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Sequencing-based assays page 84
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GSE121979: Transitions in cell potency during early mouse development are driven by Notch
The Notch signalling pathway plays fundamental roles in diverse developmental processes in metazoans...
GSE131659: Mouse models of Alzheimers disease with natural genetic variation
Classical laboratory strains show limited genetic diversity and do not harness natural genetic varia...
GSE127197: Attenuation of progesterone driven mammary stem cells population by telapristone acetate
ovariectomized mice treated with E2+Progesterone, E2+Progesterone+TPA, E2+Progesterone+RU486 and sh...
GSE127446: RNA-seq profiling of neural tissue from mouse embryos with combined loss of p53 and Bim
Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. F...
GSE137691: The role of NUP93 in breast cancer
NUP93 expression inversely correlates with the survival of triple negative breast cancer patients. H...
GSE119530: RNA expression in postnatal mouse ventricular tissue
Mammals lose the ability to regenerate their hearts within one week after birth. During this regener...
GSE128977: ERG controls B-cell development by promoting Igh V-to-DJ recombination [RNA-seq]
B-cell development is dependent on the coordinated expression and cooperation of several transcripti...
GSE129125: Single-cell RNA and electrophysiological profiling of D1+ and D2+ principal neurons of the prefrontal cortex
Dopaminergic modulation of the prefrontal cortex (PFC) circuits is crucial for cognitive processes s...
GSE131205: RNA-seq on miRNA induced mouse keratinocytes. miR-200b cluster and miR-205.
Vehicle versus Doxycycline miRNA induction. SOURCE: Glen Bjerke (Glen.Bjerke@colorado.edu) - Yi Lab ...
GSE122900: Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation
RNA sequencing was performed on VHLNP+/- and VHLNP-/- E17.5 isolated nephron progenitors. E17.5 kidn...
GSE126629: Zfr regulates ADAR-mediated RNA editing in mouse primary neurons
We used RNA-seq of mouse primary cortical neurons transfected with control shRNAs or shRNAs targetin...
GSE125782: p53 promotes cancer cell adaptation to glutamine deprivation by upregulating Slc7a3 to increase arginine uptake
Cancer cells heavily depend on the amino acid, glutamine, to meet the demands associated with growth...
GSE128615: The X chromosome gene Kdm6a modulates multiple immune response genes in CD4+ T cells and is disease-promoting in autoimmune disease
Multiple sclerosis (MS) is a T-cell mediated autoimmune disease that has a sexually dimorphic patter...
GSE132584: TFEB-induced gene expression changes in AML cells [RNA-seq]
We report gene expression changes after TFEBS211A overexpression in HL60 cell line. SOURCE: Chia-Ho ...
GSE125625: CASP8 C362A KI MLKL KO e16.5 intestine RNAseq
Caspase-8 is a protease with both pro-death and pro-survival functions: it is required for apoptosis...
GSE121354: In Vivo Profiling of Leukemic Stem Cell Fitness
By transplanting in competition multiple pre-leukemic clones in a cohort of primary recipients, we o...
GSE131728: Paxillin regulates genomic networks in prostate cancer [C4-2]
We report that the adaptor protein, paxillin, regulates some androgen responsive genes in the castra...
GSE129018: F-53B and PFOS treatments skew human cardiac differentiation towards epicardial cells by in part disrupting the WNT signaling pathway
F-53B and PFOS treatments skew human cardiac differentiation towards epicardial cells by in part dis...
GSE127319: Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves
Inflammation and dysregulation of the immune system are hallmarks of several neurodegenerative disea...
GSE124399: IFN lambda modulates dendritic cells to facilitate T cell immunity during influenza virus infection
Type I and type III interferon (IFN) are important in regulating responses to viral infection. Type ...
GSE133737: LSD1 inhibition promotes epithelial differentiation through derepression of fate- determining transcription factors [inhibitors]
We report the impact of the pharmacological inhibition of the Histone 3 Lysine 4 demethylase (H3K4) ...
