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Sequencing-based assays page 71
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GSE115659: Next generation sequencing on knockdown of AC093323.3 in lung cancer cells
In this study we predict functionally important long intergenic non-coding RNAs (lincRNAs) with a ro...
GSE117134: Dissecting the autonomy of the liver circadian clock
The mammalian circadian clock system is made up of individual cell and tissue clocks that function a...
GSE121276: CDC7 inhibition induces a senescence-like state in Hep3B and Huh7 cells
Purpose: to check senescence gene expression signature in XL413 treated liver cancer cells. Methods:...
GSE120037: Dissection of uniparental reproduction barriers in mice using haploid embryonic stem cells [RNA-Seq]
Uniparental reproduction is widespread among lower vertebrates, but not in mammals. Researchers have...
GSE124694: Arid1a loss drives nonalcoholic steatohepatitis in mice via epigenetic dysregulation of hepatic lipogenesis and fatty acid oxidation
ARID1A, a DNA-binding component of the SWI/SNF ATP-dependent chromatin-remodeling complex, contribut...
GSE119215: The effect of genetic background on cognitive and pathological traits: AD-BXD [dataset 2]
Cg.5XFAD females (MMRRC Stock No #34848-JAX) were bred to males from BXD strains. The resulting F1 p...
GSE115541: Chromatin and tissue plasticity precede commitment to intestinal differentiation during endoderm development
Intestinal differentiation during endoderm development; We used RNA-sequencing to profile gene expre...
GSE117149: Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1.
Macrophages comprise a variety of subsets with diverse biological activity, contributing to tissue h...
GSE121322: Gene expression profiling of wiltype and Ctr1 knockout MEFs with depleted cellular Cu levels
The transition metal Cu is an essential micronutrient in biological systems. The majority of Cu is t...
GSE118656: LXR-dependent gene expression in mouse bone marrow derived macrophages
Bone marrow derived macrophages were isolated from C57BL/6J (LXR positive) and LXRalpha +LXRbeta dou...
GSE124380: Next generation sequencing analysis of transcriptomes in MDA-MB-231 and LM2-4175 cell lines
LM2-4175 cell line was originally selected from MDA-MB-231,but has more aggressive characteristics i...
GSE106797: ASXL2 is recurrently mutated in t(8;21) AML and regulates hematopoietic development [RNA_Seq_Asxl2_knockout]
Chromosomal translocation t(8;21) (q22;q22) leading to generation of oncogenic RUNX1-RUNX1T1 (AML1-E...
GSE117143: UBC9 knockdown in bladder cancer T24 cell lines
UBC9 is the sole conjugating enzyme E2 in the sumoylation and plays a pivotal role in maintaining ho...
GSE116782: A robust qualitative transcriptional signature for the early diagnosis of gastric cancer
Pathological examination of gastroscopy biopsy specimens will make false diagnosis for gastric cance...
GSE122164: CEBPA Dysfunction Intiates CSF3R Mutant Acute Myeloid Leukemia Through Disruption of Myeloid Lineage Enhancers (RNA-seq - simultaneous)
Acute Myeloid Leukemia (AML) develops due to the acquisition of mutations from multiple functional c...
GSE108575: Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and during c...
GSE115687: Domain-focused CRISPR-screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patie...
GSE121137: Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells
In this study we show that ascorbate (vitamin C) shifts the hydroxymethylome and transcriptome in RP...
GSE121621: ZFP90 promotes colorectal carcinogenesis and stemness [RNA-seq]
To elucidate whether ZFP90 plays a role in colorectal cancer tumorigenesis, a RNA-seq analysis was...
GSE122489: Expression data for murine hepatocellular carcinoma in WT and Top1mt-/- mice
Murine hepatocellular carcinoma of similar size were collected from WT and Top1mt-/- livers. Total R...
GSE121343: A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA profiles of mice injected with control, Mafg and LncIRS2 LNA.
Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are re...
