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Sequencing-based assays page 113
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GSE152438: Genome-wide transcriptome analysis of human iPSC-derived cortical interneurons under inflammation conditions
We report changes in gene expression in cortical interneurons under inflammation conditions by genom...
GSE151099: Chronic Aryl Hydrocarbon Receptor Activity Causes Adverse Muscle Affect: Implications for Smoking-induced Muscle Impairment
Purpose: The goal of this study was to analyze the gene expression levels by RNA sequencing from the...
GSE151279: Metabolic Maturation Media Improves Physiological Function of Human iPSC-derived Cardiomyocytes
iPSC-derived cardiomyocytes (iPSC-CMs) have enormous potential for the study of human cardiac disord...
GSE141044: Single-nucleus RNA sequencing reveals transcriptional changes of hippocampal neurons in APP23 mouse model of Alzheimers disease
Alzheimers disease (AD) is a progressive neurodegenerative disorder that mostly strikes the elderly....
GSE149479: Synergism of chemotherapy and PD-1 immune checkpoint blockade in the PyMT mammary carcinoma mouse model
We studied the impact of a combination of chemotherapy and PD-1 immune checkpoint blockade on tumor ...
GSE139811: Mitochondrial Arginase-2 deletion enhances the function of in vivo activated murine CD8+ T cells
As sufficient extracellular arginine is crucial for T cell function, depletion of extracellular argi...
GSE150411: Transcriptional response of fibronectin fragment treatment in human articular chondrocytes
Objective: Fibronectin is a matrix protein that is fragmented during cartilage degradation in osteoa...
GSE139265: A Spatiomolecular Map of the Striatum
The striatum is organized into two major outputs formed by striatal projection neuron (SPN) subtypes...
GSE138970: Analysis of differential gene expression in the choroid plexus (ChP) of E16.5 and P60 mice
Age-appropriate regulation of cerebrospinal fluid (CSF) dynamics including production, flow, and cle...
GSE59612: MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma
We obtained radiographically-localized biopsies during glioma resection surgeries to sample the tumo...
GSE152451: Intravenous injection of oncolytic virus M1 awakes antitumor T cells and overcomes resistance to checkpoint blockade
Gene set enrichment analysis (GSEA) revealed that upon M1 treatment, apoptotic and inflammation asso...
GSE150623: Role of circulating microRNAs in patients with dengue infection
miRNAs are found to be extremely stable in extracellular fluids of mammals, such as blood plasma, se...
GSE139474: Clonal tracing reveals the contribution of both cancer-intrinsic and -extrinsic mechanisms to the heterogeneity of responses to immune checkpoint blockade [RNA-seq]
Although multiple studies have investigated the biomarkers of response to immune checkpoint blockade...
GSE150621: Gestational diabetes and human amniocytes
Context: Context: Gestational diabetes (GDM) has profound effects on the intrauterine metabolic mili...
GSE155812: RNA-seq analysis of human NK cells expanded with 221-mIL21 expansion system and K562-mIL21 expansion system
PBMCs were stimulated with irradiated K562-mIL21 and 221-mIL21 feeder cells, respectively, as well a...
GSE150703: Single-cell RNAseq of Normoxic and OIR mouse retina by Drop-seq
Proliferative retinopathy is associated with abnormal vascular development (neovascularisation) of t...
GSE149549: Whole transcriptome analysis for blue light-induced eye damage in mice
We identified 737 differentially expressed genes, including 430 upregulated genes and 307 downregula...
GSE151007: Gene expression analysis of wild-type and Tafazzin-deficient granulocyte-monocyte progenitor (GMP) clones (ER-HOXB8 conditionally immortalized)
Evaluate changes in gene expression resulting from the loss of the gene TAZ (protein tafazzin). Tafa...
GSE150666: MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction II.
MYSM1 is a transcriptional regulator essential for HSC function and hematopoiesis. We established th...
GSE149447: Shared and distinct metabolic demands for innate and adaptive cytotoxic lymphocytes during viral infection
Natural Killer (NK) cells and CD8+ T cells share many characteristics at steady state and during vir...