GSE120161: Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
How neuronal connections are established and organized in functional networks determines brain funct...
GSE120662: Serotonin signals through a gut-liver axis to regulate hepatic steatosis
Purpose: While various functions of peripheral serotonin are known, the direct role of serotonin in ...
GSE131726: Paxillin regulates genomic networks in prostate cancer [LNCaP]
We report that the adaptor protein, paxillin, regulates some androgen responsive genes in the castra...
GSE140518: RNAseq analysis of intestinal epithelial cells in stopFlox and stopdIEC mice
RNAseq analysis of laser capture microdissected ileal epithelial cells from stopFlox(control) and st...
GSE125644: R-loops Function as a Balance during Somatic Cell Reprogramming
R-loop induces genome instability and regulates gene expression. However, regulatory mechanism of R-...
GSE135497 (mouse): Targeted single-cell transcriptome readouts for high-throughput genetics and functional genomics
We show that targeted single-cell RNA-sequencing (TAP-seq) permits reliable mapping of cell (sub)typ...
GSE127275: Regulation of gene expression in undifferentiated spermatogonia by DDX5
The maintenance of spermatogenesis in adult males is dependent on a population of mitotic germ cells...
GSE135098: Effect of neuropathy-associated MCM3AP variants on gene expression in fibroblasts
An RNA sequencing analysis of fibroblasts derived from affected individuals with neuropathy, who car...
GSE128985: Time course RNA-seq profiling in sorted endothelial, epithelial, and immune cells from WT C57BL6 mice
The respiratory system undergoes remarkable structural, biochemical, and functional changes necessar...
GSE120287: -RA reduces DMQ/CoQ ratio and recues the encephalopathic phenotype in Coq9R239X mice
Coenzyme Q (CoQ) deficiency has been associated to primary defects in the CoQ biosynthetic pathway o...
GSE128003: Single-cell transcriptional profiling of late mast cell differentiation in mouse
Single-cell RNA sequencing of Lin- c-Kit+ FcRI+ cells from mouse peritoneum captured the late mast c...
GSE119851: Global transcriptional profiling unveils the interferon network in blood and tissues across different diseases [RNA-seq_blood6_module_generation]
We have performed modular analyses to decipher the global transcriptional response and capture a bre...
GSE125970: Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine
14537 epithelial cells from adult human ileum, colon and rectum are performed single-cell transcript...
GSE125697: hCyfip1 overexpression in the basolateral amygdala of mice
CYFIP1, a protein that interacts with FMRP and regulates protein synthesis and actin dynamics, is ov...
GSE119183: The relative contributions of cell-dependent cortical microcircuit aging to cognition and anxiety
Background: Aging is accompanied by altered thinking (cognition) and feeling (mood) functions that d...
GSE130252: TWIST1 direct targets during embryonic stem cell differentiation [RNA-seq]
To understand the mechanism underlying the transcriptional regulation by TWIST1-dimers, we analysed ...
GSE131306: The effects of chemokines CXCL1/2/8 on mouse lung fibroblasts
Our preliminary data show that the primary triple-negative breast tumor-derived chemokines CXCL1/2/8...
GSE126675: Inhibition of TNBC metastasis by Gpx1
Gpx1 plays a vital role in the metastasis of TNBC cells by regulating cell adhesion. Depletion of Gp...
GSE121728: Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation (1)
In this study we examine the outcomes of p16INK4a activation in the adult epidermis. We found that p...
GSE124471: Bulk RNA-sequencing and Single-cell RNA-sequencing of adult mice intestinal stromal cells and lacteal LECs with PDGFRb-specific deletion of LATS1/2 [RNA-seq]
To investigate the effect of Hippo-YAP signaling in insterinal stromal cells and lacteal LECs, we pe...
