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Sequencing-based assays page 75
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GSE136072: RNA-expression profiling of mouse B cells coexpressing LMP1 with EBNA3A, Rel or Ebf1 in vitro
mouse B cells coexpressing LMP1 with EBNA3A, Rel or Ebf1 were cultured for 6 days in vitro and analy...
GSE122045: Molecular Characterization of auditory nerve with Versican deficiency
Overall goal of the study is to identify key molecular regulators of auditory nerve development and ...
GSE121954: Transcriptomic analysis of mRNA expression changes induced by RANKL expression in the murine salivary gland
Sequencing of mRNA isolated from salivary glands of control mice and mice overexpressing RANKL in ke...
GSE119117: Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection
Most individuals exposed to hepatitis C virus (HCV) become persistently infected while a minority sp...
GSE110391: The protective effect of celastrol in ANIT-induced cholestasis
Purpose: The goals of this study was to (1) evaluate the protective effect of celastrol on alpha-nap...
GSE121665: Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors [BaseEditors - RNA]
Base Editing has been touted the most intelligent and precise application of the CRISPR platform so ...
GSE110327: TCR signal strength controls thymic differentiation of iNKT cell subsets
Three major phenotypically and functionally distinct invariant Natural Killer T (iNKT) cell subsets ...
GSE113178: Role of lncRNA BC030870 in mammary gland cell proliferation
We investigated an uncharacterized lncRNA, BC030870, that displays an epithelial cell-restricted exp...
GSE124450: Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes (ALK)
Long intergenic non-coding RNAs (lincRNAs) are emerging as integral components of signaling pathways...
GSE119866: A novel lncRNA lncRNA-AF339830 promotes colorectal carcinogenesis and glucose metabolism by stabilizing and specifying the transcription modification pattern of c-Myc [RNA-Seq]
To elucidate whether lncRNA-AF339830 plays a role in colorectal cancer tumorigenesis, a RNA-seq an...
GSE139647: "TRADES": Targeted RNA demethylation by Suntag system
We engineered a new m6A editing system consisting of GCN4 (SunTag)-dCas13b, anti-GCN4 single chain v...
GSE121024: The role of Mediator and Little Elongation Complex in transcription termination
Mediator is a coregulatory complex involved in regulating the transcription of Pol II-dependent gene...
GSE129733: Total Stranded paired end RNA Seq of wildtype and knockout Kdm4a 2 cell embryos
Purpose: The goal of this study was to generate paired-end total RNA Seq transcriptomes of wildtype ...
GSE117726: The transcriptome analysis of Treg subset
The transcriptome analysis of WT and Tcf7/Lef1 double knockout (dKO) Treg subset; ; CD4+ Foxp3+ T re...
GSE111025: RNA-seq of Tfh IL21+ single producers and Tfh IL21+ IL10+ double producers
During chronic viral infection, the inflammatory function of CD4 T cells becomes gradually attenuate...
GSE139332: Investigating the Interleukin-22 regulated transcriptome in normal and APC-mutant small intestinal epithelial organoids
Purpose: to investigate the effects of the cytokine Interluekin-22 (IL-22) on small intestinal epith...
GSE121660: Arnt2 tunes activity-dependent gene expression through NCoR2-mediated repression and Npas4-mediated activation
ChIP-, ATAC-, and RNA-seq data SOURCE: Mark,Aurel,Nagy (aurel_nagy@hms.harvard.edu) - Michael E. Gre...
GSE120928: Global gene expression analysis in Naive vs. ASC KO murine CD4 T cells post-activation
Nave CD62L+ CD44- CD25- CD4+ splenic mouse T cells from WT or ASC KO cells were left untreated or tr...
GSE122874: Comparison of NK cell developmental stages in bone marrow of Tbx21 WT versus KO mice
Bone marrow cells were isolated from wild type and Tbx21 knockout mice. iNK (Lin- NK1.1+ CD11b- CD27...
GSE123680: Hsa-miR-139-5p/HNRNPF axis modulates gene-transcripts balance in thyroid cancer cells
We explored alternative splicing events upon hsa-miR-139-5p/HNRNPF axis regulation in our cell syste...
