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Sequencing-based assays page 96
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GSE127734: TNIK signaling imprints CD8+ T memory formation early after priming
Purpose: The goal of this study is to compare NGS-derived transcriptome profiling (RNA-seq) of nave/...
GSE132306 (mouse): N6-methyladenosine (m6A) profiling of EndoC-bH1 cell line and RNA seq of Mettl14 knockout mice beta cell
In type 2 diabetes, pancreatic beta-cells fail to compensate for the presence of insulin resistance ...
GSE145888: JunB-dependent expression in colonic and Peyer's patch regulatory T cells
Foxp3-expressing regulatory T (Treg) cells are critical mediators of immunological tolerance to both...
GSE136996: Dermal sheath contraction powers stem cell niche relocation during hair cycle regression
Tissue homeostasis requires the balance of growth by cell production and regression through cellular...
GSE127795: ADAR1 mediated regulation of neural crest-derived melanocytes and Schwann cell development.
We studied the physiological requirement of A-to-I RNA editing in neural crest cells. To this end, w...
GSE154775: Single cell transcriptome profiling for hidradenitis suppurativa
Hidradenitis Suppurativa (HS) is a debilitating chronic inflammatory disease characterized by chroni...
GSE140767: ATRA enhances differentiation from human induced pluripotent stem cells into esophageal epithelium
We developed a method for the differentiation of hiPSCs into esophageal epithelium cells. SOURCE: Mi...
GSE143406: Next Generation Sequencing Facilitates Quantitative Analysis of transcriptomes in ARP-1 cells treated with DMSO and carfilzomib (Cfz)
The goals of NGS-derived retinal transcriptome profiling (RNA-seq) is to identify the signaling path...
GSE155435: Exposure to tert-butylphenyl diphenyl phosphate, an organophosphate ester flame retardant and plasticizer, alters hedgehog signaling in ex vivo murine limb bud cultures
Organophosphate esters (OPEs) have become widely used as flame retardants since the global phase out...
GSE152113: Mediator Med23 regulates adult hippocampal neurogenesis
we provide evidence that Med23 is involved in the regulation of adult hippocampal neurogenesis in mo...
GSE136623: Metabolic regulation of BCAAs and glycogen via IRF4 in skeletal muscle
Skeletal muscle is not only a primary site for glucose uptake and storage, but also a reservoir for ...
GSE138538: Delineating the Role of MITF Isoforms in Pigmentation and Tissue Homeostasis
MITF, a gene that is mutated in familial melanoma and Waardenburg syndrome, encodes multiple isofor...
GSE127768: Inhibition of glycolysis in pathogenic TH17 cells through targeting a miR-21-Peli1-c-Rel pathway prevents autoimmunity
It is well known that some pathogenic cells have enhanced glycolysis, the regulatory network leading...
GSE142695: Analysis of gene expression in lung adenocarcinoma cells following over-expression of miR-30a-5p or miR-30a-3p
RNA-sequencing was performed to gain insight into the transcriptome-wide molecular changes induced b...
GSE143404: The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids [Rh123hi-lo RNA-Seq]
CD4+ T cells are tightly regulated by microbiota in the intestine, but whether intestinal T cells in...
GSE152058 (human): Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation
The mechanisms by which mutant Huntingtin leads to neuronal cell death in Huntingtons disease are no...
GSE127809: Precise small molecule cleavage of a r(CUG) repeat expansion in a myotonic dystrophy mouse model
Myotonic dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by an expanded CTG rep...
GSE137225: Transcriptome analysis upon REXO2 silencing
Investigation of the role of human REXO2 in mitochondrial RNA metabolism. SOURCE: Sylwia Czarnomska ...
GSE137408: Splicing and gene expression changes in human MDAM-MB231 breast cancer cells with TRA2B knockdown
RNA-seq data from human MDA-MB231 breast cancer cells expressing control or TRA2B-targeting shRNAs g...
