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Sequencing-based assays page 112
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GSE141757: Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake
Exploring the complexity of host-pathogen communication is vital to understand why microbes persist ...
GSE153555: Transcriptional Profiling of Normal, Stenotic, and Regurgitant Human Aortic Valves
Purpose: The goal of this study is to characterize the gene expression profiles and identify genes o...
GSE150410: Systematic analysis of IL-17 receptor signalosome reveals a robust regulatory feedback loop
We analyzed the changes in gene-expression upon IL-17 stimulation in the presence or absence of TBK1...
GSE150933: Cancer-Related Mutations are Not Enriched in Nave Human Pluripotent Stem Cells
A recent paper reported multiple oncogenic point mutations in nave human pluripotent stem cells (hPS...
GSE141158: Transcriptome profiling of cytoplasmic fraction of nave CD8 T cells from Nxf1 mutant and control mice [Lymphocytes]
Purpose: Nxf1 is thought to be an essential nuclear exporter of messenger RNA (mRNA) in eukaryotic c...
GSE149349: Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [WTvsDP mouse RNA-seq]
Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synth...
GSE150363: Quantitative Analysis of different NK cell types Transcriptomes
We compared transcriptome of different types of NK cells including obtained from Umbilical Blood (U...
GSE153210: Creld1 deficient CD4+ T cells from 1-year-old animals under homeostatic
Transcriptomic profile of Creld1 deficient nave CD4+ T cells and control 1-year-old mice. Sorted nav...
GSE153463: SEAM: a spatial single nuclear metabolomics method for dissecting tissue microenvironment
We report a method for analyzing spatial metabolomics at single cell level. In human fibrotic liver ...
GSE149019: Rathkes Cleft-Like Cysts Arise From Isl1 Deletion in Murine Pituitary Progenitors
The transcription factor ISL1 is expressed in pituitary gland stem cells and the thyrotrope and gona...
GSE155012: Transcriptome analysis of CD45-CD31+ endothelial cells in ischemic hindlimb muscle after IL-35 injection
We report the first time of the transcriptome difference between IL35- and PBS-injected ischemic mus...
GSE139428: Gene expression analysis of motor cortex between BERKO and wild type mouse
Introduction: Male estrogen receptor beta (ER) knockout (BERKO) mice display anxiety and aggression ...
GSE153258: Global RNA stability profiling during selective chemical inhibition of human Dcp2
Multiple RNA decapping enzymes coexist in mammalian cells to regulate decay of partially overlapping...
GSE90489: Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy
To investigate the molecular basis of posterior polymorphous corneal dystrophy (PPCD) by examining t...
GSE138805: Transcriptomic changes of mouse monocytes and macrophages after ischemic stroke
Blood monocytes/macrophages infiltrate the brain after ischemic stroke and critically influence brai...
GSE149348: Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [mouse PKF RNA-seq]
Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synth...
GSE148051: Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia
RUNX1 is among the most frequently mutated genes in human leukemia, and the loss or dominant-negativ...
GSE139204: The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia [Aging-Rapamycin data set].
Purpose: Despite demonstrating that the overall effect of long-term rapamycin-treatment is overwhelm...
GSE139209: The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia [NMJ data set].
Purpose: To investigate whether our signatures of mTORC1-driven sarcopenia originate from cells resi...
GSE153512: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and METTL14 KO bone marrow-derived macrophages(BMDM) Transcriptomes
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular path...
GSE139524: Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors
Imprinted genes are highly expressed in the hypothalamus, however whether specific imprinted genes a...
GSE140975: Wapl repression by Pax5 promotes loop extrusion and V gene recombination at the Igh locus
The generation of a diverse antibody repertoire is essential for humoral immunity and requires the p...
GSE150425: Bulk transcriptional profiling of murine lung epithelial cells after expression of oncogenic KRAS
The goal of this study was to define the transcriptional changes that follow oncogenic KRAS-G12D exp...