GSE119313: Lack of NFATc1 SUMOylation protects from inflammatory diseases
Post-translational modification with SUMO is known to regulate the activity of transcription factors...
GSE145203: Transcriptional responses to TNF following HFol treatment of wild type and GCN2 depleted synoviocytes
We report the effects of Hfol on TNF induction of inflammatory genes in wild type cells versus cells...
GSE120522: Single cell transcriptome profiling of mouse and hESC-derived pancreatic progenitors
Human embryonic stem cells (hESCs) are a potential unlimited source of insulin-producing -cells for ...
GSE119709: Transcriptional responses to IFN-alpha in human dermal fibroblasts
We sought to examine the transcription response to IFNa in fibroblasts from three healthy controls (...
GSE121653: Single-cell RNAseq Reveals Developmental Origins and Ontogenetic Stability of Neurexin Alternative Splicing Profiles
Neurexins are key synaptic organizers which exist in thousands of alternatively spliced isoforms. Be...
GSE121037: RNA-seq of spleen tissue of wild type and Elf4 deficient mice after Plasmodium yoelii 17XNL infection
We infected wild type and Elf4 deficient mice with Plasmodium yoelii 17XNL, a non-lethal species, to...
GSE136001: Single cell RNA sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophages
Single cell RNA-seq analysis of CD11b+ cells sorted from murine syngeneic gliomas, indicating distin...
GSE120183: Profiling of RNAs downregulated by influenza A virus PA-X ribonuclease
The goal of this analysis was to investigate the targets of the influenza A host shutoff ribonucleas...
GSE119861: Single cell gene expression analysis of stem cell-derived cerebral organoids treated with Methamphetamine
To study the effects of fetal brain exposure to methamphetamine, embryonic stem cell-derived cerebra...
GSE136055: Physiological Histone H2B ADP-ribosylation Controls Adipogenesis
Although ADP-ribosylation of histones by PARP-1 has been linked to genotoxic stress responses, its r...
GSE125153: NF-kB regulator Bcl3 modulates bone density and turnover
B-cell lymphoma 3-encoded protein (Bcl3) is an intimate and context-specific regulator of the NF-kB ...
GSE125483: Conservation, acquisition, and functional impact of sex-biased gene expression in mammalian tissues
Sex differences are widespread in human health and disease, which are frequently modeled in other ma...
GSE123281: Large 1p36 deletions affecting Arid1a locus facilitate Mycn-driven oncogenesis in a new neuroblastoma model
Loss of heterozygosity (LOH) at 1p36 is a frequent chromosomal event in a broad range of human cance...
GSE110957: The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
Myoblast fusion (MF) is a complex process required for muscle formation. During development, post-na...
GSE120595: Jarid2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells
How specific genetic lesions contribute to transformation of non-malignant myeloproliferative neopla...
GSE110378: Kdm6b is Required for Self-Renewal of Normal and Leukemic Stem Cells Under Proliferative Stress
Recent studies have indicated that the histone 3 lysine 27 (H3K27me2/3) demethylase KDM6B (JMJD3) is...
GSE120107: Mutant p63 disrupts the key specification switch from the multipotent cell state to stratified epithelia during epithelial differentiation/in ectodermal dysplasia disorders
Transcription factor p63 is a key regulator of stratified epithelia. In humans mutations in p63 are ...
GSE121705: Sex chromsomes affect gene expression of autoantigen specific CD4+ T cells.
To determine the role of sex chromsomes in sex differences of autoimmune disease, we used high throu...
GSE125873: RNA-Seq of blood in preterm infants with Bronchopulmonary dysplasia.
RNA-Seq of peripheral blood at 36 weeks post-menstrual age, the time BPD was diagnosed. Using this w...
GSE129754: PRMT1-mediated FLT3 arginine methylation promotes FLT3-ITD+ Acute Myeloid Leukemia maintenance
We want to obtain FLT3-ITD gene signature. To do so, we transduced CB CD34+ cells with mock or FLT...
GSE120858: MYCN knock-down leads to DNA-repair deficiency in human neuroblastoma (RNA-Seq)
We knock down MYCN in human neuroblastoma cell line by RNAi. MYCN knock-down caused global epigenome...
