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Sequencing-based assays page 86
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GSE128870: Transcriptional profiling of the peri-pulmonary vein region of the adult mouse left atrium and corresponding Tbx5-dependence
The left atrium consists of three major parts: the peri-pulmonary vein portion, the appendage, and t...
GSE129106: Intraductal Adaptation of the 4T1 Mouse Model of Breast Cancer Reveals Effects of the Epithelial Microenvironment on Tumor Progression and Metastasis
Tumors were harvested at day 24 post tumor cell engraftment and dissociated into single-cell suspens...
GSE129180: ZIKV infection strongly induces antiviral immune responses in human NPCs
To investigate the cellular pathologies in human NPCs after ZIKV infection, we performed global tran...
GSE142422: Dosage dependent requirements of Magoh for cortical interneuron generation and survival
We report the transcriptome of E11.5 microdissected and FAC sorted Nkx2.1-Cre;tdTomato + MGE cells f...
GSE130343: Gata2 deficiency delays leukemogenesis while contributes to aggressive leukemia phenotype in Cbfb-MYH11 knockin mice
To clarify the role of Gata2 in the development of Cbfb-MYH11 induced leukemia, we generated conditi...
GSE129210: TNF promotes SREBP activity to regulate macrophage polarization and tissue repair [RNA-seq]
TNF-mediated macrophage polarization is important for inflammatory disease pathogenesis, but mechan...
GSE123136: SUFU and SPOP mediated downregulation of Hh signaling promotes pancreatic beta-cell differentiation through the regulation of organ-specific stromal niche signals
Purpose: Human Embryonic Stem Cell (hESC)-derived insulin-producing beta cells offer a promising cel...
GSE131792: Inhibition of Lysine-Specific Demethylase-1 in Myelodysplastic Syndrome Progenitors Restores Differentiation of CD141Hi Conventional Dendritic Cells
Immunotherapeutic approaches to treat patients with myelodysplastic syndromes (MDS) show promise but...
GSE123916: TP53/DNA Damage Response Pathway is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Caused by Lamin A/C Mutations
To gain insights into the molecular pathogenesis of DCM caused by LMNA mutation, a doxycycline-induc...
GSE129172: Setdb1 safeguards genome stability against stem cell necroptosis and bowel inflammation (RNA-seq)
The aetiology of bowel inflammatory disease (IBD) is a multifactorial interplay between heredity and...
GSE125242: Transcriptome Sequencing Facilitates Quantitative Analysis of BMDM (bone marrow induced macrophages) from FBXW7f/f and LysM-cre FBXW7f/f Transcriptomes before or after LPS treatment
Purpose: The goals of this study are to compare genes change between FBXW7f/f and LysM-cre FBXW7f/f ...
GSE131786: Transcriptional analysis of IGF1 treatment of mouse tenocytes over a 24 hour time course
We report RNA sequencing data from tenocytes treated with IGF1. Tenocytes were obtained from the tai...
GSE129228: Effects of exosomes derived from mice endothelial progenitor cells (EPCs-exo) on mice fibroblast following inducement of dexamethasone
This study sought to explore the specific effects of EPCs-exos on steroid induced osteoporosis in mi...
GSE129388: Tissue specific innate lymphoid cells promote checkpoint blockade PD-1 immunotherapy in pancreatic cancer
Transcriptomic profiling of the tumor microenvironment was performed by RNA Seq of bulk tumor and tu...
GSE122072: Shortening the half-life of Cas9 maintains its gene editing ability and reduces neuronal toxicity
Virus-mediated expression of CRISPR/Cas9 has been actively used for genome editing in animal models ...
GSE124532: Transcriptome and DNA methylome of mouse Mller glia
Mller cells are the primary glia of the neural retina and play crucial roles in maintaining the stru...
GSE128740: Alterations of the MEK/ERK, BMP, and Wnt/b-catenin pathways detected in the blood of individuals with lymphatic malformations
Lymphatic malformation (LM) is a developmental anomaly of the lymphatic system that may lead to disf...
GSE128891: Identification of a mesenchymal progenitor cell hierarchy in adipose tissue (Bulk RNA-seq)
The healthy growth of adipose tissue depends on the capacity of progenitor cells to undergo denovo a...
