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Sequencing-based assays page 91
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GSE132529: Effective treatment of immune checkpoint blockade-resistant tumors by pharmacological activation of estrogen receptor beta
In this study, we examined the differential RNA profile of LY500307 plus PD-1-treated 4T1 cells and ...
GSE132739: RNA-seq analysis of murine microglial BV2 cells treated with interferon-gamma (IFNg)
BV2 cells were treated with IFN. Wildtype cells were compared to cells made deficient for Atg5 via C...
GSE134713: Proteinase-Activated Receptor 4 (PAR4) mediates cell membrane blebbing in a Gaq/11, Gai independent, RhoA and -arrestin-dependent manner.
To gain a comprehensive understanding of *-arrestin mediated signaling downstream of PAR4 and to gui...
GSE133664: Transcriptional profile of CAOV2 ovarian cancer cells with TAZ silencing
We performed RNAseq to study the transcriptional changes of human CAOV2 ovarian cancer cells with or...
GSE127999: AMPK links acetyl-coA homeostasis to BET recruitment in acute myeloid leukemia: RNA-seq
Altered metabolism fuels two hallmark properties of cancer cells, unlimited proliferation and differ...
GSE132539: Dissecting the regulatory strategies of NFkB RelA target genes in the inflammatory response reveals differential transactivation logics [BMDM]
NFkB RelA is the potent transcriptional activator of inflammatory response genes. We stringently def...
GSE136773: Transcriptional state of T-cells from Atm-proficient and Atm-deficient mice in response to B-cell lymphoma
CD4 and CD8 murine T-cells from Atm-deficient mice show marked transcriptional changes compared to T...
GSE143261: An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [RNA-seq]
Thousands of epigenomic datasets have been generated in the past decade, but it is difficult for re...
GSE124102: RNA-seq data from C57BL/6N, cS5Ahi and cS5Alo CD8+ murine T-cells isolated from lymph nodes
Recurrent gain-of-function mutations in the transcription factor STAT5B, but not STAT5A, have been d...
GSE138239: Assessment of Viral RNA in Idiopathic Pulmonary Fibrosis Using RNA-seq [poly(A) RNA]
We identified sporadic low-level evidence of viral infections in our lung tissue specimens, but did ...
GSE131322: Oligogenic inheritance of congenital heart disease involving a NKX2-5 modifier [human]
Complex genetic inheritance is thought to underlie many human diseases, yet experimental proof of th...
GSE138709: Dissecting the transcriptomic landscape of the human intrahepatic cholangiocarcinoma by single cell RNA-sequencing
Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy arising in the liver, fea...
GSE136173: Epithelial cells in 2D and 3D culture exhibit significant differences in long-range genomic interactions [RNA-Seq]
Recent studies have characterized the genomic structures of many eukaryotic cells, often with a focu...
GSE138697: NSP4 in myeloid progenitors
Determine if there is NSP4-dependent expression of solute carriers responsible for loading histamine...
GSE132475: Loss of ANCO1 repression of AIB1/YAP drives breast cancer progression
We report the role of AIB1 in regulated YAP driven transcription and repression in normal mammary ep...
GSE143275: poly A+ RNA sequencing of cell cycle-synchronized RNA from U2OS cells
We performed paired-end poly A+ RNA sequencing using total RNA isolated from U2OS cells that are syn...
GSE138252: Differential transcriptional responses in human cardiomyocytes
We report the application of a pericentriolar material 1 (PCM-1) based cardiomyocyte-specific nuclea...
GSE125076: A mouse model of acute post-surgical pain
Pain is the leading cause of disability in the developed world but remains a poorly treated conditio...
GSE132511: Transcriptome of ROS-low LSCs isolated from phenotypically primitive and monocytic primary acute myeloid leukemia (AML) cells
To identify biological differences between primitive and monocytic primary AML, we sorted ROS-low en...
GSE138715: Transcriptome analysis of synthetic miR-155 oligo-treated mouse CD4+ T-cells
High-density gene expression profile of 20,000+ genes for synthetic miR-155 oligo-treated mouse CD4+...
