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Sequencing-based assays page 76
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GSE132127: Gene expression profiles of young and aged mammary epithelial and stromal cell populations from Wild Type and Slug/Snai2-null mice
This experiment shows RNA-Seq gene expression profiles of Wild Type and Slug/Snai2-null luminal, bas...
GSE117728: A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and postnatal growth retardation in mice
DNA methyltransferases (DNMTs) deposit repressive DNA methylation, which regulates gene expression a...
GSE120212: Investigsting the role of NF-B p50 S80 phosphorylation in regulating LPS-induced transcription in THP-1 cells
Phosphorylation of the NF-B p50 subunit is known to regulate target gene expression. The role of p50...
GSE121086: Comparison of DNA methyltransferase-1 (Dnmt1) deleted urogenital sinus epithelium compared to wildtype urogenital sinus epithelium
Dnmt1 is an important regulator of tissue development and differentiation. To assess the effects of ...
GSE123970: Role for citron kinase in prostate cancer growth
To study the effect of siRNA-mediated CIT silencing on androgen-responsive genes in LNCaP cells. SOU...
GSE119675: The BLUEPRINT Murine Lymphocyte Epigenome Reference Resource [RNA-seq II]
This data release is part of the EU BLUEPRINT reference epignome project (http://www.blueprint-epige...
GSE123002: RNA-Seq analysis of SRSF3 KO hearts compared to controls and iCLIP analysis of SRSF3 binding profile in neonatal cardiomyocytes
The goal of this study is to analyse the transcriptome of control hearts vs hearts lacking SRSF3 exp...
GSE123980: The pause-initiation limit restricts transcription activation in human cells
Eukaryotic gene transcription is often controlled at the level of RNA polymerase II (Pol II) pausing...
GSE120310: Effect of neuronal primary cilia on axonal tract development
This experiment aims to study the impact of primary cilia signaling on transcriptional programs rele...
GSE120229: m6A-seq data analysis of control and PCIF1 knockdown transcriptome
Purpose: To identify the in vivo RNA targets of PCIF1, we performed meRIP experiments for PCIF1 KD a...
GSE111092: Non-coding regions are the main source of tumor-specific antigens [mouse]
Purpose: Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but very f...
GSE121749: Altered activity-dependent nascent transcription in Rai1-knockdown mature mouse cortical cultures
We performed nascent RNA-seq technique, Bru-Seq, on mouse neuronal cultures treated with control or ...
GSE122967: Structure and degradation of circular RNAs regulate PKR activation in innate immunity
RNase Lmediated rapid degradation of circRNAs is required for PKR activation in innate immune respon...
GSE120332: PPARg-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice
Homozygous K107R mutation of PPARg in mice alters the expression of its downstream target genes and ...
GSE120628: Gene expression profile of D2.OR-EGFP and D2.A1-EGFP cells in vitro and in vivo
We analysed gene expression profiles of D2.OR-EGFP and D2.A1-EGFP cells isolated from lungs and unde...
GSE121084: Human macrophages exhibit high activity to clear intracellular biovar Microtus strain of Y. pestis
human peripheral lymphocytes were infected with the full virulent strain 141 or human avirulent Micr...
GSE119916: RNA-seq of healthy CD34+ HSPCs after co-culture with myelodyplastic syndrome patient-derived mesenchymal stromal cells
Cytopenia in at least one of the hematopoietic lineages (RBCs, WBCs or platelets) is a hallmark feat...
GSE110457: Identification of transcriptional network regulated by FGFR1 fusion kinase in stem cell leukemia and lymphoma (SCLL)
Purpose: Oncogenic transformation of hematopoietic stem cells by chimeric fusion kinases causing con...
GSE139594: Proliferation-correlated expression
To determine how gene expression varies between fast and slow proliferating cells we developed a CFS...
GSE109745: Maternal Vitamin C regulates DNA demethylation and development of the mouse embryonic germline [RNA-Seq]
Maternal Vitamin C is required in vivo for proper DNA demethylation and development of fetal germ ce...
