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Sequencing-based assays page 79
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GSE123423: Muscle stem cells give rise to rhabdomyosarcomas in severe model of Duchenne muscular dystrophy
We identified muscles as cells of origin of rhabdomyosarcoma in dystrophic mice SOURCE: Francesca Bo...
GSE121176: Quantitative Analysis of Wild Type CBL, CBL 70Z and Y371S 3T3 Stable Cell Transcriptomes
Cbl (Casitas B-lineage lymphoma) is a prominent post-translational regulator of protein tyrosine kin...
GSE130113: Single-Cell RNA Sequencing Reveals Regional Reprogramming during Adaptation to Massive Small Bowel Resection in Mice
Single-cell RNA sequencing reveals interactions between the retinoid metabolism pathway and molecula...
GSE112033: Parabiosis and single-cell RNA-Sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis
Fibrosis is the common final pathway of virtually all chronic injury to the kidney. While it is well...
GSE125667: Two distinct interstitial macrophage populations coexist across tissues in unique subtissular niches [FACs sorted]
Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation and in ...
GSE123805 (human): Transcriptome of activated human and mouse MAIT cells
We sought to describe in detail the consequences of MAIT cell activation using a transcriptomic appr...
GSE142400: Electronic cigarette exposure disrupts blood-brain barrier integrity, promotes neuroinflammation, and leads to cognitive dysfunction
Electronic cigarette (EC) use has grown substantially since entry into the US market, particularly a...
GSE116482: Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance
The epigenome, including DNA methylation, is stably propagated during mitotic division. However, sin...
GSE125318: Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency
Around implantation, the epiblast transits from nave to primed pluripotency, before giving rise to t...
GSE117798: Circular DNA tumor viruses make circular RNAs
Epstein-Barr virus (EBV) and Kaposis sarcoma herpesvirus (KSHV) cause ~2% of all human cancers. RNa...
GSE129808: Synaptic dysfunction in human neurons with Autism associated deletions in PTCHD1-AS
The Xp22.11 locus that encompasses PTCHD1, DDX53, and the long noncoding RNA (lncRNA) PTCHD1-AS is f...
GSE123468: RNA-seq of FSHD and control immortalised myoblasts II
FSHD myoblasts show a suppression of ESRRA and PPARGC1A during myogenesis SOURCE: Christopher,Raja S...
GSE124024: Serum Reponse of CF1 primary MEFs , E13
The goal of this study was to find the longitudinal transcriptional response of Mouse Embryonic Fibr...
GSE126084: High-throughput sequencing Analysis of mouse BMDM cell Transcriptomes
Purpose: Mouse BMDM is the universal cell type of studying innate immunity.This study was to analyze...
GSE125382: Gene expression profiling of human colon cancer cell lines implanted in colon and liver of mice
RNA was isolated from individual macrodissected tumors 4 weeks post implantation.; The "SAMPLE_ID" s...
GSE113329: Role of TAF5L and TAF6L in controlling the mouse ESC state [RNA-seq]
Self-renewal and pluripotency of the embryonic stem cell (ESC) state is established and maintained b...
GSE112922: Gene expression analyses of GI eosinophils and macrophages from naive colons and intra-tumor
RNA-seq was performed on eosinophlis/macrophages isolated from colons of naive or tumor bearing C57/...
GSE123835: Zika virus antagonizes interferon response in patients and disrupts RIG-I-MAVS interaction through its CARD-TM domains
The emerging threat to global health associated with the Zika virus (ZIKV) epidemics and its link to...
GSE130126: Transcriptome analysis of Riociguat and Vehicle control treatment in human hematopoietic stem and progenitor cells
The goal of this study is to compare differetial gene expressions between Riociguat and Vehicle cont...
GSE123316: Study of the role of IL-12p40-related cytokines in colitis of NEMOIEC-KO mice
Disruption of the epithelial barrier is considered a potential cause of inflammatory bowel disease (...
GSE112393: A comprehensive roadmap of spermatogenesis and testis niche from single-cell RNA-seq
Continuous sperm production is not necessary for the survival of the organism, but is essential to m...