GSE132410: Indoxyl sulfate stimulates angiogenesis by regulating reactive oxygen species production via CYP1B1
Introduction: Indoxyl sulfate (IS) is an accumulated protein-bound uremic toxin found in patients wi...
GSE130850: A stem cell-driven lymphoangiogenic switch (scRNA-seq)
Tissues rely on stem cells (SCs) for homeostasis and wound-repair. SCs reside in specialized microen...
GSE133724 (mouse): FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs
FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs. SOURCE: zhike lu (zhikel...
GSE128197: CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses
This study examines the extent to which memory CD4+ T cells share immunosurveillance strategies with...
GSE133724 (human): FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs
FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs. SOURCE: zhike lu (zhikel...
GSE132505: The fate switch between ON and OFF SACs is determined by Fezf1
The goal of this experiment was to define genes differentially expressed between E17.5 Fezf1Hete and...
GSE135057: Transcriptional correlates of pathological phenotype in a Huntingtons disease mouse model
Huntington disease (HD) is a fatal neurodegenerative disorder without cure, caused by an aberrant ex...
GSE132552: Transcriptional changes after spinal cord injury: recruitment of afferents distal to the site of injury
Nociceptors are thought to play an important role in chronic pain, but the heterogeneity of this pop...
GSE138629: The in vivo endothelial cell translatome is highly heterogeneous across vascular beds (EC-TRAP RNAseq)
The interspersed anatomic distribution of endothelial cells (ECs) and their dependence on microenvir...
GSE132428: Estrogen-independent molecular actions of mutant estrogen receptor alpha in endometrial cancer [RNA-seq]
Estrogen receptor alpha (ESR1) mutations have been identified in hormone therapy resistant breast ca...
GSE98230: RNA-Seq of treatment response of platinum sensitive and platinum resistant ovarian cancer cells
Resistance to platinum-based chemotherapy is a clinical challenge in the treatment of ovarian cancer...
GSE138302: Single cell RNA-seq analysis of feeder-free iPSC-derived gliogenic NS/PCs and neurogenic NS/PCs
We performed single cell RNA sequencing to analyze the transcriptional profile of gliogenic NS/PCs a...
GSE123938: Impact of Diet Induced Obesity on Hyperoxic Lung Injury
Background: Obesity has become a worldwide concern. Acute respiratory distress syndrome (ARDS) compr...
GSE95516: Conserved roles for murine mDUX and human DUX4 in activating cleavage stage genes and MERVL/HERVL retrotransposons [RNA-Seq Human]
To better understand transcriptional regulation during human oogenesis and pre-implantation embryoni...
GSE132829: Distinguishing smoking related lung disease phenotypes via imaging and molecular features
Using unsupervised machine learning applied to computed tomography-based imaging characteristics we ...
GSE134986: OMA1, DELE1 and HRI relay mitochondrial stress to the mammalian integrated stress response
The goal of this study is to understand how mamalian cells respond to the mitochondial stress. Using...
GSE136717: An advanced intestinal tissue model reveals host and pathogen strategies during Salmonella infection
Here, we introduce an intestinal tissue model to study human enteric infections. Our model comprises...
GSE132560: Spen regulates X chromosome inactivation (RNAseq in ESCs )
RNAseq in ESCs, before and after induction of Xist, with/without deletion of SPEN (auxin treatment)....
GSE132715: Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53
The physiological effects of the many germline mutations of TP53, encoding the tumor suppressor prot...
GSE124885: A CD4 T cell population expand and reshape autoreactive B cells, contributing to autoimmune lung pathology and post-infection autoimmunity in children
Community acquired pneumonia (CAP) is a significant risk factor for autoimmune disease development. ...
GSE127554: In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation
Recent evidence has determined that the conserved X chromosome mega-structures controlled by the Fir...