GSE131073: RNAseq analysis of lacrimal glands isolated from wild type and Aire-/- mice at 5 weeks of age
We used freshly isolated lacrimal glands isolated from wild type and Aire-/- mice on a Balbc backgro...
GSE120703: RNA isoform screens reveal the essentiality and tumor suppressor activity of ultraconserved poison exons
Paired gRNA/Cas9 delivery facilitates the removal of alternative exons and reveals splicing dependen...
GSE123983: Transcriptional Roles for STAT3 in Leptin Action
TRAP-seq from hypothalamic LepRb neurons in either control or mice lacking Stat3 in LepRb cells SOUR...
GSE124677: IL-12 From Endogenous cDC1, and Not Vaccine DC, Is Required for Th1 Induction
In this study, we generated a chimeric situation by injection of different gene-modified BM-DCs into...
GSE131047: CD73 contributes to anti-inflammatory properties of afferent lymphatic endothelial cells in humans and mice
The aim of this study is to compare gene expression differences between human lymphatic endothelial ...
GSE120222: Bulk RNA-seq U2OS cells treated with small molecules
We report the transcriptional changes associated with treatment of U2OS osteosarcoma cell line with ...
GSE123981: Age-resolved ribosome profiling and RNA-Seq data of mice liver and kidney samples
We report ribosome profiling and RNA-Seq data of liver and kidney samples taken from C57BL/6 mice of...
GSE121759: RNA-seq, ChIP-seq and TERRA CHIRT-seq from p53-/- iPS infected with a lentiviral virus carrying a control scrambled shRNA or shRNA against TRF1
The mechanisms that regulate pluripotency and cell fate are still largely unknown. Here, we show tha...
GSE121809: RNA Seq of Fmr1 NPC nuclear fractions
N6-methyladenosine (m6A) modification of mRNA is emerging as a vital mechanism regulating RNA functi...
GSE111828: Transcriptional analysis of in vivo responses to acetaminophen induced hepatic injury in the murine liver
Liver injury results in rapid regeneration through hepatocyte proliferation and hypertrophy. However...
GSE119879: Lens epithelial cell transcriptome reprogramming at 48 hours post cataract surgery (PCS) in wild type (WT) and Fibronectin Conditional Knockout (FNcKO) mice
This trancriptome analysis reveals the first detailed analysis on how the remnant lens epithelial ce...
GSE139564: CRISPR/Cas9 mediated intersectional knockout of GSK3b in D2 receptor expressing mPFC neurons reveals contributions to emotional regulation
Comparison of ribosome associated RNA between mPFC D2 neurons that lack Gsk3 with Controls SOURCE: M...
GSE126309: The lung environment controls alveolar macrophage metabolism and responsiveness during type-2inflammation.
Fine control of macrophage activation is required to prevent inflammatory disease,particularly at ba...
GSE125150: RNA-seq of human iPS derived macrophages with or without KLF1- transcription factor Activation
Red blood cells (RBCs) mature within a specialized niche (the erythroblastic island (EI)), which con...
GSE122930: Single cell sequencing of mouse heart immune infiltrate in pressure overload-driven heart failure reveals extent of immune activation
Single-cell RNA sequencing is revolutionizing the mapping of tissues in physiology and pathology. Wh...
GSE109829: Actomyosin-mediated tension orchestrates uncoupled respiration in adipose tissues
The activation of brown/beige adipose tissue (BAT) metabolism and the induction of uncoupling protei...
GSE120667: Acc1 determines memory potential of individual CD4+ T cells by regulating de novo fatty acid biosynthesis [RNA-seq]
Immunological memory is central to adaptive immunity and protection from disease. Changing metabolic...
GSE119424: Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death [RNA-Seq I]
The expression of transcription factor brachyury (TBXT) is normally restricted to embryonic developm...
GSE110422: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and NCoR1 KD CD8a+ Dendritic cells with and without CpG stimulation
Purpose: The goals of this study to dissect mechanism by which NCoR1 regulate expression of diiferen...
