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Sequencing-based assays page 89
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GSE132732: Human interleukin-4 treated regulatory macrophages promote epithelial wound healing and reduce colitis in an mouse model
Murine alternatively activated macrophages can exert anti-inflammatory effects. Expanding upon this...
GSE122865: Single-Dose CRISPR/Cas9 Therapy Extends Lifespan of Mice with Hutchinson-Gilford Progeria Syndrome
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare lethal genetic disorder characterized with sym...
GSE139293: Next Generation RNA Sequencing Analysis of AMPK Wild Type, AMPK-KO and AMPK1-2A U2OS cell Transcriptomes
Purpose: The goals of this study are to compare NGS-derived U2OS transcriptome profiling (RNA-seq) T...
GSE132333: Gene expression profile of HGC27 gastric cancer cell p53 KO and KD
HGC27 gastric cancer cells were manipulated to express mutant p53 SOURCE: Osamu Kikuchi (okikuchi@br...
GSE132321: Cell-autonomous transcriptional mechanism for enhancement of translation capacity in secretory cells [RNA-Seq AtT-20 cells]
Translation is a basic cellular process and its capacity is adapted to cell function. In particular,...
GSE132753: PRC1 catalytic activity is central to Polycomb system function. [RNA]
The Polycomb repressive system is an essential chromatin-based regulator of gene expression. Despite...
GSE140520: Amino acid levels determine metabolism and cyp450 function of stem cell derived hepatocytes and hepatoma cell lines
We identify nutrient engineering though the supplementation of amino aids to represent a novel tool ...
GSE132889: RNAseq of circulating CD34+ cells derived from TCIRG1-defective patients
Transcriptomic profile of CD34+ cells circulating in peripheral blood of TCIRG1-mutated osteopetroti...
GSE133465: Transcriptional effects of YAP/TAZ knockout in mouse gliomaspheres
We compared the transcriptomes of control and YAP/TAZ knockout gliomaspheres derived from mouse newb...
GSE122384: Alcohol metabolism directly fuels histone acetylation in the brain [RNA-Seq II]
In the adult brain, epigenetic control of gene expression has important roles in the processing of n...
GSE131373: Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation [RNA-Seq]
We show that Spen, an Xist binding repressor protein essential for XCI, binds to ancient retroviral ...
GSE132965: The imbalance of excitatory/inhibitory neuron differentiation in neurodevelopmental disorders with an NR2F1 point mutation
Recent studies have revealed an essential role for embryonic cortical development in the pathophysio...
GSE140461: Multifaceted rewiring of the hepatic lipidome during proliferation and carcinogenesis - PART 1 (Liver Regeneration)
The scope of this project is to study, using state-of-the-art systems biology approaches integrating...
GSE134888: Transcriptome wide analysis of translation efficiency in MCF7 cells using polysome profiling with and without eIF4A inhibition by hippuristanol treatment
To identify mRNAs that are most translationally repressed following eIF4A inhibition and those that ...
GSE123893: Differential Metabolic and Multi-tissue Transcriptomic Responses to Fructose Consumption among Genetically Diverse Mice [Hypothalamus]
The escalating prevalence of metabolic syndrome (MetS) poses significant risks to type 2 diabetes me...
GSE122412: Engulfment gene ELMO1 in neutrophils as a promoter of inflammatory arthritis
Rheumatoid arthritis is an inflammatory disease of the synovial joints that affects ~1% of the human...
GSE132997: Identification of Rfx6-dependent genes in the adult mouse ileon by RNAseq
The goal of this experiment was to identify Rfx6-regulated genes in the ileum of adult mice by compa...
GSE124364: miR205 Regulates Mammary Gland Development and Stem Cell Self-renewal through YAP and Wnt signaling
Mammary gland development is fueled by stem cell self-renewal and differentiation. External cues fro...
GSE132707: mRNA-Seq of BC-3 IRF4 KO, BATF KO, and vIRF3 KD
The Kaposi's sarcoma-associated herpesviruses causes several cancers including Kaposi's sarcoma and ...
GSE132294: Transcriptome of FliC-stimulated mouse bladder and dependency on TLR5
We report a transcriptional response in the mouse bladder following exposure to the major flagella f...