GSE129103: Gene expression differences between activated B cells expressing GL7 and not in Peyers patches
We report two populations of activated germinal centre B cells in the Peyers patches that are distin...
GSE123941: Loss of non-CpG methylation in inhibitory neurons impairs neural function through a mechanism that partially overlaps with Rett syndrome
Whole striatum were dissected from wild-type, as well as in mice where Dnmt3a or MeCP2 was condition...
GSE127898: Transcriptome map of the human brain at the single-cell resolution
The human brain is about three times larger than the brain of our closest relatives, chimpanzees and...
GSE130770: Identification of trans regulators of ADAR and A-to-I RNA editing using RNA-seq
A-to-I RNA editing levels differ across tissues and cell types, but regulators of the editing proces...
GSE128893: SirT7 auto-ADPribosylation regulates glucose starvation response through macroH2A1.1 (RNA-seq)
Sirtuins are key players in the response to oxidative, metabolic and genotoxic stress, and are invol...
GSE129096: Systematic comparison of single-cell and single-nucleus transcriptomes during cardiomyocyte differentiation
Purpose:To systematically assess the differences between high-throughput single-cell and single-nucl...
GSE122871: Single-cell Transcriptomics Resolves Intermediate Glial Progenitors and Uncovers a Pivotal Determinant of Cell Fate and Gliomagenesis
The identity and heterogeneity of glial progenitors and their contributions to brain tumor malignanc...
GSE142475: Genes regulated by COUP-TFII inhibitor
The orphan nuclear receptor COUP-TFII is expressed at a low level in adult tissues, but its expressi...
GSE136029: The effect of attenuated Salmonella typhimurium on the tumor epithelium in mouse colorectal cancer model
Bacterial cancer therapy (BCT) shows great promise for treatment of solid tumors, yet basic mechanis...
GSE130595: Effect of ILF3 depletion in HeLa cells on RNA steady state levels
Upon detection of viral infections, cells activate the expression of type I interferons (IFNs) and p...
GSE132289 (mouse): Mouse ovarian cancer models recapitulate the human tumor microenvironment and patient response to treatment
Although there are many prospective targets in the tumor microenvironment (TME) of high-grade serous...
GSE140062: Effect of overexpression on miR-486-5p in Healthy doncor CD34+ cells
We report the effect of overexpression of miR-486-5pin heathy donors hematopoietic stem cells SOURCE...
GSE138531: Aortic Valve Tissue: Stenosis vs. Sclerosis
We are looking at differential gene/protein expression in tissue from stenotic vs sclerotic human ao...
GSE121887: Mouse Genome-Wide Association and Systems Genetics Identifies Lipoma HMGIC Fusion Partner (Lhfp) as a Regulator of Bone Mass
Bone mineral density (BMD) is a strong predictor of osteoporotic fracture. It is also one of the mos...
GSE127918: Reconstruction of the decidual pathway in human endometrial cells using single-cell RNA-Seq
The fate of the human endometrium is determined during the mid-luteal window of implantation, coinci...
GSE128751: Global transcriptomic analysis of murine ovarian surface epithelial (MOSE) cells with PAX8 overexpression
To identify the role of PAX8 in transformation of the ovarian surface epithelium (OSE). SOURCE: Matt...
GSE138603: Response of expanded human conventional and regulatory T cells to CD3/CD28-mediated activation [Exp1]
Immune responses depend on a dynamic balance between the opposing activities of conventional (Tconv)...
GSE137646: TET1 is a tumour suppressor that inhibits bladder cancer progression
Ten-Eleven Translocation 1 (TET1) is a member of methylcytosine dioxygenase, which catalyse 5-methyl...
GSE127862: ER over-expression does not accelerate development of p53-deficient mammary tumors in mice [RNA-Seq]
About 75% of all breast cancers express the nuclear hormone receptor oestrogen receptor (ER). Howev...
GSE140059: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Otud1-/- distal colonic tumor Transcriptomes
Conclusion: Otud1-/- mice are more sensitive to azoxymethane(AOM)-Dextran sulfate (DSS) induced colo...