GSE150368: Immune signature driven by ADT-induced immune microenvironment remodeling in prostate cancer is correlated with recurrence-free survival and immune infiltration
Androgen deprivation therapy (ADT) is a cornerstone treatment for locally advanced or metastatic pro...
GSE52946: miR-155 plays a crucial role in ALS and is an immune therapeutic target [RNA-Seq]
Amyotrophic lateral sclerosis (ALS) is a paralytic degenerative disease of the nervous system. In th...
GSE146212: Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria
Acute intermittent porphyria (AIP) is an autosomal dominant inborn error of heme biosynthesis due to...
GSE149485: A simple and highly efficient method for multi-allelic CRISPR-Cas9 editing in primary cell cultures
Background: CRISPR-Cas9-based technologies have revolutionized experimental manipulation of mammalia...
GSE151263: Single Cell RNA Sequencing Identifies an Early Monocyte Gene Signature in Acute Respiratory Distress Syndrome
The acute respiratory distress syndrome (ARDS) results from overwhelming pulmonary inflammation. We ...
GSE150429: Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan McDermid syndrome and autism
We developed human induced pluripotent stem cell (hiPSC)-based models of PMS by reprogramming periph...
GSE150888: Time course Total RNA-Seq in Xbp1 flx/flx (WT, wild-type) mice and AlbCre;Xbp1 flx/flx (XBP1 LKO, liver-specific knockout) mice
We reported the hepatic total gene expression (starting at CT0 and proceeding every two hours for fo...
GSE139000: A novel FACS-based method to isolate enriched populations of neurons, astrocytes, and microglia
We developed a novel FACS-based method to isolate enriched populations of neurons, astrocytes, and m...
GSE156830: The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress [HepG2]
Organisms respond to mitochondrial stress by activating multiple defense pathways including the mito...
GSE151286: Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity in Vitro and in Vivo
The human lung tumor cell line, NCI-H526, was treated with DMSO vehicle control or 0.5 M of the nove...
GSE156671: Genome-wide structure changes during neuronal differentiation drive gene regulatory networks
RNAs structures play central roles in various cellular processes, and can be remodeled upon binding ...
GSE154920: Transcriptomes of ATG7 Knockout Microglia
Multiple Sclerosis (MS) is a leading cause of incurable progressive disability in young adults cause...
GSE149488: Purification of pancreatic endocrine subsets from mouse islets
We developed a FACS-platform for the isolation of highly purified endocrine subsets from mouse islet...
GSE150535: An activity-mediated transition in transcription in early postnatal neurons [RNA-seq]
The maturation of the mammalian brain occurs after birth, and this stage of neuronal development is ...
GSE151247: Single-cell analysis of mouse plasmacytoid dendritic cells (pDCs) unravels their activation trajectory and their molecular regulation in vivo during a viral infection [Ss2_pDC2]
The aim of the project is to characterize the heterogeneity of murine plasmacytoid dendritic cells (...
GSE139340: Somatic tissue engineering in mouse models reveals an actionable role for WNT pathway alterations in prostate cancer metastasis
To study genetic factors that influence the progression and therapeutic response of advanced prostat...
GSE141071: Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse.
This study investigated the differential responses of the epididymis and testis to infection with ur...
GSE150587: Comparative evaluation for the globin gene depletion methods for mRNA sequencing using the whole blood-derived total RNAs
Background: There are challenges in generating mRNA-Seq data from whole-blood derived RNA as globin...
GSE150688: Ursolic acid regulates inflammatory cell infiltration to prevent ulcerative colitis
Total RNA was isolated from 3 colonic tissues of each treatment group using the Qiagen RNeasy kit fo...
GSE149523: Study of transcriptional changes in MCM7-depleted and G1/S-arrested A549 and A375 cells
We tested if the changes in cell invasion and migration observed after MCM7 depletion manifested in ...
GSE155850: scRNASeq data of CD45+CD3-CD19- normal and HS skin
Hidradenitis suppurativa (HS) is a highly prevalent, morbid inflammatory skin disease with limited t...