GSE133245: Next Generation Sequencing of Wild Type and Gata2-/- LSCs
Gata2, a zinc finger TF, is essential for the generation and survival of HSCs in the embryo and has ...
GSE132996: Gene Expression Following Transaortic Constriction in Cardiomyocyte Specific Insulin Receptor Substrate Knockout Mice
mRNA expression profiles from alpha-MHC-Cre X IRS1-flox, alpha-MHC-Cre X IRS2-flox, or IRS2-flox mou...
GSE133360: CSF-1 and IL-34 drive distinct microglial programs in the brain tissue
Bulk RNA sequencing of FACS sorted primary murine microglia from WT mixed glial cultures isolated fr...
GSE133478: Influenza Vaccination Primes Human Myeloid Cell Cytokine Secretion and Natural Killer Cell Function
51 healthy adults were vaccinated with seasonal influenza vaccine and PBMC were collected before and...
GSE132811: Recapitulating the Human Segmentation Clock with Pluripotent Stem Cells - RNAseq analysis of in vitro induced human presomitic mesoderm (PSM) and identification of components of the human segmentation clock [Oscillation_Mm]
Pluripotent stem cells (PSCs) have increasingly been used to model different aspects of embryogenesi...
GSE122589: Transcription factor activity and nucleosome organisation in mitosis
Mitotic bookmarking transcription factors (BFs) maintain the capacity to bind to their targets durin...
GSE132741: Muscle and blood RNA-seq in mdx and wt mice
RNAseq data from blood and muscle was obtained to study the association of blood markers with diseas...
GSE130882: Evaluation of ultra-low input RNA sequencing for the study of human T cell transcriptome
Deeper understanding of T cell biology is crucial for the development of new therapeutics. Human na...
GSE122163: CEBPA Dysfunction Intiates CSF3R Mutant Acute Myeloid Leukemia Through Disruption of Myeloid Lineage Enhancers (RNA-seq - orders)
Acute Myeloid Leukemia (AML) develops due to the acquisition of mutations from multiple functional c...
GSE141085: CHD8 and ELK1 cooperativity regulate cellular sensitivity to MAPK/ERK pathway
The chromodomain helicase DNA binding protein CHD8 is among the most frequently found de-novo mutati...
GSE143301: Ribosome profiling under ABCE1 depletion to study aberrant translation termination
We report the effect of siRNA-mediated ABCE1 KD in HeLa cells, using a modified ribosome profiling p...
GSE132055: Targeting the mevalonate pathway to overcome acquired anti-HER2 treatment resistance in breast cancer [RNA-seq]
Despite effective strategies, therapy resistance in HER2+ breast cancer remains a challenge. While t...
GSE122566: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and 2.5ppm iAs Treated Mouse Gastrocnemius Muscle Transcriptomes
Inorganic arsenic (iAs) is a widespread environmental toxin. In addition to being a human carcinogen...
GSE133481: Target identification of hepatic fibrosis therapy using Pien Tze Huang based on mRNA and lncRNA
Pien Tze Huang (PZH) is a traditional Chinese medicine which was widely utilized in Asia for hepatic...
GSE133483: TMX2 is a key regulator of cellular redox state and its dysfunction causes severe brain developmental abnormalities
The redox state of the neural progenitors regulates physiological processes such as neuronal differe...
GSE136165: Efficient Identification of Multiple Pathways: RNA-Seq Analysis of Livers from 56Fe Ion Irradiated Mice
Background: mRNA interactions with each other and other signaling molecules define different biologi...
GSE139341: RNASeq of Healthy Human Skin Tregs and CD4 Teffs versus Psoriatic Human Skin Tregs and CD4 Teffs
The aim of the study was to compare the transcriptional profile of healthy skin Tregs to Tregs isola...
GSE132343: Suppression of FOXM1 Activities and Breast Cancer Growth in Vitro and in Vivo by a New Class of Compounds
The transcription factor FOXM1 is up-regulated and overexpressed in aggressive, therapy-resistant fo...
GSE132074: Changes in total RNA in BK deficient mice after 4h sleep deprivation [individuals]
Animals deficient for the alpha subunit of the large conductance calcium dependent potassium channel...
