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Autophagy is a highly conserved self-digestion process, essential to maintain homeostasis and viabil...
We generated single-cell RNAseq profiles of 369 microglia (183 from wild type and 186 from Trem2 kno...
PTBP1 and PTBP2 control alternative splicing programs during neuronal development, but the cellular ...
Insults to cellular health cause p53 protein accumulation and loss of p53 function leads to tumorige...
We aimed to identify astroglial transcripts preferentially translated in the neurovascular unit. The...
Nervous systems are composed of numerous cell types, but the extent of cell type diversity is poorly...
Total mRNA seq was perfomed on widtype and Ret null mouse embryonic gut at 2 stages of devlopment- E...
Melanoma genomes are often characterized by large numbers of sunlight-induced mutations. However, ep...
We investigated the effect of an oriental herbal medicine Taeeumjowuitang on phenotype characteristi...
Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associ...
Human thyroid cancer cell line BCPAP was engineered for doxycyclin-mediated inducible expressoin of ...
We performed RNA-seq 72 h after acute deletion of Smarca4 in a line of conditional knockout mouse em...
RNA sequencing and ATAC-seq of conventional NK cells and ILC1s in uninfected mice and mice that were...
In developing mammalian kidney, nephron progenitor cells (NPC) give rise to all cells in mature neph...
The maternal to zygotic transition (MZT) involves the transfer of genome regulation from the oocyte ...
Memory stabilization after learning requires transcriptional and translational regulations in the br...
Using an established mouse model of chronic exposure, previous work by our group had linked preconce...
Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engr...
Using RNA-seq, we report here that BV-2 microglial cells have a distinct transcriptomic signature an...
Despite the fact that the majority of lung cancer deaths are due to metastasis, the molecular mechan...
Discreet defects during prenatal semilunar valve (SLV) development frequently progress to pathologic...
The goal of this study is to analyzed transcriptome changes caused by POLA1 deficiency. Our data rep...
We sequenced mRNA from 6 human cell lines stably over-expressed specific gene or empty vector, and s...
Two 96-well plates per genotype wild type and Myd88 knockout, 4 hour time series in 0.5 hr incremen...
Mutations in methyl-CpG-binding protein 2 (MeCP2), a major epigenetic regulator, are the predominant...
Whole transcriptome for PRMT6 knock-out and control NT2/D1 cells with and without ATRA (all-trans re...
It has widely accepted that 5-methylcytosine is the only form of DNA methylation in mammalian genome...
We report a gene expression changes during development and maturation of the murine utricle SOURCE: ...
Purpose: The goals of this study is to determine the differential expression of transcriptome in car...
Purpose: 5A3+/del mice, which have a heterozygous germ line deletion of a 2-Mb interval of chromosom...
RNAseq is performed (50bp single end reads) on SW480, HT-29, HCT-15, HCT-116, COLO 205, and COLO 320...
We report the pro-leukemic activities of PRMT5 in AML partly via modulating the transcription of key...
The fallopian tube epithelium is one of the potential sources of high-grade serous ovarian cancer (H...
We report the transcriptome profiling (RNAseq) in hepatoblast-derived tumors, without (untreated) or...
We sequenced RNA from Pre-frontal cortex (PFC) and Amygdala from 3-6 month old adult mice. SOURCE: S...
Identification of progenitors populations through FACS in the early limb buds (E10.5 and E11.5) foll...
There is a continuing need for driver strains to enable cell type-specific manipulation in the nervo...
The exogenous expression of master transcription factors (TFs) is a powerful and exciting approach t...
Genetic variation governs protein expression through both transcriptional and post-transcriptional p...
Normal differentiation and induced reprogramming require; the activation of target cell programs and...
We have shown that activin promoted skin tumorigenesis in mice induced by the human papilloma virus ...
De novo mutations in CHD8 are strongly associated with autism spectrum disorder (ASD), however the u...
Aim: Transcriptional analysis of the duodenum of adult Nkx2.2flox/TN;Villin-Cre (TNint) mice versus ...
The rules of engagement between zinc finger transcription factors and DNA have been partly defined ...
Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X ch...
Here we present an RNAseq analysis of human bone samples, obtained from iliac crest needle biopsies,...
The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors s...
The developmental transition to motherhood requires gene expression changes that alter the brain to ...
Tumor progression is associated with an immunosuppressive microenvironment that consists of several ...
Compare transcriptomes from SS18-SSX1 and SS18-SSX2 tumors SOURCE: Kevin,B,Jones (kevin.jones@hci.ut...
Tri-PyMT cell is a breast tumor cell line established from Tri-PyMT (MMTV-PyMT/fsp1-Cre/Rosa26-RGFP)...