GSE107053: Tumor-associated macrophages derived from circulating inflammatory monocytes degrade collagen through cellular uptake
Physiologic turnover of interstitial collagen is mediated by a sequential pathway, in which collagen...
GSE115710: The RNA exosome contributes to gene expression regulation during stem cell differentiation [CAGE]
Gene expression programs change during cellular transitions. It is well established that a network o...
GSE122562: Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity
All types of facioscapulohumeral muscular dystrophy (FSHD) are caused by the aberrant myogenic activ...
GSE117121: To investigate the decay constants (half-lives) of transcript isoforms generated by alternative polyadenylation in proliferating and quiescent cells
Purpose: Alternative polyadenylation (APA) can result in the generation of transcripts that terminat...
GSE111604: Defects in the alternative splicing-dependent regulation of REST cause deafness - [mouse utricles].
The DNA-binding protein REST forms complexes with histone deacetylases (HDACs) to repress neuronal g...
GSE107832: Epigenetic control of transposable elements in the mouse male germ line by Tex15
The piRNA biogenesis was evaluated in the mouse testes lacking TEX15. Total small RNAs, MILI-, and M...
GSE116722: Gene expression, epigenetic modification, and chromatin landscape of skin dermal cells in different body positions [RNA-Seq]
we report that regional expression of the Hoxc genes is regulated by antagonistic switch between rep...
GSE122536: Transcriptomic analysis to functionally map the intrinsically disordered domain of EWS/FLI [Experiment 2]
The purpose of this study was to define unique classes of EWS/FLI target genes and the distinct set ...
GSE121162: The differences in local translatome across distinct neuron types is mediated by both baseline cellular differences and post-transcriptional mechanisms
Local translation in neurites is a phenomenon that enhances spatial segregation of proteins and thei...
GSE111125: Therapeutic effects of Rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor
Statins are efficient in preventing cardiovascular disease progression, but their effects in the abs...
GSE111666: Quantitative Analysis of Neurog2 Heterozygote, Mutant and and Mash1KI Retinal Transcriptomes by RNA Sequencing
To generate an unbiased view of changes to the retinal gene network in Neurog2 retinal mutants as we...
GSE121382: Transcriptome Analysis of CircMRPS35 mediated mRNA expression profiles
Purpose: To explore the mechanism of circMRPS35-mediated suppression of proliferation and invasion i...
GSE115523: The role of Twist1 in mutant huntingtin-induced transcriptional alterations
The role of Twist1 in mutant huntingtin-induced transcriptional alterations SOURCE: Hiroko Yano (yan...
GSE108057: Lysosomal signaling licenses embryonic stem cell differentiation via inactivation of Tfe3
Self-renewal and differentiation of pluripotent murine embryonic stem cells (ESCs) is regulated by e...
GSE115495: Macrophage responses to MDR M.tuberculosis infection
The emergence of multidrug resistant (MDR) Mycobacterium tuberculosis (Mtb) strains, resistant to th...
GSE117942: RNA-seq of breast cancer cell lines post ligand treatment I
Goal: study the impact of estrogen receptor ligands on gene expression in HR+ breast cancer cells; M...
GSE122761: Acetylation of spliceosome protein PHF5A modulates stress responses and colorectal carcinogenesis through alternative splicing mediated upregulation of KDM3A
The process utilized by cancer cells for adapting to cellular stress is a key point for carcinogenes...
GSE115758: Loss of Sirt2 increase and prolongs a chemically induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mouse
Transcriptome analysis by RNA-seq in pancreas identified 529 differentially expressed genes between ...
GSE115526: Molecular profiling of reticular gigantocellularis neurons
we used technique that allows the molecular characterization of particular neuronal subpopulations b...
GSE120073: Lung adenocarcinoma UNC0638 gene expression
Experiment was to determine the effects of G9a inhibition using chemical inhibitor UNC0638 on murine...