GSE133343: Analysis of gene expression in MEL cell before and after erythroid-like differentiation.
To promote the development and understanding of the in vitro erythroleukemia model, we analyzed the ...
GSE133534: RNA sequencing for human induced pluripotent derived cerebral organoids
Total RNA sequecing for human induced pluripotent derived cerebral organoids from healthy controls a...
GSE132355: Single cell RNA-Seq identifies mechanisms controlling hypothalamic patterning and differentiation
The hypothalamus is a central regulator of many innate behaviors that are essential for survival, bu...
GSE132081: Analysis of Roquin targetome during HCMV infection
To investigate how Roquin regulates cellular transcripts during Human cytomegalovirus (HCMV) infecti...
GSE132773: RNA sequencing comparing normal and premalignant EuMyc B220+ cells in Max WT and conditional Max KO mice
The goal of this study was to compare expression profiles of B cells in the presence and absence of ...
GSE133486: Single cell sequencing of stromal vascular fraction (SVF) under B3-adrenergic agonist stimulation and mature adipocytes under cold exposure and B3-adrenergic agonist stimulation
A single cell suspension was generated from B3-adrenergic agonist (CL; 1 mg/kg/day) for 4 days and s...
GSE131015: Zfp281 orchestrates interconversion of pluripotent states by engaging Ehmt1 and Zic2 (RNA-seq)
Developmental cell fate specification is a unidirectional process that can be reverted in response t...
GSE122225: UVB drives different stages of epigenome alterations during progression of skin cancer [RNA-Seq]
Exposure to UVB irradiation results in multitude of cellular responses including generation of react...
GSE132642: Droplet-based single-cell RNA-sequencing of mouse and naked mole-rat spleen and circulating immune cells, in natural conditions, following lipopolysaccharide (LPS) challanege, and saline control
Single-cell RNA-sequencing was performed in the mouse and naked mole-rat immune systems in order to ...
GSE133489: Regionally specified human pluripotent stem cell-derived astrocytes
Bulk RNA-seq of highly pure regionally specified human pluripotent stem cell-derived astrocytes SOUR...
GSE134870: RNA-Seq of human adipose tissue (siNT vs siRND3 KD)
Total RNA-Seq of Human adipose tissue were sequenced on the Illumina HiSeq4000 platform SOURCE: Laur...
GSE104602: RNA-seq analysis of apoptotic HCT116 cells shows widespread mRNA decay and limited noncoding RNA decay.
Rapid and widespread mRNA decay is a previously unappreciated feature of apoptosis. Previous work sh...
GSE134623: TOPORS, a tumor suppressor protein, maintains higher-order chromatin organization in mouse hepatocytes [RNA-seq]
Within mammalian nuclear space, chromosomes are hierarchically folded into active (A) and inactive (...
GSE133499: Glucocorticoid resistance in pediatric leukemia is associated with altered splicing profiles and vulnerability to spliceosome modulation
The aim of the current study is to characterize the global alternative splicing profiles associated ...
GSE125784: CRAC channel-mediated gene expression in Treg cells
T regulatory (Treg) cells maintain immunological tolerance and their depletion in humans and mice re...
GSE132121: Analysis of redundancy between RNAi and piRNA pathways in the mouse oocytes
Suppression of retrotransposons is an integral part of germline genome defense. The PIWI-associated ...
GSE145495: RNAseq analysis on e9.5 mutant mouse hearts
We report RNAseq analysis on RNA from e9.5 hearts of Asb2 mutant and Asb2.Flna double mutants with c...
GSE132695: Prevention of chromatin destabilization by FACT is crucial for malignant transformation [gene expression]
Histone chaperone FACT is commonly expressed and essential for the viability of transformed but not ...
GSE138636: SRSF6-regulated alternative splicing of genes involved in DNA repair is associated with prostate cancer progression
Alternative splicing (AS) occurs in nearly all human genes and abnormal AS has a close connection wi...
GSE126151 (mouse): A systematic analysis of nuclear heat-shock protein 90 identifies a metazoan-specific regulatory module
Molecular chaperones such as heat-shock proteins (HSPs) help in protein folding and complex assembly...