GSE148111: Search for biomarkers of response to MitoQ in human breast cancer cell lines
For this projected we aimed to identifybiomarkers of response to a mitochondrial ROS inhibitor, Mito...
GSE153183: Gene expression profiling of drug-tolerant persister PC9 non-small cell lung cancer cells derived from osimertinib treatment
Targeting drug tolerant persister (DTP) cells may present a therapeutic opportunity to eliminate res...
GSE148405: Single cell RNA-seq of microglia isolated from different brain regions of WT and 5xFAD mice.
Single cell RNA-seq data were obtained from FACS sorted microglia isolated from different brain regi...
GSE138940: Muscle specific MyD88-/-confers a sexual dimorphism protecting female mice from inactivity-induced fat accumulation
We demonstrate whole body inflammation (miR146a-/-) exacerbated inactivity-induced fat gain and gluc...
GSE150169: single-cell RNA-seq profile of microglia under acute Csf1r inhibition and early repopulation in adult brain
Microglia are the resident myeloid cell in the central nervous system (CNS). Like other terminally d...
GSE149370: SFPQ depletion is synthetically lethal with BRAFV600E in colorectal cancer cells II
Oncoproteins such as the BRAFV600E kinase entrust cancer cells with malignant properties, but they a...
GSE149935: Functional genomic landscape of cancer-intrinsic immune evasion to cytotoxic T lymphocyte killing [RNA-seq II]
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain p...
GSE150452: Whole lung gene expression from nave Bpifb1 WT and KO mice
We performed RNAsequencing on whole lung tissue from nave Bpifb1 WT and KO mice. SOURCE: Samir Kelad...
GSE138945: MBOAT7's role in the progression of Non-alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH)
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound O-a...
GSE149353: Drug screen combining RNA landscape analysis reveals targetable pathways in HIV-1 reactivation
We invesitgated cellular pathways required for HIV-1 activation using HIV-1-suppressing agents. Desp...
GSE154823: Next Generation Sequencing Facilitates Quantitative Analysis of the effects of DR-3 agonist on sorted mouse VAT ILC2 Transcriptomes
Disturbances in glucose homeostasis and low-grade chronic inflammation culminate into metabolic synd...
GSE140952: RNA-seq libraries for splenic and colonic MHCII+ APCs and colonic CD11b+, CD11c+, CD11b+CD11c+ MNP/DC
The gut-brain axis, a reciprocal interaction between the central nervous system (CNS) and peripheral...
GSE141308: Transcriptional profile of human macrophages stimulated by cartilage fragments
Accumulating evidence suggests that synovitis is associated with osteoarthritic process. Macrophages...
GSE150257: Characterizing transcriptomic profiles with human SORLA overexpression in mice
The purpose of this study is to determine global changes in mRNA expression with transgenic expressi...
GSE147983: Novel circRNA_103758-miRNA-19b-3p-CIT axis is associated with proliferation and migration of bladder cancer via RhoA-ROCK signaling pathway [RNA-seq]
Purpose:The purpose of this study is to investigate the potential mechanisms that triggering the ons...
GSE138932: RNA-seq analysis of WT and NCOR1f/f,Cd4Cre in vitro-generated Th1 cells
The differentiation of nave CD4+ T cells into T helper (Th) subsets is key for a functional immune r...
GSE138153: Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice
Epigenetic regulation of gene expression through histone modifications like methylation of various l...
GSE149345: Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [human PKF RNA-seq]
Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synth...
GSE138028: Chromatin environment and cellular context specify compensatory activity of paralogous MEF2 transcription factors
Compensation among paralogous transcription factors (TFs) confers genetic robustness of cellular pro...
GSE149356: Single cell RNA-seq reveals high heterogeneity among human T cells.
Human T cells take a small but important part in the immune system. Human T cells are usually cate...
GSE150770: Suprachiasmatic VIP neurons are required for normal circadian rhythmicity with a subset expressing a molecularly distinct pacemaker profile
The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined cell groups th...