GSE128759: Neonatal hematopoietic stem and progenitor cell ontogeny at single cell resolution (RNA-seq)
RNA-seq analysis of HSCs and HPCs during fetal, neonatal and adult stages of development SOURCE: Jef...
GSE133660: Gene expression data from IMR90 control, IMR90 shRRM2 and shRRM2/shp16
Transformed and tumorigenic cells require increased deoxyribonucleotide synthesis to fuel the genome...
GSE128532: Genome wide RNA sequencing to profile response to IL-1 in control and IFT88 depleted cells
Purpose: RNA sequencing across whole genome downstream to IL-1 to investigate scope and nature of ef...
GSE130822: Ascl2-dependent cell differentiation drives regeneration of abated intestinal stem cells
Functions of Ascl2 in colonic stem cell maintenance and regeneration. We used RNA-sequencing to prof...
GSE123126: Mutationally-activated PI3-kinase-a promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase
Human lung adenocarcinoma exhibits a propensity for de-differentiation, which complicates diagnosis ...
GSE130289: Dynamics of Trophoblast Differentiation in Peri-implantation Stage Human Embryos
Single cell RNA sequencing of cells from cultured human blastocysts has enabled us to define the tra...
GSE134048: HEK293 TFAM Knockout Expression Study
HEK293 cells with CRISPR KO were analyzed using RNA-Seq. Abstract: Mitochondrial DNA copy number (mt...
GSE133693: Myocardial RNA Sequence Analyses throughout the Course of Mouse Cardiac Laminopathy Identify Differential Expressions of the Key Genes for Cell Cycle Control and Mitochondrial Function
Gene expression profiling in homozygous LMNA-/- mouse model with cardiomyopathy phenotype unraveled ...
GSE124312: An atlas of vagal sensory neurons and their molecular specialization
Sensory functions of the vagus nerve are critical for specific aware perceptions and for monitoring ...
GSE127995: Sensory experience remodels genome architecture in neural circuit to drive motor learning
Neuronal activity-dependent transcription couples sensory experience to adaptive responses of the br...
GSE129882: RNA-seq transcript and gene data on zika exposed and zika nave samples
RNA-seq count data at 3 timepoints was generated for Zika-exposed and Zika-nave individuals in order...
GSE122235: Role of CIZ1 in maintenance of epigenetic landscape in primary differentiated mouse embryonic fibroblasts
The inactive X chromosome (Xi) serves as a model for establishment and maintenance of repressed chro...
GSE123735: Next Generation Sequencing Facilitates Quantitative Analysis of the effects of DTA-1 treatment on sorted mouse adipose tissue ILC2 Transcriptomes
Metabolic syndrome is characterized by disturbances in glucose homeostasis and the development of lo...
GSE130306: DNMT1 drives 4D genome rewiring during oncogene induced senescence
While, transcriptional and epigenetic changes associated senescence processes are well studied, the ...
GSE130187: High-throughput exploration of the network dependent on AKT1 in mouse ovarian granulosa cells.
We depleted Akt1 in murine primary granulosa cells and assessed the molecular consequences at the tr...
GSE130897: The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1 [RNA-seq]
We demonstrate that TRIM71 alters stem cell splicing patterns through modulation of MBNL1 levels. SO...
GSE120429: AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose
Purpose: To investigate alterations in subcutaneous white adipose gene expression induced by genetic...
GSE132270: Gene expression profiles of macrophage and multinucleated cells programmed by IL15
We report gene expression profiles of macrophage and multinucleated cells programmed by IL15 includi...
GSE131856: Nuclear receptor ROR is a targetable master regulator of cholesterol in a subtype of breast cancer [RNA-Seq]
We show that triple-negative breast cancer (TNBC) exhibits a hyper-activated MVA-CB program that is ...
GSE128742: Total RNA sequence under control and PD-L1 knockdown
Detect overall RNA level change under PD-L1 knockdown. SOURCE: Zhenkun Lou Mayo Clinic
GSE120701: Developmentally controlled expression of Cxcr4 by hematopoietic progenitors allows tracing of monocyte function in stroke
Monocyte-derived and tissue-resident macrophages, such as microglia, belong to independent lineages ...