GSE138085: Gene expression changes in cervical motor neuron transcriptomes after loss of Hox5 transcription factors
The goal of this study was to identify potential Hox5 target genes in cervical motor neurons (C3-C6)...
GSE136640: CXCR5+PD-1+CD8+ T cells are a distinct sublineage of CD8+ Tfh cells and Stat5 suppresses the expression of the Tfh-specific genes in CXCR5+PD-1+CD8+ T cells [RNA-Seq]
Many autoimmune diseases are characterized by the production of autoantibodies. The current view is ...
GSE152146: TNF induced inflammatory transcription dynamics and epigenetic changes
TNF can induce inflammatory responses in cells, including transcriptional and epigenetic changes. To...
GSE130406: Rescue of T cell exhaustion by ingenol mebutate
Inhibitory receptors (IR) and inhibitory ligands function as critical regulators of immune responses...
GSE127955: Single-cell RNA-seq of human cardiovascular progenitor cells generated with a chemically defined, xeno-free laminin based differentiation protocol
Regeneration of injured human heart muscle is limited and an unmet clinical need. There are no metho...
GSE138165: Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40
We report a new immunodeficiency disorder in mice caused by a viable hypomorphic mutation of Snrnp40...
GSE127790: Nuclear exosome targeting complex core factor Zcchc8 regulates the degradation of LINE1 RNA in early embryos and embryonic stem cells
The nuclear exosome targeting (NEXT) complex is responsible for recruiting RNA exosomes to degrade s...
GSE130254: Regional Analysis of The Brain Transcriptome In Mice Bred For High And Low Methamphetamine Consumption
Transcriptome profiling can broadly characterize drug effects and risk for addiction in the absence ...
GSE137460: Identification of a unique subtype of lung squamous cell carcinoma defined by SOX2 and a neural differentiation factor BRN2 [RNA-seq]
Lineage-specific transcriptional regulators control differentiation states not only during normal de...
GSE137391: Transcriptomics profiling of some commonly used cell lines at the base-line culture condition
In vivo, melanoma cells transition though distinct phenotypic states in response to a changing micro...
GSE137967: Human lung and lung draining lymph node T cell sequencing
We report the transcriptional profiles of human lung and lung draining lymph node T cell subsets tha...
GSE145919: Gene expression profiling of murine tumors derived from Renca control knockout vs Pbrm1 knockout tumor clones
We investigated the influence of Pbrm1 on the tumor microenvironment in murine tumors. We employed a...
GSE140771: Differential gene expression profiles in imatinib-resistant cell lines
The study reports deregulated gene expression profiles underlying imatinib resistance in leukemic ce...
GSE131847: Molecular determinants and heterogeneity of circulating and tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing
We generated a single-cell transcriptomic resource dataset encompassing the gene-expression patterns...
GSE137228: Blockade of lL17 signaling reverses alcohol-induced liver injury, and excessive alcohol drinking in mice.
Chronic alcohol abuse has a detrimental effect on the brain and liver. There is no effective treatme...
GSE137627: Analysis of transposable element expression in a time course RNA-seq of mouse ESC differentiation to EpiLCs
Mouse embryonic stem cells(ESCs) were differnetiated to Epiblast-like cells (EpiLCs) according to th...
GSE138164: Transcriptome of RABV infected mouse brain
Here we show the transcriptome of brain from RABV infected B6 mice and TLR7 KO mice. These different...
GSE141834: Transcriptional Heterogeneity within the Glucocorticoid Response
Steroid hormone receptors such as the Glucocorticoid Receptor (GR) mediate the transcriptional respo...
GSE138024: RGS4 Maintains Chronic Pain Symptoms in Rodent Models
There is an imminent need for safe and efficient chronic pain medications. Regulator of G-protein si...
GSE138170: Profiling of the reprogramome and quantification of fibroblast reprogramming to pluripotency
Recognized as being intensive and extensive, the degree of pluripotency reprogramming, however, has ...