GSE122992: Rna-seq transcriptome data for Neurod1-homozygous null and Neurod1-heterozygous null murine E17 pancreatic endocrine cells
The purpose of this study was to identify genes regulated by Neurod1 during murine pancreatic endocr...
GSE122969: Checkpoint blockade immunotherapy induces dynamic changes in PD-1-CD8+ tumor-infiltrating T cells
An improved understanding of the anti-tumor CD8+ T cell response after checkpoint blockade would ena...
GSE125853: RNA sequencing and small RNA sequencing in WT and mir-138 DKO CAD cell lines
MicroRNAs (miRNAs) play roles in diverse developmental and disease processes. Distinct miRNAs have h...
GSE129757: Whole transcriptome profiles and ribosome profiling of thapsigargin- and tunicamycin-treated LN308 cells
Accumulation of unfolded proteins in the endoplasmic reticulum triggers the unfolded protein respons...
GSE122995: The aldosterone-induced transcriptome of isolated mouse collecting duct cells
Analysis of collecting duct response to low NaCl or high NaCl diet at the gene expression level. Res...
GSE121751: Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7 dependent lupus
Peptidylarginine deiminases (PADs) play critical roles in the development and progression of autoimm...
GSE133798: Functional interrogation of immature -cells reveals their role in insulin release
Immature -cells are present in adult islets. However, their contribution to insulin release is not f...
GSE115055: RNA-seq showed suppressed immune-related profile rescue pregnancy in an abotion mouse model
Purpose:We hypothesize that there were some beneficialeffects in survive fetaland protected fetal fr...
GSE124453: Genome-wide identification of cancer-specific alternative splicing in circRNA
Circular RNA (circRNA) is a group of RNA family generated by RNA circularization, which was discover...
GSE125903: Non-coding and coding transcriptional profiles are significantly altered in pediatric Retinoblastoma tumors
To find out the transcriptomic signature of Retinoblastoma compared to adult Retina. The methadology...
GSE121766: BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors
CD4+ T helper 17 (Th17) cells protect vertebrate hosts from extracellular pathogens at mucosal surfa...
GSE124661: Transcriptional profiling of intestinal changes following KRasG12D mutation in an APC deficient mutation
Activation of KRas in the intestinal epithelium alongside APC loss under the control of VilCreER SOU...
GSE124513: Reversing Abnormal Neural Development by Inhibiting OLIG2 in Down Syndrome Human iPSC Brain Organoids and Neuronal Mouse Chimeras
Down syndrome (DS), caused by triplication of human chromosome 21 (HSA21), is the most common geneti...
GSE113830: Expression regulation by Yaf2 in mouse embryonic stem cells
The Polycomb group (PcG) proteins are the key epigenetic regulators with well-established roles in s...
GSE121866: SIX4 acts as a master regulator of genes associated with the malignant phenotype of non-small cell lung cancer cells
In this work, we evaluated SIX4, a member of the Homeobox gene, acts as a master regulator of oncoge...
GSE125300: TOP2B disturbed the quality of human oocytes with advanced maternal age
STUDY QUESTION: Does maternal age affect the maturated oocyte quality and the fol-lowing development...
GSE140184: SMG1, a Nonsense-Mediated mRNA Decay (NMD) regulator, as a therapeutic target in multiple myeloma
RNA expression was profiled in B-cell lymphoma cell lines treated with CC0483115 (CC-115) using stra...
GSE133757: Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4
Sertoli cells are essential nurse cells in the testis that regulate the process of spermatogenesis a...
GSE121757: Assessing the effect of SUPT4H1 RNAi on the transcription of a repeat-containing reporter construct
SUPT4H1 is a transcription elongation factor comprising part of the RNA polymerase II complex. Recen...
GSE123020: Regulation of adenosine-to-inosine (A-to-I) RNA Editome by ADARs-interacting Partner Death Associated Protein 3 (DAP3) in Cancer
We constructed strand-specific cDNA libraries of 6 total RNA samples and sequenced the libraries usi...
GSE124474: Characterization of human ILC2 subsets
To characterize a novel human ILC2 subset found in peripheral blood, RNAseq was performed. Other ILC...
