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Sequencing-based assays page 85
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GSE129212: IL-23 producing IL-10R-deficient gut macrophages elicit an IL-22-driven pro-inflammatory epithelial cell response [dataset 2]
we define critical cell-type-specific contributions to the induction and effector mechanism of macro...
GSE146395: Brain endothelial cells are exquisite sensors of age-related circulatory cues
single cell RNAseq of brain endothelial cells in normal aging, aged and young plasma treatment, and...
GSE122838: Tet1-mediated Epigenetic Programming Regulates Calcium Homeostasis and Stage-specific CNS Myelination and Regeneration
DNA hydroxymethylation by epigenetic modifiers TET dioxygenases is critical for gene transcription i...
GSE119362: Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity.
An understanding of how heterozygous loss-of-function mutations in ASD risk genes, such as TBR1, con...
GSE131263: Next Generation Sequencing Analysis of Prenatal Chlorpyrifos Exposure embryonic kidneys
Purpose: In order to study signaling pathway changes of prenatal chlorpyrifos exposure embryonic kid...
GSE130910: To investigate whether recover DNMT3A expression permitted adult beta cell of RapKO establishing proper transcriptome
Murine islets were isolated from 8-week-old WT and RapKO mice and initially recovered in 1640 RPMI s...
GSE119953: Animal model of acute-on-chronic alcoholic liver injury [DDC study]
Background and aims: Liver is a major target organ for alcohol-induced disease and the spectrum of p...
GSE121785: Neuroprotective effect of miR-204 OE in mouse models of Inherited Retinal Disease (IRD)
Transcriptome profile of retinas from wild-type (c57BL/6) and RHO-P347S mice following AAV-mediated ...
GSE131232: RNA-seq analysis of YAP-overexpressing mouse embryonic fibroblasts in the context of reprogramming
Here, we report that YAP-overexpression inhibits the establishment of the pluripotency network. SOUR...
GSE86308: Transcription profiling of PfSPZ Malaria Vaccine trial subjects in a malaria endemic region
The Sanaria PfSPZ Vaccine can confer sterilizing protection against liver stage infection by Plasmod...
GSE119348: Dependence on Myb expression is attenuated in myeloid leukemia with N-terminal CEBPA mutations
Mutations altering the normal function of C/EBP are frequent in acute myeloid leukaemia with normal ...
GSE131765: Establishment of hTERT immortalized mouse cardiosphere derived cell line
The analysis showed differences of transcriptomes between primary CDCs and immortalized CDCs as well...
GSE129006: Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice
Respiratory failure is a life-threatening problem for pre-term and term infants, yet many causes rem...
GSE131297: Transcriptome of ESCs upon VD3 treatment (+/-) MLL1 inhibition
This study describes the transcriptome profiling of: 1) Mll1fl/fl mESCs in LIF/Serum medium as contr...
GSE119376: Adverse Events of anti-EGFR Therapy are Triggered by Hair Eruption and Commensal Skin Microbiota
EGFR targeted anti-cancer therapy induces severe skin toxicities, which affect life quality in patie...
GSE136033: RNA-seq from the liver and ileum of mice on ND, WD, and WD with either Lactobacillus gasseri or Lactobacillus johnsonii
Type 2 diabetes (T2D), the most common form of diabetes, is one of the leading causes of death in th...
GSE136079: RNA-seq analysis of Actn2 knockout in mouse cardiomyocytes
The goal of this study is to analyze the impact of Actn2 depletion on transcription during cardiomyo...
GSE121098: Adipose-Derived Lipocalin-2 Causes Metabolic Dysfunction Only in Female Mice
Lipocalin-2 (LCN2) is a secreted protein involved in innate immunity and also has been associated wi...
GSE120408: A neutropenia-associated transcription factor mutation differentially impacts target genes in the cell-states traversed during granulocyte specification and commitment [WT-GMP-P]
Advances in genetics and sequencing have lead to a deluge of disease-associated and disease-causing ...
GSE131739: Transcriptome profiling of cybrids cells with and without m.14487T>C mutation
Transcriptome profiling is a sensitive strategy to uncover the change of mitochondrial to nucleus si...