GSE125280: Identify novel TGF--regulated genes by RNA-sequencing from MCF10A cells
TGF- signaling and its induced EMT (Epithelial to mesenchymal transition) play fundamental roles in ...
GSE122305: Dissociating fibrosis from inflammation in systemic sclerosis the case of interleukin-17A
Objectives. Interleukin-17A (IL-17A) levels are increased in SSc skin and other organs but its role ...
GSE112038: A model that cancer cells metastatic competence is determined by their states
A polyclonal mouse model of breast tumor heterogeneity using model cell line 4T1 was developed previ...
GSE73470: Identification of Resistance Genes to BRAF Inhibitor in Melanoma by piggyBac Transposon Activation Mutagenesis Screen
Genotype directed anti-cancer therapies such BRAF inhibitor in BRAF mutant melanoma can show remarka...
GSE125642: RNA-sequencing of human mammary epithelial cells (HMLEs) engineered to express either ER or ER-SOX4 with and without 4-OHT to induce nuclear translocation
Through RNA-sequencing we analysed the differentially expressed genes upon inducible activation of S...
GSE128133: Transcriptome sequencing ofSKA3 knockdown laryngeal squamous cell carcinoma cells
Laryngealsquamous cell carcinoma (LSCC) is a common form of head and neckcancerwith poor prognosis. ...
GSE112022: Control of early B cell development by mRNA N6-methyladenosine
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA (mRN...
GSE123861: Analysis of SIN3A/B functions within HEK293T cells.
Transcription products influenced by decreased SIN3A or SIN3B are analyzed and compared. SOURCE: Gay...
GSE123526: Differentially expressed genes in hematopoietic stem cells after loss of Mettl3
Hematopoietic stem cells (HSCs) maintain balanced self-renewal and differentiation according to phys...
GSE75487: Determination of a comprehensive alternative splicing regulatory network and the combinatorial regulation by key factors during Epithelial-to-Mesenchymal Transition [EMT.time course]
The epithelial to mesenchymal transition (EMT) is an essential biological process during embryonic d...
GSE127251: Transcriptome differences between white and brown adipose tissue from wildtype and uncoupling protein 1 knockout mice exposed to different diets and ambient temperatures
We analyzed transcript abundance in interscapular brown and inguinal white adipose tissue of wildty...
GSE123467: Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model
Background: Activation of microglia, the resident immune cells of the central nervous system, is a p...
GSE112582: Gene expression signature of brown and inguinal white fat of mice kept at 30C vs. 5C
Activation and recruitment of thermogenic cells in human white adipose tissues (browning) can counte...
GSE125015: Translational profiling of proximal tubule in fibrotic kidney
Injury to the proximal tubule plays a central role in the initiation and progression of kidney fibro...
GSE125719: Transcriptomic analysis of LSD1i-sensitive and resistant AML cells
The goal of this study is to identify the molecular mechanisms underlying the resistance/sensitivity...
GSE125301: Inhibition of Phosphoinositide-3-kinase signaling promotes the stem cell state of trophoblast
We found that PI3K inhibition increased the expression of stem cell markers in trophoblast stem cell...
GSE135945: Integrative Epigenomic and Transcriptomic Analysis Reveals Robust Metabolic Switching During Intermittent Fasting in the Brain
Intermittent fasting (IF) is a dietary regimen aimed to restrict energy intake via alternate periods...
GSE124521: MARS Seq data from primary cortical neurons
We analyze gene expression data of Lis1 and MeCP2 mutant mice SOURCE: Orly Reiner (orly.reiner@weizm...
GSE124649: Analysis of mouse lymph node fibroblastic reticular cells (FRC) gene signature during autoimmune inflammation (EAE)
We determined differentially regulated gene expression profile in WT and Il17RA-/- FRC during EAE. g...
GSE126345: Transcriptome analysis of different brain areas in Hcrt gene and Hcrt cell ablated mice
Hypocretin (HCRT) and melanin concentrating hormone (MCH) are brain neuropeptides regulating a wide ...