GSE132596: Loss of TET2 results in gene expression represssion in mouse nave B-cells and lymphoma cells [RNA-seq]
Absence of Tet2 at mouse cells results in reduced gene expression SOURCE: Sheng LiLi Lab The Jackson...
GSE131826: RNA-binding Protein PCBP1/hnRNP E1 is an Intracellular Checkpoint for Balancing Effector versus Regulatory T Cells
Distinct lineages of T cells can act in response to various environmental cues to either drive or re...
GSE131861: RNA-seq Analysis of Gs-linked GPCRs expressed in mouse inguinal white adipocytes (iWAT), epididymal white adipocytes (eWAT) and brown adipose tissues (BAT)
Purpose: The goals of this study are to identify Gs-linked GPCRs that are endogenously expressed by ...
GSE128743: EBF-1 mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential
Here, we investigate the role of Early B-cell factor 1 (EBF1) in MSCs to support hematopoiesis. Ebf1...
GSE130242: Inhibition of protein arginine methylation alters RNA metabolism and DNA damage response providing a new therapeutic strategy in PDAC
We show a strong correlation between PRMT1 substrates and complexes that are physically associated a...
GSE87641: Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly-dividing de-differentiated state
Treatment of BRAF-mutant melanomas with MAP-kinase pathway inhibitors is paradigmatic of the promise...
GSE135220: Human cell line and subcutaneous tumor
To find different gene expression signature in OVCAR5 cells with PTPRR -WT expression or PTPRR-DA ex...
GSE129726: Hematopoietic stem cells in perisinusoidal niches are protected from ageing [young and aged BM CD45-CD31+ endothelial cells]
With ageing, intrinsic hematopoietic stem cell (HSC) activity decreases, resulting in impaired tissu...
GSE130353: Transcriptome analysis of circulating monocytes in QFS and CFS compared to various control groups
Transcriptomes of circulating monocytes in Q fever fatigue syndrome (QFS) patients, chronic fatigue ...
GSE134843: RNA seq analysis of SHP099 treated Leukemic Cells Expressing Genetic and Epigenetic Mutations
10 to 30% normal karyotype acute myeloid leukemia (AML) patients express mutations in regulators of ...
GSE130201: RNA-seq and ATAC-seq to study dendritic cell heterogeneity
The cDC2 subset is heterogeneous. We found the expression of T-bet delineates two distinct cDC2 subs...
GSE131874: Sexually dimorphic crosstalk at the maternal-fetal interface
The first trimester is a critical window of maternal-fetal communication for pregnancy. RNA-sequenci...
GSE127465: Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species
Tumor-infiltrating myeloid cells (TIMs) comprise monocytes, macrophages, dendritic cells and neutrop...
GSE133799: Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80 [RNA-seq]
Chromatin regulates spatiotemporal gene expression during neurodevelopment, but it also mediates DNA...
GSE134020: Mammalian RNA decay pathways are highly specialized and widely linked to translation
RNA decay is crucial for RNA turnover and surveillance, and misregulated in many diseases. This comp...
GSE130613: The effect of acute sustained hypoxia on gene expression in liver, kidney and lung on different times-of-day
Many hypoxia related diseases present a time of day dependency. Here, we examine the difference in t...
GSE128066 (mouse): A Bayesian mixture model for clustering droplet-based single cell transcriptomic data from population studies
Abstract: The recently developed droplet-based single cell transcriptome sequencing (scRNA-seq) tech...
GSE131858: Low input RNA sequencing of GPR35-positive and negative intestinal macrophages
Aim: We aimed to determine differences in transcriptional profiles of GPR35-positive and negative ma...
GSE130356: BAP1 loss triggers DNA methylomic repatterning in highly aggressive Class 2 uveal melanomas [RNA-Seq]
The strong association between BAP1 mutations and highly aggressive Class 2 uveal melanoma (UM) sugg...