GSE137492: Dissecting the dynamics of signaling events in the BMP,WNT and NODAL cascade during self-organized fate patterning in human gastruloids
To determine the in vivo cellular identity of BMP-treated human embryonic stem cells (hESCs), we per...
GSE133582: The RNA N6-methyladenosine regulates chromatin remodeling and transcription [seq_nascentRNA]
The N6-methyladenosine (m6A) has been shown to regulate stability and translation of messenger RNA (...
GSE146000: Regional gene expression profiling upon loss of NFIA in adult astrocytes
The goal of this study is to determine how the loss of the transcription factor NFIA affects the mol...
GSE129490: Avidity Selection of Natural Killer Response to MCMV
Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity, such as...
GSE139348: RNA-seq to measure gene expression changes caused by Dicer1 knockout in mouse embryonic stem cells (mESCs)
The identification of miRNA targets by Ago2-CLIP methods has provided major insights into the biolog...
GSE137370: Transcriptome profiling of influenza-specific memory CD8 T cells following transfer into the airways or in vitro culture
To examine differences in the transcriptome of resident memory CD8 T cells in the lung, influenza nu...
GSE137213: Enriched environmental conditions modify the gut microbiome composition and fecal markers of inflammation in Parkinsons disease
We used a transgenic mouse model overexpressing the complete human SNCA genes modeling familial and ...
GSE143453: Single-nucleus RNA-seq identifies divergent populations of FSHD2 myotube nuclei [Time course]
FSHD is characterized by the misexpression of DUX4 in skeletal muscle. Although DUX4 upregulation is...
GSE127804: Non-core subunits of the PRC2 complex are collectively required for its target site specificity
The Polycomb repressive complex 2 (PRC2) catalyzes H3K27 methylation across the genome, which throug...
GSE127854: Repurposing an anti-cancer drug for the treatment of hypertrophic heart disease
Coronary microvascular dysfunction combined with maladaptive cardiomyocyte morphology and energetics...
GSE132583: Circulating tumor cells exit circulation while maintaining multicellularity augmenting metastatic potential
Metastasis accounts for the majority of all cancer deaths, yet the process remains poorly understood...
GSE138052: mRNA sequencing analysis of a novel model of 'NAFLD in a Dish'
The goal of this study was to determine the changes to cellular transcriptional programs following i...
GSE139427: Ibrutinib-mediated atrial fibrillation
The aim of this study is to perform transcriptome analysis on mouse left atrium tissue after long-te...
GSE127902: Next Generation Sequencing Facilitates Quantitative Analysis of Macrophage (RAW264.7) with and without arctigenin treatment
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular path...
GSE139406: LOC90024-encoded small protein SRSP regulates mRNA splicing
The mRNA transcriptome profiling and splicing profiling mediated by LOC90024 and LOC90024-encoded sm...
GSE137449: Role of Cyp2b in diet-induced nonalcoholic steatohepatitis (NASH)
To investigate the role of hepatic CYP2B in diet-induced nonalcoholic steatohepatitis (NASH), a Cyp2...
GSE137561: Desmoplastic small round cell tumor is dependent on EWS-WT1
Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive soft tissue malignancy. The dis...
GSE127932: Tox4 Modulates Cell Fate Reprogramming
Reprogramming to induced pluripotency induces the switch of somatic cell identity to induced pluripo...
GSE137606: Identification of novel genes involved in postnatal longitudinal muscle growth
Overall goal: To identify genes involved in postnatal longitudinal muscle growth through misregulati...
GSE130355: Spontaneous direct fate conversion of neuroblasts into oligodendrocytes upon demyelination in the adult mouse brain
After demyelinating insult, the neuronal progenitors of the adult mouse sub-ventricular zone (SVZ) c...
GSE137253: MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription
The goal of this study is to dig out the downstream gnens of NIPBL SOURCE: Jingyu Lang (cscttlab@163...
GSE139536: Investigating the role of Foxp1 in murine A20 lymphoma cells
Purpose: to investigate the role of transcription factor Foxp1 in murine A20 lymphoma cells, which c...