GSE131724: RNA sequencing for transcriptional profiling of cardiac and cavity macrophages
We report that cavity macrophages from the pericardial, pleural and peritoneal cavities have distinc...
GSE119299: Transformation of megakaryocyte-erythroid progenitors to acute myeloid leukemia-initiating cells: RNA-seq
Oncogenic mutations confer aberrant replicative capacity to cells with little or no replicative capa...
GSE123187: Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids
Gastruloids are three-dimensional aggregates of embryonic stem cells (ESCs) that display key feature...
GSE119318: Knockdown of heterochromatin protein 1 binding protein 3 recapitulates phenotypic, cellular, and molecular features of aging [RNA-Seq]
Identifying genetic factors that modify an individuals susceptibility to cognitive decline in aging ...
GSE135612: PEG project: effect of fluid flow on stromal populations in the peyer's patch
Here, we set out to delineate the effect of fluid flow on stromal populations in the peyer's patch. ...
GSE131244: Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape [rna-seq]
Gene expression data in 4 populations of intestinal epithelial cells defined by different levels of ...
GSE131935: Identification of novel regulators of Th2 cells in HDM model (RNA-Seq)
Nave CD4 T cells differentiate into functionally diverse subsets of T helper (Th) cells. Gene expres...
GSE119228: A cell atlas of mouse lung development reveals a signaling role for lung basophils in alveolar macrophage maturation
Lung development and function arises from the interactions between diverse cell types and lineages. ...
GSE127222: AmpliSeq transcriptome profiling of human adipose tissue progenitor cell types
Three different progenitor cell subsets in subcutaneous and visceral adipose tissues derived from 5 ...
GSE122956: Deciphering the m6A code via quantitative profiling of m6A at single-nucleotide resolution [II]
N6-methyladenosine (m6A) is the most abundant modification on mRNA, and is implicated in critical ro...
GSE127459: The Wnt pathway inhibitor, LGK974 has suppressive effects for LPS-induced endotoxemia
We demonstrated that Wnt/-catenin pathway was activated in in endotoxemic mice, and the modulation o...
GSE119854: Global transcriptional profiling unveils the interferon network in blood and tissues across different diseases [RNA-seq_Test_HDM_model_BAL_Blood]
We have performed modular analyses to decipher the global transcriptional response and capture a bre...
GSE122715: Functional Landscape of PCGF Proteins Reveals Both RING1A/B Dependent and Independent Specific Activities
Polycomb repressive complexes 1 and 2 (PRC1 and PCR2) control cell identity by establishing facultat...
GSE126046: Fetal and trophoblast PI3K p110 have distinct roles in regulating resource supply to the growing fetus
Using RNA-seq we identified several genes downstream of p110 in the trophoblast that are important i...
GSE128854: A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. [scRNA-Seq]
While the roles of parenchymal microglia in brain homeostasis and disease are fairly clear, other br...
GSE126964: Genomic characterization of Chinese clear cell renal cell carcinoma
Large-scale initiatives like The Cancer Genome Atlas (TCGA) performed omics studies on hundreds of k...
GSE132168: Intestinal expression of ASBT determines the sclerosing cholangitis phenotype.
Purpose: Determine the impact of ASBT genotype on the onset and progression of liver disease, using ...
GSE126218: GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis
We report the application of next generation sequencing (RNA-seq) to characterize the transcriptome ...
GSE126678: Enduring and sex-specific changes in hippocampal gene expression after subchronic immune challenge
The goals of this study include examining long-lasting changes in hippocampal gene expression in mal...
GSE127457: IL-1 induces the rapid secretion of the antimicrobial protein IL-26 from Th17 cells
We investigated how IL-1 and anti-CD3/CD28 stimulation affected gene expression in IL-1RI+ and IL-1R...
GSE120867: Transcriptome profiling of wildtype, nonoperated mouse hearts compared to wildtype, sham operated hearts
The purpose of the present study was to investigate the activation of the cardiac inflammatory respo...
