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Sequencing-based assays page 59
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GSE104365: Notch1 haploinsufficiency causes aortic aneurysms in mice
Ascending aortic aneurysms (AscAA) are a life-threatening disease whose molecular basis is poorly un...
GSE97380: Macrophages and osteoclasts stem from a bipotent progenitor that lies downstream of the common macrophage/osteoclast/dendritic cell progenitor
Macrophages (Ms), osteoclasts (OCs) and dendritic cells (DCs) are closely related, but the exact ste...
GSE104727: Distinct populations of embryonic epithelial progenitors generate Lgr5+ intestinal stem cells
To follow the changes in the transcriptional programs accompanying the specification of the embryoni...
GSE104171: Transcriptomic analysis of Multiple Myeloma bone marrow microenvironment
We report the RNA sequencing of the non-tumoral CD138- fractions of 74 MM patient BM aspirates taken...
GSE94920: Dual angiopoietin-2 and VEGFA inhibition elicits anti-tumor immunity that is enhanced by PD1 checkpoint blockade
Pathological angiogenesis is a hallmark of cancer and therapeutic target. Vascular-endothelial growt...
GSE105152: Trnascriptome analysis of HeLa cells infected with rTHOV-wt, -dML, -SW mutant or mock-treated
The goal of the study was to compare transcriptome changes in HeLa cells after infection with recomb...
GSE106305: ONECUT2 Drives Neuroendocrine Prostate Cancer Through Hypoxia Signaling
To determine the underlying mechanism of ONECUT2 in prostate cancer hypoxia, we conducted a series o...
GSE108543: Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors
Skeletal muscle harbors quiescent stem cells termed satellite cells and proliferative progenitors te...
GSE99972: Thiol-linked alkylation for the metabolic sequencing of RNA [Transcriptional output measurement by SLAM-seq in wildtype mES cells]
Gene expression profiling by high-throughput sequencing reveals qualitative and quantitative changes...
GSE127475: The mTOR pathway is necessary for survival of mice with short telomeres.
Gene expression profiles of Terc+/+ and generation 2 (G2) Terc-/- male mice fed rapamycin or control...
GSE103788: Elimination of liver cancer cells by YAP activated hepatocytes
Liver tumors activate a regeneration-like genetic program in surrounding liver tissue akin to the re...
GSE106159: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and TWIST1 knock out U87 xenograft mice transcriptomes
Purpose:Next-generation sequencing has revolutionized sytems-level celluar pathway analysis. The goa...
GSE104670: Bmp2 and Notch pattern the embryonic endocardium
Our study describes in detail the role of Bmp2 during cardiac valve developmnent and its implication...
GSE108844: Transcriptional profiles of lung macrophage subsets in Mycobacterium Tuberculosis infection
We investigated transcriptional responses of different lung macrophage lineages during M.tuberculosi...
GSE97859: Oocyte Specific Homeobox 1 (Obox1) Facilitates Somatic Cell Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyper-proliferation
Mammalian oocytes possess fascinating unknown factors, which can reprogram terminally differentiated...
GSE108706: Transcriptome analysis in Neobractatin treated cells
The goal of this study is to use RNA seq and rMATS analysis to identify the anticancer mechanism of ...
GSE103849: UTX guided neural crest function underlies craniofacial features of Kabuki Syndrome
We report RNA-seq and ChIP-seq from flow-sorted E12.5 primary mouse neural crest from WT and UTX kno...
GSE106161: RNAseq data on single dose KMO inhibitor (CHDI-00340246) treated R6/2 mice.
Dysregulation of the kynurenine (Kyn) pathway has been associated with the progression of Huntington...
GSE103722: Skeletal muscle ERalpha action is critical for the maintenance of mitochondrial dynamics and metabolic homeostasis in male mice
Impaired estrogen production and action are associated with obesity and insulin resistance in male m...
GSE96839: Peripheral and systemic antigens elicit an expandable pool of resident memory CD8+ T cells in the bone marrow
Bone marrow (BM) has been put forward as a major reservoir for memory CD8+ T cells. In order to ful...
