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Sequencing-based assays page 90
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GSE132828: Effect of Ramoplanin treatment on hESC-RPE transcriptome during POS phagocytosis
we report the effect of Ramoplanin on the transcription profile of RPE cells in comparison to DMSO (...
GSE136138: Global transcriptomic changes in aged mouse kidney podocytes
Like many cell types, the mechanisms and pathways underlying healthy aged-related changes to podocyt...
GSE131379: Hypoxia effects on the transcriptome of HeLa cells
Hypoxia is associated with several diseases, including cancer. Circular RNAs (circRNAs) are a novel ...
GSE131380: High-throughput propagation of human prostate tissue from induced-pluripotent stem cells.
We demonstrate a new high-throughput model where rapidly proliferating and easily handled induced pl...
GSE131512: Extracellular RNA in a single droplet of human serum reflects physiologic and disease states
We developed SILVER-seq (Small Input Liquid Volume Extracellular RNA Sequencing) to efficiently sequ...
GSE141088: RASSF2 knockdown in THP-1 AML cells
Large-scale chromosomal translocations are frequent oncogenic drivers in acute myeloid leukemia (AML...
GSE124834: Toxic C9orf72 poly(PR) binds heterochromatin, disrupts HP1 and causes dsRNA accumulation
How G4C2 repeat expansions in C9orf72 cause frontotemporal dementia (FTD) and amyotrophic lateral sc...
GSE132123: Transcriptome Analysis of IL-33-Deficient Early Developing B Cells
We identified that IL-33 is expressed in pro-B (B220+ IgM- CD19+ CD43+) and large pre-B cells (B220+...
GSE138677 (mouse): Sex-specific role for the long non-coding RNA linc00473 in depression
Depression is a common disorder that affects women at twice the rate of men. Here we report that lon...
GSE132831: Type 2 Diabetes reduces the enteroendocrine GLP-1 cell lineage in human obesity: characterization in enriched human enteroendocrine cells
Obesity and type 2 diabetes (T2D) can be associated with altered secretion of enterohormones in cond...
GSE131193: Long-Term Gene Expression Dynamics at the Neurovascular Unit After Cerebral Ischemia/Reperfusion Injury in Mice
With increasing distribution of endovascular stroke therapies, transient middle cerebral artery occl...
GSE122740: Single cell RNA sequencing identifies the developmental origin of C-Myc dependent T-bet+thymic intraepithelial lymphocyte precursor
Natural intraepithelial lymphocytes (IELs) are thymus-derived adaptive immune cells, which are impor...
GSE124760: Protective role of endothelial p53 in stress induced vascular malignancy.
Accumulation of cellular stress induced mutations has a potential risk for oncogenic transformation....
GSE133298: Longitudinal Blood Transcriptomic Changes Predict Lung Function Decline in patients with Idiopathic Pulmonary Fibrosis
Rationale: Molecular markers of disease progression in idiopathic pulmonary fibrosis are needed.; Ob...
GSE133398: Alterations in alternative RNA splicing in Srsf3-flox/flox hepatocytes with AAV-CRE mediated deletion of SRSF3 vs hepatocytes with AAV-GFP
Hepatocytes were isolated and infected in vitro, then RNA extracted and subjected to RNAseq SOURCE: ...
GSE127980: Transcriptome analysis of erythroblastic island macrophages
The erythroblastic island (EBI), composed of a central macrophage and surrounding erythroid cells, w...
GSE132129: Low-dose quercetin positively regulates mouse healthspan
we reported for the first time a geroprotective effect of low-dose quercetin alone that improved the...
GSE123873: Proteasome dysfunction in alveolar type 2 epithelial cells is associated with acute respiratory distress syndrome
Proteasomes are a critical component of quality control that regulates turnover of short-lived, unfo...
GSE132854: The role of Erg in B cell development (RNA-Seq)
RNA-seq of pre-proB, proB and preB populations from Ergfl/fl bone marrow, pre-proB cell population f...
GSE133341: Single-cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos
Human T lymphogenesis includes emergence, migration and thymus-seeding of T lymphoid precursor, foll...
