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Sequencing-based assays page 82
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GSE120001: Effect of Miz1 POZ domain deletion on expression profiles of B and T leukemia cells
Acute lymphoblastic leukemia (ALL) is an aggressive blood cancer mainly affecting children. Relapse ...
GSE126401: Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate [Isl1_RNA_seq]
Generation of widely differing and specialized cell types from a single totipotent zygote involves l...
GSE133819: Transcriptomic analysis of class I odorant receptor enhancer deletion [eC]
We used RNAseq based transcriptome analysis to compare gene expression changes in the olfactory muco...
GSE115437: HDAC1 modulates OGG1-initiated oxidative DNA damage repair, brain aging, and Alzheimers disease pathology
Unrepaired DNA damage contributes to brain aging and neurodegenerative diseases. However, the factor...
GSE74896: The conserved transcriptional landscapes in human spermatogenesis
Spermatogenesis is a complex and highly orchestrated combination of processes in which male germline...
GSE124304: Fubp1 knockdown in BCR-ABL1 induced chronic myeloid leukemia (CML) like myeloproliferative neoplasm mouse model
We examine the oncogenic function of the Far Upstream Element Binding Protein 1 (FUBP1) in leukemia-...
GSE124359: 8-OxoG in GC-rich Sp1 binding sites enhances gene transcription during adipose tissue development in juvenile mice [RNA-Seq]
We observed that transcriptional activity and the number of active genes were significantly correlat...
GSE124763: Myopalladin promotes muscle growth through modulation of the serum response factor pathway
Myopalladin (MYPN) is a striated muscle-specific protein located in the Z-line and I-band of the sar...
GSE115258: Six3 and Six6 are jointly required for the maintenance of multipotent retinal progenitors through both positive and negative regulation
Purpose: the goal of this experiment was to identify differentially expressed genes in Six3 null, Si...
GSE115447: RNAseq data of brain cortex from mice at d10 post-microglia depletion and non-depleted controls
Previous studies have reported that microglia depletion leads to impairment of synapse formation and...
GSE114261: BET Inhibition Improves NASH and Liver Fibrosis
Non-alcoholic fatty liver disease (NAFLD) is a leading form of chronic liver disease with large unme...
GSE124302: LncRNA Spehd regulates hematopoietic stem cells and progenitors and is required for multilineage differentiation
Long non-coding RNAs (lncRNAs) show patterns of tissue- and cell-type-specific expression that are v...
GSE124316: Next generation sequencing analysis of transcriptomes at different timepoints after chlorprothixene treatment in NB4 and Kasumi-1 cells
To understand the mechanisms of chlorprothixene in acute myeloblastic leukemia (AML) therapy, gene e...
GSE133971: RNA sequencing analysis of mouse follicular B cells, memory B cells, plasmablasts and plasma cells
The purpose of this study was to compare relative mRNA transcript levels between mouse follicular B ...
GSE134439: Mapping Gata2 enhancer-dependent developmental trajectories by single-cell RNA-sequencing
We compared single-cell transcriptomes of fetal liver myeloid progenitor pools (CMP/GMP pool) from G...
GSE109658: Single-Cell RNA Sequencing Reveals Metallothionein Heterogeneity during hESC Differentiation to Definitive Endoderm [RNA-Seq]
Differentiation of human pluripotent stem cells toward definitive endoderm (DE) is the critical firs...
GSE136158: CSF1R inhibitor-mediated microglial depletion prevents reductions in striatal volume, extracellular matrix alterations, and perineuronal net loss in a mouse model of Huntingtons disease
This dataset allows for the exploration of gene expression of microdissected striatum from 11 week o...
GSE121314: Lineage-specific reorganization of nuclear peripheral heterochromatin and H3K9me2 domains
Dynamic and regulated organization of chromatin within the 3-dimensional space of the nucleus has be...
GSE125108: RNA-Seq transcriptome analysis of whole newborn lenses from FVB/N, Le-Cre and P0-3.9GFPCre mice
Here we report RNA-Seq data from RNA isolated from newborn lenses from FVB/N control mice as well as...