GSE105414: Genome-wide search for differentially expressed RNAs responsible for the effects induced by Ebola virus replication and transcription
In this study, we conducted a genome-wide screen to identify differentially expressed long noncoding...
GSE106364: Transcriptomic signature of spinal cord from SOD1 G86R mice
We report transcriptomic dysregulations in the spinal cord of symptomatic SOD1 G86R mice by RNA sequ...
GSE106500: Immune Profiling of Premalignant Lesions in Patients with Lynch Syndrome
mRNA expression from adenomas of patients with Lynch Syndrome and Familial Adenomatous Polyposis SOU...
GSE103813: RUNX1 and the endothelial origin of blood
The transcription factor RUNX1 is required in the embryo for formation of the adult hematopoietic sy...
GSE104453: Gcn5 regulates FGF signaling outputs through c-Myc during early differentiation of embryoid bodies [RNA-Seq]
Precise control of gene expression during development is orchestrated by transcription factors and c...
GSE129797: Tau-P301S sorted neurons and astrocytes
Mice of indicated genotypes were perfused and their brains dissected and dissociated. Cells were fix...
GSE97077: Xi-reactivation: A mixed modality approach to MECP2 restoration for Rett Syndrome and other X-linked disorders
The X-chromosome harbors hundreds of disease genes whose associated diseases predominantly affect ma...
GSE97139: The role of IFN-I and IL-27 in the expansion of virus-specific CD8+ T cell subtypes during persistent infection
Chronic infection and cancer are associated with suppressed T cell responses in the presence of acti...
GSE106083: Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells
Here, we generated mouse genetic models to ablate or activate Ahr expression specifically in Tregs. ...
GSE106361: Differential Notch target genes expression profile upon HDAC3 loss-of-function.
The Notch signaling pathway regulates several differentiation and developmental processes in both pr...
GSE96819: Plexin B2 and Semaphorin 4C guide T-cell recruitment and function in the germinal center
Follicular T-helper (TFH) cells are essential for germinal center (GC) responses. TFH localization i...
GSE109262: Joint profiling of chromatin accessibility, DNA methylation and transcription in single cells
Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory re...
GSE97939: Interferon- drives T reg fragility to promote anti-tumor immunity
Regulatory T cells (Tregs) are a barrier to effective anti-tumor immunity. Neuropilin-1 (Nrp1) is re...
GSE106201: Distinct effects of genetic and pharmacological inhibition of galectin-3 on cardiac fibrosis and function in a mouse model of dilated cardiomyopathy
Background: Galectin-3 is upregulated in heart disease, and its inhibition has been reported to conf...
GSE110013: Transcript sequencing of mononuclear fractions from dissociated murine skeletal muscle
The important role of mesenchymal progenitors is quickly emerging in various biological processes. T...
GSE99971: Thiol-linked alkylation for the metabolic sequencing of RNA [RNA-seq and Cap-seq of wildtype mES cells]
Gene expression profiling by high-throughput sequencing reveals qualitative and quantitative changes...
GSE107919: Chromatin remodeler CHD8 in CNS myelination and remyelination
Mutations in CHD8, an ATP-dependent chromodomain-helicase-DNA-binding protein 8, are known to cause ...
GSE130012: METTL3 promotes carcinogenesis in colorectal cancer
To elucidate whether METTL3 plays a role in colorectal cancer tumorigenesis, a RNA-seq analysis wa...
GSE98436: Activation of LINE-1 after fertilisation regulates global chromatin accessibility
Upon fertilisation, the highly differentiated gametes reprogram to a totipotent state to initiate a ...
GSE103846: Transcriptome analysis of human embryonic stem cells (hESCs) upon siRNA-mediated knockdown of hESC-essential genes
The maintenance of pluripotency requires the coordinated expression of a set of essential genes. Tho...
GSE99674: Transcriptome analysis of whole hippocampus from wild-type and TET1-deficient mice after electroconvulsive shock
We examined the effect of TET1 deletion on activity-dependent gene regulation by comparing RNA-seq e...