GSE123309: Next Generation Sequencing (NGS) Facilitates Quantitative Analysis of Differentially Expressed Genes in Liver Regeneration After Combined Treatment With Ethanol And Carbon Tetrachloride
Purpose: The goals of this study are to use NGS-derived liver transcriptome profiling (RNA-seq) and ...
GSE121040: Transcriptome analysis of Brucella abortus S19per (a perosaminesynthetase gene mutant of strain S19) immunized mice spleen revealed activation of MHC-I and MHC-II pathways
Goal: High-throughput sequencing-by-synthesis (Illumina) RNA sequencing technology was carried out w...
GSE129482: RNAseq of NTCU-induced mouse lung squamous cell carcinoma
Topical treatment with N-nitrosotris-(2-chloroethyl)urea (NTCU) induces lung squamous cell carcinoma...
GSE120977: Transcriptomic analysis of liver mRNA from TSP-1 KO and WT mice fed with normal diet or choline deficient amino acid defined diet (CDAHFD, human NASH model)
Transcriptomic profiles of wild type and TSP1 knockout mice that were fed control (normal) diet or C...
GSE123957: RNA-binding chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing [Non-synchronized RNA-seq]
The processing of RNAs by chromatin-associated proteins (CAPs) is highlighted by the latest findings...
GSE111902: Compendium of CD8+ T cell Data
Compendium of high-throughput sequencing datasets derived from murine CD8+ T cells responding to inf...
GSE123723: Polycomb dysfunctional transcriptional repression in muscle stem cells contributes to lamin dependent muscular dystrophy [RNA-seq]
Polycomb group of proteins (PcG) and the nuclear Lamin A are key factors in the maintenance of chrom...
GSE121573: Recruiting Endogenous ADARs with Antisense Oligonucleotides to Reprogram the Transcriptome
Huge efforts are made to engineer safe and efficient genome editing tools. An alternative might be t...
GSE120146: Transcriptomic signatures indicative of a non-genotoxic adverse outcome pathway for small intestine cancer in the duodenum of mice exposed to hexavalent chromium, captan, or folpet
We evaluated duodenal tissues of B6C3F1 mice exposed to either Cr(VI) (180ppm in drinking water), ca...
GSE143143: Neutrophil extracellular trap induced dendritic cell activation leads to Th1 polarization in type 1 diabetes
We performed a comparison of transcriptome between monocyte-derived dendritic cells (moDC) cultured ...
GSE122984: Comparing the transcriptomes of islets in high fat induced obesity mice and normal mice
Islets mRNA profiles of 27 weeks high fat induced obesity mice and normal mice were generated by RNA...
GSE116313: Changes in mitochondrial function and browning markers of subcutaneous and visceral white adipose tissue of C57BL/6j mice from weaning to young adulthood
White adipose tissue (WAT) distribution and WAT mitochondrial function contribute to total body meta...
GSE115033: CLEAR: Coverage-based Limiting-cell Experiment Analysis for RNA-seq (mouse)
Direct cDNA preamplification protocols developed for single-cell RNA-seq (scRNA-seq) have enabled tr...
GSE121753: Delineating functional enhancers (cis-regulome) in LPS-activated murine splenic B cells
LPS activated murine splenic B cells (aB) were subjected to FAIRE-Seq, STARR-Seq, Hi-C, ChIP-seq, Na...
GSE110397 (mouse): NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
Accumulating evidence suggests that molecularly targeted therapies, which were originally developed ...
GSE110795: RNA-seq expression profiling of cortical bone from ephrin B2 deficient and control mice
Within the bone matrix is an interconnected network of cells termed osteocytes. These cells are deri...
GSE123683: Transcriptome analysis upon C6orf203 silencing
In our studies we were searching for the new factors engaged in mitochondrial nucleic acids metaboli...
GSE121044: RNA seq analysis of the mouse pNC and Cornea transcriptome
Purpose: The goal of this study is to provide a detailed transcriptome expression profile of the mou...
GSE111173: De novo DNA methylation at imprinted loci during reprogramming into nave and primed pluripotency
CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo m...