GSE137702: Gene expression (RNA-Seq) in pediatric high-grade glioma cell lines treated with selinexor and vehicle
Cultured pediatric high-grade glioma cell lines (SU-DIPG-IV, HSJD-DIPG-007, HSJD-GBM-001,BT 245 (RRI...
GSE137630: RNA-seq of mouse sperm samples from different treatment groups
The goal of this project was to explore the effect of NH3 and/or H2S effect on the mouse sperm RNA e...
GSE137792: Sex chromosomes affect gene expression of healthy CD4+ T cells in SJL.
To determine the role of sex chromsomes in sex differences of autoimmune disease, we used high throu...
GSE127833: Derivation of functional oocytes from granulosa cells
Limited oocyte and ovarian reserve in vivo or chemo-therapy leads to reproductive aging or premature...
GSE142706: Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence
Chronic IL-1 treatment selects for cells that are less sensitive to cytotoxicity associated with ser...
GSE131842: Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development [RNA-Seq]
Aim: Innate circadian rhythms are critical for optimal tissue-specific functions, including skeletal...
GSE131845: TIP5 primes prostate luminal cells for the oncogenic transformation mediated by PTEN-loss
Prostate cancer (PCa) is the second leading cause of cancer death in men. Its clinical and molecular...
GSE137775: CREB5 promotes resistance to androgen-receptor antagonists and androgen deprivation in prostate cancer
Inhibition of androgen-receptor (AR)signaling is the foundation of therapeutic regimens for advanced...
GSE130330: Pygopus2-Histone interaction is important for de-differentiation and breast cancer progression [RNA-Seq]
Pygopus2 (Pygo2), a co-activator of Wnt/ -catenin signaling can also bind H3K4me2/3 and participate ...
GSE137387: Gene expression profiles of mouse colitis epithelial tissues induced by DSS or DSS/PhIP
We reported the gene expression profiles of hCYP1A mouse colitis epithelial tissues on Day 1, 3 and ...
GSE137491: A functional link between nuclear RNA decay and transcritional control mediated by the Polycomb Repressive Complex 2
Pluripotent embryonic stem (ES) cells constitute an essential cellular niche in animal development. ...
GSE137636: Transcriptomic profiling of mouse lung tumor cells in response to CDK7 inhibitor treatment
We performed RNA sequencing analysis on the mouse lung tumor cells treated with CDK7 inhibitor YKL i...
GSE140559: The RNA N6-methyladenosine regulates chromatin remodeling and transcription [HEC-1-A_seq_RNA_nascent]
The N6-methyladenosine (m6A) has been shown to regulate stability and translation of messenger RNA (...
GSE140683: WT and Aire-KO mouse MEChi RNAseq profiling
Aire-sensitive genes exhibit short 3'UTR transcript isoform preference in WT and Aire-KO mTEChi SOUR...
GSE137649: Sequencing analysis of sorted bone marrow endothelial cells
The purpose of the study is to examine the pathway differences and the differential gene expression ...
GSE137576: Transciptome analysis of human aortic smooth muscle cells (HASMCs) with 2-hydroxypropyl--cyclodextrin (HPbCD) treatment
HASMCs were treated with HPbCD (10mg/kg) for 24 hours and harvest for RNA sequence. SOURCE: Haochen ...
GSE138026: Cytosolic phospholipase A2 alpha regulates TLR signaling and migration in metastatic 4T1 cells
We aimed at characterizing the response to reduced cPLA2 activity in metastatic versus non-metastati...
GSE138539: Gene network analysis reveals a role for striatal glutamatergic receptors in dysregulated risk-assessment behavior of autism mouse models
Autism Spectrum Disorder (ASD) presents a wide, and often varied, behavioral phenotype. Impulsivity ...
GSE129287: Influence of CD200R-deficiency on gene expression in primary murine neutrophils
RNA-seq analysis at steady state of primary bone marrow neutrophils isolated from WT and CD200R-/- C...