GSE141533: Macrophage-Tumor Cell Interaction Promotes ATRT Progression and Chemoresistance (NODSCID)
Atypical teratoid/rhabdoid tumors (ATRT) are known for their heterogeneity concerning pathophysiolog...
GSE139813: Analysis of transcriptomes in intestinal stem cells in response to Interferon gamma
There is limited understanding of how immune-mediated damage impacts intestinal stem cells (ISCs). W...
GSE149522: The transcriptomic profile of the hippocampal microglia in the irradiated juvenile mouse brain
Cranial irradiation (IR), an effective tool to treat malignant brain tumors, triggers a chronic pro-...
GSE152517: Loss of G protein pathway suppressor 2 in human adipocytes triggers lipid remodeling through upregulation of ATP binding cassette subfamily G member 1
Here we demonstrate that the loss of GPS2 triggers the reprogramming of cellular processes related t...
GSE152448: UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters
To gain a deeper insight into roles of UTX in hESCs derived neurons, we performed ChIP-seq and RNA-s...
GSE141062: Transcriptional profilling of In vitro-primed C.rodentium-specific WT or Caspase-1 deficient Th cells
Introduction: We reported that caspase-1 is highly expressed in in vitro-primed C.rodentium-specific...
GSE151317: Gene Expression Profiling of TNBC and OVCA in response to Azacitidine and Talazoparib (RNA-Seq)
Triple negative breast cancer and ovarian cancer cells were treated with Azacitidine, Talazoparib, o...
GSE155837: Gene expression profiling of Dermal Papilla cells isolated from wild type (WT) and Fgfr1/Fgfr2 double mutant mice during anagen (at P14 and P16) was performed by RNA-seq analysis
Gene expression analysis revealed that the DP transcriptome is altered in the Fgfr1/Fgfr2 double mu...
GSE150579: Timing of tumor initation predicts medulloblastoma heterogeneity, stem cell composition and probability of relapse
Using scRNA-seq, we show in a murine medulloblastoma model that tumors initiated earlier in developm...
GSE150876 (human): Coupled single cell RNA-seq and intracellular protein activity reveals immune-suppressive role of Trem2 in cancer II
Cell function and activity is regulated through integration of signaling, epigenetic, transcriptiona...
GSE145611: Transcription Factor GATA2 Promotes Chromatin Remodeling at the Super-Enhancers of the Key Mast Cell Identity Genes and Primes Enhancers to Respond to Antigenic Stimulation [RNA-seq]
Mast cells are critical effectors in causing allergic inflammation and in protecting against certain...
GSE149565: EDF1 binds collided ribosomes and facilitates recruitment of translational repressors GIGYF2/EIF4E2 and initiates JUN-mediated transcriptional response
RNA-seq analyses of wild-type and DEDF1 cell lines show that the immediate-early JUN-dependent trans...
GSE155863: Strand-specific RNA-seq analysis about Ssrp1 knocked out
Endogenous retrovirus MERVL is specifically expressed in a minority of embryonic stem cells. To dete...
GSE148563: Next Generation Sequencing Facilitates Analysis of The Mouse OocyteCumulus cells and Blastocyst Transcriptomes From PM2.5 Exposure Group And Filtrated Air Group
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular path...
GSE139818: Investigation of the gene expression changes triggered by the lung mesenchymal Tsc2KO in each major cell subpopulation of the adult mouse lung
Tumor suppressor Tuberous sclerosis complex 2 (TSC2) is a key negative regulator of mammalian target...
GSE149566: Statins affect gene expression in pancreatic cancer
The statin family of cholesterol-lowering drugs was shown to influence the risk of multiple types of...
GSE150431: Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice [amygdala]
Background: The schizophrenia associated gene, BRD1, encodes an epigenetic regulator which chromatin...
GSE153396: Transcriptional profiling following knockdown of RNA binding proteins
Human cancer cell lines were profiled by RNAseq following knockdown of RNA binding proteins, BRCA1, ...
GSE148506: Single-cell profile of atrial human fibroblasts in cardiac arrhythmia atrial fibrillation (AF) - SmartSeq2
Atrial fibrillation (AF), the most common cardiac arrhythmia, is a major contributor to population m...