GSE107898: Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14
The purpose of this study was to assess transcriptome changes in primary human airway epithelial cel...
GSE106231: O-GlcNAcylation of human TATA-Box binding protein is required to sustain key metabolic enzyme gene expression
Cellular homeostasis is ensured by myriad cellular processes that integrate environmental changes an...
GSE106349: Transcriptome of lung tissue from C57BL/6 mice with or without neutrophil depletion at ZT04 and ZT16
Our study looks at the dirsruption of lung circadian transcriptome that occurs when neutrophils are ...
GSE106084: White adipose tissue resident macrophages are required for adipogenesis and energy storage.
White adipose tissue (WAT) stores energy in the form of lipids. WAT macrophages cause adipose tissue...
GSE106216: mRNA-seq analyses for the differentially expressed genes (DEGs) among Con, NF VM-astrocytes, Ctx-astrocytes, and control Ctx-NPCs
To gain further molecular insight into the observed astrocyte functions, we performed RNA-sequencing...
GSE107530: RNA analysis of Sox7- and Sox17-deficient mouse endothelial cells from high grade glioma
Glioblastoma multiforme (GBM) is a highly aggressive and vascularized malignant brain tumor. SoxF tr...
GSE103880: RNA-seq expression analysis of mouse liver treated with locked nucleic acids (LNAs) that inhibit mmu-miR-802-5p and mmu-miR-1948-5p
Total RNA-seq analysis of mouse liver following LNA treatment in vivo to identify mRNA targets of mm...
GSE104424: The diphenylpyrazol compound anle138b blocks A channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Alzheimers disease is a devastating neurodegenerative disease eventually leading to dementia. An eff...
GSE110229: Targeting CREBBP/EP300 bromodomains in cancer
Changes in gene expression caused by CREBBP/EP300 bromodomain inhibitors in a CML cell line SOURCE: ...
GSE108789: Transcriptomic profile of the retinal ganglion cell type J-RGC in Tbr1 KO and control mice
The goal of this experiment is to identify genes with altered expression in Tbr1 mutant J-RGCs. SOUR...
GSE111520: mRNA sequence Analysis of Apocynin treated MKN45
Noxo1, a component of NADPH oxidase 1 (NOX1) complex, is upregulated in gastric cancer cells in a in...
GSE106272: Leucegene: AML sequencing (part 6)
RNA-sequencing of human acute promyelocytic leukemias SOURCE: Guy Sauvageau Institute for Research i...
GSE110212: Obesity expands a distinct population of adipose-resident T cells and increases vulnerability to infection
Obesity in humans is associated with worsened health outcomes following infections compared to non-o...
GSE142209 (mouse): RNA-seq of human and mouse brain microvessels isolated by laser capture microdissection and matched whole brain samples
Brain microvessels form the blood-brain barrier, and are dysfunctional in several neurological disor...
GSE104447: The abundantly expressed microRNA locus miR-144/451 regulates only about 100 target mRNAs during erythroid development [RNA-seq]
MicroRNAs inhibit gene expression by recruiting the RNA-induced silencing complex (RISC) to mRNAs in...
GSE97805: Polycomb-like proteins link the PRC2 complex to CpG islands
The Polycomb repressive complex 2 (PRC2) mainly mediates transcriptional repression and has essentia...
GSE108275: Analysis of gene expression profile in the control and CHD7-knockdown hiPSC-derived lt-NES cells (scRNA-Seq)
CHARGE syndrome is a congenital disorder caused by mutations in Chromodomain Helicase DNA-binding do...
GSE112413: Increased FGF8 Signaling Promotes Chondrogenic Rather Than Osteogenic Development in the Embryonic Skull
RNA-seq of RNA isolated from E14.5 mouse embryos- wildtype cranial base tissue, Msx2-Cre;CAGFgf8 mut...