GSE124059: Inhibition of NF-B-dependent signaling enhances sensitivity and overcomes resistance to BET inhibition in uveal melanoma
Bromodomain and extra terminal protein inhibitors (BETi) are epigenetic therapies aimed to target dy...
GSE137297: p53-bound enhancer elements require locally acting transcription factors
Using a massively parallel reporter assay (MPRA), we examined the effect of local sequence context o...
GSE130579: Pro-infammatory Aorta-Gonad-Mesonephros-associated macrophages are involved in embryonic development of hematopoietic stem cells
Hematopoietic stem cells (HSC) are generated from specialized endothelial cells of the embryonic aor...
GSE142204: Effect of RAGE on macrophage transcriptome in regression of diabetic atherosclerosis
Ldlr null (Ager+/+ Ldlr-/-) diabetic mice were raised on a Western diet.; Their aortas were transpla...
GSE140703: An Integrative Transcriptome Proteome Approach Reveals a Robust Expression Pattern of Small Intestinal Epithelial Organoids from Germ-Free and Microbiota Associated Donors
The goal of this study is to analyze the influence of different donor microbiota on small intestinal...
GSE137255: Gene expression profilings in human embryonic stem cell-derived cardiomyocytes in vivo and in vitro
RNA sequencing of human embryonic stem cell-derived cardiomyocytes SOURCE: Shin Kadota (shinkadota@s...
GSE137760: Ex-vivo transcriptional analysis of splenic autophagy deficient dendritic cell subsets in an atherogenesis mouse model
Analysis of the transcriptional signature of FACS-purified splenic DC subsets from Ldlr deficient mi...
GSE134083: DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation
Actively transcribed genes in mammals are decorated by H3K79 methylation, which is correlated with t...
GSE139028: RNA-seq analysis on tissues derived from normal skin and burn eschar
The study was designed to determine the differential gene expression occurring in burn eschar tissue...
GSE142209 (human): RNA-seq of human and mouse brain microvessels isolated by laser capture microdissection and matched whole brain samples
Brain microvessels form the blood-brain barrier, and are dysfunctional in several neurological disor...
GSE137756: An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
Electrophilic compounds originating from nature or chemical synthesis have profound effects on immun...
GSE138096: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Diabetic db/db Mice Islets Transcriptomes
Circular RNAs constitute an extensive fraction of the mammalian transcriptome.In this study, circula...
GSE137633: Expression profiling of murine rhabdoid tumor model
To characterize tumors developing in our SMARCB1 deficient mouse model, we performed mRNA sequencing...
GSE130147: Transcriptome comparison of white adipose tissue between control and adipose specific HuR knockout mice
Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins and is involved in many p...
GSE139408: Effects of chronic intermittent ethanol exposure and withdrawal on neuroblastoma cell transcriptome
Cycles of heavy drinking and abstinence can lead to ethanol abuse disorder. We studied the effects o...
GSE138161: Isogenic patient-derived human iPSCs, wild-type or heterozygous for PIK3CA-E418K
The PIK3CA-related overgrowth syndrome (PROS) patient-derived induced pluripotent stem cell (iPSC) l...
GSE137428: STING, IRF1 and IRF3/7 dependent gene expression in response to c-di-GMP stimulation of bone marrow derived dendritic cells
STING activation induced IRF 1 dependent transcriptional programs in dendritic cells (DCs) determine...
GSE138032: EZH2 mutations reprogram the immune response to yield a pre-malignant lymphoma niche [RNA-Seq]
The mechanism through which lymphoma-associated EZH2 gain-of-function mutations disrupt the immune s...
GSE130315: Chromatin restriction by the nucleosome remodeler Mi-2 and functional interplay with lineage-specific transcription regulators controls B cell differentiation
Coordinated induction but also repression of genes is key to normal differentiation. Although the ...
GSE140844: RNA Transcriptome of Tregs in Idiopathic Aplastic Anemia
Our report demonstrates that the dominant Treg population in AA are FasL resistant but do not respon...