GSE147599: Effect of sesaminol on C2C12 cells on myogenesis pathway
Adipocytes are key players in maintaining energy homeostasis and are classified into two different c...
GSE120407: A neutropenia-associated transcription factor mutation differentially impacts target genes in the cell-states traversed during granulocyte specification and commitment [Gfi1-R412X-Irf8]
Advances in genetics and sequencing have lead to a deluge of disease-associated and disease-causing ...
GSE126649: RNA sequencing of denervated white and brown adipose tissue of lean mice
We report differential expressed genes in white and brown adipose tissues with surgical denervation ...
GSE126810: Transcription factor Bach2 attenuates T cell receptor induced transcription to control regulatory T cell differentiation and homeostasis [RNA-seq]
The differentiation and homeostasis of Foxp3+ regulatory T (Treg) cells is strictly controlled by T ...
GSE119869: RNA-seq expression profiling of ductal macrophages and antigen presenting cells from virgin mouse mammary glands
Macrophages are diverse immune cells that reside in all tissues to regulate development, function an...
GSE141725: Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension
Experimental ocular hypertension (IOP) induces senescence of retinal ganglion cells (RGCs) that mimi...
GSE119850: Global transcriptional profiling unveils the interferon network in blood and tissues across different diseases [RNA-seq_blood4_module_testing]
We have performed modular analyses to decipher the global transcriptional response and capture a bre...
GSE139516: Transcriptomic Analysis Of circRNAs/miRNAs/mRNAs upon Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection
Human circular RNAs can function in competing endogenous RNA (ceRNA) network by sponging miRNA and r...
GSE132185: Gene expression analysis of Mtb-infected mouse alveolar macrophages from mice lacking Nrf2 in LysM- or CD11c-expressing cells
The aim of this study was to measure the immune response of alveolar macrophages (AMs) from mice lac...
GSE119878: The role of fibronectin in the post natal lens
This trancriptome analysis reports genes that are differentially expressed upon deletion of the fibr...
GSE120244: Gene expression profiles of Setd2 fl/fl BMSCs infected with lentivirus expressing GFP and Cre respectively
During the aging process, bone marrow mesenchymal stem cells (BMSCs) exhibit declined osteogenesis a...
GSE126302: Loss of Setd2 promote Kras-induced acinar-to-ductal metaplasia and epitheliamesenchymal transition during pancreatic carcinogenesis
TCGA(PAAD) public database and PDAC tissue array with SETD2/H3K36me3 staining was used to investigat...
GSE141735: Transcriptomics analysis of FAM122A knockout and NC K562 cells
To understand the molecular mechanism associated with increased erythroid differentiation upon FAM12...
GSE122173: The Chromatin Remodelling Contributions of Snf2l in Cerebellar Granule Neuron Differentiation [RNA-Seq]
Snf2l and the closely related protein, Snf2h, play a critical role in embryonic and post-natal brain...
GSE121746: Loss of DUX causes minor defects in zygotic genome activation and is compatible with mouse development
How maternal factors in oocytes trigger zygotic genome activation (ZGA) is a long-standing question ...
GSE85534 (human): Single Cell Transcriptome Conservation in Cryopreserved Cells and Tissues
Sample preservation method that maintains transcripts in viable single cells and so allows to discon...
GSE122880: Hobit- and Blimp-1-driven CD4+ P2X7+ tissue resident memory T cells critically control chronic intestinal inflammation
Although tissue resident memory T (TRM) cells have been shown to regulate host protection in infecti...
GSE130195: Differences in gene expression between WT and IRF2 KO cells
Gasdermin-D (GSDMD) is cleaved by caspase-1/4/11 in response to canonical and non-canonical inflamma...
GSE128545: Gene expression of Cell populations sorted from exocrine cells reprogrammed to beta-like cells
Bulk MARS-seq analysis of gene expression in reprogrammed exocrine cells exhibit many similarities t...