GSE132206: Endogenous beta-galactosidase activity marks TREM2-expressing Kupffer cell population in the livers of carbon tetrachloride-treated Lgr5-LacZ mice
Lgr5+ cells isolated from liver organoids act as bipotent liver progenitors. Beta-galactosidase (bet...
GSE128998: SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal cancer by interacting with AIF
Thousands of long noncoding RNAs (lncRNAs) are aberrantly expressed in various types of cancers, how...
GSE122205: Transcriptomic profiles of retinal ganglion cells are defined by the magnitude of intraocular pressure elevation in adult mice
Elevated intraocular pressure (IOP) is the major risk factor for glaucoma, a sight threatening disea...
GSE132308: RNA-Seq analysis of galaninergic neurons from ventrolateral preoptic nuleus identifies expression changes between sleep and wake
Galanin neurons at ventrolateral preoptic nuleus (VLPO) have been hypothesized to be sleep-active ne...
GSE131869: Cx3cr1-deficient microglia exhibit a premature aging transcriptome
CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerou...
GSE130633: Effects of losmapimod on antigen-specific response in aged skin
Older humans are more susceptible to infections, even those to which they were immune to in their yo...
GSE130240: Sympathetic nerves and arrector pili muscles form a dual component niche to regulate hair follicle stem cells
Piloerection (goosebump) requires concerted actions of the hair follicle, the arrector pili muscle (...
GSE131011: Mesenchymal stem/stromal cell engulfment reveals metastatic advantage in breast cancer
We isolated the engulfing MDA-MB-231 breast cancer cells and would like to see the differences as co...
GSE130814: Next Generation Sequencing Analysis of CircRNAs/linear RNA in Isolated Renal Proximal Tubule tissues from Acute kidney injury mice
The goal of this study was to find the differentially expressed circRNAs/linear RNA in AKI mice mode...
GSE130950: RNA-seq data of PatchSeq dataset from Pvalb-Cre positive interneurons in the mouse hippocamus CA1 region
This study takes on the problem of bridging transcriptional data to neuronal phenotype and function ...
GSE130879: Identification of tissue regulatory T cell precursors in lymphoid organs [scRNA]
Regulatory T (Treg) cells maintain self-tolerance in lymphoid tissues, and specialized Treg cells ac...
GSE122085: Characterisation of young, old and old repopulating microglia in spinal cord and brain of C57BL/6 wild type male mice
To address whether, after depletion by Csf1r inhibition, microglia repopulating the CNS revert to a ...
GSE131871: TOX Transcriptionally and Epigenetically Programs CD8 T cell Exhaustion
Transcriptional and epigenetic features were detected in WT versus TOX-/- P14 T cells following 8 da...
GSE138561: RNA-sequencing of dura mater or brain ECs isolated from 8-week-old mice
To further elucidate fundamental molecular differences between dura mater and brain ECs, we performe...
GSE129465: Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials
Plant homeodomain finger gene 6 (PHF6) encodes a 365-amino-acid protein containing two plant homolog...
GSE123103: Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool
During mouse embryogenesis, progenitors within the liver known as hepatoblasts give rise to adult he...
GSE134095: Colorectal cancer cells respond differentially to autophagy inhibition in vivo
inhibition of autophagy in vivo had a substantial cell line-dependent impact on tumor growth of diff...
GSE130886: Effect of IL6 inhibition on the gene expression of erythroid progenitors in aged mice
Gene expression analysis has revealed that Interleukin-6 signalling in murine erythroid progenitors ...
GSE131868: RNA sequencing of mouse hepatic response to compounds with predicted lifespan-extending effect
This dataset consists of hepatic gene expression profiles of mice subjected to 4 compounds predicted...
GSE132688: Unique microglia expression profile in developing white matter.
Recently we demonstrated that amoeboid microglia in white matter regions are essential for proper ol...
GSE130376: Next-generation sequencing of cholinergic interneurons in the nucleus accumbens of cocaine-addicted and non-addicted mice
Cholinergic interneurons (ChINs) in the nucleus accumbens (NAc) play critical roles in processing in...
GSE130898 (human): The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1 [RNA-seq & Ribo-seq]
We demonstrate that global effects of TRIM71 on the cellular transcriptome of mouse embryonic stem c...