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Sequencing-based assays page 97
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GSE143139: RNA-Seq of Day 6 in vitro generated cells with and without Mdr1 expression and Elacridar treatment
Multidrug resistance (MDR)-1 acts as a chemotherapeutic drug efflux pump in tumor cells, although it...
GSE140731: Transcriptomic analysis of adhesive capsulitis of the shoulder
We compared genes from tissue of patients with adhesive capsulitis (AC) with those having surgery fo...
GSE138232: RNA-Seq analysis of cSCC cells after siRNA-induced gene knockdown of lncRNA PRECSIT
Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin can...
GSE139044: Antagonistic inflammatory phenotypes dictate tumor fate and response to immune checkpoint blockade (RNA-seq dataset: SZ3)
In this study we searched for primary regulators of cancer-inhibitory inflammation using murine tumo...
GSE134450: Metabolic control of imprinted gene expression in naive pluripotent cells
Naive pluripotent epiblast cells of the preimplantation embryo and their in vitro counterpart, naive...
GSE129478: Cohesin-dependent regulation of dynamic gene expression during differentiation is lost in Cohesin-mutated myeloid malignancies
The Cohesin complex critically controls interactions between proximal and distal cis-regulatory elem...
GSE134035: RNA-seq analysis of murine KMT2A-MLLT3 with DOT1L overexpressed
We transduced two individual murine KMT2A-MLLT3 AML samples with DOT1L and three days after sorting ...
GSE144120: PLCG2 Regulates Divergent Microglial Functions via TREM2-Dependent and -Independent Signaling
We use genetically engineered human iPSC-derived microglia-like cells (iMG) to show that TREM2 signa...
GSE137143: Cell-Type-Specific Transcriptome of CD4+, CD8+ T cells and CD14+ monocytes in multiple sclerosis
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system in which both genetic...
GSE137314: Genome-wide analysis of the transcriptional profile of IL1b/TNFa-treated and EAE astrocytes in B6 mice.
We identify pathways regulated by IL1b/TNFa ICV injection and EAE in astrocytes SOURCE: Michael Whee...
GSE140715: Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis [blood]
We implemented transcriptomic analyses of blood of 8-10M mice; These mice with the treatment of metf...
GSE143451: PC-3M-1E8 transcriptome
The transcriptome sequencing analyse the differential expression genes between scramble and nc886+ c...
GSE77128: EPCR Expression Defines the Most Primitive Subset of Human HSPC and Is Required for Their In Vivo Activity
Cell purification technology combined with whole transcriptome sequencing and small molecule agonist...
GSE137413: RNA sequencing of Jejunum of WT and IL23 expression mice (KSR23)
The goal of this study is to check if elevated level of IL-23 and/or its downstream cytokines affect...
GSE140689: Direct induction of retinal ganglion cell-like neurons
Retinal ganglion cells (RGCs) are the projection neurons in the retina that connect the visual sensi...
GSE141808: Enteric Nervous System Derived IL-18 Orchestrates Mucosal Barrier Immunity [RNA-seq]
Using RNA sequencing, we report that neuron derived-IL-18 is required for intestinal antimicrobial p...
GSE134067: RNA Sequencing of Wild Type and CCR2-/- mouse esophageal tumor transcriptomes
Wild type and CCR2-/- C57 mice were gavaged with carboxyl methyl cellulose (1%) or N-nitrosomethylbe...
GSE137300: Immune effector monocyte - neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer
Metastatic behaviour varies significantly among breast cancers. Mechanisms explaining why the majori...
GSE132592: RNA-seq analysis of mouse embryonic stem cells cultured in medium containing MEK and Akt inhibitors
Cell-to-cell heterogeneity in gene expression can even be observed in the same type of cells, presen...
GSE137052: Neuropeptides modulate local astrocytes to regulate adult hippocampal neural stem cells and neurogenesis
It has been well established that parvulbumin (PV) interneurons in the adult dentate gyrus (DG) regu...