GSE125204: Calcium signaling controls pathogenic Th17 cell-mediated inflammation by regulating mitochondrial metabolism
Pathogenic Th17 cells play an important role in many autoimmune and inflammatory diseases. Their fu...
GSE130741: Tie2 regulates endocardial sprouting and myocardial trabeculation
The ang1-Tie2 pathway is required for normal vascular development, but its molecular effectors are n...
GSE120611: Next Generation Sequencing Facilitates Quantitative Analysis of normal and YTHDF2 Overexpressing SMMC7721 cells in normoxia and hypoxia condition
Dynamic N6-methyladenosine (m6A) modification was previously identified as a ubiquitous post-transcr...
GSE128631: Rdh1 supresses adiposity by promoting brown adipose adaptation to fasting and re-feeding
Rdh1 is one of the several enzymes that catalyze the first of the two reactions to convert retinol i...
GSE131438: RNA Seq In Isolated Crypts from Duodenum, Jejunum, and Ileum
RNA was extracted from crypts from the three portions of the small intestine SOURCE: Patrick Seale U...
GSE132675: RNA-sequence of epithelial-specific active mTOR transgenic mouse lung
The purpose of this study is to identify the roles of epithelial active mTOR in lung fibrosis. We ge...
GSE141321: RNAseq of DUX KO mouse 2-cell embryos
Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a doub...
GSE129243: LOSS OF THE TUMOR SUPPRESSOR, TP53, ENHANCES THE ANDROGEN RECEPTOR MEDIATED ONCOGENIC TRANSFORMATION AND TUMOR DEVELOPMENT IN THE MOUSE PROSTATE
Androgen signaling is essential for prostate tumorigenesis. The tumor suppressor p53 has been implic...
GSE122066: Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
Acute myeloid leukaemia (AML) affects children and adults of all ages. AML remains one of the major ...
GSE130843: Next Generation Sequencing Facilitates Quantitative Analysis of primary myoblast cell treated with different concentration glycine Transcriptomes
Purpose: The goals of this study are to analyze primary myoblast cell from mdx mice skeletal muscle ...
GSE135413: Zika Virus Noncoding sfRNA Sequesters Multiple RNA Binding Proteins and Impacts mRNA Decay and Splicing
Previous reports studying similar flavivirus infections (DENV, WNV, etc.) revealed an increase in bo...
GSE132253: Transcriptome analysis of half-brain tissue from Bahd1+/+ (WT) and Bahd1-/- (KO) mice (about 70 weeks old)
Comparisons of brain gene expression profiles of Bahd1-KO mice to those of wild-type littermate mice...
GSE135507: Low power of single clone CRISPR-Cas9 mutagenesis to fine-map eQTL credible intervals
We report gene expression of four and three single-cell derived clones from HL60 and HL60/S4 cell li...
GSE142482: Downstream targets of ATR in CIN612 HPV-positive cells
High-risk human papillomaviruses (HPVs) constitutively activate the ataxia telangiectasia and Rad3-r...
GSE122097: RNA-seq data for: A conserved mito-cytoplasmic translational balance links two longevity pathways
Slowing down mRNA translation in either the cytoplasm or the mitochondria are both conserved longevi...
GSE129211: IL-23 producing IL-10R-deficient gut macrophages elicit an IL-22-driven pro-inflammatory epithelial cell response [dataset 1]
we define critical cell-type-specific contributions to the induction and effector mechanism of macro...
GSE134011: Urine-derived podocytes from Alport patients as a model for glomerular filtration barrier defects
Alport syndrome (AS) is a genetic defect involving mutations of collagen IV 3, 4 or 5 genes, resulti...
GSE125920: Genome-wide screen of transcription co-regulators identifies GLIS2 as a repressor for p53 target genes [RNA-seq]
GLIS2, a member of the sub-family of Krppel-like zinc finger proteins, has been linked to the develo...
GSE132283: Identification of ESX-1-dependent transcriptional response of human macrophages to Mycobacterium tuberculosis infection
Human macrophage transcriptional response to Mtb infection diverges at late timepoints post-infectio...