GSE112302: Comprehensive Molecular Characterizations of Gastric Tissue and Gastric Cancer Revealed by Single-cell RNA-seq
Molecular knowledge of normal gastric tissues and gastric cancers remains incomplete. Here, we used ...
GSE123909: Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signaling
Disruption of the circadian rhythm is associated with inflammatory diseases, metabolic syndrome and ...
GSE132835: Primary Human B-cell Temporal Response to CD40L Stimulation
RNAseq was used to identify primary human B-cell responses to CD40L stimulation. Primary human peri...
GSE133259: RNAseq data from mtDNA mutator induced pluripotent stem cells
RNAsequencing data from POLG D257A mutant mouse iPS (induced pluripotent stem) cells. These mice acc...
GSE131985: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type LNCaP95 cells and Androgen receptor knocked-out clones Transcriptomes
Purpose: To compare the gene expression changes in parental LNCaP95 cells when androgen receptor is ...
GSE133314: Asxl1 and Cebpa cooperation in AML revealed by a novel Asxl1 mutant mouse model
Asxl1 is one of the most commonly mutated genes in malignancies including myelodysplastic syndromes ...
GSE124772: A nutritional memory impairs transcriptional, metabolic and survival response to dietary restriction in old mice
Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic health i...
GSE136731: RNA-seq of circulating inflammatory human cDC2 dendritic cells
Distinct subsets of circulating human cDC2 dendritic cells were sorted based on CD5, CD163 and CD14 ...
GSE133287: Transcriptomics analysis of wild type and Wdr26 knockout MEL cells
Wdr26 is a gene induced during red cell development. In order to understand the function of wdr26 du...
GSE137092: Mouse transcriptome reveals novel signatures of protection and pathogenesis in human tuberculosis [blood]
Characterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis in...
GSE124815: Transcriptomics of mouse ileal stem cell-derived epithelium grown on transwells
Purpose: The goal of this study was to identify transcriptional changes that occur in mouse ileal st...
GSE134906: RNA Sequencing Facilitates Quantitative Analysis of Transcriptomes of H1 derived CD31+ cells and H1 after HAND1-overexpression derived CD31+ cells at Day8 after human early hematopoietic differentiation .
Purpose: The goals of this study are to verify HAND1 overexpression is suffice to upregulate other M...
GSE143191: MMRN2 mutation underlies a rare form of autosomal-dominant laryngeal malformation
The aim of this study was to investigate the genetic basis and pathogenic mechanism of nonsyndromic ...
GSE123919: Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain
Acute pain serves as a protective mechanism, guiding the organism away from actual or potential tiss...
GSE132383: Validation of small molecule activators and identification of altered signaling pathways underlying the age-related decline in proliferative capacity in human dermal progenitors
Intrinsic dysfunction of hair follicle dermal progenitors underlies phenotypic changes observed in a...
GSE133028: CSF B cells in relapsing multiple sclerosis are driven towards an antigen-experienced, inflammatory fate
Central nervous system B cells have several potential roles in multiple sclerosis (MS): secretors of...
GSE133309: Low KLF11 Determines the CSClike Identity in Sarcoma via restraining YAP transactivity [RNA-seq]
We conducted transcriptome comparison of control and KLF11-knockdown MG63 cells. SOURCE: Le Qu (sept...
GSE128148: Transcriptomic response of the arcuate nucleus to oral corticosterone treatment
Glucocorticoids (GCs) are widely prescribed to treat inflammatory and autoimmune conditions. However...
GSE143213: Human naive CD4 T cell subsets on young and old donors
We report the application of single-molecule-based sequencing technology for high-throughput profili...
GSE132386: Gene expression profile of mouse liver in response to activation of PPARA by WY-14643.
Gene expression in adult male mouse liver was assayed by RNA-seq, as part of a study of liver transc...
GSE126205: PDGFR and SMA mark two distinct mesenchymal cell populations involved in parenchymal and vascular remodeling in pulmonary fibrosis
We utilized a fate-mapping approach to investigate alpha-smooth muscle actin (SMA)+ and platelet der...