GSE113368: Medial prefrontal cortex (mPFC) transcriptome analysis of Shank3-overexpressing mice
Shank3 is a core excitatory postsynaptic protein expressed in multiple brain regions including the m...
GSE104882: Diet-Induced Obesity Leads to Infarct Expansion, increased neuroinflammation, and Worsened Outcomes after Stroke
We used RNA-seq to show that high-fat-diet-fed mice have a larger neuroinflammatory response followi...
GSE109032: High Throughput sequencing of NLRC4-T337S/T337S and WT mouse duodenal epithelium
Purpose: Nlrc4-T337S mice have shown phenotypic differences in their intenstinal epithelia. The goal...
GSE112445: Gene expression profile in breast cancer cells
We report the gene expression patterns in MDA-MB-231 (a line selected for low metastatic ability), M...
GSE111497: Regulation of neuroregeneration by long noncoding RNAs [RNA-seq]
In mammals, neurons in the peripheral nervous system (PNS) have regenerative capacity following inju...
GSE106298: Context-dependent compensation among phosphatidylserine-recognition receptors
Analysis of gene expression in RPE from Mertk KO, Mertk WT, Bai1-Tg+, and Bai1-Tg- mice. The hypothe...
GSE110528: Effect of LXR agonist T0901317 on the intestinal transcriptome in mice.
Mice were treated for three days by oral gavage with the synthetic LXR ligand T0901317 (Cayman chemi...
GSE99974: Thiol-linked alkylation for the metabolic sequencing of RNA [SLAM-seq in wildtype and Mettl3 knockout mES cells]
Gene expression profiling by high-throughput sequencing reveals qualitative and quantitative changes...
GSE107893: Identification of Glucocorticoid-Induced Leucine Zipper (Gilz) gene targets in undifferentiated spermatogonia
Sustained spermatogenesis in adult males and recovery of fertility following germ cell depletion are...
GSE106550: Next Generation Sequencing Facilitates Quantitative Analysis of pancreatic tissue transcriptomes from Wild Type and miR-21-/- mice treated with caerulein
Purpose: Purpose: we used next generation sequencing to analyze gene expression profiles of pancreat...
GSE107925: Genome wide study of microglia in Specific-pathogen-free (SPF) and Germ-free (GF) mice at different stages in males and females (RNA-Seq)
RNAseq was performed on microglia from male and female, SPF or GF mice to elucidate the genetic diff...
GSE109326: Transcriptional changes after overexpression of proliferation drivers in human mammary epithelial cells.
Genomics has provided a detailed structural description of the cancer genome. Identifying oncogenic ...
GSE107555: Transcriptome analysis of SKI knock-out in HL60 cells
Whole transcriptome for SKI knock-out and control HL60 cells was sequenced. SKI control and knockout...
GSE107900: RNA-sequence analysis of immortalized, differentiated preadipocytes derived from inguinal subcutaneous white adipose tissue.
In acute cold stress in mammals, JMJD1A, an H3K9 demethylase, up-regulates thermogenic gene expressi...
GSE104209: Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells
We report RNA sequencing data from enriched prostate circulating tumor cells (CTCs) from clinical bl...
GSE97806 (mouse): Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy
Myotonic dystrophy type 1 (DM1) is a CTG microsatellite expansion (CTGexp) disorder caused by expres...
GSE107934: Transcriptome response of human skeletal muscle to divergent exercise stimuli
While acute aerobic and resistance exercise stimulate a number of shared genes, each exercsie mode s...
GSE108222: Defining reprogramming checkpoints from single cell analysis of induced pluripotency
Elucidating the mechanism of reprogramming of somatic cells to induced pluripotency is confounded by...
GSE104174: Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk
Integration of differential expression (DE) and expression QTL (eQTL) analysis in monocyte-derived m...
GSE109245: Next Generation Sequencing of Transcriptomes of Cutaneous Melanocytes and Metastatic Melanoma Cell Lines (mRNA-Seq)
The goal of the study is to compare NGS-derived transcriptome (mRNA-seq) profiles of melanocytes and...
