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Sequencing-based assays page 81
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GSE117470: Tissue signals imprint ILC2 identity with anticipatory function [RNA-Seq]
Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in r...
GSE126940: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis
P53 activation in response to cellular stress has long been known to result in downregulation of c-m...
GSE126939: Small Heterodimer Partner and Fibroblast Growth Factor-19 Inhibit Intestinal Npc1l1 Expression and Cholesterol Absorption
Small Heterodimer Partner (SHP/NR0B2) is an unusual orphan nuclear receptor that does not have a DNA...
GSE123894: Differential Metabolic and Multi-tissue Transcriptomic Responses to Fructose Consumption among Genetically Diverse Mice [Liver]
The escalating prevalence of metabolic syndrome (MetS) poses significant risks to type 2 diabetes me...
GSE116105: Transcriptional profiles of IL-4 stimulated mouse peritoneal macrophages derived from different cellular lineages and of different genetics backgrounds
Interleukin-4 (IL-4) activates macrophages to adopt a distinct phenotype important for tissue repair...
GSE126879: Suppressive function of MDSC is under bidirectional control of intrinsic and immunotherapy-induced type I IFN in pancreatic cancer
Tumors entertain a highly immunosuppressive network by merging features of regulatory cytokines and ...
GSE126973: Transcriptome analysis of various TOX+ and TOX- tumor-infiltrating CD8 T cells and in vitro TOX over-expressing T cells.
TOX is selectively expressed in tumor-infiltrating CD8 T cells however the role of TOX in peripheral...
GSE114624: Differential Expression of Immune Related Genes in Taste Buds of Fed and Fasted Mice
Purpose: The goal of this study is to compare the taste bud transcriptome of fasted and fed mice. By...
GSE137989: RNA-seq of mouse small intestine samples from different treatment groups
The aim of this project was to explore the role of Alginate oligosaccharides (AOS) on the developme...
GSE124881: FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [Ezh2]
Tfr cells from Ezh2 floxed FoxP3 Cre mice SOURCE: Peter SageSage Lab Brigham and Women's Hospital
GSE133928: A topological atlas reveals layers of genome reorganization in colorectal cancer
To understand how nuclear architecture is altered in cancer, we profiled genome topology along with ...
GSE115401: Impaired immune surveillance accelerates accumulation of senescent cells and aging [RNA-seq]
Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged cells, pre...
GSE114608: Genome-wide maps of gene expression in alkaline sphingomyelinase knockout mice
Intestinal alkaline sphingomyelinase (alk-SMase) generates ceramide and inactivates platelet-activat...
GSE126174: Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [20wRNA-seq]
Investigation of the gene expression changes induced by Bcor loss in myeloid progenitors SOURCE: Mad...
GSE129935: RNA sequencing human monocytes
Aim:; To improve risk stratification in patients with stable coronary artery disease (CAD), we aimed...
GSE113914: Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a [RNA-Seq]
Embryonic stem cells (ESCs) maintain pluripotency through unique epigenetic states. When ESCs commit...
GSE132877: RNA-Seq profiling of BIN1 knock-out mouse microglia cells
Experimental Questions: Does knocking out BIN1 have an effect on gene expression in microglia cells...
GSE113691: Glucocorticoid receptor dimers control intestinal STAT1-mediated IFN- and TNF-induced inflammation in mice
Tumor Necrosis Factor (TNF) is an important mediator in numerous inflammatory diseases, e.g. in infl...
GSE120404: A neutropenia-associated transcription factor mutation differentially impacts target genes in the cell-states traversed during granulocyte specification and commitment [Gfi1-R412X-HMZ]
Advances in genetics and sequencing have lead to a deluge of disease-associated and disease-causing ...
GSE133887 (mouse): Compensatory Csf2-driven macrophage activation blunts long-term efficacy of therapeutic Csf1r inhibition in breast-to-brain metastasis
Tumor microenvironment-targeted therapies are emerging as promising treatment options for different ...