GSE140651: Transcriptome analysis of P3HR-1 cells expressing control, smc1a, supt16h, med12, or tada2b sgRNAs and Akata EBV+ cells expressing control or myc sgRNAs
To gain insights into how EBV latency is maintained, we performed a human genome-wide CRISPR screen ...
GSE142210: Identification of transcripts induced after treatment with protein disulfide isomerase inhibitor E64FC65 and panobinostat in PANC-1 cells
Protein disulfide isomerase and histone deacetylase inhibition induces a synergistic pro-apoptotic r...
GSE137659: Single Cell and Bulk RNA Sequencing Analysis on the Effects of Cytoskeletal Modulation on Stem Cell Derived Pancreatic Progenitors
We revealed that the cytoskeletal state of pancreatic progenitors can influence differentiation into...
GSE128692: Next-Generation Sequencing Characterization of Hematopoietic Stem and Progenitors Cells in Murine Systemic Lupus Erythematosus
Purpose: Next-generation sequencing (NGS) technology was exploited to map genome-wide expression pro...
GSE128940 (mouse): IL-11 neutralising therapies for the treatment of nonalcoholic steatohepatitis
Background and aims: Here we investigate the role of IL-11 signalling in the pathogenesis of nonalco...
GSE132323: RNA-seq analysis of differentially expressed genes between 2-week WT and Ngn3MettlsKO mice.
Using RNA-seq, we identified over 500 differentially expressed genes in KO islets, compared to WT. A...
GSE135548: Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
Development of treatments for vocal dysphonia has been inhibited by lack of human vocal fold (VF) mu...
GSE140607: Pioglitazone induces extensive PPARg-dependent hepatic expression of nuclear-mitochondrial genes [RNA-seq]
We report the results of RNA-seq analysis on 5 month old wildtype and liver specific PPARg knockout ...
GSE131883: Predominant Requirement of Mitochondrial Transcriptional Factor A in Tissue-resident Regulatory T cell Maintenance and Function
Regulatory T cells (Tregs) are pivotal for immune suppression. Cellular metabolism is important for ...
GSE140645: Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development
We studied alveolar macrophage (AM) development after single and competitive transplantation of diff...
GSE140744: Trem2 effects on brain resident myeloid cells in PS2APP model
Comparing Trem2-KO;PS2APP and Trem2-WT;PS2APP CD11b+ cells reveals; the role of Trem2 in microglial ...
GSE137431: Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils
Our objective was to identify the genes in tumor-associated neutrophils that are differentially expr...
GSE137325: Copanlisib modulates HAIR-M transcriptome
Exposure to copanlisib in an MZL cell line heavily affected the lymphoma cell transcriptome, downreg...
GSE129148: QuantSeq analysis in the hippocampus of WT and PHF2 t/g mice
Long-term memory formation is attributed to experience-dependent gene expression. Dynamic changes in...
GSE140609: Comparing the Transcriptomes of wild type (WT) oocytes with Dpagt1-Mutant (MUT), Dpagt1F/FAmhr2-CER/+ (Amcko) and Dpagt1F/FGdf9-CER/+ (GCKO) oocytes by RNA-Seq Analysis
The goal of this study is to reveal the globle effect of point mutation of Dpagt1, oocyte-specific d...
GSE139057: Ectopic Tcf1 expression reprograms exhausted CD8+ T cells to acquire stem cell-like features [RNA-seq]
The goal of this study is to determine the capacity of Tcf1 to reprogram exhausted CD8+ T cells for ...
GSE140709: Impact of ETV7 activity on interferon-stimulated gene expression in 293T cells treated with interferon alpha
293T cells constitutively expressing ETV7 have reduced expression of interferon-stimulated genes. SO...
GSE140707: Identifying a novel candidate diagnostic and prognostic biomarker SPRR3 for oral squamous cell carcinoma via mRNA Sequencing and Bioinformatics
Oral squamous cell carcinoma (OSCC) has always been one of the most aggressive and invasive malignan...
GSE151069: Generation of an in vitro 3D Engineered Colorectal Cancer Patient-Derived Xenograft Model
We report on the development of an vitro model of colorectal cancer using cells isolated from a pati...