GSE117781: Cellular origin, tumour progression and pathogenic mechanisms of cutaneous neurofibromas revealed by mice with Nf1 knockout in boundary cap cells
Patients carrying an inactive NF1 allele develop tumours of Schwann cell origin called neurofibromas...
GSE121697: Epidermal growth factor activates -catenin via integrin-linked kinase to control proliferation of mesenchymal stromal cells.
Mesenchymal stromal cells (MSCs) are located in bone marrow where they help to maintain bone homeost...
GSE123657: mRNASeq of z_Q175 knock-in mouse lines with and without neo cassette
In order to determine the effect of neoR gene in Q175 locus, mRNASeq was performed to compare the tr...
GSE121790: Transcriptomic analysis of trophoblast interactions with receptive vs. non-receptive endometrial epithelium: an in vitro model for human implantation
The aim of this study was to establish an in vitro model to investigate the initial stages of human ...
GSE120330: Global Long Terminal Repeat activation participates in establishing the unique gene expression program of classical Hodgkin Lymphoma [RNA-Seq]
Long terminal repeat (LTR) elements are wide-spread in the human genome and have the potential to ac...
GSE108679: Immune Resistance Emerges from Tumor-Initiating Stem Cells
Tumors are initiated and maintained by a stem cell-like population. However, our bodies have a power...
GSE120087: Cardiac ReductomiRs: Identification of Novel Nrf2-Dependent microRNAs as Post-Transcriptional Regulators of Myocardial Gene Expression [mRNA]
Background: Although modern advances in the treatment of heart disease have reduced mortality rates,...
GSE111080: RNA-seq analysis of Slc39a8(neo/neo) versus wild-type mice: yolk sac, placenta and fetal liver, kidney, lung, heart and cerebellum
Slc39a8 encodes ZIP8, a ubiquitous divalent cation/bicarbonate symporter expressed in pluripotent mo...
GSE110787: Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-induced Acute Liver Injury in Mice
Acetaminophen overdose is the most common cause of acute liver injury (ALI) or acute liver failure i...
GSE121768: Transcriptomics and chromatin accessibility analysis of MLL-AF9 early responses in mouse bone marrow cells
We investigated early changes of gene expressions and chromatin accessibilities in hematopoietic ste...
GSE123734: Functional dissection of MIEN1 trans-regulation provides new evidence for colorectal cancer genome editing-based therapeutics
MIEN1 has been described as a key actor in colorectal cancer (CRC) biogenesis. We have used CRISPR/C...
GSE143847: Whole transcriptome RNAseq analysis of somatic cells in Inhba fetal testes
We performed RNA-seq on testicular somatic cells from fetal activin A-deficient mice (Inhba KO) and ...
GSE120874: Transcriptome analysis of Bcl11b-deficient regulatory T cells at steady state
T regulatory (Treg) cells have been studied in depth since their discovery for their potential use i...
GSE122175: Differentially expressed genes in Oesophageal tumours in Grhl3 cKO mice in comparison with WT mice
RNA Seq analysis was performed on tissue from tumours from five Grhl3 knock out mice and five wild t...
GSE109171: RNA sequencing of sorted microglia from NEFH-tTa/tetO-hTDP43 transgenic mouse whole spinal cord
Microglia are the resident myeloid-lineage cells in the central nervous system. Despite myriad obser...
GSE136002: Transcriptome analysis of control and ERK3-depleted Human Colonic Primary Epithelial cells (HCPECs)
RNA sequencing analysis of control and ERK3 knockdown HCPECs was performed to understand the physio...
GSE123738: Nr4a transcription factors limit CAR-T cell function in solid tumors [RNA-Seq]
Chromatin accessibility with ATAC-seq and gene expression with RNA-seq for CD8 T cells expressing ch...
GSE121842: Next Generation Sequencing Analysis of Colorectal Cancer Tissue Transcriptomes
Non-codingRNAs play an important roles in cancers. However, the expression profiles of circRNAs (cir...
GSE126352: Transcriptomes of human monocytes from patients with familial hypercholesterolemia before and after statin treatment
Innate immune memory, also refered to as trained immunity (TRIM) is the phenomenon whereby innate im...
GSE120844: Pomalidomide inhibits PD-L1 induction to promote anti-tumor immunity
We examined genome-wide how pomalidomide affects IFN-gamma-induced PD-L1 expression in human melanom...