GSE147771: Differential gene expression in murine olfactory epithelium: effect of aging and loss of APP, APLP2 and PSEN2.
RNAseq differential gene expression profiling of olfactory mucosa in young wild type, aged wild type...
GSE123335: Single-cell transcriptomic analysis of mouse neocortical development
The development of the mammalian cerebral cortex depends on careful orchestration of proliferation, ...
GSE119884: Novel MVA Vector Expressing Anti-apoptotic gene, B13R, Delays Apoptosis and Enhances Humoral Responses
Modified vaccinia virus Ankara (MVA) has been explored as a vaccine vector for use against infectiou...
GSE123961: Gene expression in adult neural precursor cells from the hippocampus or subventricular zone
Regulating the cell cycle entry of neural stem cells (NSCs) is critical for continued adult neurogen...
GSE120345: RNA-sequencing on sorted infiltrating CD8 T cells from vehicle or JHU083, pro-drug of 6-Diazo-5-oxo-L-norleucine (glutamine antagonist) treated MC38 (colon cancer) tumor bearing mice
RNA-sequencing was performed on sorted CD11b-CD11c-B220-CD45+TCRbeta+CD44+CD8+ TIL from vehicle or J...
GSE131252: Monocyte-derived alveolar macrophages induced by influenza infection confer long-term antibacterial protection [RNA-seq 2]
To investigate transcriptomic differences using RNA-seq. This was done in macrophages isolated from ...
GSE131673: Protein proximity analysis unravels a complex interplay between lymphoid transcription factors and ARID1a in T-cell development.
Maturation of lymphoid cells is controlled by the action of stage and lineage restricted transcripti...
GSE128518: Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner
Immune cells residing in white adipose tissue have been highlighted as important factors contributin...
GSE131230: Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties
To explore the molecular basis of the distinct intrinsic membrane properties and other dstinguishing...
GSE131729: RNA sequencing of mouse placenta in control and protein restricted pregnancies
We used RNA sequencing to identify differentially expressed genes in whole mouse placentas. Pregnant...
GSE119354: RNA-Seq as part of a study to investigate impact of Atg16l on Il22 signalling in the intestinal mucosa
A coding variant of the inflammatory bowel disease (IBD) risk gene ATG16L1 has been associated with ...
GSE135486: Next Generation Sequencing Facilitates Quantitative Analysis of the Role of Transcriptional Factor FoxM1 in Muscle Satellte Cells
Purpose:To identify genes and the molecular pathways involved in the transcriptional factor FoxM1 re...
GSE142409: Acute CD8+ T cell responses to viral infection harbor Tcf1-dependent stem-like cells that quantitatively yield central memory [RNA-seq]
Central memory CD8+ T cells (TCM) can protect from secondary pathogen infection, from chronic infect...
GSE148349 (human): Transient in vivo base editing with no detectable RNA- and DNA off-target mutations
RNA-programmable deaminases, known as base editors (BEs), enable precise single base conversions on ...
GSE138490: FBXW7 is a defining driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition
Fbxw7 is a tumor supressor frequently mutated in endometrial cancer. To analyze the signaling pathwa...
GSE123968: Comprehensive Transcriptome Analysis of Cerebral Cavernous Malformation Across Multiple Species and Genotypes
Purpose: To determine important genes, functions, and networks contributing to the pathobiology of c...
GSE144032 (human): m6A profiling of early, adolescent, aged and Alzheimer brains
m6A-seq was performed on 4 brain regions (cortex, cerebellum, hypothalmus and hippocampus) of 2 week...
GSE128707: Regulatory T cell depletion causes compensatory immune suppression and accelerated pancreatic carcinogenesis.
Regulatory T cells (Treg) are common in the tumor microenvironment in both human pancreatic cancer a...
GSE130938: Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons
We report the comparative gene expression between embryonic stem cell derived cranial and spinal mot...