GSE139292: Comparison of different shear stress conditions on gene proflile modulation in HCASMC and HCAEC, in the presence or absence of BVS+Everolimus
We have analyzed the global gene expression modulation induced by mechanical stress (shear stress) o...
GSE143214: Single cell RNA sequencing of human naive CD4 T cells on young and old donors
We report the application of single-molecule-based sequencing technology for high-throughput profili...
GSE145464: Next Generation Sequencing Facilitates Quantitative Analysis of Transcriptome profile in IEC 4.1 cells in response to Cryptosporidium parvum
The lincRNA-NR_033736 is an early-primary gene controlled by the type I IFN signaling in murine inte...
GSE128780: Mitofusin 2 is essential for oocyte and follicle development, and to maintain ovarian follicular reserve during reproductive aging [GV]
We performed RNAseq analysis to determine the effect of MFN2 deletion on oocyte global gene expressi...
GSE132329: An epigenetic program established by gene environment interactions initiates pancreatic carcinogenesis [Set2]
Damaged tissues have increased risk of cancer development through poorly understood mechanisms. In t...
GSE138676: The effect of modulating substratum biochemical properties on lung epithelial specification in vitro
Bulk RNA-Seq of all epithelial cell populations from both 2D-Gelatin and 3D-Matrigel conditions, nam...
GSE143147: Cyclin K interacts with -catenin to induce Cyclin D1 expression and facilitate tumorigenesis and radioresistance in lung cancer
Radioresistance has remained the major cause of local relapse and distant metastasis in lung cancer....
GSE139358: Transcriptomic, epigenetic and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus [RNA-seq]
Two subpopulations of low density granulocytes (LDGs) were defined in terms of different gene expres...
GSE132774: Dissecting the regulatory strategies of NFkB RelA target genes in the inflammatory response reveals differential transactivation logics [MEFs_3]
NFkB RelA is the potent transcriptional activator of inflammatory response genes. We stringently def...
GSE133606: Gata2 rescue assay
RNA-seq data of primary hematopoietic progenitor cells from -77 knockout mice which expressing Gata2...
GSE132075: Changes in total RNA in BK deficient mice after 4h sleep deprivation [pools]
Animals deficient for the alpha subunit of the large conductance calcium dependent potassium channel...
GSE135315: RNA sequencing of uninfected, H37Rv- or Rv0222Ko-infected mouse peritoneal macrophages
RNA sequencing for 6 samples SOURCE: Lin Wang Shanghai Pulmonary Hospital
GSE136752: PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis
Spermatogenesis is a complex process of sperm generation, including mitosis, meiosis, and spermiogen...
GSE134647: Targeting of IL-1 activity to CD8+ T cells mounts a strong antigen-specific cellular immune response and protects against influenza virus infection in mice
Abstract: Annual administration and reformulation of influenza vaccines is required for protection a...
GSE145453: RNA-Seq of resting and activated Jurkat E6.1 cells
Purpose: to examine the early transcriptional responses to stimulation in Jurkat E6.1 cells, and the...
GSE133516: KAT7 maintains myeloid leukemogenesis recruits BRD4 to the promoters of target loci to maintain then MLL-AF9 transcriptional programme
Here we investigate the essentiality of lysine acetyltransferase KAT7 in AMLs driven by the MLL-X fu...
GSE131019: Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signaling [RNA-Seq]
The Tousled like kinases 1 and 2 (TLK1/2) control histone deposition through the ASF1 histone chaper...
GSE134900: The interplay between IL-15, gluten and HLA-DQ8 drives the development of coeliac disease in mice
Coeliac disease (CeD) is a complex, polygenic inflammatory enteropathy with autoimmune features caus...
GSE123875: Differential Metabolic and Multi-tissue Transcriptomic Responses to Fructose Consumption among Genetically Diverse Mice [Adipose]
The escalating prevalence of metabolic syndrome (MetS) poses significant risks to type 2 diabetes me...
GSE145529: CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions [RNA-seq]
RNA-seq was performed to identify genes affected by CRISPRi (dCas9-KRAB) with sgRNA (sgTGFB1_B9D2) t...
GSE134686: RNAseq data comparing iKPC cells overexpressing WT-USP21 and ED-USP21
USP21 belongs to ubiquitin specific protease (USP) family. To dissect the molecular mechanisms that ...