GSE151080: RNAseq of ISP CD28+ cells stimulated with ImmunoCult
The generation of TCR and TCR T cells proceeds through distinct developmental stages in which changi...
GSE138019: Decapping enzyme NUDT12 partners with BLMH for cytoplasmic surveillance of NAD-capped RNAs
RNA polymerase II transcripts receive a protective 5 m7G cap early during transcription. An alternat...
GSE151094: PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5
PDCD2 is an evolutionarily conserved protein that is essential for cell proliferation and embryonic ...
GSE148997: Alleviating FGF19s tumorigenic risk by suppressing its FGF Receptor dimerization ability
Administration of FGF19 - a physiological regulator of bile acid homeostasis - to diabetic and diet-...
GSE148158: A PIANO (Proper, Insufficient, Aberrant, and NO reprogramming) response to the Yamanaka factors in the initial stages of human iPSC reprogramming
Yamanaka reprogramming is revolutionary but inefficient, slow and stochastic. The underlying molecul...
GSE139658: Local Modulation of Lymph Node Stroma by Sensory NeuronsII
Immune responses within barrier tissues are regulated, in part, by nociceptors, specialized peripher...
GSE151469: cRel Expression Regulates Distinct Transcriptional and Functional Profiles Driving Fibroblast Matrix Production in Systemic Sclerosis
The scope of this project is to investigate transcriptional differences bewteen wild type and Rel-/-...
GSE150119: Transcriptomic changes in response to modulation of long-non-coding RNA LINC00473
Human thermogenic adipose tissue mitigates metabolic disease, raising much interest in understanding...
GSE138147: A novel IFN-induced long noncoding RNA, lncMX1-215, negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma
Interferon-alpha (IFN) plays a ciritical role in immune regulation, especially in tumor microenviron...
GSE150137: Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford Progeria Syndrome (RNA-Seq)
Hutchinson-Gilford Progeria Syndrome (HGPS) is a progeroid disease characterized by the early onset ...
GSE150171: RNA Seq profiling of transcriptional response in IFNg-primed C57BL6 mouse primary bone marrow derived macrophages exposed to vehicle, compound 2062 and an inactive control analog at 0, 1, 2 and 6 hours post treatment
The goals of this study were to probe cellular networks that became engaged upon small molecule 2062...
GSE138117: CTCF-dependent chromatin architecture and SUZ12/PRC2 complex recruitment are required for peripheral myelination and repair
Chromatin organization is critical for cell growth, differentiation, and disease development, howeve...
GSE131391: Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution
The human bronchial epithelium is composed of multiple, distinct cell types that cooperate to defend...
GSE149452: Single-cell RNA-sequencing of control aortic isografts of mouse models
We reported the transcriptional profiling of cells from aortic isografts by single-cell RNA sequenci...
GSE153523: DUX4-expressing immortalised FSHD lymphoblastoid cells express genes elevated in FSHD muscle biopsies, correlating with the early stages of inflammation
RNAseq of FSHD and control LCLs and primary myoblasts with corresponding in vitro differentiated myo...
GSE143823: Microglial homeostasis requires balanced CSF-1/CSF-2 receptor signaling
ALSP is a CSF1R-deficiency dementia associated with increased CSF2 expression; Monoallelic deletion ...
GSE150616: Transcriptional analysis of induced trophoblast stem cells and their derived plancenta subtypes.
We report the transcriptional analysis of induced trophoblast stem cells (iTSCs) and their derived p...
GSE150150: Transcriptional landscape of fate choices in the sensory lineages
Somatic sensation is defined by the existence of a diversity of primary sensory neurons with unique ...
GSE157658: Consequences of postnatal Tshz3 deletion: implications for autism spectrum disorder
We recently identified heterozygous deletions of the gene TSHZ3, which encodes a Zn-finger transcrip...
GSE48812: Genome-wide transcriptome analysis of the dietary chemopreventive phytochemical sulforaphane on normal and prostate cancer cells.