GSE130110: CD8+ T Cells Promote Maturation of Liver-Resident NK Cells via the CD70-CD27 axis
We discovered that LrNK cells exhibit a relatively immature phenotype and impaired cytotoxic capacit...
GSE109281 (mouse): Subclonal cooperation drives metastasis through modulating local and systemic immune microenvironments
Bulk RNA-Seq: Gene expression analysis of stromal and tumor fractions of primary and metastatic lesi...
GSE124522: Transcriptome of human coronory endothelial cells in response to nitro-conjugated linoleic acid
In the present study, a distinct transcriptome regulated by NO2-CLA was revealed in primary human co...
GSE124008: A reference map of cardiac transcription factor chromatin occupancy identifies dynamic and conserved transcriptional enhancers
Mapping the chromatin occupancy of transcription factors (TFs) is a key step in deciphering the tran...
GSE144998: Determining transcriptome changes in whole spinal cord of GarsP278KY/+ adult mice [16NGS-003-burgess]
To determine transcriptome changes in adult spinal cord induced by the GarsP278KY mutation.; How mut...
GSE109863: Hepatic pyruvate kinase muscle isoform 2 (Pkm2) induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-elicited oxidative stress is independent of NRF2 (RNA-Seq)
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces hepatic oxidative stress following ac...
GSE130080: Gene expression changes in Neil1 / Neil2 / Neil3 triple knockout mouse teratoma
The bifunctional DNA glycosylases / AP lyases NEIL1 and NEIL2 excise oxidative base damages, but can...
GSE125913: Genome-wide sequencing of male and female TCR1640 immune cells
Sequencing of TH1/TH17 differentiated immune cells isolated from secondary lymhoid organs from male ...
GSE138412: Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis [RNA-Seq]
Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms governing metasta...
GSE123278: Therapeutic opportunities for diffuse midline glioma identified from high-throughput combination drug screening
Diffuse midline gliomas (DMG) are a group of molecularly related malignancies occurring in midline s...
GSE123021: Bulk RNA-seq of adult homeostatic microglia from 4 brain regions
To compare microglial regional heterogeneity, we generated bulk RNA-seq profiles of postnatal day 60...
GSE124519: lncRNA-PCAT1 knockdown effect on the gene expression of androgen independent LNCaP (LNCaP-AI) cell line
We generated and characterized an androgen-independent LNCaP-AI cell line by long-term culture of an...
GSE123714: Molecular features of PDGFRa+ mesenchymal progenitors and progeny in the mammary gland
We performed RNA-seq on FACS-purified GFP+ and tdTomato+ stromal and luminal mammary populations fro...
GSE112196: Chd2 is necessary for neural circuit development and long-term memory
Considerable evidence suggests loss of function mutations in the chromatin remodeler, CHD2, contribu...
GSE123018: Translational control of cardiac fibrosis (I)
Cardiac fibroblasts from 4 patients treated for up to 24 hours with TGFB1 SOURCE: Sonia Chothani (e0...
GSE139631: Next Generation Sequencing facilitates Quantitative Analysis of mouse CD4+ T cells treated with butyrate
The goal of this study is to analyze the effect of butyrate in mouse CD4+ T cells. SOURCE: Yingzi Co...
GSE111236: CAR T cell related cytokine release syndrome mouse model
Chimeric antigen receptor (CAR) therapy targeting CD19 is an effective treatment for refractory B ce...
GSE121774: RNA-sequencing analysis of paternal low-protein diet-induced gene expression change in mouse offspring adipocytes
Increasing evidence indicates that parental diet affects the metabolism and health of offspring. It ...
GSE123985: Gene expression associated with morphological changes in osteoblasts.
In the field of bone-tissue engineering, bone morphogenetic protein (BMP)-2 plays a central role bec...
GSE123913: A stem cell-driven lymphoangiogenic switch coordinates tissue regeneration
Tissues rely on stem cells (SCs) for homeostasis and wound-repair. SCs reside in specialized microen...