GSE135445: RNA-sequencing of epicardial adipose tissue of patients with atrial fibrillation
Accumulating studies have suggested that epicardial adipose tissue play an important role in the pat...
GSE123017 (mouse): Differential requirement for centriolar satellites in cilium formation and ciliary signaling among different vertebrate cells
Centriolar satellites are an array of membrane-less granules that localize and move around the vert...
GSE129325: Immune homeostasis and regulation of the Interferon pathway require myeloid-derived Regnase-3
The RNase Regnase-1 is a master RNA regulator in macrophages and T cells that degrades cellular and ...
GSE129381 (mouse): An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer [RNA-Seq]
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can lead to immunotherapy resistanc...
GSE129363: Single Cell RNASeq profiling of stromal vascular fraction from Subcutaneous and visceral adipose tissue
The complex relationship between metabolic disease risk and body fat distribution in humans involves...
GSE128832: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Larp7 Knock-out Staged Male Germ Cells Transcriptomes
Analysis the difference in the transcriptomes (expression and alternative splicing) of either sperma...
GSE133998: Transcriptomic sequencing of breast cancer
We did transcriptomic sequencing of blood samples from 6 breast cancer patients. Total RNA were extr...
GSE129773: Genome-wide analysis of the transcriptional profile of WT and CSF2RB astrocyte conditional KO during EAE in B6 mice [Csf2rb RNA-seq]
We identify pathways regulated by Csf2rb in astrocytes during EAE; Multiple sclerosis (MS) is an aut...
GSE128724: Gene expression profiling of Trop2+ and Trop2- luminal epithelial cells and stromal cells from young adult and old mouse prostates
We set out to determine if distinct prostate luminal epithelial cell-types exhibited age-related dif...
GSE129379: Identification of novel neuroprotective loci modulating ischemic stroke volume in a cross between wild-derived inbred mouse strains
We employed RNA-sequencing to identify differentially expressed genes between two wild-derived inbre...
GSE121770: Endothelial-specific mitochondiral complex III KO leads to lung endothelial cell gene deregulation.
Endothelial cells (ECs) require glycolysis for proliferation and migration during angiogenesis; howe...
GSE128705: Transcriptome analysis of bone marrow in Phc2 knock out mice
This study investigated the biological function of Phc2 by Phc2 knock out mice. Polycomb group (PcG)...
GSE129036: RNA-seq time course of MSC during osteogenesis
RNA-seq time course of MSC during osteogenesis SOURCE: chao jiang (c.mikejiang@gmail.com) - Opperman...
GSE129158: SIRT1 regulates enhanced mitochondrial respiration and leukemogenicity in CML stem cells
Chronic myeloid leukemia (CML) results from hematopoietic stem cell transformation by the BCR-ABL ty...
GSE145485: RNA-Sequencing of LPS-stimulated TLR4 HEK293 cells with CRISPRi treatment at an immune enhancer
In order to investigate the role of an IRF1-associated trans-response eQTL in immune response, we ut...
GSE121099: Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice [bulk RNA]
SETD5, a gene linked to intellectual disability (ID) and autism spectrum disorder (ASD), is a member...
GSE128660: Transcriptome of heat-stressed lactating mice in hypothalamus, pituitary and mammary gland
Purpose: Using RNA-seq, this study explored the possible cross-talk between the hypothalamic-pituita...
GSE128926: RNAseq of Notch signaling responsive and unresponsive thymus DN1a/b cells
We report the gene expression profile of thymus DN1a/b cells that are either responsive to Notch sig...
GSE129012: RNA-seq data corresponding to: AZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells
A time-course RNA-seq experiment testing the effect of drug treatment using selective CDK9 inhibitor...
GSE129344: Differential lncRNA expression upon hypoxia affects splicing efficiency
RNA sequencing was performed to identify long non-coding RNAs that are dysregulated upon hypoxia in ...
GSE129714: Transcriptome analysis of gene expression in control and Kiaa1429Zp3cKO samples (RNA-Seq)
The goals of this study are to compare transcriptome profiling (RNA-seq) data and quantitative rever...