GSE110741: Novel Alzheimer risk genes determine the microglia response to amyloid- but not to TAU pathology
Polygenic risk scores have identified that genetic variants without genome-wide significance still a...
GSE124510: Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
Resistance to proteasome inhibitors (PIs) is a ubiquitous clinical concern in multiple myeloma (MM)....
GSE120852: Wipi1 is a Genetic Hub that Mediates Right Ventricular Failure
Right ventricular dysfunction (RVD) independently predicts worse outcomes in both heart failure (HF)...
GSE136046: RNAseq analysis of bone marrow aspirates from Plasmodium vivax patients in the Amazon State, Brazil
We analyzed bone marrow aspirates from seven patients with vivax malaria and RNAseq analysis identif...
GSE121671: Tet inactivation disrupts YY1 binding and long-range chromatin interactions to cause developmental defects in embryonic heart
Tet-mediated DNA methylation oxidation plays an important role in shaping the epigenetic landscapes ...
GSE141262: Expression profiling of tumor lymphatic endothelial cells upon acute Ang2 inhibition
Lymphatic endothelial cells (LEC) were isolated from MT-ret tumor tissue 12h after treatment with an...
GSE120425: c-Maf is an essential commitment factor for IL-17-producing gd T cells [RNA-seq]
IL-17-producing gd T (Tgd17) cells are early mediators of immunity and autoimmunity that undergo eff...
GSE123903: The single cell transcriptional landscape of a mouse model of lung cancer metastasis
Transcriptionally profiling of single cells isolated from progressive stages of metastatic outbreak ...
GSE120660: Genomic Analysis of DNA Repair Genes and Androgen Signaling in Prostate Cancer
Abstract Background. The cellular effects of androgen are transduced through the androgen recepto...
GSE120833: Genome wide RNA-seq of wild-type and Safa-/- BMDMs upon HSV-1 infection.
SAFA deficiency affects various gene expression upon HSV-1 infection. SOURCE: lili Cao (caolili@bjmu...
GSE127976: Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons
Purpose: The goals of this study are to compare the LGE-derived cells changes gene expression pfofil...
GSE110415: Characterization of host responses during Pseudomonas aeruginosa acute lung infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002
Pseudomonas aeruginosa is an opportunistic pathogen that causes nosocomial pneumonia and infects pat...
GSE123179: Gene Expression Changes in Major Cell Types of the Glomerulus in a Mouse Model of Focal Segmental Glomerulosclerosis
We characterize the gene expression changes which occur in the mouse glomerular podocyte, mesangial,...
GSE119630 (mouse): Extraction-Free Whole Transcriptome Profiling from Specific Subareas of Unstained or H&E Stained FFPE Tissues
We describe the use of a ligation-based targeted whole transcriptome expression profiling assay, Tem...
GSE119380: RNA-Seq Data
We report here the RNA-Seq data for Control_Untreated_BMDMS, Control_LPS Treated_BMDMs and SRF-KO-LP...
GSE122990: Rna-seq transcriptome data for 12 week pancreatic islets from Neurod1 beta cell specific (Neurod1Floxed/Floxed; RipCre+) and control (Neurod1Floxed/Floxed) mice.
The purpose of this study was to identify genes regulated by Neurod1 in murine adult pancreatic isle...
GSE123190: Setdb1 regulates Cohesin at H3K9me3-independent topological domains [RNA-Seq]
Identification of SMC1a and Setdb1 bound-loci in E14 mESCs. SOURCE: Chadi El FarranEpigenetics and C...
GSE126260: Functional Cardiac Fibroblasts Derived from Human Pluripotent Stem Cells via Second Heart Field Progenitors
Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease. The li...
GSE120504: Role of ACLY in gene regulation during adipocyte differentiation
RNA-sequencing from Aclyf/f and Acly-/- preadipocytes generated from Aclyf/f mice and induced to dif...
GSE122903: Global analysis of circRNA-associated ceRNA network for investigating underlying pathogenesis of constrictive pericarditis (RNA-Seq)
Purpose:The purpose of this study is to investigate the potential mechanisms that triggering the ons...