GSE130125: Delineating the molecular pathways regulated by IFN-gamma and IL-17 in the small intestines of humanized mice during staphylococcal superantigen-induced toxic shock syndrome
RNASeq identified several pathways that were differentially expressed/regulated in the small intesti...
GSE127161: Transcriptome profiles of distinct mechanoreceptive somatosensory neuron subtypes
The objective of the study was to identify molecules that are selectively expressed in proprioceptiv...
GSE128255: Norrie Disease Protein (NDP) gene knockdown patient-derived glioblastoma stem cell lines
RNA-Seq to test differential gene expression in response to Norrie Disease Protein (NDP) gene knockd...
GSE128154: Integrative proteomics reveals increased non-degradative ubiquitylation during CD4+ T cell activation
In spite of gathering evidence that ubiquitylation can direct non-degradative outcomes, most investi...
GSE138529: Long-range Pitx2c Enhancer Promoter Interactions Prevent Predisposition to Atrial Fibrillation [RNA-seq]
Genome-wide association studies (GWAS) have found that increased risk for atrial fibrillation (AF), ...
GSE131602: antigenic KPC model_bulk pancreas RNASeq
We report the application of bulk RNAseq of live cells from pancreas of KPC or KPC-OG genetic mice a...
GSE124872: Multi-modal analysis of the aging mouse lung at cellular resolution
A) Whole lung tissue from 24 months (n=7) and 3 months old (n=8) mice was dissociated and single-cel...
GSE125016: Both Fallopian Tube and Ovarian Surface Epithelium Can Act as Cell-of-Origin for High Grade Serous Ovarian Carcinoma
The cell-of-origin of high grade serous ovarian carcinoma (HGSOC) remains controversial, with fallop...
GSE133922: Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation
RNA-sequencing of a longitudinal comparison of four principal mesenchymal and endothelial stromal ce...
GSE130127: Genome-Wide Transcriptome Analysis Reveals Intermittent Fasting-Induced Metabolic Rewiring in the Liver
Intermittent fasting (IF) has been extensively reported to participate in improved energy homeostasi...
GSE113280: Single cell RNAseq of Wild Type and IL27ra KO Tumor infiltrating lymphocytes isolated from B16F10 melanoma batch 2
Expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechani...
GSE124868: Expression profiling of microglia lacking Tgfbr2
Microglia contribute to maintaining brain homeostasis by interacting with neurons and macroglial cel...
GSE134355: Construction of A Human Cell Landscape by Single-cell mRNA-seq
We used single-cell RNA sequencing to determine the cell type composition of all major human organs ...
GSE127004: SETD5 is a H3K36 methyltransferase which preserves transcriptional fidelity during brain development and neuronal wiring [RNA-seq]
We assess the role of Setd5 on trancription elongation, by profiling nascent chromatin bound RNAs af...
GSE113858: Next Generation Sequencing Facilities Quantitative Analysis of Wild type CD8+ T cells with 0.3T static magnetic field or not
Purpose:Next Generation Sequencing applying for compare the CD8+ T cells with 0.3T static magnetic f...
GSE135662: Next-generation sequencing of RNA samples from the mice heart of Control, ABHD5-KO and ABHD5-KO transduced with AAV9 expressing HDAC4-NT (AAV9-NT)
The purpose of this experiment is to investigate the consequences of ABHD5 deletion in the heart and...
GSE113707: Postprandial FGF19 signaling-induced phosphorylation of FXR by Src modulates its activity in bile acid homeostasis
Farnesoid-X-Receptor (FXR) plays a central role in maintaining bile acid (BA) homeostasis by transcr...
GSE126407: Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges
We show that the epididymal white adipose tissue harbors 4 subpopulations of macrophages (VAM1, VAM2...
GSE127106: Dynamic allelic imbalance in early mouse embryo
We used a reciprocal crosses model to assess the allelic imbalance in early mouse embryo SOURCE: Wen...
