A miR-23~27~24 regulon that controls follicular helper T cell differentiation
Follicular helper T (Tfh) cells are essential for generating protective humoral immunity. To date, m...
GSE120281: RNA-sequence data of hepatic stellate cells and liver sinusoidal endothelial cells from control and CCl4-treated mice
We utilized RNA-sequencing strategy to explore the characterstics of gene expression profile of LSEC...
GSE118773: Cell-to-cell variation in defective virus expression and effect on host response during influenza virus infection
Virus and host factors contribute to cell-to-cell variation in viral infection and determine the out...
GSE111169: Next Generation Sequencing analysis of Hes1+/+ Cre-ERT2 and Hes1fl/fl Cre-ERT2 bone marrow derived macrophages transcriptomes.
To evaluate the potential role of Hes1 in regulation of type I IFNs and the downstream ISGs expressi...
GSE112627: RNA-seq analysis of Scn1+/- Dravet mice on susceptible and resistant strains at postnatal days 14 and 24
Dravet syndrome is a severe, early-onset epileptic encephalopathy frequently resulting from de novo ...
GSE120272: Whole-Transcriptome Profiling of Canine and Human in Vitro Models Exposed to a G-Quadruplex Binding Small Molecule
G-quadruplexes (G4) are secondary nucleic acid structures that have been associated with genomic ins...
GSE125756: p53-inducible long non-coding RNAs encode functional peptides in hepatocellular carcinoma cells [RNA-seq]
To identify p53-regulated lncRNAs responsive to DNA damage in human hepatocellular carcinoma (HCC) c...
GSE118821: Transcriptome analysis of antigen-specific T follicular helper (Tfh) cells and non-Tfh cells
To identify transcription factors critically involved in the Tfh cell transcriptional network, antig...
GSE120776: Single-cell RNA sequencing of mouse Circulating tumor cells (CTCs) and tumor cells
To analyze transcriptional expression profile in CTC and tumor cells SOURCE: Yi Fan (Yi.Fan@uphs.upe...
GSE118173: Transcriptome analysis of mesenchymal CSC-like cells harboring mutant p53
We show that mesenchymal CSC-like cells express an embryonic stem cell signature that is mutant p53 ...
GSE117681: Next Generation Sequencing Facilitates Quantitative Analysis Of Wild Type And Epithelium-specific Cox10-/- Renal Transcriptomes
Description: We find multiple evidence that mitochondria are directly and indirectly involved in the...
GSE121475: Evalutation of global gene expression changes in NGLY1 deficient mouse embryonic fibroblasts (MEF)
the gene expression profiles of 3 cultured MEFs from NGLY1 knockout mice was compared to 3 cultured ...
GSE129748: Nasal Allergen Challenge and Environmental Exposure Chamber Challenge: A Comparison of Clinical and Biological Responses to Cat Allergen
A direct comparison of NAC and EEC allergen challenges revealed differences in the kinetics and magn...
GSE120675: Gene expression analysis in response to hypoxic pathway inhibition
Gene expression analysis of HeLa cells exposed to hypoxia (1% Oxygen), treated with a PHD inhibitor ...
GSE125458: A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells
Long noncoding RNAs (lncRNAs) have emerged as important components of gene regulatory network in emb...
GSE128305: Hypoxia induces the dormant state in oocytes through expression of Foxo3
In mammals, most immature oocytes remain dormant in the primordial follicles in order to ensure the ...
GSE120799: Transcriptome profiling of Dek over-expressed quiescent muscle stem cells in vivo
To understand the molecular signatures of Dek over-expressed quiescent muscle stem cells in vivo, we...
GSE118948: Single-cell profiling of the myeloid landscape identifies cell subsets with distinct fates during neuroinflammation
The innate immune cell compartment is highly diverse in the healthy central nervous system (CNS) inc...
GSE118870: Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation II
The transcriptional profile of A673 parental, and SP-2509 drug resistant washout cells (4 and 6 mon...
GSE119075: Epigenetic safeguards are coordinately removed to reverse cell identity [RNA-Seq]
Epigenetic modifications operate in concert to maintain cell identity, yet how these interconnecte...