GSE133296: Matched primary ovarian cancer, omental metastases, and non-omental metastases from 10 patients with high-grade serous ovarian carcinoma
Matched high-grade serous ovarian carcinoma samples collected from the ovary (ov), omental metastasi...
GSE125816: RNA sequencing of lung innate lymphoid cell (ILC) populations
A transitory, interleukin-25-responsive, KLRG1high Group 2 innate lymphoid (ILC2) cell subset that m...
GSE132082: RNA-seq of tumor cells following angiopellosis extravasation
Tumor cells were observed to undergo extravasation through intrivital imaging and immediately follow...
GSE123878: Enhancer Profiling Reveals Regulators of Skeletal Muscle Identity and Reprogramming [RNA-seq]
Chromatin immunoprecipitation sequencing of H3K4me2, H3K27ac as well as, ATACseq and RNA-seq reveals...
GSE132338: Characterization of the immunologic impact of sarcoidosis in peripheral blood mononuclear cells via single-cell RNA-seq
Sarcoidosis is a systemic inflammatory disease characterized by infiltration of immune cells into gr...
GSE132533: Stat3-Bdnf-TrkB axis promotes alveolar regeneration [scRNA-seq]
Regenerating new alveolar epithelium is essential for recovery from many lung diseases. This multi-c...
GSE131377: SPOCD1 is a novel executor of piRNA-directed DNA methylation that links MIWI2 to the de novo DNA methylation machinery
In mammals, the acquisition of the germline from the soma provides the germline with an essential ch...
GSE134685: Transcriptomes of several organs of lean and obese mice infected with avian influenza
Influenza A virus (IAV) causes a wide range of extra-respiratory complications, ranging from central...
GSE133218: An integrated multi-omics approach identifies the landscape of interferon-a-mediated responses of human pancreatic beta cells [RNA-seq]
Proinflammatory cytokines are important mediators of pancreatic beta cell dysfunction and demise in ...
GSE85610: Gene expression profiles in response to proanthocyanidins in pancreatic cancer cells
Proanthocyanidins (PAs) that are naturally occurring compounds have shown the potential chemoprevent...
GSE132108: Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR
GFP-PR28 homozygous mice show decreased survival time, while the heterozygous mice show motor imbala...
GSE131471: Next generation sequencing facilitates quantitative analysis of STRAP-dependent alternative splicing events
We report the application of next generation sequencing for evaluating alternative splicing (AS) eve...
GSE134693: The effect of MSR1 knockout in macrophages in a co-culture system with BMSCs
To investigate the altered gene expression levels in MSR1 knockout and wild type macrophages in co-c...
GSE133253: Transcriptional response in ileum tissue from wild-type and Fat1+/- male mice
Males were placed onto an all liquid diet with gradually increasing amounts of ethanol as follows: ...
GSE131094: Vascularized human cortical organoids (vOrganoid) model cortical development in vivo
Modeling the processes of neuronal progenitor proliferation and differentiation to produce mature co...
GSE122450: Parkinson-associated SNCA enhancer variants revealed by open chromatin in mouse dopamine neurons
The progressive loss of midbrain (MB) dopaminergic (DA) neurons defines the motor features of Parkin...
GSE132369: Deep sequencing of human fibroblastic cell line IMR90, either proliferating or senescent, expressing either empty vector or Parkin, with or without CCCP treatment
Gene expression changes were compared in proliferating and senescent human IMR90 cells, with either ...
GSE145524: Pex1-G844D NMRI mouse model of mild Zellweger spectrum disorder: liver gene expression profiles
Zellweger spectrum disorders (ZSD) are inborn metabolic diseases cause by genetic alterations in PEX...
GSE126383: Modeling ribosome dwell times and relationship with tRNA loading and codon usage in mammals (Ribosome Profiling)
Protein translation depends on mRNA-specific initiation, elongation, and termination rates. While th...
GSE137065: RNA-seq Transcriptome Analysis of AD169 and AD169-UL26 infected MRC5 fibroblasts.
We employed RNA-seq to map the transcriptome of human MRC5 fibroblasts during HCMV infection with AD...