GSE129821: Shox2 deficiency leads to a unique loss of the palatine process of the maxilla
In order to profile genome-wide effect of Shox2 in regulating osteogenesis in the developing palate,...
GSE114231: Transcriptome Analyses of Loss of Pitx2 Gene Function at Fetal/Neonatal Mouse Muscle
Ablation of the homeobox gene Pitx2 in skeletal muscles resulted in abnormally elevated levels of bl...
GSE128295: UM171 expands distinct types of myeloid and lymphoid progenitors from human pluripotent stem cells.
Overall, our studies revealed that UM171 differentially enriches specific populations of hematopoiet...
GSE123485: Human models of NUP98-KDM5A megakaryocytic leukemia contribute to uncover new biomarkers and therapeutic vulnerabilities
We generated human synthetic models of NUP98-KDM5A leukemia and compared gene expression profiles to...
GSE119697: Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition
The zinc finger CCCTC-binding protein (CTCF) carries out many, at times contradictory, functions in ...
GSE119713: Insulin signaling and reduced glucocorticoid receptor activity attenuate post-prandial gene expression in liver
C57BL/6J mice were subjected to night restricted feeding (ZT12-ZT24) and livers were isolated immedi...
GSE145215: Transcriptional changes in Krt13 knockout mouse tongues
We used RNA-Seq to search for potential downstream effectors of Krt13 during the development of Whit...
GSE125732: Gene expression and whole-transcriptome analysis of heart tissue isolated from mutant transgenic mice after 16 weeks of treatment with AAV9-M7.8L shRNA
Purpose: Assess the effects of the myocardial transcriptional program and off-target delivery or end...
GSE151356: RNAseq anaysis of entorhinal cortex layer II neurons upon Ptbp1 modulation
Purpose: To identify gene expression changes in entorhinal cortex layer II (ECII) neurons upon Ptbp1...
GSE115899: FoxA1 and FoxA2 are required for gastric differentiation in NKX2-1-negative lung adenocarcinoma [total RNA-seq analysis]
Profound changes in cancer cell identity can alter malignant potential and therapeutic response. Lo...
GSE115282: Transcriptional regulation of Th17 differentiation by mitochondrial oxidative phosphorylation
We found that mitochondrial oxidative phosphorylation (OXPHOS) plays a critical role in Th17 lineage...
GSE123950: Chemotherapeutic agent doxorubicin alters uterine gene expression in response to estrogen in ovariectomized CD-1 adult mice
Chemotherapy can potentially impair fertility in premenopausal cancer patients. Female fertility pre...
GSE115904: Unique transcriptional architecture in airway epithelial cells and macrophages shapes distinct responses following influenza virus infection ex vivo.
Airway epithelial cells and macrophages differ markedly in their responses to influenza A virus (IAV...
GSE113027: KLF15-WntDependent Cardiac Reprograming Up-Regulates SHISA3 in the Mammalian Heart
Sustained cardiac stress promotes the transition from an adaptive response to heart failure. Underst...
GSE125725: RNA-seq and ribosome profiling of heat shocked wild type and Mettl14 -/- mouse embryonic stem cells
N6-methyladenosine (m6A) is a dynamic and reversible nucleotide modification in mRNA. m6A alters mRN...
GSE115900: FoxA1 and FoxA2 are required for gastric differentiation in NKX2-1-negative lung adenocarcinoma [single cell analysis]
Profound changes in cancer cell identity can alter malignant potential and therapeutic response. Lo...
GSE114906: Quantitative Analysis of Musashi2-reporter positive and Musashi2-reporter negative KPf/fC pancreatic cancer cell transcriptomes
Purpose: The goal of this study is to compare the transcriptome of pancreatic cancer stem cells (Mus...
GSE140046: Analysis of transcriptome in dorsal hippocampus in response to over-expression of hepatic leukemia factor (Hlf) in dentate gyrus neurons
We report differential gene expression analysis of brain tissue (dorsal hippocampus) in adult mice o...