GSE118864: Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation I
The transcriptional profile of A673 parental and SP-2509 Drug resistant cells treated with DMSO and ...
GSE118187: Identification of the genes under the control of the transcription factor Prdm12 in somatosensory neurons
Prdm12, a novel key regulator of the Nerve Growth Factor-TrkA signaling pathway, is required for noc...
GSE108328: The extent of liver injury determines hepatocyte fate toward senescence or cancer
Induction of hepatocyte senescence is known to inhibit hepatocellular carcinoma (HCC). Until now, it...
GSE122923: AR-V7 targets the oncogenic genes in castration resistant prostate cancer. [RNA]
To identify the AR-V7 target genes in human prostate cancer, two cell lines (LNCaP, LNCaP95) were s...
GSE125808: The RNA helicase DDX6 regulates self-renewal and differentiation of human and mouse stem cells [polysome RNA-seq]
Analysis of adult and embryonci stem cells depleted for DDX6. Results provide insight into the regul...
GSE118926: A versatile mouse model of epitope-tagged histone H3.3 to study epigenome dynamics
H3.3 knock-in mice serve as a useful experimental model to study epigenome regulation in development...
GSE119080: Effects of fructose on liver gene expression profile in DEN-induced HCC model.
Excessive fructose consumption causes fatty liver disease and steatohepatitis, conditions that eleva...
GSE137674: Gene expression profile of thymic AML generated by NP23 and NHD13 transgenes
Gene expression profile of AML generated via 3 related transgenes is compared. SOURCE: Peter Aplan C...
GSE94993: The cohesin release factor WAPL restricts chromatin loop extension. [RNA-Seq]
The spatial organization of chromosomes influences many nuclear processes including gene expression....
GSE119336: RNA over-editing leads to aggressiveness of intrahepatic cholangiocarcinoma [RNA-Seq]
Alteration in RNA editing has been connected to tumor progression and many other important human dis...
GSE116259: Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2 [RNA-seq]
Pioneer transcription factors (PTF) can recognize their binding sites on nucleosomal DNA and trigger...
GSE125747: The contribution of adenosine receptor 3-mediated signaling to TLR4-induced responses by human dendritic cells
Human dendritic cells were exposed to LPS, in the absence and presence of adenosine receptor 3 inhib...
GSE119762: Hair follicle stem cells (HF-SCs) can initiate psoriasis-like disease in mice
Using lineage-tracing in a well-established psoriasis-like mouse model with inducible epidermal dele...
GSE120728: Transcription factor T-bet in B cells controls germinal centre polarization and antibody affinity maturation in response to malaria (RNA-seq)
Despite the key role that antibodies play in protection against malaria, the cellular processes modu...
GSE120800: Differentially expressed (DE) genes analysis in synovial fluid mesenchymal stem cells (SF-MSCs), SF-MSC derived iPSCs and iPSC derived MSCs (iPSC-MSCs)
We report the application of next-generation sequencing (NGS) to analysis the gene expression profil...
GSE120609: Hypothalamus transcriptome analysis of Shank3-overexpressing mice
Shank3 is a core excitatory postsynaptic protein expressed in multiple brain regions including the m...
GSE112670: The m7G tRNA methylome regulates embryonic stem cell self-renewal and differentiation
tRNAs are subject to numerous modifications including methylation. Mutations in the human N7-methylg...
GSE108452: Transgenerational inheritance of chronic adolescent stress: Effects of stress response and the amygdala transcriptome
Adolescent stress can impact health and well-being not only during adulthood of the exposed individu...
GSE127064: Inferring dynamic regulatory programs in non-stationary expression time courses with applications to early human neural development
We generated RNA-seq data to measure transcriptional profiles of twenty hPSC-derived NSC populations...
GSE89232: Single-cell RNA-seq reveals heterogeneity within human pre-cDCs
Here, we use a microfluidics-based approach to prepare single-cell RNA-Seq libraries from 164 primar...