GSE114634: Cooperative Regulation of Normal and Neoplastic Hepatocyte Proliferation by Myc and ChREBP
By analogy to the c-Myc (Myc)/Max family of transcription factors, there also exists a parallel netw...
GSE117096: PRMT1-dependent histone arginine methylation regulates mature beta cell identity (RNA-Seq)
Purpose: Loss of functional cell mass is an essential feature of type 2 diabetes and recent studies...
GSE126789: Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
Activation of tumor suppressors for the treatment of human cancer has been a long sought, yet elusiv...
GSE114673: Gene expression profiling in Dis3l2-null and wild-type nephron progenitor cells
Purpose: Loss of DIS3L2 in humans is associated with congenital overgrowth in Perlman syndrome, as w...
GSE128361: Hepatic transcriptomics reveals that lipogenesis is a key signaling pathway in isocitrate dehydrogenase 2 deficient mice
The present study was conducted to capture signatures of isocitrate dehydrogenase 2 deficient (Idh2-...
GSE125144: Identification of key molecules involved in tertiary lymphoid organ formation in the central nervous system
We have induced experimental autoimmune encephalomyelitis (EAE) in mice to mimic B cell aggregate fo...
GSE117167: Tissue-specific transcriptomic and epigenomic profiles explain differential damage and repair of anti-cancer drug cisplatin induced DNA-adducts across mouse organs
Platinum-based drug cisplatin is a widely used first-line therapy for several cancers. Cisplatin in...
GSE126681: Pleiotrophic roles of VEGF during neonatal thymic development
In this report, we show that VEGF-blockade in neonates induces rapid changes in all three stromal co...
GSE126962: Circadian transcriptome in mouse skeletal muscle after exercise in the early rest versus active phase
We performed the circadian transcriptome analysis using the skeletal muscle from sedentary and exerc...
GSE133018: KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
The acquisition of neuronal identity requires the coordinated action of transcription factors and ch...
GSE133725: Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification [Gastrulation2_scRNAseq_embryo_SJC]
Formation of the three primary germ layers during gastrulation is an essential step in the establish...
GSE114674: Therapeutic effects of ASO-mediated reduction of Atxn1 in a SCA1 Mouse Mode: Proof of concept with distinct disease-associated transcriptome profiles in cerebellum and medulla
RNA-targeting approaches have improved disease symptoms in preclinical rodent models of several neur...
GSE115714: The RNA exosome contributes to gene expression regulation during stem cell differentiation [RNA-Seq]
Gene expression programs change during cellular transitions. It is well established that a network o...
GSE132173: RNA-seq of tissues from MC903- and Ethanol-treated mice
We report transcript abundance in skin, spinal_cord, and trigeminal ganglia from animals treated wit...
GSE126766: Transcriptome profiling in primary human skeletal myotubes with MondoA knockdown
It is well known that insulin resistance in the obese state is associated with accumulation of neutr...
GSE128198: The 11q13.5 immune disease risk locus contains a distal enhancer required for Treg-mediated suppression of gut inflammation [RNA-Seq]
Much of the genetic variation underlying susceptibility to common autoimmune and allergic diseases i...
GSE115490: Transcriptome-wide analysis of HuD (ELAVL4) RNA interactome and post-transcriptional regulation in a motor neuron cell line
The neuronal ELAV-like RNA-binding protein HuD (ELAVL4) plays important roles in multiple post-trans...
GSE143144: Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia
Patients with frontotemporal dementia (FTD) resulting from granulin (GRN) haploinsufficiency have re...
GSE124883: FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [tissue]
Tissue Specific Transcriptional Profiling of Tfh, Tfr, Treg and Tcon SOURCE: Peter SageSage Lab Brig...
GSE136004: circSamd4 represses myogenic transcriptional activity of PUR proteins
By interacting with proteins and nucleic acids, the vast family of mammalian circRNAs is proposed to...
GSE122313: Ikaros prevents autoimmunity by promoting anergy induction and restraining Toll-like receptor signaling in B cells
Establishment of a diverse B-cell receptor (BCR) repertoire by V(D)J recombination generates autorea...