GSE128337: Niche-Specific Re-Programming of Epigenetic Landscapes Drives Myeloid Cell Diversity in NASH [RNA-seq]
Tissue resident macrophages and recruited monocyte-derived macrophages contribute to host defense bu...
GSE133029: The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage
We report a global impact of the depletion of RNF113A on splicing, especially in cells treated with ...
GSE133097 (human): Identification of ALPPL2 as a novel specific and functional surface marker for nave pluripotency
We report ALPPL2 as a prominently specific and functional surface marker for nave pluripotency. By p...
GSE133731: RNA sequencing for PDX1, NGN3 and MAFA transduced iPSCs cell
Global gene expression profiling identifies accelerated induction of genes upon PDX1, NGN3 and MAFA ...
GSE136233: Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock (RNA-seq at ZT10)
Purpose: Identifying the biological pathways affected by the deletion of the zona pellucida binding ...
GSE134741: Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles (RNA-Seq)
We evaluted the effects of extracellular vesicles of bleomycin-injured wild-type and syndecan-1 defi...
GSE132791: Dissecting the regulatory strategies of NFkB RelA target genes in the inflammatory response reveals differential transactivation logics (RNA-seq.WT.p53ko.MEFs_4)
NFkB RelA is the potent transcriptional activator of inflammatory response genes. We stringently def...
GSE132579: Transcriptome analysis of whole brain tissue from Bahd1+/+ (WT) and Bahd1-/- (KO) mouse embryos (stage E16.5)
Comparisons of brain gene expression profiles of Bahd1-KO mouse embryos to those of wild-type litter...
GSE133251: The effect of YAP/TAZ on the expression of the heat shock transcriptome
We found that heat stress induces a strong and rapid YAP dephosphorylation and activation. To determ...
GSE133162: Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons
RNA sequencing analysis of Hb9::RFP human induced motor neurons generated using transcription factor...
GSE131416: p53 exon 11 mutants generated by CRISPR/Cas9 result in aberrant alternative splicing.
The Tp53 gene encodes the famous tumor suppressor protein p53. This gene is encoded in 11 exons and ...
GSE124215: Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues [RNA-Seq]
Background: Genomic imprinting is an epigenetic phenomenon that allows a subset of genes to be expre...
GSE145912: Aurothioglucose Enhances Pro-Angiogenic Pathway Activation in Lungs from Room Air and Hyperoxia-exposed Newborn Mice
Acute neonatal muring hyperoxia exposure to evaluate the impact of the TXNRD1 inhibitor aurothiogluc...
GSE124096: Transcriptome Analysis of Drp1-mediated biological pathways under physiological and ischemia conditions in Drp1-knockdown mice
Purpose:to verify Drp1-mediated biological pathways under physiological and ischemia conditions.Meth...
GSE133054 (mouse): mRNA sequencing of mouse and human heart tissue
We deposit the data of single-cell and bulk-cell rna-seq of normal mouse heart. In addition, we cond...
GSE125290: Foxp1 drives striatal projection neuron specification and organization via cell-type specific mechanism
The molecular mechanisms that underlie striatal development and organization remain largely unknown....
GSE124182: Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via inducing inflammatory ILC3s
Breastfeeding is thought to influence the immune system development of infants and may even affect v...
GSE133100: Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome
The effects of how obesity and elevated androgen levels in women with polycystic ovary syndrome (PCO...
GSE136824: Characterization of extraembryonic endoderm-like cells from mouse embryonic fibroblasts induced using chemical alone
We reprogrammed mouse embryonic fibroblasts (MEFs) into extraembryonic endoderm-like cells by small ...
GSE133568: Genome wide transcriptome analysis of palbociclib or GSK3326595 treated A375 cells [Palbociclib_GSK_RNASeq]
RNA-seq was performed to compare the transcriptional programmes of A375 cells treated with Palbocic...
GSE126406: Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate [Isl1_E8_75_RNA_seq]
Generation of widely differing and specialized cell types from a single totipotent zygote involves l...