GSE134036: Circadian transcriptome of intestinal ILC2 and ILC3
Identification of cycling genes in intestinal ILC2 and ILC3 cells SOURCE: Alexandra Garnham (garnham...
GSE123005: Loss of Apc impairs Lgr5+ intestinal stem cell fate programs [RNA-seq]
Loss of APC is the main driving alteration associated with colorectal cancer (CRC) development. We i...
GSE131768: Generation of mature lung alveolar epithelial cells from human pluripotent stem cells
We perform time-series global transcriptomic profiling of a directed differentiation protocol for ge...
GSE129033: Endoplasmic reticulum stress regulates immunosuppressive function of myeloid derived suppressor cells in leprosy that can be overcome by IFNg production
Transcriptome analysis of human HLADR-CD33+ (MDSC) from ENL (n=4), RR (n=5) and healthy donors (n=3)...
GSE129150: Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
Single-cell (inDrops) analysis of primary somatosensory cortex after early postnatal unilateral whis...
GSE129368: Regulation of fetal liver transcription by maternal nutritional stress
Pregnancy is a time of extreme metabolic demand that requires coordinated adaptations between mother...
GSE135616: FBP1 loss disrupts liver metabolism and results in distinct transcriptome
This study set out to globally compare the liver transcriptomes from 24-week old wild type (WT) and ...
GSE128688: Effects on gene expression of ibrutinib treatment in human stem cells-derived atrial- and ventricular-like cardiomyocytes
To gain further insight into the mechanisms underlying the different response of atrial- and ventric...
GSE136834: DJ-1 is dispensable for human stem cell homeostasis
our data showed that the absence of DJ-1 had no adverse effects on proliferation, differentiation, a...
GSE129311: CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis
In B lymphopoiesis, activation of the pre-B cell antigen receptor (pre-BCR) is associated with both ...
GSE129045: YAP and AP-1 cooperate to initiate rapid pancreatic cancer development from the ductal cell population in mice
Purpose: We aimed to elucidate the unique consequences of YAP/TAZ activation in pancreatic ductal ce...
GSE129365: Genome-wide transcriptome profiling of wild-type and Kmt2d-deficient ATDC5 differentiated chondrocytes and undifferentiated mesenchymal cells
We performed genome-wide transcriptome profiling in stable Kmt2d-/- (bi-allelic deletion of the cata...
GSE136121: Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the anti-tumor response under PD-1 blockade [bulk RNA-seq]
Immunotherapy using checkpoint-blocking antibodies against PD-1 has produced impressive results in a...
GSE142449: Single-cell RNA sequencing in human retinal degeneration reveals distinct glial cell populations.
Purpose: The goals of this study were to identify cell specific expression patterns from a donor wit...
GSE140430: Stem and effector CD8 T-cells from human cancers
Tumor infiltrating lymphocytes (TILs) are associated with a survival benefit in several tumor types ...
GSE129044: Gene expression profiles of primary human NK cells before and after expansion on CSTX002 feeder cells, with and without IL-21 stimulation
NK cell development, maturation, and activation by cytokines is driven by alterations in gene expres...
GSE121811: Compartmentalized gut lymph node drainage dictates adaptive immune responses
Purpose: The intestine's main function is to digest and absorb dietary nutrients, with help from the...
GSE128722: Modeling and characterization of the dynamic gene regulatory networks underlying cancer drug resistance based on time-course RNA-seq data
Drug resistance is a major cause for the failure of cancer chemotherapy or targeted therapy. However...
GSE129060: RNA-Seq JunB WT and KO Tregs Mus musculus
To understand the mechanisms through which JunB regulates Tregs-mediated immune regulation, we exami...
GSE129290: RNA-seq expression data from Human iPSC-derived Brain Microvascular Endothelial-like Cells (iBMECs)
Comparison of Human iPSC-derived Brain Microvascular Endothelial-like Cells (iBMECs) grown in poly(d...
