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Talk to our team for accessPluto has a large database of published data, available to explore, conduct your own analysis, and view QC reports.
Talk to our team for accessStore large, raw sequencing data files and transform them into biologically-meaningful results in your browser. Gain critical QC information, quantify targets within and across data sets, and run best-in-class computational biology analyses specific to each assay type.
Vestibulospinal neurons are organized into discrete groups projecting from brainstem to spinal cord,...
Bone marrow was harvested from Rosa26CreER; Stk40+/+ (WT; n = 3) and Rosa26CreER; Stk40loxp/loxp (St...
Exome and whole genome sequencing of matched primary tumor and lung metastases was used to identify ...
X-chromosome inactivation (XCI) is a global silencing mechanism by which XX and XY mammals equalize ...
DNA methylation and Polycomb are key factors in the establishment of vertebrate cellular identity an...
Gene expression pattern in murine 3T3-L1 adipocytes treated with saturated fatty acid (palmitate) in...
Macrophages (Ms) play a critical role in tumor growth, immunosuppression and inhibition of adaptive ...
Internal modification of RNAs with N6-methyladenosine (m6A) is a highly conserved and widely used me...
Background: LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Desp...
Targeting autophagy in cancer cells and in the tumor microenvironment are current goals of cancer th...
Expression of co-inhibitory receptors, such as CTLA-4, on effector T cells is a key mechanism for th...
The goals of this study are to identify ectopic expression of microglial odorant receptors and to de...
The purpose of this project was to find key long non-coding RNAs and mRNAs in rectal adenocarcinoma...
Macrophages (MQs) are key immune infiltrates in solid tumors and serve as major drivers behind tumor...
Fat-specific knockout of Mecp2 results in downregulation of adipogenesis genes and upregulation of t...
Graft-versus-host disease (GVHD) is the most serious complication of allogeneic hematopoietic cell t...
Mammalian sexual reproduction relies on the dichotomy of male and female germ cell development. Howe...
Urinary tract infections (UTI) are common and recurrent. Both host genetics and UTI history impact s...
Maternal Vitamin C is required in vivo for proper DNA demethylation and development of fetal germ ce...
Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their rol...
In order to delineate the molecular mechanisms leading to the therapeutic effect of BI 853520 on pri...
In mice, complement C5a and its receptor C5aR1 elicit systemic and local inflammation and drive tiss...
We sequenced the cerebral cortex transcriptome of both male and female mice either infected with T. ...
In order to identify specific transcripts that might be necessary for CTA learning within the BLA, w...
Purpose:To asses changes in gene expression profiles of cortices from the P0 wild type littermate co...
One of sleeps putative functions is mediation of adaptation to waking experiences. Chronic stress is...
Normal T-cell differentiation requires a complex regulatory network which supports a series of matur...
We performed a transcriptome comparison of double-negative developing thymocytes from the DN3 popula...
Here, we use single-cell RNA-seq to define a cellular taxonomy of the mouse bone marrow stroma and i...
We report the effects of vitamin E deficiency using the Ttpa-null mouse model on transcriptome profi...
An excess in thyroid hormone during rodent neonatal life causes abnormal prolifration and maturation...
Elongation factor Paf1C regulates several stages of the RNA polymerase II (Pol II) transcription cyc...
Gene expression by RNAseq in murine germinal centers induced by SRBC in RagC T89N mice (YRT codes) ...
Transcription factor Zscan4 was newly discovered to be a marker of the intermediate state of 2-cell ...
Cell competition (CC)the sensing and elimination of less fit loser cells by neighbouring winner cell...
Identification of new targets involved in MSLN signaling by comparing mRNA expression patterns in MS...
Ovariectomized BDNF Val66Met mice, a model that is genetically susceptible to stress, exhibited anxi...
We found that fibroblasts derived from lung metastases display specific gene signatures related to d...
Hepatocyte nuclear factor-1 (HNF-1) is a tissue-specific transcription factor that is essential for ...
Brown adipose tissue (BAT) generates heat via uncoupled respiration, providing mammals with an evolu...
We used single-cell mRNA sequencing to analyze the response of tumor-specific CD4+ TILs and draining...
Smarcad1 is one of the most conserved chromatin remodelling factors, from yeast to human, with sugge...
Xist requires Repeat-A, a protein binding module in its first two kilobases (2kb), to repress transc...
The intestinal epithelium requires trophic factors and signaling gradients to maintain proper positi...
Mutations in presenilin 1 (PSEN1) cause a familiar form of Alzheimer's disease (AD). We have obtaine...
Gene expression programs change during cellular transitions. It is well established that a network o...
Increasing evidence shows that many transcription factors execute important biologic functions indep...
Angelman syndrome (AS) is a genetic disorder which entails autism, intellectual disability, lack of ...
To examine how the transcriptome of circulating memory CD8 T cells isolated from the spleen are repr...
Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and ...
IGF2BP1 promotes leukemia stem cell phenotype by regulating HOXB4, MYB and ALDH1A1. Inhibition of I...
Pioneer transcription factors (PTF) can recognize their binding sites on nucleosomal DNA and trigger...
Aging results in altered gene expression patters in HSCs expressing ARID3A transcirpts, with a numbe...
Here, we developed mouse models expressing inducible lysine to methionine mutants of histone H3, whi...
The UPR (Unfolded Protein Response) is a well-orchestrated response to ER protein folding and proces...
Plasma cell differentiation involves coordinated changes in gene expression and functional propertie...
Residual cell-intrinsic innate immunity in cancer cells hampers infection with oncolytic viruses. Co...
Numerous microRNAs and their target mRNAs are co-expressed across diverse cell types. However, it is...
Cell-cell communications via ligand-receptor signaling are a fundamental feature of complex organs. ...
Iron and heme play central roles in red blood cell production. However, the mechanisms by which iron...
ALKBH5 is the RNA N(6)-methyladenosine (m6A) demethylase. To under sthand the function and mechnism ...
Despite recent advances in highly effective androgen receptor (AR)-directed therapies for the treatm...
The effects of doxorubicin on mammary tumors SOURCE: James,G,Jackson (jjacks8@tulane.edu) - James Ja...
Sleep abnormalities are common with aging. Studies show that sleep plays important roles in brain fu...
RNA-seq analysis of nonlesional skin, whole blood, and cultured primary keratinocytes of wild-type a...
Lung and hindgut directed differentiations with multiple protocols and time points SOURCE: Carlos Vi...
To investigate the role of CYP2B in lipid metabolism, a Cyp2b triple knockout mouse lacking Cyp2b9, ...
The endocardium interacts with the myocardium to promote proliferation and morphogenesis during the ...
Background. Mutations in GNE cause a recessive, adult onset myopathy characterized by slowly progres...
Early mammalian development entails a series of cell fate transitions that includes transit through ...
Scn1b null mice are a model of a severe developmental and epileptic encephalopathy called Dravet Syn...
To understand the role of LSD1 in splenic B cell development, spleens from mice with B cell conditio...
The balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) is orchestra...
CD40-stimulating immunotherapy elicits potent anti-tumor responses, which are mainly T-cell dependen...
We describe a methyl histone writer-eraser double-mutant animal that corrects phenotypes of single-m...
To determine the molecular mechanisms by which expression of Gata4, Mef2c, and Tbx5 (GMT) induces di...
RNAseq of Adult Brain in ADAR1 E861A, ADAR2 knock out, ADAR1 E861A x ADAR2 knock out het, and ADAR1...
The seed-and-soil hypothesis was described over a century ago to describe why cancer cells (seeds) g...
Eukaryotic chromosomes are composed of chromatin, in which regularly spaced nucleosomes containing ~...
When mutant superoxide dismutase 1 (SOD1) was first linked to amyotrophic lateral sclerosis (ALS), i...
RNA-sequencing results for cells expressing sgRNA targetting Slc25a1, Slc25a11, or an empty vector c...
Cell fate transitions are essential for specification of stem cells and their niches, but the precis...
Chronic psychosocial stress is a risk factor for psychiatric disorders, and genetic factors interact...
Caspase-8 is a critical regulator of apoptosis, programmed necrosis, and inflammatory gene expressio...
Azm affects the integrity of the bronchial epithelial barrier. To better understand these unexpected...
Transcriptional silencing of endogenous retroviruses (ERV) defends against active retrotransposition...
To address the role of INO80/SWR-type remodeling complexes, we deleted Ep400 in developing Schwann c...
Regulatory T cells (T regs) maintain host self-tolerance but are a major barrier to effective cancer...
Purpose: We used next-generation sequencing (NGS) to identify genes which oscillate during cell cycl...
To investigate the transcriptional consequences of TLE3 loss in the presence/absence of AR inhibitor...
Control of neuronal precursor cell proliferation is essential for normal brain development, and dere...
RNA-Sequencing analysis of murine lung adenocarcinoma cell lines in the presence and absence of Rb. ...
Adult T-cell leukemia/lymphoma (ATLL) patients are in severely poor prognosis partially because of t...
To study the role of GADD45 proteins in early mouse development, RNA-seq expression profiling was pe...
The lung microvasculature is essential for gas exchange and commonly considered homogeneous. We sho...
The advent of Next Generation Sequencing has allowed transcriptomes to be profiled with unprecedente...
Pathogens and hosts require rapid modulation of virulence and defense mechanisms at the infection ax...
This work describes the alteration in the expression of genes in response to quinolinol treatment, w...
The transcriptional regulator YAP orchestrates important cell functions, determining tissue homeosta...
Single cell RNA sequencing of FACS purified mouse microglia from embryogenesis to old age, and follo...