GSE157008: Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness
Individual cell shape and integrity must precisely be orchestrated during morphogenesis. Here, we de...
GSE124954: Genetic and Behavioural Requirements for Structural Brain Plasticity
Human MRI studies show that experience can lead to changes in the volume of task-specific brain regi...
GSE142432: Tissue neutrophil heterogeneity in germ free mice
Purpose: The goals of this study are to compare bulk RNAseq profiles of tissue neutrophils in germ f...
GSE123484: Loss-of-function of PTPN2 promotes pathogenic loss of FoxP3+ in RORgt+ Tregs [RNA-seq]
Genetic variants at the PTPN2 locus, which encodes the tyrosine phosphatase PTPN2, cause reduced ge...
GSE124063: The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction
Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transi...
GSE135434: Tumour Cell Heterogeneity Instructs Fibroblast Diversity and Reciprocal Signalling [dataset 2]
We investigated changes to murine pancreatic fibroblast gene expression in response to co-culture wi...
GSE125748: Whole transcriptome sequencing of 6.5 d.p.c embryos
Whole transcriptome sequencing of 6.5 d.p.c emrbyos SOURCE: Diana,HP,Low (dlow@imcb.a-star.edu.sg) -...
GSE145246: RNA sequencing LSK cells after Cxxc5 knockdown
To study the effect of knockdown of Cxxc5 on stem/progenitor cells, we used retrovirus to knockdown ...
GSE123345: Tristetraprolin targets Nos2 expression in the colonic epithelium
Tristetraprolin (TTP), encoded by the Zfp36 gene, is a zinc-finger protein that regulates RNA stabil...
GSE136105: Gene expression profiling in lung and breast cancer cells treated by Bloom-specific siRNAs
A549 and MDA-MB-231 cells were transfected with the Bloom-specific siRNA. Total RNA was extracted us...
GSE123815: Developmentally programmed tankyrase activity upregulates -catenin and licenses progression of embryonic genome activation
Embryonic genome activation (EGA) is orchestrated by an intrinsic developmental program initiated du...
GSE124266: TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge [bulk RNA-seq]
TREM2 is a microglial-specific gene implicated in late-onset Alzheimer's Disease (AD). Recent studie...
GSE119701: PHF7 Links H3K4 Methylation to H2A Ubiquitination During Spermiongenesis [RNA-seq]
Histone ubiquitination has been suggested to serve as a tag for nucleosome removal during histone-to...
GSE116515: The inner ear heat shock transcriptional signature identifies otoprotective compounds against aminoglycoside ototoxicity
RNA-Seq analysis of adult mouse cultured utricles exposed to 43C heat shock for 30 minutes and recov...
GSE113164: Transcriptional defects and reprogramming barriers in somatic cell nuclear reprogramming as revealed by single-embryo RNA sequencing
Nuclear reprogramming reinstates totipotency or pluripotency in somatic cells by changing their gene...
GSE124089: Malt1 protease is critical in maintaining function of Treg cells and may be a therapeutic target for anti-tumor immunity
We report that the paracaspase Malt1 is required for the development and function of Treg cells. By ...
GSE126355: Gene expression analysis of mouse alveolar macrophages and whole-blood from mice with contained Mycobacterium tuberculosis infection
The aim of this study was to measure the impact of contained infection with Mycobacterium tuberculos...
GSE131075: Effect of Omomyc treatment on MYC mediated transcription
Purpose: Identify MYC sensitive enes that are affected by treatment with Omomyc SOURCE: Mark Demma (...
GSE134580: Obesity tuning human Sperm RNA Chromatin remodeler cofactors, RNA interactors, Writers and Erasers
This study was designed to identify the population of sperm RNAs responding to obesity as measured b...
GSE125733: Transcriptomic analysis of frontal fibrosing alopecia
We undertook transcriptome profiling with RNA-sequencing of scalp skin from seven cases of European ...
GSE124395: A Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors
We perfomed single-cell RNA-sequnecing of around 10,000 cells from normal human liver tissue to cons...