GSE129384: Analysis of gene expression in colonic epithelial cells following DSS treatment
Mice with and without IFNAR expression were treated with broad-spectrum antibiotics for more than 10...
GSE133689: Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification [Gastrulation2_scRNAseq_EB_SJC]
Formation of the three primary germ layers during gastrulation is an essential step in the establish...
GSE130444: Transcriptome profiles in MRC5 and CS1AN cell lines upon UV irradiation
Cockayne syndrome (CS) is mainly caused by mutations in CSB gene encoding a protein belonging to SWI...
GSE127713: Cellular gene expression during Hepatitis C Virus replication revealed by Ribosome profiling
Background: Hepatitis C virus (HCV) infects human liver hepatocytes, often leading to liver cirrhosi...
GSE129143: A Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules (RNA-Seq)
High-throughput screening and gene signature analyses frequently identify lead therapeutic compounds...
GSE129315: Next Generation Sequencing identifies lymph node lymphatic endothelial cell genes regulated by RANKL
Purpose: The objective was to identify genes regulted by RANK signalling in lymph node lymphatic end...
GSE129337: Chromatin-informed inference of transcriptional programs in gynecologic cancers [RNA-Seq]
RNA-seq of MDA-MB-436 cells in control cells (shRen) and upon knockdown of MITF ( shQa, sh962) were...
GSE127723: Hippocampus RNA-seq in CD x Gtf2i*
Williams syndrome is a neurodevelopmental disorder caused by a 1.5-1.8Mbp deletion on chromosome 7q1...
GSE128738: T cell regeneration from pluripotent stem cells by defined transcription factors Runx1 and Hoxa9 [single hematopoietic cells (iR9-iHEC&iR9-iHPC) II]
We identified that the coordinated expression of exogenous Runx1 and Hoxa9 during the haematopoietic...
GSE128814: Early-life microbial exposure imprints the abundance of mucosal-associated invariant T cells and subsequent interactions modulate their function
How early exposure to the microbiota impacts long-term host immunity remains poorly understood. Here...
GSE129084: Prdm16 overexpression effect on inguinal white adipose tissue:stromal-vascular cells
Analysis of SV cells transducted with control or Prdm16 retrovirus. Results provide insight into mol...
GSE129196: Comprehensive characterization of a next-generation antiviral T-cell product and feasibility for application in immunosuppressed transplant patients
Viral infections have a major impact on morbidity and mortality of immunosuppressed solid organ tran...
GSE128711: RNA-seq of human foreskin fibroblast cells lacking RB and/or p130 after doxorubicin treatment
We used human foreskin fibroblast cells with CRISPR-Cas9 mediated knockout of RB1 and p130 (RBL2) (C...
GSE127740: Slow transcriptional elongation causes embryonic lethality and perturbs kinetic coupling of long neural genes [4sURDB-Seq]
The rate of RNA Polymerase II (RNAPII) elongation has an important role in the control of Alternativ...
GSE128651: Next Generation Sequencing Facilitates Quantitative Analysis of SCs in mice exposure to exercise
Purpose:To identify genes and the molecular pathways involved in the regulation of muscle satellite ...
GSE129056: Transcriptomic analysis of murine splenic basophils in steady-state or on day 14 of Trichuris muris infection
Whole transcriptome analysis of genes expressed by spleen basophils in response to gasttrointestinal...
GSE129083: Age effects on CL-induced beige fat remodeling
Analysis of iWAT tissues from young (2 month) and aged (12 month) C57bl/6 male mice with vehicle or ...
GSE129277: Illumina sequencing analysis of LINC00998 knockdown and control in Huh7 cell line
shRNA knockdown against LINC00998 in Huh7 cells followed by RNA-seq. LINC00998 is also known as SMIM...
GSE131428: Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons
The autism-associated synaptic-adhesion gene Neuroligin-4 (NLGN4) is poorly conserved evolutionarily...
GSE121780: Mandibular dysmorphogenesis due to abnormal osteogenic activity in FGFR2-related craniosynostosis mouse models
Mutations within FGFR2 are causative for various craniosynostosis syndromes. The mandibular dysmorph...