GSE115865: Neurotropism and Neurotoxicity Comparison among Retrograde Viral Tracers and Their Combinational Application in High-order Circuit Tracing
Here, we demonstrated the neurotropism of different retrograde viral tracers are distinct through pa...
GSE129586: Transcriptome analysis of pineal glands in a mouse model of Alzheimers disease
The pineal gland maintains the circadian rhythm in the body by secreting the hormone melatonin. Alzh...
GSE126279: Local administration of IFN--iPSC-pMCs alters gene expression profiles in tumor microenvironment.
Local administration of IFN--producing proliferating myeloid cells (IFN--iPSC-pMCs) inhibited the tu...
GSE126899: Dietary intake regulates the circulating pro-inflammatory monocyte pool
Caloric restriction is considered to be anti-inflammatory. In this study we examined the effect of f...
GSE126395: Characterisation of the EZH2 regulated transcriptome in de novo transformed cells (RNA-Seq)
Epigenetic regulators are often hijacked by cancer cells to sustain and enhance their malignant phen...
GSE113974: Sorting leukemia initiating cells from adult and neonatal leukemia
The defining characteristics of leukemia, such as lineage and genetics, are associated with a typica...
GSE115204: E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo
Cell polarity and correct mitotic spindle positioning are essential for the maintenance of a proper ...
GSE114079: Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development [RNA-seq]
Smad4 is a central mediator of canonical TGF/BMP signaling and plays important roles in mesenchymal ...
GSE126277: IFN--producing proliferating myeloid cells reveal type I IFN-stimulating gene signature
We previously established a method to generate myeloid lineage cells with proliferation capacity fro...
GSE126402: Negative regulation of lymphoid specification by the transcription factor TAL1
Lymphoid primed multipotent progenitors are a subset of MPPs that are undergoing specification to th...
GSE113733: Next-generation sequencing analysis of chemically induced neurons from wild type (WT), Actb+/- (HET) and Actb-/- (KO) mouse embryonic fibroblasts (MEFs)
Purpose: The goals of this study are to use NGS to perform transcriptome profiling (RNA-seq) to find...
GSE129831: Outcomes of MSL2 domain-swap mutation in mouse embryonic stem cells
RNA-association can confer targeting specificity to protein complexes and trigger their assembly int...
GSE124876 (mouse): Transcriptomic analysis of primary human T cells and murine RAW 264.7 macrophages 3D cultured in different collagen densities
The density of the extracellular matrix has a dramatic impact on the gene expression profile of T ce...
GSE132044 (mouse): Systematic comparative analysis of single cell RNA-sequencing methods
A multitude of single-cell RNA sequencing methods have been developed in recent years, with dramatic...
GSE113761: RNA-Seq transcriptome profiling of embryonic age 17.5 or E17.5 ventricles of cardiac specific-estrogen-related receptor alpha and gamma (ERRa/g) knock out (KO) mouse generated by Nkx2.5-Cre driver and its control wild type.
Transcriptional regulatory circuits that drive cardiomyocyte maturation during the developmental pro...
GSE124745: The Tug1 locus is required for male fertility and comprised of DNA, RNA and Protein regulatory elements
We have sequenced mouse embryonic fibroblasts (MEFs) and 6 organs (testes, prostate, liver, heart, s...
GSE114091: A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem cells
It remains largely unclear if efficient H3K4 methylation, an epigenetic modification associated with...
GSE125380: eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with limited treatment options. Althou...
GSE128147: Single-Cell Transcriptome Analysis Of CD8+ T-cell Memory Inflation
We sought to define the nature of the transcriptional mechanisms underpinning memory inflation at di...
GSE113982: A radical switch in clonality reveals the formation of a stem cell niche in the epiphyseal growth plate
A radical switch in clonality reveals the formation of a stem cell niche in the epiphyseal growth pl...
GSE115903: Understanding Early Stage Myelodysplastic Syndrome Pathobiology
Delineating key HSC regulators is of significant interest for informing the treatment of hematologic...