GSE119733: RNA-sequencing on sorted tumor-associated macrophages from vehicle or JHU083 pro-drug of 6-Diazo-5-oxo-L-norleucine (glutamine antagonist) treated 4T1 (breast cancer) tumor bearing mice
RNA-sequencing was performed on sorted tumor-associated macrophages (CD45+7AAD-CD11b+F4/80+CD8-Ly6C-...
GSE114555: Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70 [RNA-Seq]
Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions devel...
GSE122383: Epigenome regulation during epidermal lineage commitment [RNA-seq]
Recent advances in human pluripotent stem cell (hPSC) technology provide a unique resource for skin ...
GSE123853: Comparative RNA-Seq transcriptome analyses of diabetic nerve and kidney disease
Treating insulin resistance with pioglitazone normalizes renal function and improves small nerve fib...
GSE126027: Single-cell transcription profiling in KS1 patient iPSCs and NPCs
We conducted single-cell RNA-seq (scRNA-seq) in human-derived induced pluripotent stem cells (iPSCs)...
GSE123582: Intergenerational transmission of the positive effects of physical exercise on brain and cognition
Parental moderate exercise induces positive effects on sedentary litters behavior, and on hippocampa...
GSE113157: Transcriptome comparison between WT and GPS2 liver knockout (LKO) livers and GPS2 NCOR PPARa cistrome and epigenome analysis in livers.
Obesity-associated lipid overload triggers non-alcoholic fatty liver diseases (NAFLD), which in part...
GSE125022: STAT3 Signaling Pathway in Keloid Pathogenesis Implicated by Preliminary Transcriptome and ATAC Analyses
Keloids are wounding-induced fibroproliferative human tumorlike skin scars of complex genetic makeup...
GSE124817: Glucocorticoids Promote Breast Cancer Metastasis
Next Generation Sequencing was applied to investigate the heterogeneity between tumors and distant m...
GSE131089: RNA-sequencing of human lymph node and peripheral blood T follicular helper cells
Total mRNA-sequencing on memory T helper cell populations from human blood and lymph nodes. SOURCE: ...
GSE114036: Chromatin organization in the female brain fluctuates across the estrous cycle
Brain structure and function are sexually dimorphic. As neuroscience research has largely focused on...
GSE123559: Ectopic expression of the homeobox gene Cdx2 in the epiblast
This dataset describes the transcriptomic profiling by mRNA-seq of head tissues of E10.5 control or ...
GSE131099: Synthetic lethal and resistance interactions with BET bromodomain inhibitors [RNA-Seq]
BET bromodomain inhibitors (BBDI) are promising therapeutic agents in triple-negative breast cancer ...
GSE115462 (mouse): TP63-mediated enhancer reprogramming drives the squamous subtype of pancreatic ductal adenocarcinoma (RNA-seq)
The aberrant expression of squamous lineage markers in pancreatic ductal adenocarcinoma (PDA) has be...
GSE125050: Alzheimer's gene expression by cell type - SFG
AD patients all had Braak stages V or VI, and were also pathologically confirmed to have amyloid pla...
GSE124357: Transcriptome of human keratinocytes with or without HPV16 oncogene expression
We used freshly established immortalized human keratinocytes with a well-defined HPV16 E6 E7 express...
GSE125342: Effect of sodium hydrosulfide on gene expression of intestinal epithelial cells
The transcriptome sequencing was used to study effects of H2S on the intracellular processes in huma...
GSE116478: RNAseq TX1072 WT and HDAC3KO
During development, changes in gene transcription are accompanied by changes in chromatin modificati...
GSE123498: Large-scale Production of Human Liver Organoids with Improved Hepatocyte Differentiation
The establishment of a new method for the expansion of human adult stem cell-derived liver organoids...
GSE123891: EOFAD-causing mutations in psen1 orchestrate dedifferentiation through remodeling of the chromatin landscape in hiPSC-derived neurons [RNA-Seq]
In this work, we used an integrative, multi-omics approach and systems-level analysis to generate a ...