Explore curated data sets and assays
Pluto has a large database of published data, available to explore, conduct your own analysis, and view QC reports.
Talk to our team for access
Sequencing-based assays page 31
Store large, raw sequencing data files and transform them into biologically-meaningful results in your browser. Gain critical QC information, quantify targets within and across data sets, and run best-in-class computational biology analyses specific to each assay type.
GSE84357: RNA-seq of Asxl2 KO LSK cells
The goals of this study are to compare transcriptome profiling (RNA-seq) of Asxl2 KO LSK cells to th...
GSE66377: Disruptions of Topological Chromatin Domains Causes Pathogenic Rewiring of Gene-Enhancer Interactions [RNA-Seq]
Mammalian genomes are organized into megabase-scale topologically associated domains (TADs) that hav...
GSE62804: An siRNA screen identifies CHD4 as a target for epigenetic therapy
AIM: We performed RNA-sequencing experiments seeking genes whose expression changed after siCHD4 tre...
GSE128928: Spinal cord RNA-seq
RNA-seq with male and female juvenile and adult spinal cords SOURCE: Megan Wilson (meganj.wilson@ota...
GSE67528: Evidence for proliferation and synaptogenesis impairments in neural cells derived from idiopathic autistic patients
Reprogramming of human somatic cells to a pluripotent state (induced pluripotent stem cells or iPSC)...
GSE63265: Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphoma
Aggressive double and triple hit (DH/TH) DLBCL feature activation of Hsp90 stress pathways. Herein,...
GSE69731: Determination of astrocyte transcripts regulated by neuronal contact
We co-cultured P0 TdTomato-expressing hippocampal neurons with wild type cortical astrocytes for 2, ...
GSE63078: Epigenetic stability in the adult cortex is counterbalanced by the expression of long non-coding RNA
Adult neural tissue was treated with an HDAC inhibitor, TSA to assess changes in gene expression, wh...
GSE126925 (mouse): The transcription factor IRF4 plays a critical role in plasma cell identity and function
IRF4 regulates the plasma cell signature but also regulates plasma cell metabolism SOURCE: Wei Shi (...
GSE58523: Embryonic stem cell-derived cerebral cortex largely reproduces the in vivo epigenetic control of imprinted gene expression [RNA-seq]
In vitro differentiation of embryonic stem cells (ESC) provides models that reproduce in vivo develo...
GSE62936: RNA-Seq Analysis in hES/ iPS cell-derived neuronal samples
We characterized the gene expression by Hierarchical Clustering and one-matrix clustering in hESC, d...
GSE62889: Genome-wide expression profile of the Tet-On HCT116 inducible cell line that express either the human HNF42 or HNF48 under control of Doxycycline (DOX) [RNAseq]
Purpose: Aim of the study is to identify functional differences between the P1 and P2-HNF4 isoforms....
GSE60238: The RNA-binding protein Sfpq regulates long neuronal genes in transcriptional elongation [RNA-seq, rRNA-depleted]
Mammalian neurons express extra-long pre-mRNAs which are vulnerable to misregualtion of transcriptio...
GSE77624: Expression profiling by high throughput sequencing of tumors derived from human prostate epithelial cells transformed with the oncogenes N-Myc and myrAKT1.
MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, ...
GSE63576: Somatosensory Neuron Types Identified by High-Coverage Single-Cell RNA-Sequencing and Functional Heterogeneity
Sensory neurons are distinguished by distinct signaling networks and receptive characteristics. Thus...
GSE63555: miR-191 regulates human cell proliferation and directly targets multiple oncogenes
We constructed a genome wide target profile of hsa-miR-191 by sequencing RNA isolated from Ago2 immu...
GSE61656: Coding mutations and loss-of-imprinting in human pluripotent cells derived by nuclear transfer and defined factors [RNA-Seq]
Human pluripotent stem cells can be derived from somatic cells by forced expression of defined facto...
GSE78728: Analysis of gene expression changes in early mouse embryos lacking Tgif1 and Tgif2
We report the differences in gene expression between wild type and Tgif1;Tgif2 double null mouse emb...
GSE151949: GDNF drives rapid tubule morphogenesis in novel 3D in vitro model for ADPKD [GDNF RNAseq]
We report a significant change in epithelial differentiation pathways and principal cell specific tr...
GSE62074: Mutation independent activation of the Notch pathway is associated with Lapatinib resistance in Her2+ breast cancer cell lines
We compared untreated HCC1419 cells with Lapatinib resistant HCC1419 cells that were either treated ...
GSE63137: Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain
We developed an affinity purification approach to isolate tagged nuclei in mice (similar to INTACT; ...
GSE128402: Transcriptomic analysis of intervertebral discs isolated from wild type and Adgrg6-deficient mice
Purpose: Degenerative changes of the intervertebral disc are a leading cause of back pain and disabi...