GSE114797: Histone acetyltransferase Kat2a stabilises pluripotency with control of transcriptional heterogeneity
Cell fate transitions in mammalian stem cell systems have often been associated with transcriptional...
GSE132177: A systematic dissection of whole transcriptome profiling in the APP/PS1 mouse brain
This study is the first to provide a systematic dissection of whole transcriptome profiling in the A...
GSE128382: Identification and characterization of artery and vein enhancers in the human genome
Our goal was to identify artery- and vein-specific cis regulatory elements in the human genome and u...
GSE124279: The RNA-binding protein HuR is a negative regulator in adipogenesis [Ribo-seq_RNA-seq_matched]
Human antigen R (HuR) protein, a RNA binding protein (RBP), has been reported to regulate essential...
GSE126551: Lats1/2 suppress NFkB and aberrant EMT initiation to permit pancreas progenitor differentiation
The Hippo pathway directs cell differentiation during organogenesis, in part by restricting prolifer...
GSE128958: TGF- and RREB1 coordinate EMT programs in NMuMG cells
Epithelial-to-mesenchymal transitions (EMT) play prominent roles during development, regeneration an...
GSE114827: Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD1 expression on NK cells
Purpose: Controlling the balance between immunity and immunopathology is crucial for host resistance...
GSE122393: The epigenetic regulator Histone Deacetylase 3 regulates the ontogeny and maintenance of tissue-resident macrophage [RNA-Seq]
Tissue-resident macrophages (TRMs) play central roles in local tissue development and immunity. Howe...
GSE125099: Effector differentiation potential determined at the level of human CD8+ nave T cell subsets [RNA-Seq]
Antigen recognition by CD8+ nave T cells induces immune activation and rapid effector differentiatio...
GSE124140 (mouse): Antagonism of IAPs enhances CAR T cell efficacy
Chimeric antigen receptor (CAR) T cell therapy has proven highly successful in the treatment of hema...
GSE125147: Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [RNA-seq]
In this study, use of a gene-targeted mouse model that is defective for pRb-condensin II interaction...
GSE114690: Next Generation Sequencing Facilitates Quantitative Analysis of the control 3T3-L1 (3T3-L1-NC) and LIGHT (tnfsf14) overexpression 3T3-L1 cells (3T3-L1-LIGHT) before and after differentiation into beige adipocytes
Purpose: The goals of this study are to compare NGS-derived 3T3-L1-NC transcriptome profiling (RNA-...
GSE128196: Transcriptional characterization of LV of Nppb KO
Expression analysis of LV in Nppb KO SOURCE: Vincent,M.,Christoffels (v.m.christoffels@amc.nl) - Ac...
GSE118703: Gene expression changes in liver upon LCMV Cl13 infection
2-3 month old female C57Bl/6J mice were intravenously infected with 2x10^6 focus forming units of l...
GSE126988: RNA-seq analysis of gene regulations by the combination treatment of crizotinib plus cisplatin in established MCA205 tumors
Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and stimulates a...
GSE121340: A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA profiles of obese and lean mice.
Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are re...
GSE114933: Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
The aim is to analyze the transcriptome profiling (RNA-seq) of Mettl3 knockout mesenchymal stem cell...
GSE127081: Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells
A key mechanism of tumor resistance to immune cells is mediated by expression of peptide-loaded HLA-...
GSE115510: Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation
A missense mutation in RHOA encoding p.Gly17Val has been reported to occur frequently in angioimmuno...
GSE114967: Mammalian Nucleolar Protein DCAF13 Confers Developmental Competence on Growing Oocytes
During mammalian oocyte growth, chromatin configuration transition from the nonsurrounded nucleolus ...
GSE122726: REV-ERBa regulates TH17 cell development and autoimmunity
RORt is well recognized as the lineage defining transcription factor for TH17 cell development. How...
GSE115950: Neonatally imprinted mesenteric lymph node stromal cell subsets induce tolerogenic dendritic cells [migDC]
Gut-draining mesenteric lymph nodes (mLNs) play a key role in peripheral tolerance towards food and ...