GSE152467: Hnrnpa21 regulates myogenic fate plasticity
RNA-binding proteins (RBPs) are essential for skeletal muscle regeneration and RBP dysfunction cause...
GSE139812: Regulated snoRNA expression during differentiation corresponds with a change in ribosomal RNA pseudouridylation and altered pre-ribosomal RNA processing [RNA-seq and ncRNA-seq]
H/ACA small nucleolar RNAs (snoRNAs) guide pseudouridylation as part of a small nucleolar ribonucleo...
GSE151119: RNA-seq analysis of HSF1 knockout on LiCl treatment
Heat shock transcription factor 1(HSF1) is an important transcription factor which regulates the exp...
GSE150586: Next generation sequencing identifies differentially expressed genes between breast cancer with diabetes and breast cancer without diabetes
We report the application of RNA-sequencing for high-throughput profiling of transcriptomes in tumor...
GSE151251: Next generation RNAseq from human hepatic stellate cells treated with TGFb
next generation RNAseq data from human hepatic stellate cells treated with TGFb compared to non-trea...
GSE148739: A Distinct Role for GLUT3 in Glioblastoma Invasion
In a study of GLUT1 and GLUT3, we used RNA-sequencing to assess the affects of GLUT1 and GLUT3 knock...
GSE145827: WT/AtohKO/TNFdARE Ileum
An inverse correlation between countries endemic for helminth infestation and Crohn's disease (CD) i...
GSE146211: Activation of a collaborative innate-adaptive immune response suppresses metastatic breast and ovarian cancer in mice
Many cancers recruit monocytes/macrophages and polarize them into tumor-associated macrophages (TAMs...
GSE149613: Transcriptional dynamics of iPSC differentiation into cells revealed by single-cell RNA sequencing
Induced pluripotent stem cells can be differentiated in vitro into insulin-producing cells. In this...
GSE152576: Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes...
GSE150603: Inducible smooth muscle specific deletion of Yap1/Wwtr1 in mouse
YAP and TAZ are transcriptional co-activators and downstream effectors of the Hippo pathway, which p...
GSE153261: The Lyme disease bacterium, Borrelia burgdorferi, stimulates an inflammatory response in human choroid plexus epithelial cells
We report the results of gene expression profiling via RNA-sequencing of primary human choroid plexu...
GSE154748: The osteocyte transcriptome is extensively dysregulated in mouse models of Osteogenesis Imperfecta
Osteocytes are long-lived, highly interconnected, terminally differentiated osteoblasts which reside...
GSE151121: Analysis of gene expression upon deletion of Yap/Taz in the posterior palatal shelves prior to elevation in mouse
The goal of this RNA-Sequencing experiment was to determine gene targets of Yap/Taz in the posterior...
GSE148843: -catenin is a node at orchestrating distinct aspects of epithelial-mesenchymal transition (EMT) and malignant mammary tumor progression
Canonical Wnt signaling plays crucial roles in the progression of many cancer types. In canonical Wn...
GSE148740: Novel Dopamine Receptor 3 Antagonists Inhibit the Growth of Primary and Temozolomide Resistant Glioblastoma Cells
In a study focused on the role dopamine receptor 3, we completed RNA-sequencing of D456 and JX39, gl...
GSE139911: DNMT3A and TET2 Mutations Increase Hematopoietic Stem Cell Fitness Through Distinct Mechanisms
Epigenetic modifying enzymes DNMT3A and TET2 are recurrently mutated in hematological disorders desp...
GSE149598: RNA-seq of iPSC-derived astrocytes that are capable of exerting pro-maturational effect on synaptic networks
Astrocytes interact closely with neurons and facilitate neuronal maturation and function by providin...
GSE141420: Transcriptomic analysis of nave B cells and antigen-specific activated B cells and plasma cells from 4dpi NP-LPS immunized mice [NPLPS_PC]
Little is known about the earliest transcriptomic events in plasma cell differentiation. Indeed, ac...
GSE151061: Genome-wide RNA-expression analysis after p53 activation in hepatocellular carcinoma
In order to characterize the differentially expressed mRNAs after the p53 activation ,RNA-seq were u...