GSE121288: Bmi1 suppresses adipogenesis in the hematopoietic stem cell niche: RNA-Seq
Bone marrow mesenchymal stromal cells (MSCs) that express high levels of stem cell factor (SCF) and ...
GSE145062: KDM3A/Ets1/MCAM axis promotes growth and metastatic properties in Rhabdomyosarcoma.
The goal of this study was to understand the function and mechanisms of action of the chromatin fact...
GSE126753: CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape
Chimeric antigen receptors (CARs) are synthetic receptors for antigen that reprogram T cell specific...
GSE134456: Next generation sequencing facilitates the mapping of the transcriptomes of two E3 ligase knock out macrophages
The goal of this study was to compare RNA-seq data generated from WT, Ing4-/- and Socs1-/- RAW 264.7...
GSE113857: PDGFB-expressing MSCs improve human hematopoietic stem cell engraftment in immunodeficient mice
The bone marrow (BM) niche regulates multiple HSC processes. Clinical treatment for hematological ma...
GSE113876: CD47 in the tumor microenvironment and CD47 antibody blockade regulate natural killer cell recruitment and activation
Elevated CD47 expression in some cancers is associated with decreased survival and limits phagocytic...
GSE114956: Robust apoptotic and microglial responses to brain somatic genome damage following Casc5 deletion
The brain is a genomic mosaic. Here, we manipulated somatic genome stability by conditional Casc5 de...
GSE126762: RNA Sequencing Facilitates Quantitative Analysis of Albumin-Cre (Control, Ctl) and Liver-specific Klf15 Knockout (Li-KO) Mouse Liver Transcriptomes
The goals of this study are to compare control and liver Klf15 deficient mouse liver transcriptome p...
GSE121364: Ageing affects DNA methylation and transcriptional cell-to-cell variability in muscle stem cells [scRNA-seq]
Age-related tissue alterations have been associated with a decline in stem cell number and function....
GSE130128: Intrahepatic lipocalin 2 promotes liver fibrosis in alcoholic hepatitis [RNA-Seq]
Our project is to explore the molecular subtypes for targeted therapies in Alcoholic Hepatitis (AH)....
GSE130490: Context-dependent requirement of H3K9 dimethyltransferase activity during reprogramming to pluripotency
The methylation of histone 3 at lysine 9 (H3K9) is widely regarded as a major roadblock for cellular...
GSE138253: Differential transcriptional responses to cardiomyocyte-specific Notch activation in right versus left atria of murine cardiac tissue
We report the mRNA sequencing of right and left atria from an adult inducible, cardiomyocyte-specifi...
GSE128153: RNA sequencing of mTC and mTN cells
The goal of the study is to define the impact of long-term administration of antioxidants on lung ca...
GSE124904: Single-Cell RNA-seq Transcriptome Profiling from Male Germ Cells Isolated from Late Fetal and Neonatal Mouse Testes
To better understand the underlying dynamics driving formation of the spermatogonial stem cell (SSC)...
GSE124952: Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction
Coordinated activity-induced transcriptional changes across multiple neuron subtypes of the prefront...
GSE142261: Ultra-Processed Foods drive Intestinal Barrier permeability increasing Microvascular Disease risk
Abstract: Our intake of ultra-processed foods has dramatically increased over the past few decades i...
GSE115226: The HDAC3 Enzymatic Activity Regulates Skeletal Muscle Fuel Metabolism
We address whether the functions of HDAC3 in skeletal muscle require its enzyme activity. By mutatin...
GSE138272: FOXP3 protects conventional human T cells from premature restimulation-induced cell death
Transcriptome profiling and functional analyses on expanding Tcons revealed that FOXP3 enhances expr...
GSE130965: Next generation sequencing allows the comparison between Ectodysplasin knock-out mutant and wild-type murine lacrimal glands
We used RNAsequencing to reveal the differential gene expression in Ectodysplasin knock-out lacrimal...
GSE138459: Reversible mitochondrial dysfunction drives terminal T-cell exhaustion
The failure of T-cells to control tumor growth has been associated with several functional defects t...