GSE121603: Prenatal Bisphenol A Exposure in Mice Induces Multi-tissue Multi-omics Disruptions Linking to Cardiometabolic Disorders (RNA-Seq)
The health impacts of endocrine disrupting chemicals (EDCs) remain debated and their tissue and mole...
GSE128050: Niche Derived Netrin-1 Regulates Hematopoietic Stem Cell Dormancy via its Receptor Neogenin-1
We have performed RNA-seq in highly purified Hematopoeitic Stem cells (HSC, LSK/SLAM) from young (4-...
GSE115746: Shared and distinct transcriptomic cell types across neocortical areas
Neocortex contains a multitude of cell types segregated into layers and functionally distinct region...
GSE123829: Autologous microgratf accelerates endogenous wound healing response through ERK-induced cell migration.
Defective fibroblast migration cause delayed wound healing (WH) and chronic skin lesions. Autologous...
GSE119942: Single-Cell Transcriptomics Identifies TOX as a Key Transcriptional Regulator of Progenitor-Like CD8 T Cells in Chronic Infection [RNA-seq]
Stem-like CD8 T cells maintain long-term antiviral CD8 immunity during chronic infection, and share ...
GSE129020: RNA sequencing of wildtype and PHOSPHO1 knockout brown fat
We report the RNA expression of the mature brown fat from 6 week old wild type (WT) and PHOSPHO1 kno...
GSE129707: Dinucleotide regulation by REXO2 maintains promoter specificity in mammalian mitochondria
Oligoribonucleases are conserved enzymes that degrade short RNA molecules of up to 5 nt in length, a...
GSE128363: Modular architecture of the STING C-terminal tail allows interferon and NF-B signaling adaptation
Stimulator of Interferon Genes (STING) is a key regulator of type I interferon and pro-inflammatory ...
GSE128034: Transcriptional characterization of the myocardial infarct border zone
Expression analysis of cardiomyocytes in the border and remote myocarium SOURCE: Vincent,M.,Christof...
GSE128808: Mitofusin 2 is essential for oocyte and follicle development, and to maintain ovarian follicular reserve during reproductive aging [SFO]
We performed RNAseq analysis to determine the effect of MFN2 deletion on oocyte global gene expressi...
GSE122774: Runx1 and Runx3 cooperatively repress Pmp22 to drive neurofibromagenesis [RNA-seq]
Neurofibromatosis type 1 (NF1) patients are predisposed to develop neurofibromas but the underlying ...
GSE126226: N6-methyladenine in DNA antagonizes SATB1 in early development [RNA-seq]
The recent discovery of N6-methyladenine (N6-mA) in mammalian genomes suggests that it may serve as ...
GSE149156: Transcriptome and Retrotranscriptome profiling in HIV infected women with Breast Cancer (RNA-seq)
In order to determine the impact of HIV infection on the breast cancer microenvironment, we sequence...
GSE117967: Loss of PRC1 activity in different stem cell compartments activates a common transcriptional program with cell-type dependent outcome
Polycomb Repressive Complexes (PRCs) are evolutionary-conserved multiprotein complexes that maintain...
GSE126490: Uncovering the hepatic gene expression variations and sex-differences as response to high-fat diet consumption in the highly genetically diversity of the Collaborative Cross mouse model
Hepatic gene expression variations and sex-differences due to high-fat diet consumption using the Co...
GSE128909: NK cell-derived GM-CSF potentiates autoantibody-induced inflammatory arthritis and is negatively regulated by CIS
To examine the effect of CIS-deficiency on neutrophil inflammation-associated transcriptional profil...
GSE115096: HOXBLINC is aberrantly expressed in acute myeloid leukemia and functions as a potent oncogenic long non-coding RNA in leukemogenesis
Dysregulation of HOXA/B genes is a dominant mechanism of leukemic transformation.HOXB locus-associat...
GSE115766: Rapid recapitulation of non-alcoholic steatohepatitis upon loss of HCF-1 function in mice [RNA-seq]
Background and Aims: Host-cell factor 1 (HCF-1), encoded by the ubiquitously expressed X linked gene...
GSE128419: A time course study by mRNA Sequencing to identify transcriptional changes in mice lung development
Mammalian fetal lung development is a complex biological process.Despite considerable progress, a co...