GSE151338: RNA-seq analysis in residual pancreatic -cells of Bmal1KO/DTA mice following massive ablation
We aimed to fill the gap in understanding functional roles of the islet cellular oscillators under d...
GSE148300: Modelling and rescue of RP2 Retinitis Pigmentosa using iPSC Derived Retinal Organoids
Mutations in RP2 lead to a severe form of X-linked retinitis pigmentosa (XLRP). RP2 functions as a ...
GSE152461: Transcriptomic analysis of brian tissues identifies a role for CCAAT enhancer binding protein in HIV- associated neurocognitive disorder
In this study, using 33 postmortem frontal cortex (FC) tissues, neuropathological, molecular, and bi...
GSE149611: Assess the effects of antipsychotic use on gene expression changes in dementia
In order to elucidate mechanisms underlying adverse effects of antipsychotic use in dementia we gene...
GSE139992: Loss of hepatic Mboat7 leads to liver fibrosis
Objective: The rs641738C>T variant located near the membrane-bound O-acyltransferase domain containi...
GSE149635: Single cell mapping of breast tumor stroma reveals dynamically evolving compositions of cancer-associated fibroblasts along tumor progression (scRNA-seq dataset)
Tumors are complex ecosystems, in which malignant and non-malignant cells engage in continuous inter...
GSE146224: Recapitulation of murine thymopoiesis in vitro from single hematopoietic stem cells
We report a serum-free, 3-D murine artificial thymic organoid (ATO) system that mimics normal murine...
GSE148519: Expression data of CD107aLow and CD107aHigh cells isolated from human adipose tissue
The tunica adventitia of vessels within adipose tissue (AT) represents a heterogenous microanatomica...
GSE149594: RNA-sequencing of the infarct border zone of the mouse hearts transplanted with FOXO3-GE-MPCs
RNA-sequencing of the infarct border zone of the mouse hearts transplanted with FOXO3-GE-MPCs SOURCE...
GSE141330: In situ maturation and tisuse adotion of type 2 innate lymphoid cell progenitors
We analyzed the full spectrum of lung ILC2s at single-cell transcriptome resolution and identified a...
GSE152497: Anti-lymphoma activities of different compounds
4 lymphoma cell lines (DOHH2, OCILy10, TMD8 and Toledo) have been treated with DMSO, CB103, NEO02734...
GSE153303: The response of A549 transcriptome to RNA Pol II slowdown with alpha-amanitin and DRB
According to current estimates, more than 40% of nascent introns are spliced co-transcriptionally an...
GSE145019: Stabilization of Heterochromatin by CLOCK Counteracts hMSC Senescence and Articular Degeneration
Accumulating evidence indicates the close association between the circadian clock and the aging proc...
GSE145001: Determining transcriptome changes in whole spinal cord of GarsP278KY/+ pre-disease onset mice [18-burgess-001]
To determine transcriptome changes in pre-disease onset spinal cord induced by the GarsP278KY mutati...
GSE150591: DSCAM-AS1-driven proliferation of breast cancer cells involves regulation of alternative exon splicing and 3-end usage
Background: DSCAM-AS1 is a cancer-related long noncoding RNA with higher expression levels in Lumina...
GSE148560: Gene expression profiling of human DLD-1 cells after block of CRM1 receptor with Leptomycin B inhibitor.
We used RNA-seq approach to define a contribution of mammalian export receptor CRM1 (Chromosomal Mai...
GSE153606: Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7
GdA induces the differentiation of human monocytes into dM-like phenotypes in terms of transcriptome...
GSE148731: Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages
The success of Mycobacterium tuberculosis (Mtb) as pathogen is tightly linked to its ability to reca...
GSE152600: PTEN-dependent regulation of genome-wide transcription during metabolic stress [RNA-Seq]
PTEN is implicated in a wide variety of pathophysiological conditions and traditionally studied in t...
GSE152562: Transcriptomic analysis of APC knock down HCEC 1CT cells compared to the wild type HCEC 1CT cells.
We performed RNA sequencing analysis of two human colon epithelial cell lines (HCEC 1CT_WT and HCEC ...