GSE117225: Single cell RNA sequencing of primary-isolated erythroid progenitors [BFUE & CFUE]
single cell RNA sequencing of freshly isolated mouse burst forming unit-erythroid (BFU-E) and colony...
GSE132538: Dissecting the regulatory strategies of NFkB RelA target genes in the inflammatory response reveals differential transactivation logics [MEF]
NFkB RelA is the potent transcriptional activator of inflammatory response genes. We stringently def...
GSE115550: Spatially Constrained Tandem Bromodomain Inhibition Bolsters Sustained Repression of BRD4 Transcriptional Activity for TNBC Cell Growth
We performed RNA-seq of MDA-MB-231 cells that were treated with MS645 or JQ1 at 50 nM and 500 nM in ...
GSE116773: Analysis of Notch2 conditional knockout (CKO) and wild type mouse hippocampal stem cells
Regulated genes downsteam of Notch2; Methods: mRNA profiles of adult wild type and Notch2 CKO neural...
GSE130054: Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
The maintenance of genetic integrity is critical for stem cells to ensure homeostasis and regenerati...
GSE115739: Role of GATA in DN3 stage thymocytes
RNA-seq in DN3 stage thymocytes isolated from wild type and Gata3 hypomorphic mutant mouse SOURCE: T...
GSE112352: Gene expression profiling of the olfactory tissues from sex-separated and sex-combined female and male mice
We sought to investigate the scope of cellular and molecular changes within a mouses olfactory syste...
GSE114963: RNA-seq profiling of mouse embryonic fibroblasts treated with WM-2474 or DMSO
Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization ...
GSE115730: Mitofusins Regulate Lipid Metabolism to Mediate the Development of Lung Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a devastating chronic lung disease, where lung function decli...
GSE115916: Genetic Background and Gender Influent Salt-Evoked Hypertension in Prostacyclin Receptor-Deficient and Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice
Background- Inhibitors of microsomal prostaglandin E synthase-1 (mPges-1) are in the early phase of ...
GSE121355: A pliable mediator acts as a functional, rather than an architectural bridge, between promoters and enhancers
Our mechanistic understanding of Mediator derives largely from studies of the 25-subunit yeast compl...
GSE107152: Haematopoetic RNA-seq from ultra low input
The correct balance between self-renewal and differentiation of hematopoietic stem cells (HSC) is or...
GSE135985: Acquisition of a unique mesenchymal precursor-like blastema state underlies successful adult mammalian digit tip regeneration
Here, we investigate the origin and nature of blastema cells that regenerate the adult murine digit ...
GSE116155: Transcriptome of day 6 EBs [WT, hWDR5iRescue,Wdr5 KO clone #3 with or without early (T12h) and late rescue (T48h)]
This study describes the transcriptome profiling of day 6 SFEBq embryonic bodies (EBs): 1) WT; 2) Wd...
GSE119549: mRNA-seq of bypass grafts in mice, utilizing the vena cava as carotid artery bypass graft
Surgical interventions on blood vessels bear a risk for intimal hyperplasia and atherosclerosis as a...
GSE107180: Comprehensive analysis of Long non-coding RNA expression in dorsal root ganglion reveals cell type specificity and dysregulation following nerve injury [rodent DRG]
Dorsal root ganglion (DRG) neurons provide connectivity between peripheral tissues and spinal cord. ...
GSE115522: Transcriptional dysregulation in a primary cortical neuron model of Huntington's disease
Transcriptional dysregulation in a primary cortical neuron model of Huntington's disease SOURCE: Hir...
GSE120012: RNA-seq expression profiling of cardiac macrophages and splenic monocytes from nave and CAWS challenged mice
The adult heart contains macrophages derived from both embryonic and adult bone-marrow derived precu...
GSE107153: Single-cell RNA from Haematopoetic progenitor cells
The correct balance between self-renewal and differentiation of hematopoietic stem cells (HSC) is or...