GSE132708: Networks of enhancers and microRNAs drive variation in cell states
We measure gene expression changes in three naturally arising states of embryonic stem cells. These...
GSE138289: SIRT7 safeguards genome stability and suppresses colorectal tumorigenesis
SIRT7 is a member of the mammalian sirtuin family and functions as a NAD+-dependent deacylase. Studi...
GSE134918: Single-cell RNA sequencing (scRNAseq) data from Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) cells, and Scope-Seq data from Ventricular-Subventricular Zone (V-SVZ)
We performed large-scale single cell profiling of dissociated V-SVZ and OB cells from the same anima...
GSE138671: Formula Feeding and Immature Gut Microcirculation Promote Intestinal Hypoxia leading to Necrotizing Enterocolitis
Major risk factors for necrotizing enterocolitis (NEC) are formula feeding and prematurity, however,...
GSE132370: Deep sequencing of human fibroblastic cell line IMR90, either proliferating or senescent, with or without TSA treatment.
Gene expression changes were compared in proliferating and senescent human IMR90 cells, with or with...
GSE132154: Dual modulation of neuron specific microRNAs and the REST complex promotes functional maturation of induced human adult neurons
Direct neural reprogramming can be achieved using different approaches, including by expressing neur...
GSE123954: Demethylation and derepression of genomic retroelements in the skeletal muscles of aged mice
Changes in DNA methylation influence the aging process and contribute to aging phenotypes, but few s...
GSE133329: Transcriptome analysis of A549 cells expressing a SUMOylation-deficient TRIM28 mutant in the context of influenza A virus infection
Aim: Identify differentially expressed genes in human lung epithelial cells expressing a SUMOylation...
GSE125125: Overriding FUS autoregulation triggers gain-of-toxic dysfunctions in autophagy-lysosome axis and RNA metabolism
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The lat...
GSE132396: Epigenetic regulator genes direct the fate of multipotent precursor cell of origin in lineage switched MLL-AF4 leukaemia [RNA-Seq]
Malignant transformation in a multipotential precursor has recently been shown to underlie mixed phe...
GSE134881: Single-cell analysis of Crohns disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
Purpose: IBD diagnosis correlation with failure to achieve corticosteroid-free durable remission up...
GSE139364: Drug-induced mitochondrial oxidative stress is responsible for various effects of the survivin inhibitor Sepantronium Bromide (YM155) in triple negative breast cancer cells
Sepantronium bromide (YM155), a transcriptional inhibitor of anti-apoptotic protein survivin, is con...
GSE137200: Pattern occupation of HDACs on chromatin determines PI3K/AKT inhibitor resistance in cancers [RNA-seq]
Blocking BRD4 or HDACs induces paradoxically similar gene expression, comparably attenuates PI3K/AKT...
GSE125095: Chemically Induced CD24+ hepatocyte-derived liver progenitor-like cells revert chronic hepatic dysfunction
Administration of soluble molecules to induce endogenous adult liver progenitor-like cells may provi...
GSE132402: A Cancer rainbow mouse for visualizing the functional genomics of field cancerization
Comparison of mouse intestinal crypt epithelial cells isolated from wild-type or ROBO-Crainbow small...
GSE135352: Napabucasin-mediated transcriptomic changes in human pancreatic cancer cell lines
This study aimed to determine what genes are differentially expressed following 2 hours' treatment w...
GSE132722: Transcriptome profiling of A549 RB1 wild-type/knockout cell lines
A549 cells were co-transfected with CRISPR/Cas9 (containing sgRNA and GFP) and HDR donor plasmids (c...
GSE138687: Gene expression analysis from placenta of Cornelia de Lange Syndrome (CdLS) mouse models
CdLS is caused by mutaion in cohesin and associated proteins, such as Nipbl and Hdac8. We performed ...
GSE134659: Structural cells are key regulators of organ-specific immune response
The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathoge...