GSE124140 (human): Antagonism of IAPs enhances CAR T cell efficacy
Chimeric antigen receptor (CAR) T cell therapy has proven highly successful in the treatment of hema...
GSE124278: The RNA-binding protein HuR is a negative regulator in adipogenesis [RNA-seq]
Human antigen R (HuR) protein, a RNA binding protein (RBP), has been reported to regulate essential...
GSE123033: RNA sequencing - Microglial A20 is a critical gatekeeper of CNS homeostasis
The goal of this study is to elucidate the role of microglial A20 in maintaining brain homeostasis, ...
GSE121789: Study of the signaling modulated by HDAC4 in skeletal muscle in ALS
BACKGROUND: Histone deacetylase 4 (HDAC4) has been proposed as a target for the treatment of Amyotro...
GSE123362: Esrrb function in the extraembryonic ectoderm is required for proper primordial germ cell specification [RNA-seq]
Estrogen related receptor beta (Esrrb) is an orphan nuclear receptor that is required for self-renew...
GSE123939: Next Generation Sequencing provides insights into pancreas tumor-educated adipocytes
We performed RNA sequencing to compare the transcriptomes of 3T3-L1 mature adipocytes alone and cocu...
GSE124061: Sexually Dimorphic Control of Parenting Behavior by the Medial Amygdala
Single-cell RNA sequencing of male and female mouse medial amygdala using Drop-Seq SOURCE: Ye,Emily,...
GSE114855: Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control
Elevated branched chain amino acids (BCAAs) are associated with obesity and insulin resistance. How ...
GSE121793: Epigenetic regulation of NfatC1 transcription and osteoclastogenesis by nicotinamide phosphoribosyl transferase in the pathogenesis of arthritis
Nicotinamide phosphoribosyltransferase (NAMPT) functions in NAD synthesis, apoptosis, and inflammati...
GSE121800: Super-resolution imaging reveals disrupted higher-order heterochromatin organization at early-stage carcinogenesis on pathological tissue
Abnormal chromatin structure is one of the hallmarks in cancer and has long been used for cancer dia...
GSE122117: The role of beta-catenin signaling in regulating barrier vs. non-barrier gene expression programs in circumventricular organ and ocular vasculatures
The mammalian brain, spinal cord, and retina are supplied by capillaries that do not permit free dif...
GSE127987: The long noncoding RNAPnkyis atrans-actingregulator of cortical developmentin vivo
While it is now appreciated that certain longnoncodinginvivo,particularly with genetic strategies th...
GSE111050: Quantitative Analysis of PPARD RNA-Seq Transcriptomes of Mouse Gastric Corpus Epithenial Cells by Next Generation Sequencing (NGS)
Purpose: NGS has revolutionized systems-based analysis of cell signaling pathways. The goal of this ...
GSE123417: Targeting the evolution of persistent clones in Jak2-mutated neoplasms
Inactivation of Ybx1 results in RNA mis-splicing, retained intron enrichment and disruption of the t...
GSE125932 (human): Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program
Expression analysis of mouse sinoatrial nodes and working cardiomyocytes SOURCE: Vincent,M.,Christof...
GSE133764: CHCHD2 gene KO effect in iPSC drived motor neurons
We investigate the transcriptional changes caused by the knock-out of neuropathy linked gene CHCHD2....
GSE135539: mRNA sequencing of SOD1 mice identifies differentially expressed genes in disease and after shRNA treatment
We report the transcriptome of cervical and lumbar spinal cords from SOD1 G37R ALS model mice in unt...
GSE124710: Two distinct ontogenies confer heterogeneity to mouse brain microglia
Hoxb8 mutant mice show compulsive behavior similar to trichotillomania, a human obsessive-compulsive...
GSE122567: A coronin 1-dependent signaling axis in T cells essential for allograft rejection
The goal of this analysis was to assess the similarity in transcriptomes between WT and Coro1-/- acr...
GSE124514: Interferon-regulated lncRNA analysis identifies IRF1-AS as a tumor suppressor in esophageal squamous cell carcinoma (ESCC)
Interferons and its downstream pathway play pleiotropic roles in antitumor reaction. However, target...