GSE132945: The developing lens transcriptome depends upon a counterbalance of Fgfr2- and Pten-regulated downstream signaling and transcription factor targets
FGFR signaling plays important roles in development and disease pathogenesis. FGFR activation initia...
GSE135728: Robust mitotic regeneration by hidden progenitors after ablation of Lgr5+ cochlear cells
We identified a subpopulation within the Lgr5+ cells serving as progenitor cells for supporting cell...
GSE139035: Sex chromsomes affect gene expression of immunized CD4+ T cells in SJL
To determine the role of sex chromsomes in sex differences of autoimmune disease, we used high throu...
GSE140627: Urinary sediment transcriptomic and longitudinal data to investigate renal function decline in type 1 diabetes
Using a discovery/validation approach we investigated associations between a panel of genes selected...
GSE137846: Single-cell Transcriptomic Atlas of the Human Retina Identifies Cell Types Associated with Age-Related Macular Degeneration [Seq-Well]
Here we perform massively parallel single-cell RNA sequencing (scRNA-seq) of human retinas using two...
GSE140740: Random mono-allelic expression in MECP2-mutated cells
To improve our knowledge on this largely unknown phenomenon, and to study the role of MeCP2 in RMAE,...
GSE129392: RNA-Seq comparison between BrafCA;Cdkn2af/f control and BrafCA;Cdkn2af/f; Arf6Q67L mouse tumors
We analyzed transcriptomes from BRAFV600E/CDKN2ANull + ARF6Q67L mouse melanoma tumors to identify no...
GSE137850: RNA-seq of control shRNA and BHLHE40 shRNA HeLa-S3 cells
In this study, we investigated gene expression profile in HeLa-S3 cells transfected with control shR...
GSE140589: Cd302 and Cr1l restrict human hepatotropic virus cross-species transmission to mice[6PMH siRNA]
Virus species- and tissue-tropism is governed by host dependency and restriction factors. Hepatitis ...
GSE143394: Airway Smooth Muscle Differentiation is Essential for Promoting Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching
The goals of this study are to evalute the role of airway smooth muscle during mouse lung developmen...
GSE131898: 5hmC RNA role in mouse Embryonic stem cell differentiation to Embryonic bodies [RNA-seq]
Tet-enzyme-mediated 5-hydroxymethylation of cytosine in DNA plays a crucial role in mouse embryonic ...
GSE141195: RNA sequencing of 112kb congenic and C57BL/6J (B6) wild-type littermates reveals differential splicing
We previously utilized interval-specific congenic lines derived from C57BL/6J (B6) and DBA/2J SOURCE...
GSE139045: Antagonistic inflammatory phenotypes dictate tumor fate and response to immune checkpoint blockade (RNA-seq dataset: SZ8)
In this study we searched for primary regulators of cancer-inhibitory inflammation using murine tumo...
GSE140742: ASK1 Inhibition Reduces Cell Death and Hepatic Fibrosis in an Nlrp3 Mutant Liver Injury Model
The aim of the current study was to investigate whether pharmacologic inhibition of ASK1 could atten...
GSE143422: Transposase assisted tagmentation of RNA/DNA hybrid duplexes
Tn5-mediated transposition of double-strand DNA has been widely utilized in various high-throughput ...
GSE134443: TRPM5 Negatively Regulates Lipopolysaccharide-Induced Ca2+ Signaling of B Lymphocytes
Ca2+ signaling cascades are essential for various immune cell functions. As such, most cells have ne...
GSE139439: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and cd36-/- murine peritoneal macrophage Transcriptomes
Oxidized LDL induce macrophages to turn into foam cells in a CD36 dependent manner. The Goal of this...
GSE137804: Transcriptomic Characterization of neuroblastoma by Single Cell RNA Sequencing
Neuroblastoma (NB) is the most common malignant solid tumor in the abdomen of children, with high de...
GSE140739: Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T Cell Leukemogenesis
Depletion of AURKB reduced the steady-state levels of MYC protein. We predicted that inactivation of...
GSE132881: Protein amounts of the MYC transcription factor determine germinal center B cell division capacity
High affinity B cell selection in the germinal center (GC) is governed by signals delivered by folli...