GSE132771: Single cell RNA-sequencing of normal and fibrotic lungs in mouse and human
We performed scRNA-seq of cells obtained with a protocol designed to capture all of the collagen-pro...
GSE140529: CTCF is dispensable for cell fate conversion but facilitates acute cellular responses [RNA-Seq]
Studies of genome topology, chromatin state and gene expression dynamic during human B cell to macro...
GSE124822: DNA methylation disruption reshapes the hematopoietic differentiation landscape
Somatic mutations in genes implicated in DNA methylation (DNAme; e.g., TET2, DNMT3A and IDH2), are f...
GSE132408: RNA-Seq in control and TET2 Knockout cells with IFN treatment
Detect overall RNA level change under TET2 knockout in response to IFN. Loss of TET2 alters IFN tran...
GSE133399: CD103hi lung-resident regulatory T cells constrain the fibrotic responses induced by CD103low tissue-resident pathogenic CD4 T cells
Tissue-resident memory T (TRM) cells are crucial mediators of adaptive immunity in non-lymphoid tiss...
GSE133524: Modeling Human Cancer-induced Cachexia (Mouse)
Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In cancer, cachexi...
GSE133585: The RNA N6-methyladenosine regulates chromatin remodeling and transcription [seq_nuclearRNA]
The N6-methyladenosine (m6A) has been shown to regulate stability and translation of messenger RNA (...
GSE134645: Cdk1 controls global epigenetic landscape in embryonic stem cells
In this study, we found that in ES cells the majority of Cdk1 substrates are localized on chromatin....
GSE131613: The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress [Mus musculus]
Organisms respond to mitochondrial stress by activating multiple defense pathways including the mito...
GSE145863: Transcriptional analysis of tenocytes from mice with a targeted deletion of scleraxis
We report RNA sequencing data from tenocytes cultured from the tail tendons of adult male mice in th...
GSE124014: RNA sequencing of NNMT overexpression in 3T3 fibroblasts
High grade serous carcinoma (HGSC) arising from either the fallopian tube or ovary has a poor progno...
GSE133555: RNA seq to compare gene expression profiles between Npm1 WT and Npm1 knockdown cells
Mouse KrasG12D/P53-/-(KP) lung tumor cells were transfected with pLKO.1-Tet on-shNpm1-3(N3), pLKO.1-...
GSE124047: RNAseq E15.5 mouse skin WT, Irf6 KO, Ripk4 KD, and Irf6 S413A.S424A knockin
The integrity of the mammalian epidermis is essential for organism survival, and it depends on a bal...
GSE136656: Activity-dependent regulome and transcriptome of human GABAergic neurons reveal new patterns of gene regulation and neurological disease heritability
Neuronal activity-dependent gene expression is essential for healthy brain development. Emerging stu...
GSE132385: Impact of Gm15441 knockdown on gene expression profile of mouse liver in response to activation of PPARA by WY-14643.
Gene expression in livers of wild type adult male mice and in Gm15441 knockdown adult male mouse liv...
GSE133039: Epigenetic footprint of hepatoblastoma defines a novel integrative molecular classification with clinical implications [RNA-seq]
Hepatoblastoma (HB) is the predominant pediatric liver cancer with limited therapeutic options for p...
GSE94736: Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women.
Purpose: Identification of relevant genetic pathways that are altered with aging knowing that the p...
GSE133566: Shp-deletion induces dissociation of steatosis and inflammation in NASH
Two months-old Shp flox/flox male mice were injected with either AAV8 expressing Cre recombinase dri...
GSE141093: Genome-wide transcriptional profiles of intestinal macrophages from WT and Csf1r-EP4-/- mice during dextran sodium sulfate induced colitis.
To define the mechanisms that underlie regeneration driven by EP4+ macrophages, we transcriptionally...
GSE133679: Hematopoietic stem cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia [RNASeq_Cdx2_4weekspost_Tamoxifen]
The caudal-related homeobox transcription factor CDX2 is ectopically expressed in the majority of pa...