GSE115487: CXCL4 links inflammation and fibrosis through transcriptional and epigenetic reprogramming of inflammatory monocyte-derived cells [RNA-seq]
Fibrosis is a condition shared by numerous inflammatory diseases. The molecular mechanisms underlyin...
GSE117976: Optic atrophy 1 controls human neuronal development by preventing aberrant nuclear DNA methylation
Gene expression analysis was performed to investigate the role of OPA1 in human neuronal development...
GSE115743: GATA3 abundance is a critical determinant of T cell receptor beta allelic exclusion [GATA3 overexpression]
RNA-seq in DN3a stage thymocytes isolated from wild type and GATA3 overexpression Tg mouse SOURCE: T...
GSE119952: Profiling of tumor-associated macrophages (TAM) after anti-MerTK treatment
RNA was isolated from purified TAMs from MC-38 tumor-bearing mice after 24 hours of anti-MerTK singl...
GSE120269: Interleukin-1 induces mitochondrial DAMP production to activate STING-dependent innate immune programs
Here we report that exogenous IL-1 induces TBK1-mediated interferon regulatory factor 3 (IRF3) activ...
GSE107705: iRhom2 Promotes Lupus Nephritis through ADAM17-Dependent TNF- and EGFR Signaling
Lupus nephritis (LN) often results in progressive renal dysfunction. The inactive Rhomboid 2 (iRhom2...
GSE109395: Xist RNA antagonizes the chromatin remodeler, BRG1, from the inactive X chromosome
The noncoding Xist RNA recruits silencing factors to the inactive X (Xi) and facilitates re-organiza...
GSE122116: Molecular characterisation of muscle and spinal cord tissues from young, old and old exercised C57BL/6 wild type male mice
To investigate the effect of exercise in several tissues, mice had free access to the wheel for two ...
GSE119970: RNA-seq of three Ewing sarcoma cell lines (A673, SK-N-MC, RDES), transfected with either siControl or siMYBL2.
Deciphering principles of inter-individual tumor heterogeneity is essential for refinement of person...
GSE115497: Interferon Regulatory Factor 8 (IRF8) Deficiency Promotes Osteoclast Transcriptional Program
Irf8 functions as negative regulator of osteoclastogenesis. Genetic deletion of Irf8 in mice results...
GSE110614: Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade
Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryo...
GSE117972: Developmentally regulated isoform of HNF4 reprograms the adult liver
Hepatocyte Nuclear Factor 4 (HNF4), master regulator of hepatocyte differentiation, is regulated by ...
GSE137964: Genome-wide transcriptome analysis of organotypic rafts derived from human papillomavirus type 16 infected primary keratinocytes [3D raft]
HPV alters the host transcriptional program to establish infection and complete its lifecycle. Infec...
GSE117155 (mouse): LEDGF and HDGF2, histone H3K36 methyl-binding proteins that assist RNA polymerase II transcription through nucleosomes
FACT (facilitates chromatin transcription) is a protein complex that allows RNAPII to overcome the n...
GSE113811: Single cell RNAseq of Wild Type and IL27ra KO Tumor infiltrating lymphocytes isolated from B16F10 melanoma batch 5
Expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechani...
GSE120162: TFIIIC binding to Alu elements controls gene expression via chromatin looping and histone acetylation
How repetitive elements, epigenetic modifications and architectural proteins interact ensuring prope...
GSE120225: Channelopathy pathogenesis in a human neural cell model of Angelman Syndrome
Angelman syndrome (AS) is a neurogenetic developmental disorder that results from the loss of E3 ubi...
GSE122401: Proteogenomic characterization of human early-onset gastric cancer
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young population. Phosphoproteo...
GSE119564: Zfp217 orchestrates m6A mRNA methylation and gene expression to promote adipogenic differentiation
We performed RNA sequencing (RNA-seq) and m6A methylated RNA immunoprecipitation sequencing (MeRIP-s...
GSE117978: Erythro-myeloid progenitors contribute endothelial cells to developing blood vessels
The earliest blood vessels in the mammalian embryo are formed when endothelial cells (ECs) different...