Epidemiological studies provide strong evidence that consumption of cruciferous vegetables, such as ...
GSE140168: RNA-seq analysis of the Innate Lymphoid Cells type 2 (ILC2) or their precursors (ILC2p ) sorted from WT and Tgfbr2-/- mice
Purpose: The molecular pathways underlying the development of innate lymphoid cells (ILCs) are mostl...
GSE138954: Transcriptional analyses of a RPMax-/- cell line upon Max restoration using an inducible lentiviral vector.
We analyze transcritpional changes upon Max restoration in a RPMax-/- cell line. SOURCE: Arnaud,A,Au...
GSE150537: An activity-mediated transition in transcription in early postnatal neurons [10X]
The maturation of the mammalian brain occurs after birth, and this stage of neuronal development is ...
GSE150426: Somatic Gain of KRAS Function in the Endothelium is Sufficient to Cause Vascular Malformations that Require MEK but not PI3K Signaling
Rationale We previously identified somatic activating mutations in the KRAS gene in the endothelium...
GSE155526: RNA sequencing reveals distinct immune responses in the chorioamniotic membranes of women with preterm labor and microbial or sterile intra-amniotic inflammation
Chorioamniotic membrane samples were profiled using paired-end Illumina RNAseq to evaluate transcrip...
GSE152441: Effect of folic acid deprivation on on transcriptome upon OTX treatment
Deciphering the impact of metabolic intervention on response to anticancer therapy represents a path...
GSE150049: Trancriptional signatures of dexamethasone-treated sarcoidosis monocytes.
The goal of this study was to determine the effect of dexamethasone treatment on trancriptional siga...
GSE153362: RNA-Seq of MADM induced UPD of Chr. 7 (SMARTer)
In mammalian genomes a subset of genes is regulated by genomic imprinting resulting in silencing of ...
GSE154800: Heparin Binding Epidermal Like Growth Factor-Mediated Marrow Adipocyte Ablation Induces Profound Bone Formation
Products of adipocytes control bone cells and may therefore lead to new anti-osteoporosis therapies....
GSE150474: Malignant melanotic Xp11 neoplasms exhibit a clinicopathological spectrum and gene expression profiling akin to alveolar soft part sarcoma: a proposal for reclassification
We employed RNA sequencing-based clustering analysis to better understand the relationship of this u...
GSE138980: RNA-sequencing and ChIP-sequencing in murine mesenchymal stem cells treated with Ezh2 inhibitor GSK126 or -catenin siRNA
During mesenchymal stem cell (MSC) differentiation, both Wnt signaling and the development of a rigi...
GSE150481: Resilience and susceptibility in a mouse model of immune-mediated neurodevelopmental disorders
We identify and characterize subgroups of isogenic mouse offspring exposed to identical maternal imm...
GSE149468: Multi-organ transcriptomic profiling of short-term fasted mice
To investigate the global gene expression dynamics associated with short-term fasting, we used mRNA-...
GSE150613: Transcriptomes of MCSF- and MUC1-ST-treated monocyte derived human macrophages
RNAseq was used to analyse transcriptomic differences between matched healthy human MCSF-treated mac...
GSE155517: Temporal study of the effect of acute systemic inflammation on the cerebral endothelial cells (CECs) and microglia in mice
To capture the global gene expression patterns in the CECs and microglia following acute systemic in...
GSE138217: SOX1 Determines the Regional Identity of Neural Progenitors Differentiated from Human Embryonic Stem Cells
During human embryogenesis, primitive neural cells start to be generated at the time of gastrulation...
GSE140974: Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia: LPS Experiment RNA-Seq Data
Studies of neuroepigenetic mechanisms in health and disease are hindered by a lack of approaches to ...
GSE150093: The hepatic microenvironment uniquely protects leukemia cells through induction of growth and survival pathways mediated by LIPG
Transcriptome comparison between leukemia stem cells residing in bone marrow and liver in a leukemia...