GSE132528: Expression of deregulated MYC with activated NeuNT in mammary gland developed mammary tumors with molecular heterogeneity
The goal of this study is to investigate the role of deregulated c-MYC in cooperation with activated...
GSE134701: Lipopolysaccharide-dependent transcriptional regulation of PU.1 in microglial cells
We knocked out PU.1 in murine BV-2 cells using the CRISPR-Cas9 system to investigate the role of PU....
GSE133707: Single nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling
We report a single-nuclei RNA-seq (snRNA-seq) transcriptomic study on human neural retinal tissue to...
GSE132531: The magnitude of IFN-g responses is fine-tuned by DNA architecture and the non-coding transcript of Ifng-as1
IFN-g, critical for host defense and tumor surveillance, requires tight control of its expression. M...
GSE124029: Gene-expression patterns at transcriptional ans translational levels in the tissues of colorectal cancer are different from that in the correspondent adjacent regions
In the interest of gene expression status responsive to CRC, the colorectal tissues from the tumor a...
GSE136813: Cell-type-specific miRNA profiling sheds light into proatherogenic gene regulation
Regulation of coding and non-coding genes is studied from primary human aortic endothelial cells (HA...
GSE132091: Toxoplasma gondii infection of human retinal pigment epithelial cells
We performed RNA-Sequencing (RNA-Seq) of primary human retinal pigment epithelial cells and the ARPE...
GSE138685: Novel RvD6 stereoisomer induces corneal nerve regeneration and wound healing post-injury by modulating trigeminal transcriptomic signature
We performed the RNA-seq analysis to unravel the underlying mechanism of corneal nerve regeneration ...
GSE132418: The profiles of circRNAs, lncRNAs and mRNAs in drug-resistant non-small-cell lung cancer cell lines by RNA sequencing
We detected the expression profiles ofcircRNAs, lncRNAs and mRNAs in two drug-resistant NSCLC cell l...
GSE132506: An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [RNA-seq]
RNA-seq was carried out to evaluate the molecular mechanisms that contribute to the distinguishing e...
GSE134728: Mitigating antagonism between transcription and proliferation allows near-deterministic cellular reprogramming (CNN)
RNA sequencing analysis of Hb9::GFP mouse embryonic fibroblasts infected with control or reprogrammi...
GSE133400: Alterations in alternative RNA splicing in hepatocytes from high-fat diet fed C57BL/6 male mice
C57BL/6J male mice were fed a 60% HFD for 10 weeks, then hepatocytes were isolated, RNA extracted an...
GSE133659: FXR isoform selective effects on hepatoma cell line HepG2
The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids that regulates bile aci...
GSE124048: RNAseq E16.5 mouse skin Irf6 KO vs WT
The integrity of the mammalian epidermis is essential for organism survival, and it depends on a bal...
GSE132433: Estrogen response in breast cancer cell line MCF-7 is dependent on NR2F2 [RNA-seq]
We show that most binding events of NR2F2 occur together with the ER binding sites.To address the f...
GSE133626: Genome wide transcriptome analysis of patient matched prostate cancer using NGS technology
Purpose: The goal of present study is to compare transcript level changes between normal and tumor o...
GSE138702: Highly multiplexed proteomic assessment of the human bone marrow microenvironment reveals elevated levels of CCL23 in acute myeloid leukemia
Acute myeloid leukemia (AML) is a genetically heterogeneous disease that is characterized by abnorma...
GSE132900: RNA sequencing of WT and Srp72+/- LT-HSCs from aged mice
To investigat the role of Srp72 in hematopoiesis and the development of myelodysplasia and bone marr...
GSE136825: Whole-transcriptome sequencing reveals heightened inflammation and defective host-defense responses in inflammation and defective host-defense responses in chronic rhinosinusitis with nasal polyps
The pathways underlying chronic rhinosinusitis with nasal polyps (CRSwNP) are unclear. We conducted ...
GSE124097: TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimers disease variant TREM2R47H on murine myeloid cell function
Triggering receptor expressed on myeloid cells 2 (TREM2) is an orphan immune receptor expressed on c...