GSE128350: Multi-species tomo-sequencing identifies new major hematopoietic stem cell regulators in the microenvironment of the embryonic aorta
The behavior of (stem) cells is regulated by their local microenvironment through biochemical and bi...
GSE133328: Cathepsin D deficiency in mammary epithelium transiently stalls murine breast cancer by interference with mTORC1 signaling
Cathepsin D (CTSD) is an aspartic protease mainly located within the endosomal/lysosomal compartment...
GSE133177: Functional dissection of RanBP2 and Nup88/Nup214 subcomplex in nucleocytoplasmic transport
RNA-Seq was performed upon protein depletion to examine whether the loss of RanBP2, Nup88 or Nup214 ...
GSE133633: Effects of pre-pubertal DSS treatment on mouse ovary
We report the changes on ovarian gene expression that follow pre-pubertal colitis in mice SOURCE: Ph...
GSE138677 (human): Sex-specific role for the long non-coding RNA linc00473 in depression
Depression is a common disorder that affects women at twice the rate of men. Here we report that lon...
GSE135308: Oligodendrocyte intrinsic miR-27a controls myelination and remyelination
The goal of this study was to understand miR-27a gene regulation in mouse OPCs SOURCE: Ranjan Dutta ...
GSE133334: Sleep Deprivation Alters the Pituitary Stress Transcriptome in male and female Mice
We performed a comparative, whole-transcriptome, analysis to identify stress-induced genes and relev...
GSE133926: RRBS profiling and Transcriptome profiling of Stat3 wild-type, Stat3 knock-out, Dnmt3a/b wild-type and Dnmt3a/b knock-out mouse embryonic stem cells (mES cells)
Naive pluripotent epiblast cells of the preimplantation murine embryo and their in vitro counterpart...
GSE143170: RNA-seq analysis of human monocyte-derived dendritic cells generated in vitro with M-CSF, IL-4 and TNF-a
RNA-seq analysis of human monocyte-derived dendritic cells generated in vitro with M-CSF, IL-4 and T...
GSE134598: Identification of PIKfyve kinase as a target in multiple myeloma
The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was initially id...
GSE136684: Hepatic transcriptome phenotypes after mTORC1 activation through Tsc1 and Depdc5 mutations
We report RNA-seq results from liver tissues of control mice, liver-specific Tsc1 knockout mice, liv...
GSE157217: Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart
We have discovered that the alternative splice form of MYH7b is a regulatory non-coding RNA in the h...
GSE135432: Comparative study of gene expression in lower and upper first molar cap stage tooth germs of DUHi and FVB mice
The dataset aims at comparing gene expression in the developing lower and upper first molars of two ...
GSE141116: Epithelial to Mesenchymal Plasticity and Differential Response to Therapies in Pancreatic Ductal Adenocarcinoma
PDAC epithelial (E) and quasi-mesenchymal (QM) subtypes can be modulated by different therapies demo...
GSE138471: Detection of differences in gene expression in the noradrenergic nuclei in the brain
The goal of this study was to compare the transcriptome of neurons from the locus coeruleus (LC) fro...
GSE137068: Integrative genomic and epigenomic profiling reveals cell-type specific signaling networks in activated lung mononuclear phagocytes [RNA-seq/ATAC-seq]
The lung is inhabited by resident alveolar and interstitial macrophages as well as monocytic cells t...
GSE125044: Single cell analysis of diverse pathogen responses defines a molecular roadmap for generating antigen-specific immunity
The immune system generates pathogen-tailored responses. The precise innate immune cell types and pa...
GSE136810: Inactivation of the nuclear interacting SET domain protein 1 (NSD1) impairs GATA1-regulated erythroid differentiation and causes erythroleukemia. NSD1 Add-back experiment, mRNASeq cultured erythroblasts.
In vitro differentiation of Nsd1-/- erythroblasts with retroviral expression of wildtype Nsd1, or a ...
GSE137095: Endothelial mutagenesis screen identifies genetic risk factors in the development vascular anomalies [adipose]
mRNA transcriptional comparison between two pieces of VA from eight SBxVEC-Cre+ animals and four con...