GSE128807: Generation of diffuse intrinsic pontine glioma mouse models by brainstem targeted in utero electroporation
Diffuse intrinsic pontine gliomas (DIPGs) are highly lethal childhood brain tumors. Their unique gen...
GSE126477: Genome-wide characterisation of replication and transcription changed induced by G4-stabilisation with PhenDC3
Genome-wide characterisation of replication and transcription programs upon G4-stabilisation by Phen...
GSE125007: Genome-wide expression profiling of Uhrf1hepKO mouse livers at baseline and following PHx
This study was carried out to investigate the mechanism behind the enhanced liver regenerative respo...
GSE125331: Transcriptomic Characterization of Human Beige Adipocyte Differentiated From Adipose Mesenchymal Stem Cells
Beige adipocytes are a distinct type of thermogenic fat cells in human. Since beige adipocytes are d...
GSE113315: Adipocyte long noncoding RNA transcriptome analysis of obese mice identified Lnc-leptin which regulates Leptin
Obesity induces profound transcriptome changes in adipocytes; recent evidence suggests that lncRNAs ...
GSE116092: The subtype-specific transcriptional regulatory networks of intestinal innate lymphoid cells (RNA-seq)
Innate lymphoid cells (ILCs) comprise a population of immune cells that promote tissue homeostasis, ...
GSE126426: Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation
Here we report that Axitinib, an inhibitor of VEGFRs currently in use as a second line treatment for...
GSE136220: Single-cell transcriptomics reveals temporal dynamics of critical regulators of germ cell fate during mouse sex determination
Despite the importance of germ cell differentiation for sexual reproduction, gene networks underlyin...
GSE128343: A large panel of isogenic APP and PSEN1 mutant human iPSC neurons reveals shared endosomal abnormalities mediated by APP b-CTFs, not Ab [RNA-seq]
Human iPS cells with different mutations linked to Alzheimer's Disease were differentiated into neur...
GSE125037: The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation
Interphase chromatin is hierarchically organized into higher-order architectures that are essential ...
GSE114482: Transcriptional profiles of miR-155 overexpressing CD8T cells during chronic infection
Persistent viral infections and tumors drive development of exhausted T (TEX) cells. In these settin...
GSE130514: Lmx1b is required at multiple stages to build expansive serotonergic axon architectures
Formation of long-range axons occurs over multiple stages of morphological maturation. However, the ...
GSE136231: MBNL2 knockdown in hypoxic breast cancer cells
The transcriptome-wide response of hypoxic breast cancer cells upon MBNL2 knockdown was analyzed. Di...
GSE128175: Single-cell RNA-Seq analysis of WT and Bach2-deficient Foxp3+ Treg cells
These are the FastQ files used for scRNA-Seq analysis of WT and Bach2-deficient splenic Foxp3+ Treg ...
GSE117482: The histone methyltransferases Suv420h regulate PPAR- and energy expenditure in response to environmental stimuli
The rising prevalence of obesity and its associated metabolic abnormalities have become global disea...
GSE119985: Activin A and BMP4 Signaling Expands Potency of Mouse Embryonic Stem Cells in Serum Free Media
Inhibitors of Mek1/2 and Gsk3b, known as 2i, and together with leukemia inhibitory factor, enhance t...
GSE136216: EGR1 as gatekeeper of inflammatory enhancers during immune cell development
We investigated the function of EGR1 in macrophage differentiation and activation. We generated EGR1...
GSE128240: Transcriptome Analysis of Cyclophosphamide Effects on Ovarian Development in Mice
The role of cyclophosphamide (CTX) as a first-line chemotherapy drug in the reproductive health of y...
GSE131651: NSD2 overexpression links drives clustered chromatin and transcriptional changes in a subset of insulated domains of insulated domains
We analyzed the impact of NSD2 overexpression on 3D genome reorganization and gene expression in mul...
GSE116342: Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2
RNA localization is one mechanism that neurons use to spatially and temporally regulate gene express...