GSE121626: Overexpression of UGT2B17 in MEC1 and JVM2 leukemia cell lines
UGT2B17 is a recently identified molecular marker for poor prognosis in Chronic Lymphocytic Leukemia...
GSE133749: Human pulmonary artery endothelial cells (hPAECs) with downregulated BMPR2 signaling demonstrate a unique gene expression signature after exposure to overexpression of AdAlox5
Bmpr2 mutations are critical risk factors for hereditary pulmonary arterial hypertension (hPAH) with...
GSE122424: Gene expression in p75NTR knockout mouse liver
Comparison of gene expression patterns in liver of wildtype and p75NTR knockout mice SOURCE: Dan Lin...
GSE120573: Cardiac Glucocorticoid Receptor Transcriptome Profiling in normal and cardiomyocyte-specific GRKO males and females
We report the cardiac glucocorticoid receptor transcriptome is sexually dimorphic SOURCE: John Cidl...
GSE108609: RNA Sequencing Analysis of Control and Blnc1 liver specific knockout mice (LKO) Liver Transcriptomes after 24 weeks NASH diet feeding
Hepatic lipogenesis is a central aspect of the feeding response and is aberrantly induced in the pro...
GSE155412: RNA-Seq of UXT KO in Primary Sertoli cells
We created a knockout model of ART-27(UXT) specially in the Sertoli cells of the mouse testes. In or...
GSE114962: RNA-seq profiling of a mouse B cell lymphoma cell line treated with the KAT6A/B inhibitor WM-1119
Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization ...
GSE121410: Resident Macrophages Reprogram Toward a Developmental State After Acute Kidney Injury
Background Acute kidney injury (AKI) is a devastating clinical condition affecting at least two-thi...
GSE122441: Increased expression of cytokine receptor Ccr2 is a hallmark of the aged mouse intestine epithelium
We characterize changes in gene expression during late ageing in intestinal epithelium-derived cells...
GSE136062: Gene expression changes in adult mammary fibroblasts followin in utero BPA exposure
Mammary fibroblasts (CD1 strain of mouse) that were exposed to BPA or oil control in utero were isol...
GSE108106: RNA sequence on the fed and fasted state of kidneys in mice
We studied whether the accumulation of lipids in the fasted kidney are derived from lipoproteins or ...
GSE122781: RNA sequencing of mutant AKT tumors
Goal: Comparison of mRNA expression profiles in primary tumors based on activation of different AKT ...
GSE117156: Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma
Multiple myeloma (MM), a plasma cell (PC) malignancy, is the second most common blood cancer. Despit...
GSE107711: Revealing cellular and molecular transitions in neonatal germ cell differentiation using Single-cell RNA sequencing
Neonatal germ cell development provides the foundation of spermatogenesis. However, a systematic und...
GSE122828: Comparison of NK cells and ILC1 in lean versus obese mouse livers by RNASeq
Mice were weaned onto standard RM1 diet or onto a highly palatable obesogenic diet (824018 45% AFE ...
GSE107293: TREM2 haploinsufficiency impairs microglias response to injury and exacerbates tau pathology in a tauopathy mouse model [RNA-Seq]
Alzheimer's disease (AD), the most common form of dementia, is characterized by the abnormal accumul...
GSE115760: Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21 (RNA-Seq)
PARP inhibitors (PARPi) prevent cancer cell growth by inducing synthetic lethality with DNA repair d...
GSE140576: Plag1 in the mouse Epididymis
RNA sequencing of Plag1 mouse epididymides. 5 each of Plag1 WT, HET and KO whole epididymis tissues ...
GSE107470: Fenofibrate Prevents Skeletal Muscle Loss in Mice with Lung Cancer
The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by the cataboli...
GSE132711: Endometrial transcriptome and PGR cistrome in cycling fertile women [RNA-seq]
We report the transcriptomic profile and PGR cistromic profile for endometrial biopsies obtained fro...