Mammalian oogenesis is an intricate and coordinated process involving dramatic changes in the transc...
Purpose: Aim of the study is to identify changes in hepatic gene expression induced by either a 40kc...
Nrf2(A502Y) mutant failed to recognize cis-element required for induction of Nrf2 target genes.To ex...
Using RNA sequencing and de novo transcript assembly, we identified 4516 lncRNAs expressed in 8 diff...
In this work we aim to improve the understanding of the mouse transcriptome complexity, investigate ...
Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are the most common oncogen...
Bone marrow (BM)-derived progenitor cells (BMDPCs) are known to migrate and give rise to endometrial...
Eukaryotic transcription factors (TFs) are key determinants of gene activity, yet they bind only a f...
Small cell carcinomas from different tissues exhibit transcriptional and epigenetic convergence and ...
Gene expression analysis of purified thymopoiesis-initiating progenitors/early thymic progenitors, l...
The inability of the adult mammalian heart to regenerate following injury represents a major barrier...
Background & aims: Polycystic liver disease (PLD) is an autosomal dominantly inherited disorder caus...
Heterogeneous pools of adult neural stem cells (NSCs) contribute to brain maintenance and regenerati...
Using a microfluidic device, circulating epithelial cells (CECs) were enriched from peripheral blood...
Background & Aims: Spasmolytic polypeptide/TFF2-expressing metaplasia (SPEM) is known to emerge foll...
Blood cell formation is a tightly regulated process initiated from a rare population of multipotent ...
The mechanisms underlying enhancer activation and the extent to which enhancer-promoter rewiring con...
Ectopic expression of the double homeodomain transcription factor DUX4 causes facioscapulohumeral mu...
Here we identify the c-kit+ CILP population which generates all ILC subsets including NK cells, and ...
Cancer stem cells (CSC) dictate tumor cell heterogeneity in diverse cancer types and arise, in part,...
Lgr6-positive cells have been shown to label stem/progenitors cells in several tissues including ton...
The Hippo pathway plays an important role in regulating tissue homeostasis, and its effectors YAP an...
Our previous study identified a small molecule, orally active ER-464195-01, inhibits the calreticuli...
Mouse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) exhibit a pluripotent d...
EBNA1 is the EBV-encoded nuclear antigen required for viral episome maintenance during latency. EBN...
Primordial germ cells (PGCs) are fate restricted to differentiate into gametes in vivo. However whe...
The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic cell nucle...
miRNA-1343 is an uncharacterized miRNA predicted to target a number of genes involved in epithelial ...
To assess the impact of AdV-VP55 mediated degredation of host miRNAs on the cellular transcriptome. ...
Polycomb complexes are essential regulators of stem cell identity, yet very little is known about th...
We report a new unsupervised clustering tool for single cell RNA-seq data called SC3. We show that b...
Diurnal oscillations of gene expression are a hallmark of rhythmic physiology across most living org...
Zinc finger and SCAN domain-containing 10 (Zscan10, also known as Zfp206) encodes a transcription fa...
RNA editing is a mutational mechanism that specifically alters the nucleotide content in sets of tra...
Krppel-like factor 4 (KLF4) is a critical regulator of macrophage activation. Here, we report transc...
Rare heterozygous coding variants in the triggering receptor expressed in myeloid cells 2 (TREM2) ge...
Mammary ducts and alveoli are composed of basal and luminal cells, with the fate and differentiation...
We could establish the advanced protocol for generating homogeneous and mature midbrain organoids by...
Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly expressed and mu...
The objective of the experiment is to compare the transcriptomes of LSD1 knockout (KO) and control o...
Examination of PRDM15 binding targets and those of SIN3A in WT vs. Prdm15 KO mESCs SOURCE: Jingxian ...
Cancer stem cells (CSC) dictate tumor cell heterogeneity in diverse cancer types and arise, in part,...
The aim of the study was to analyze the transcriptional profile of Tregs and CD4 Teffectors present ...
The short chain fatty acid (SCFA) receptor (free fatty acid receptor-3; FFAR3) is expressed in pancr...
We investigated how misactivation of the Hedgehog (Hh) pathway causes medulloblastoma, and found tha...
Over 90% of chondroblastomas contain a heterozygous mutation replacing lysine 36 with methionine (K3...
Gene expression analysis of spontenously immortalized mouse submandibular salivary gland epithelial ...
Dose-dependent femoral gene expression was examined following repeated exposure (every 4 days for 28...
RNA-Seq profiling of MCF-7 and MDA-MB-231.; We profiled RNA expression in the estrogen-receptor-posi...