GSE121330: Transcriptomic profiling reveals distinct modes of aging in the kidney
The kidney is an excellent model for studying organ aging, but little is known about the molecular c...
GSE115102: Cryptochrome deletion in p53 mutant mice enhances apoptotic and anti-tumorigenic responses to UV damage at the transcriptome level
Previous studies have demonstrated that deletion of Cryptochromes (CRY) protects p53-/- mutant mice ...
GSE130161: Effect of 6-TG on apoptosis and cell cycle in MCF-7 breast cancer cells and its mechanisms through the regulation of DNMT1
Thioguanine (6-TG) as conventional drug has anti-tumor activity in various cancer cell lines. Howeve...
GSE126922: RNAi Screening for Ubiquitin Ligases that Regulate Myofiber Size Identifies a Key Role for UBR4 in Myofiber Hypertrophy in Drosophila and Mice
Sequencing of RNA isolated from the tibialis anterior muscles of 6 month old C57BL/6J mice that had ...
GSE115147: YAP-TEAD signaling promotes Basal Cell Carcinoma development via c-JUN/AP1 axis [RNA-seq]
The mammalian Hippo signaling pathway, through its effectors YAP and TAZ, coerces epithelial progeni...
GSE138419: Neutralization of Oxidized Phospholipids Restrains Nonalcoholic Steatohepatitis
Oxidized phospholipids (OxPL) are pro-inflammatory and pro-atherogenic, but their roles in non-alcoh...
GSE130156: Global chromatin occupancy and epigenetic signature analysis reveal new insights into the function of GATA1 N-terminus in erythropoiesis
Mutations in GATA1, which lead to expression of the GATA1s isoform that lacks the GATA1 N-terminus, ...
GSE135438: Neural progenitor cells mediated by histone variant H2A.Z.2 regulate microglia development in the embryonic brain
Next-generation sequencing (NGS) has revolutionized systems-based analysis of gene expression. The g...
GSE126920: DPPA2 and DPPA4 are necessary to establish a 2C-like state in mouse embryonic stem cells [RNA-seq]
After fertilization of the transcriptionally silent oocyte, expression from both parental chromosome...
GSE148617: Mitochondrial fatty acid synthesis coordinates mitochondrial oxidative metabolism
Cells harbor two systems for the synthesis of fatty acids, one in the cytoplasm (FASN or fatty acid ...
GSE115155: Plasmodium-specific atypical memory B cells are short-lived activated B cells
Chronic infections such as HIV, tuberculosis and malaria in humans are associated with the appearanc...
GSE126259: TFEB-driven lysosomal biogenesis is pivotal for PGC1a-dependent renal stress resistance
Because injured mitochondria can accelerate cell death through the elaboration of oxidative free rad...
GSE130229 (mouse): EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (RNA-Seq)
We identified a novel cofactor of PRC2, expressed predominantly in the gonad, that limits PRC2 enzym...
GSE126936: MicroRNA-202 is a gatekeeper of meiosis initiation and regulates recombination in male germ line
We preformed RNA sequencing to identify differentiatially expressed mRNAs after miR-202 knockout in ...
GSE131622: E18.5 DRG: Identification of a sacral, visceral sensory transcriptome in embryonic and adult mice
Visceral sensory neurons encode distinct sensations from healthy organs and initiate pain states tha...
GSE129441: Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of human bladder cancer
In bladder, loss of mammalian Sonic Hedgehog (Shh) accompanies progression to invasive urothelial ca...
GSE116793: Serial Inversions Induce Tissue-specific Architectural Stripes, Gene Misexpression and Congenital Malformations [RNA-Seq]
Here we study the effect of balanced chromosomal rearrangements (BCRs) on gene expression in vivo in...
GSE128193: Mouse wound healing [RNA-seq]
Purpose: To explore the changes of genes expression in different time points during mouse wound heal...
GSE126507: Sexual dimorphism of gut microbiota dictates therapeutics efficacy of radiation injuries [RNA-seq]
Accidental or iatrogenic ionizing radiation exposure precipitates acute and chronic radiation injuri...