GSE155489: Comprehensive molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells
We aimed to elucidate the molecular features and identify causative factors for PCOS through an inte...
GSE150620: Physical activity modulates macrophage phenotype in mammary tissue and inhibits tumor progression
We generated RNAseq results from the mammary tissues of mice from a 2 x 2 factorial design experimen...
GSE150518: 7-Hydroxycoumarin attenuates colistin-induced kidney injury in mice through the inhibition of HDAC1 and the activation ofNrf2signaling
RNA sequencing of kidney tissues was performed to investigate the mechanism of 7-Hydroxycoumarin at...
GSE150918: Transcriptional responses of GII.4 human norovirus infection in jejunal human intestinal enteroids
The goal of this project was to evaluate intestinal epithelial responses to GII.4 human norovirus in...
GSE140963: ANDROGEN RECEPTOR WITH SHORT POLYGLUTAMINE TRACT PREFERABLY ENHANCES WNT/BETA-CATENIN MEDIATED PROSTATE TUMORIGENESIS
Polyglutamine (polyQ) tract polymorphism within the human androgen receptor (AR) shows population he...
GSE138296: Cooperation of MYC and b-catenin in liver tumorigenesis requires Yap/Taz
One of the transcriptional targets of b-catenin/TCF and a key downstream effector of the WNT/b-caten...
GSE138381: Defining the adult hippocampal neural stem cell secretome: in vivo versus in vitro transcriptomic differences and their correlation to secreted protein levels.
Recent evidence shows that adult hippocampal neural stem and progenitor cells (NSPCs) secrete a vari...
GSE153622: The next-generation RNA and ATAC sequencing of MLL-ENL transformed cell lines reveals that C/EBP transcription factors coordinate the expression of the MLL-ENL/Hoxa target genes [RNA-seq]
We report the application of next-generation RNA and ATAC sequencing technology for high-throughput ...
GSE150401: Analysis of the response to PD1 therapy in B16R2L mouse melanoma tumors knockdown for Mdk.
Gene expression analysis in tumors generated by B16R2L cells injected in C57BL/6J mice and treated w...
GSE151498: High fat effect on mouse intestinal stem cells
Examination of transcriptomic profiles of intestinal stem cells fed with different diets SOURCE: Wen...
GSE141440: Sphingosine 1-phosphate receptor signaling establishes AP-1 transcriptional factor gradients and permits retinal endothelial specialization
Transcriptional mechanisms that drive angiogenesis and organotypic endothelial specialization are po...
GSE149497: IFN-b treatment of primary murine hepatocytes
Primary murine hepatocytes were isolated from C57Bl/6J (wild type) animals and treated with 1000 U/m...
GSE138403: Propranolol exhibits activity against hemangiomas independent of beta blockade
Propranolol is a widely used beta blocker that consists of a racemic mixture of R and S stereoisomer...
GSE149446: Shock waves induce an evolutionary conserved mechanism of spinal cord regeneration via Toll-like receptor 3
Shock wave therapy (SWT) is improving motor function and decreasing lesion size in wild-type but not...
GSE139213: The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia [TSCmKO data set].
Purpose: Sustained muscle fiber-specific mTORC1 activity, through deletion of the mTORC1 upstream in...
GSE150640: Gene Expression Profiling in high-grade serous ovarian cancer mouse models
Gene Expression Profiling in high-grade serous ovarian cancer mouse models SOURCE: Jaeyeon Kim (jaey...
GSE139229: IL-33 signaling alters regulatory T cell diversity in support of tumor development [2018]
Regulatory T cells (Tregs) can impair anti-tumor immune responses and are associated with poor progn...
GSE139648: Next generation sequencing facilitates promoter-level analysis of pancreatic cancer cell lines transcriptomes
Both pancreatic intraepithelial neoplasia (PanIN), a frequent precursor of pancreatic cancer, and in...