GSE132721: Transcriptome analysis of B cell lymphomas in several c-myc Igh transgenic mice
Investigation of B cell lymphomas (IgM+ IgD+) located in various places (lung, mesenteric lymph node...
GSE133145: Bedaquiline remodels the macrophage response
Background: Infectious diseases are still a leading cause of death and, with the emergence of drug r...
GSE126534: Transcriptional profiling (RNA-seq) of wild-type and Arhgap35 knockout embryonic motor neurons (E12.5)
Ventral spinal cord regions micro-dissected from E12.5 Arhgap35 (aka, p190) knockout embryos or cont...
GSE137081: Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function
With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a ne...
GSE136840: The intestinal microbiota programs DNA methylation to control tissue homeostasis and inflammation [RNA-seq]
Although much research has been done on the diversity of gut microbiome, little is known about the w...
GSE131929: Gene expression profiling reveals insights into infant immunological and febrile responses to capsular group B meningococcal vaccine
We report gene expression profiles, using RNA-sequencing, in whole blood samples taken before and af...
GSE131619: Adult DRG: Identification of a sacral, visceral sensory transcriptome in embryonic and adult mice
Visceral sensory neurons encode distinct sensations from healthy organs and initiate pain states tha...
GSE138729 (human): Induction of extracellular adenosine salvage and metabolic quiescence regulate the transitional to follicular B cell checkpoint in humans.
Transcriptional profiling of transitional and follicular B cells showed that metabolic quiescence wa...
GSE141140: Transcriptomic profile of T cell acute lymphoblastic leukemia (T-ALL) cell from patients in CHCQMU
The T cell acute lymphoblastic leukemia cells and normal T cells were collected from the patients in...
GSE134730: Mitigating antagonism between transcription and proliferation allows near-deterministic cellular reprogramming (iMN)
RNA sequencing analysis of Hb9::GFP mouse embryonic fibroblasts infected with control or reprogrammi...
GSE138304: Wnt inhibition facilitates RNA-mediated reprogramming of human somatic cells to nave pluripotency
We report conditions for transgene-free reprogramming of human somatic cells to nave pluripotency. W...
GSE157292: Single-cell transcriptomics of mouse kidney transplants reveals a potentially novel myeloid cell pathway for transplant rejection
We used a murine kidney transplantation model and single-cell transcriptomics to dissect the contrib...
GSE143218: RNA-seq of knocked-out oocytes and directly induced oocyte-like cells (DIOLs)
During female germline development oocytes become a highly specialized cell type, and form a materna...
GSE134737: Modeling hypoxia induced neuropathies using a fast and scalable human motor neuron differentiation system
Human pluripotent stem cells carry great potential to provide novel insights into disease mechanisms...
GSE128092: Transcriptomic profiling of a eIF2B mutant mouse with a chronic Integrated Stress Response
Purpose: The integrated stress response (ISR) attenuates the rate of protein synthesis while inducin...
GSE124243: Comparing the transcriptoms of Mettl14fl/fl and Mettl14 fl/fl; Olig2-Cre oligodendrocyre precursor cell (OPCs) and mature oligodendrocytes using Next Generation Sequencing
The goal of the experiment is to determine the transcriptome alternation of Mettl14 gene inactivatio...
GSE134911: RNA Sequencing Facilitates Quantitative Analysis of Transcriptomes of H1 and H1 after SNAI1 deletion at Day2 after human early hematopoietic differentiation .
Purpose: The goals of this study are to verify SNAI1 deletion is suffice to downregulate other MAGs ...
GSE138712: Whole blood transcriptional responses of very preterm infants during late-onset sepsis
Host immune responses during late-onset sepsis (LOS) in very preterm infants are poorly characterise...
GSE136295: Transcriptional profiling of p53 mutants in KP LUAD cells
Transcriptional profiling of KP LUAD cells expressing a panel of p53 mutant cDNAs. SOURCE: Yu-Jui Ho...