GSE120688: Next Generation Sequencing of Wild Type and PTPRO-/- ESCC tumoral Transcriptomes
To induce tumorigenesis in the esophagus, 100 mg/mL of the water-soluble carcinogen 4NQO (Sigma-Aldr...
GSE111740: UXT is required for spermatogenesis in mice
Male mammals must simultaneously produce prodigious numbers of sperm and maintain an adequate reserv...
GSE120689: Transciptome analysis of TP63 regulated pathways in HNSCC
Purpose: To identify TP63 expression regulated pathways in HNSCC; Methods: A recombinant lentivirus ...
GSE124447: A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor a-dependent transcriptional activation and breast carcinogenesis (RNA-seq)
While protein arginine methyltransferases (PRMTs) and PRMT-catalyzed protein methylation have been w...
GSE119828: Genome-wide transcriptome analysis of NIPBL hematopoeitic progenitors and megakaryocytes
The purpose of this study was to compare the transcriptome of NIPBL patient derived Hematopoietic pr...
GSE120816: RNA-seq expression profiling of individual clones sorted from mouse mammary tumors
Breast tumors are characterized by inherent heterogeneity but the evolving cellular organization of ...
GSE121403: Dynamic enhancer partitioning instructs Zdbf2 activation during epigenetic reprogramming [RNA-Seq]
Early mammalian development is accompanied by a profound global remodeling of chromatin-based regula...
GSE119893: Deconstructing Retinal Organoids: single cell RNA-Seq reveals the cellular components of human pluripotent stem cell-derived retina
The rapid improvements in single cell sequencing technologies and analyses methods afford greater sc...
GSE119819: DUX-miR-344-ZMYM2-mediated activation of MERVL LTRs induces a totipotent 2C-like state [RNA-seq]
Mouse embryonic stem cells (ESCs) sporadically express preimplantation two-cell-stage (2C) transcrip...
GSE121425: LSD1 pharmacological inhibition in SET-2 containing wild type and mutant LSD1 [RNA-Seq]
We characterized the effect of GSK-LSD1 treatment on gene expression for both wt SET-2 and drug-resi...
GSE124660: mRNA expression profile of mouse CD4 T cells (treated vs. untreated with PM2.5 suspension)
Purpose: PM2.5 can impact mouse TH17 cell differentitation. To Investigator the genes altered by PM2...
GSE119852: Global transcriptional profiling unveils the interferon network in blood and tissues across different diseases [RNA-seq_HDM_sorted_CD4_Tcells]
We have performed modular analyses to decipher the global transcriptional response and capture a bre...
GSE109753: The fate of CD8+ T cells during infection is linked to their developmental origin [VirtualMemory_and_TrueNave_timestamp]
During immune ontogeny the thymus is colonized by distinct waves of hematopoietic stem cells that gi...
GSE135960: CDK12 inhibition in Hep3B, Huh7 and SNU449 cells
Purpose: to analyze gene expression in THZ531 treated liver cancer cells. Methods: Hep3B and Huh7 ce...
GSE127963: Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
Single cell RNAseq of Old (19 month) and Young (3 month) mouse brain endothelial cells isolated from...
GSE109510: The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells
The CCCTC-binding factor (CTCF) is a versatile transcriptional regulator required for embryogenesis,...
GSE120173: Characterization of ST2+ and ST2- mTh cells in helminth infection
CD4+T cells are differentiated into Th1, Th2, Th17 and Treg cells after Antigen presentation by othe...
GSE120376: Genome-wide histone modification and accessibility maps of mESCs, in the pluripotent state and after induced differentiation
Gene expression networks are tightly regulated by transcription factors (TF) and their targeted regu...
GSE108300: Direct Conversion of Mouse Fibroblasts into Neural Stem Cells by Chemical Cocktail Requires Stepwise Activation of Growth Factors and Nup210
Neural stem cells (NSCs) are valuable for both basic research and clinical application. We previousl...
GSE119832: The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth
The overall goal of this study was to characterize the activity and mechanism(s) of action of the pa...
GSE125872: iPS derived microglia like cells cultured with human neurons and astrocytes
In this article, Jose Polo and colleagues molecularly compare existing microglia differentiation met...