GSE129265: Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation [RNA-seq_Mm]
Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardia...
GSE140843: Total RNA sequencing for human induced pluripotent derived cerebral organoids [controls only]
Total RNA sequencing for human induced pluripotent derived cerebral organoids from healthy controls ...
GSE139042: Single Cell Transcriptome Mapping of Human Thymopoiesis Reveals a Continuum of Cell States During T-Lineage Specification and Commitment
Single cell studies elucidating the transcriptional continuum underpinning lineage commitment in the...
GSE140748: Temporal control of species-specific motor neuron differentiation [Mm]
How species-specific developmental timing is controlled is largely unknown. By following human embry...
GSE132909: Senescence rather than apoptosis of alveolar progenitor cells drives pulmonary fibrosis (mouse_bulk RNAseq)
bulk RNAseq comparison of global transcription profiles of mouse lung AT2 Sin3a-LOF at different tim...
GSE139034: Sex chromsomes affect gene expression of healthy CD4+ T cells in B6 gonadal males
To determine the role of sex chromsomes in sex differences of autoimmune disease, we used high throu...
GSE146074: LY6E blocks coronavirus fusion and confers immune control of viral disease
Zoonotic coronaviruses (CoVs) are significant threats to global health, as exemplified by the recent...
GSE143799: Tissue specific dual RNA-seq defines host-parasite interplay in experimental visceral leishmaniasis caused by Leishmania donovani and Leishmania infantum
FIve 6/8 week old female BALB/c mice were infected with the LV9 L. donovani strain,five mice were i...
GSE137878 (human): Regulation of RNA localization by FMR1
We use subcellular fractionation to probe the regulation of RNA localization by FMR1 in neuronal cel...
GSE137851: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia
In this work we dissect the functional role of the HOXB-AS3 long non coding RNA in patients with NPM...
GSE129244: Ldb1 is required for Lmo2 oncogene-induced thymocyte self-renewal and T-cell Acute Lymphoblastic Leukemia
Prolonged or enhanced expression of the proto-oncogene Lmo2 is associated with a severe form of T-ce...
GSE141178: Critical role for P53 in regulating the cell cycle of ground state embryonic stem cells [RNA-seq]
Mouse Embryonic Stem Cells (ESCs) grown in serum-supplemented conditions are characterized by an ext...
GSE154820: HuR-dependent gene expression in brown adipose tissue
We utilized adipocyte-specific deletion of HuR followed by RNA-seq of total BAT mRNA to identify HuR...
GSE139049: TET1 and 5-hydroxymethylation preserve the stem cell state of mouse trophoblast
Analysis of 5mC and 5hmC and associated transcription in trophoblast stem cells cultured and differe...
GSE137843: Gene expression changes in HSV-1 infected HeLa cells with knockdown of B2M
To understand the global effects of B2M knock-down on host gene expression, the RNA-seq study was ca...
GSE143782: Colon, rectum and rectal tumor organoids. Effects of calcitriol (active form of Vitamin D) treatment
We have established three-dimensional (3D) organoids from healthy colon and rectum tissue and from t...
GSE129431: Global analyses of the dynamics of miRNA metabolism
Rates of production and degradation together specify microRNA (miRNA) abundance and dynamics. Here, ...
GSE138782: Gene expression profiles of PGAM5-knockout brown adipose tissue
PGAM5 is a mitochondria-localized protein phosphatase. To analyze the effect on gene expression prof...
GSE139013: Discrimination of dormant and active hematopoietic stem cells by G0 markers reveals dormancy regulation by cytoplasmic calcium
Quiescent hematopoietic stem cells (HSCs) are typically dormant, and only a few quiescent HSCs are a...
GSE138748: Transcriptome data from human endocrine cells recovered from mouse grafts with pre-engraftment controls
We examined the transcriptomes of alpha and beta cells recovered from mouse sub-renal capsule grafts...
GSE140729: Structure of LINC00511-siRNA-conjugated nanobubbles and improvement of cisplatin sensitivity on triple negative breast cancer
In the present study, we prepared a novel theranostic agent loaded with LINC00511-siRNA, which not o...