GSE107662: Murine donor age-dependent acute myeloid leukaemia
To investigate the effect of age on AML (acute myeloid leukaemia) in mice. SOURCE: Tyrone Chen (tyro...
GSE111085: Distinct Transcriptomic and Exomic Abnormalities within Myelodysplastic Syndrome Marrow Cells
Prior studies using DNA microarray platforms have shown alterations of gene expression profiles (GEP...
GSE107933: Transcriptome analysis of TNFR1-knockout mouse colon
We have compared mRNA expression in full-thickness mouse colon between wildtype mice and mice with a...
GSE109102: Von Hippel-Lindau (VHL) mutations disrupt vascular patterning and maturation via Notch
Von Hippel-Lindau (VHL) gene mutations induce neural tissue hemangioblastomas as well as highly vasc...
GSE98063: Mll3 and Mll4 facilitate enhancer RNA synthesis and transcriptional elongation from promoters independently of H3K4 monomethylation
Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at lysine 27 (H3K2...
GSE109886: The Molecular Dissection of the Oncogenic Role of ETS1 in the Mesenchymal Subtypes of Head and Neck Squamous Cell Carcinoma [RNA-seq knock-down]
RNA-Sequencing Analysis of gene expression changes due to ablation of Ets1 in SCC25 Cells. SOURCE: S...
GSE109279: Small molecule screen identifies de novo nucleotide synthesis as a vulnerability of cells lacking SIRT3
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase downregulated in aging and age-associated disease...
GSE98117: Analysis of experience-regulated transcriptome and imprintome during critical periods of mouse visual system development
Visual system development is light-experience dependent, which strongly implicates epigenetic mechan...
GSE104583: Nave ESRRB+ iPSCs with the capacity for rapid neural differentiation
Several groups have reported the existence of a form of pluripotency that resembles that of mouse em...
GSE104205: Critical role for very-long chain sphingolipids in invariant natural killer T cell development and homeostasis
The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due...
GSE108330: Next Generation Sequencing Facilitates Quantitative Analysis of mRNA lifetime of Wild Type and Mettl3-/- mice
Considering m6A modification in mRNA was reported to be intensively correlated with RNA decay, for e...
GSE121515: RNA sequencing to determine gene expression changes in HMCES knockout cells
The purpose of this study was to deteremine gene expression changes in when HMCES is inactivated. We...
GSE100293: Apelin absence in endothelial cells
First, transcriptome analysis of purified CD31+ endothelial cells (ECs) from VEGF-treated sprouting ...
GSE107691: Expression data from Wild-type (WT) and Astrocyte elevated gene-1 (AEG-1) knockout (KO) bone marrow derived macrophages (BMDM)
AEG-1 is overexpressed in human hepatocellular carcinoma (HCC) and positively regulates inflammation...
GSE104917: RNASeq analysis of NB1691 neuroblastoma cells treated with MDM2-p53 inhibitor RG7388 alone and in combination with temozolomide
To further identify potential mechanisms involved in combining RG7388 with temozolomide, GSEA was pe...
GSE104065: Differential Expression Analysis of wildtype, E12-/- and E47-/- neuronal stem cells
RNA sequencing of neuronal stem cells from wildtype, E12-/- and E47-/- mice isolated at E14.5 SOURCE...
GSE107194: Investigate A2M treatment in liver of mice
Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome a...
GSE106858: A MYC/GCN2/eIF2alpha negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer
Tumours depend on altered rates of protein synthesis for growth and survival, suggesting that mechan...
GSE99637 (mouse): Universal alternative splicing of noncoding exons
The human transcriptome is so large, diverse and dynamic that, even after a decade of investigation ...
GSE131553: Capture of mouse and human stem cells with features of formative pluripotency [mouse, RNA-Seq 1]
Pluripotent cells emerge as a nave founder population in the blastocyst, acquire capacity for germli...
GSE107096: Transcriptome analysis of HGC-27 after infection with Sendai virus
To better understand the interactions between Hippo signaling and antiviral signaling at transcripti...