GSE112663: Transcriptome analysis of a MECP2 conditional KO mouse model
Rett syndrome is a severe neurodevelopmental condition that rsults primarily from mutations in the M...
GSE136023: Genome-wide view of the impact of Spt5-Pol II inhibitors (SPIs) on mRNA levels [RNA-Seq 24h]
We identified the first Spt5-Pol II inhibitors (SPIs). SPIs faithfully reproduced Spt5 knockdown eff...
GSE120309: Transcriptome of Prmt5-deficient and control mouse activated B cells
Quiescent splenic B cells purified from Cg1-cre Prmt5F/F cells and Cg1-cre control mice. Resting B c...
GSE119808: Next generation sequencing quantitatively analyzes transcriptomes of primary CLL cells co-culture with Wild Type or prkcb-/- bone marrow mesenchymal stromal cells
RNA-seq profiles of patient-derived primary CLL cells when co-cultured with bone marrow derived mese...
GSE125657: Keratinocyte-intrinisic MHCII expression controls Microbiota-specific Th1 cell responses
The crosstalk between the microbiota and the immune system plays a fundamental role in the control o...
GSE118974: Quantitative mass spectrometry-based proteomics reveals the dynamic protein landscape during initiation of human Th17 cell polarization
CD4+ T cells play a key role in the adaptive immune system. Their subset, Th17 cells contribute to p...
GSE109671: Genome organisation and chromatin analysis identifies transcriptional downregulation of insulin-like growth factor signalling as a hallmark of ageing in developing B cells
Background Ageing is characterised by loss of function of the adaptive immune system, but the under...
GSE127825: Noncoding regions are the main source of targetable tumor-specific antigens
Purpose: Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but very f...
GSE111035: Maternal Plag1 deficiency delays two-cell stage embryo development and embryonic genome activation [Uterus]
Pleomorphic adenoma gene 1 (PLAG1) encodes a transcription factor involved in cancer and growth. We ...
GSE135983: Integrin 31-dependent mRNA expression profile of hair bulge keratinocytes and their progeny during DMBA/TPA-mediated skin tumorigenesis
Integrin 31 in hair bulge population affects the tumor formation following DMBA/TPA carcinogenesis p...
GSE121700: The use of targeted next-generation sequencing to determine the regulatory function of TGF1 in kidney fibrosis [RNA-seq]
Transforming growth factorbeta (TGF1) plays an important regulatory role in the progression of chron...
GSE133430: Effects of Korean red ginseng against the influence of bisphenol A on ovariectomized mouse liver and uterus
Bisphenol A (BPA), known as an endocrine disruptor, is widely used in the world. BPA is reported to ...
GSE75602: Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
Although mechanisms of acquired resistance of EGFR mutant non-small cell lung cancers to EGFR inhibi...
GSE125662: RNA-seq data of alveolar type 2 epithelial cell derived from organoids treated with IL-1b or TNFa
Treatment with IL-1b or TNFa enhance the proliferation of alveolar type 2 cells in organoid culture....
GSE115256: Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells
The human pluripotent stem cells cultured on Low-adhesion substrates formed two morphologically diff...
GSE119596: High-throughput RNA-sequencing-based transcriptomic profiles of embryonic lens development for cataract gene discovery
We applied previously established in silico whole-embryo body (WB)-subtraction-based approach to id...
GSE119844: Screening regulated pathway and genes expression in polyI:C treated cerulein-induced AP mice models
Pancreas tissue derived from mice with intraperitoneal injection of saline, cerulein or polyI:C plus...
GSE120303: Identification of gene signature in ascitic fluid-isolated mesothelial cells from high grade serous ovarian cancer patients
RNA-sequencing analysis was carried out on ascitic fluid-isolated mesothelial cells from ovarian can...
GSE121471: Gut-Resident IL10+CX3CR1hi Macrophages Induce Tertiary Lymphoid Structures and IgA Response in Situ
Gut resident IL10+CX3CR1hi macrophages drive development of mucosal tertiary lymphoid structures tha...