GSE130653: Cortical Foxp2 supports behavioral flexibility and developmental dopamine D1 receptor expression
FoxP2 encodes a forkhead box transcription factor required for the development of neural circuits un...
GSE139072: Nuclear Poly(A)-binding Protein 1-like (PABPN1L) Mediates Cytoplasmic mRNA Decay As a Placeholder during Maternal-to-zygotic Transition
Maternal mRNA degradation is a critical event of maternal-to-zygotic transition (MZT) that determine...
GSE140747: Temporal control of species-specific motor neuron differentiation [Hs]
How species-specific developmental timing is controlled is largely unknown. By following human embry...
GSE135799: Simple differentiation method using FBS identifies DUSP6 as a marker for fine-tuning of FGF-ERK signaling activity in human pluripotent stem cells
Assessment of differentiation potential is a basic requirement to obtain qualified human pluripotent...
GSE148442: Transcriptomic analysis of IRAK4 in murine pancreatic cancer cells (KP2)
We perform CRISPR knockout of IRAK4 usig two different sgRNAs in murine KP2 cells, and then reexpres...
GSE141788: RNA-seq analysis about Ssrp1 knocked out and Usp7 knocked down samples
Endogenous retrovirus MERVL is specifically expressed in a minority of embryonic stem cells. To dete...
GSE137500: An atheroprotective transcriptome induced by JQ1 (a BRD4 inhibitor) in human endothelial cells
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, ...
GSE135838: Transcriptomic Profiles of Sepsis in the Human Brain
The purpose of this study is to examine the transcriptomic profiles (RNAseq) of post-mortem brain ti...
GSE141745: Tissue neutrophil heterogeneity
Purpose: The goals of this study are to compare bulk RNAseq profiles of tissue neutrophils.; Methods...
GSE129881: IL-27 receptor signaling regulated stress hematopoiesis drives Abdominal Aortic Aneurysm development
Abdominal Aortic Aneurysm (AAA) is a prevalent life-threatening disease, where aortic wall degradati...
GSE143809: T cell-derived miR-214 mediates perivascular fibrosis in hypertension
Despite increasing understanding of the prognostic importance of vascular stiffening linked to periv...
GSE137426: The fibronectin mediated endothelial rescue effect in CCM3-deficient cells is independent from acute mRNA changes
Using CRISPR/Cas9 genome editing and RNA sequencing, we demonstrate that fibronectin supplementation...
GSE146046: Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma [RNA-Seq]
CD4+ helper T cells (TH) and regulatory T cells (Treg) that respond to common allergens play an impo...
GSE137448: S-phase enriched non-coding RNAs regulate gene expression and cell cycle progression
We infer that non-coding RNAs can function as key effectors during cell cycle, acting on distinct re...
GSE130410: FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer
FoxM1 activates genes that regulate S-G2-M cell-cycle progression and, when overexpressed, is associ...
GSE129689: RNA sequencing of mouse carotid arteries after sacubitril/valsartan treatment
Purpose: To get insight into mouse strain-dependent differences in vascular remodeling, we analyzed ...
GSE131922: Targeting kidney proximal tubules by protein nanocages via glomerular filtration
Nature exploits cage-like proteins for a variety of biological purposes from molecular packaging and...
GSE137324: IL-33 blockade impacts mediators of persistence and exacerbation in a model of chronic airway inflammation
Summary: Blocking IL-33 signaling ameliorates inflammation, tissue remodeling and preserves lung fun...
GSE137405: Transcriptional profiling of colonic Regulatory T (Treg) cells, CD4+ conventional T (Tconv) cells, dendritic cells (DCs), and epithelial cells (ECs) from Vdr WT- or Vdr KO-Foxp3 reporter mice
We reported transcriptional characterization of Treg cells, Tconv cells, and DCs isolated from coloi...
GSE140763: CBX4 role in U2OS/MTX300
In our study, we found that CBX4 was critical to osteosarcoma metastasis.CBX4, also known as polycom...