GSE63751: Next Generation Sequencing Facilitates Quantitative Analysis of Bone Marrow Macrophages and Spleenic Macrophages Transcriptomes in mouse T cell acute lymphoblastic leukemia
The goals of this study aim to reveal functional and phenotypic diversity of leukemia-associated mac...
GSE59571: Striatal genes regulated by super-enhancers and displaying low paused RNAPII are preferentially down-regulated in Huntingtons disease [RNA-seq]
Huntington neurodegenerative disease (HD) is associated with extensive down-regulation of neuronal g...
GSE63764: A novel lncRNA GAS1 promotes gastric carcinogenesis and acts as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern [RNA-seq]
To elucidate whether GAS1 plays a role in gastric cancer tumorigenesis, a RNA-seq analysis was perfo...
GSE78772: Next Generation Sequencing Facilitates Comparison of Long-Term Cultured Nephron Progenitor Cells with Their Cognate Primary Cells
Purpose: Nephron progenitor cells generate nephrons, the basic units of kidney. We developed methods...
GSE59073: Identification of epigenetic barrier that prevents reprogramming in somatic cell nuclear transfer
Mammalian oocytes can reprogram somatic cells into totipotent state, which allows animal cloning thr...
GSE137204: Impact Of Oil Spill To Human Lung Health Next Generation Sequencing And Mouse Model Based Analysis
This project addresses the question of impact of oil spills on lung health. Specifically the project...
GSE61999: RNA-sequencing of the GSI treatment of the CUTLL1 cell line
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of onc...
GSE94975: Differential gene expression in IDH1-R132H Low Grade Glioma animal brain tumors brain in response to 10 Gy of radiation
IDH1-R132H is expressed in Low Grade Glioma (LGG) in combination with loss of function mutation in A...
GSE62207: Ileal immune maturation in Pediatric Crohn's Disease
We report the global pattern of ileal gene expression in a cohort of 310 treatment-nave pediatric Cr...
GSE67363: Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.
We report that Dnmt1 is crucial during perinatal intestinal development. Loss of Dnmt1 in intervillu...
GSE99737: Platelet Transcriptome Profiling in HIV and ABCC4 as a Biomarker of Platelet Activity
The purpose of this study was to perform an unbiased RNA expression profile in platelets from HIV su...
GSE55385: Systematic analysis of the pro and anti-inflammatory activation of mouse myeloid cells
Inflammation is a fundamental physiological process and a key line of defense against pathogen invas...
GSE94579: Embryonic stem cells-derived neural progenitor cells
J14 ES cells differentiated into MGE-like cells.; Three groups of single-cell preparations were anal...
GSE71294: Cell type-specific HITS-CLIP reveals differential RNA processing in motor neurons
We report cell type specific Nova HITS-CLIP using BAC-transgenic lines expressing GFP-Nova under the...
GSE63816: Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome
Somatic mutations in the spliceosome gene ZRSR2 located on the X chromosome are associated with mye...
GSE61969: Gene expression alterations in Dnmt3aKO/FLT3-ITD leukemia
We assessed global gene expression profiles in two mouse models of oncogenic FLT3-driven leukemia in...
GSE66216: Nucleosome dynamics in human colorectal cancer specimens reveal activation of a CNOT3-regulated pathway of embryonic stem cell self-renewal
Temporal chromatin dynamics can reveal transcriptional determinants of cell differentiation, and we ...
GSE70657: Single cell global gene profiling reveals molecular and functional platelet bias of aged hematopoietic stem cells
Single cell whole transcriptome analysis of young (2-3 months) and old (20-25 months) mouse HSCs, d...
GSE72509: SLE lupus RNA-seq
RNA-seq of systemic lupus erythematosus (SLE) whole blood and healthy controls to determine the gene...
GSE62129: HuR- dependent regulation of mRNA splicing is essential for the B cell antibody response [RNA-Seq]
Post-transcriptional regulation of mRNA by the RNA binding protein HuR is required in B cells for th...
GSE69241: Analysis of human, chimpanzee, macaque and mouse tissue transcriptomes using Next Generation Sequencing
We performed deep strand-specific sequencing of poly-adenylated RNA (polyA+ RNAseq) from human, chim...
GSE62669: Cosplicing network analysis of mammalian brain RNA-Seq data using WGCNA and Mantel correlations
Gene network analysis aims to understand how large groups of genes coordinate their activity to supp...
GSE126559: 16p11.2 Reciprocal Genomic Disorder Tissue-Specific Mouse Molecular Signatures
Transcriptome analyses of 16p11.2 reciprocal genomic disorder (RGD) deletion and wild type mouse acr...
GSE60367: CXCL12/CXCR4 signaling mediates niche occupancy and tumor maintenance in T-cell leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized ...
GSE76419: Dino-dependent gene expression signature in MEFs
Genetically modified Dino mice were generated with loxP sites flanking the mouse Dino gene. We set o...
GSE61996: m6A RNA Methylation is Critical for Adequate Exit from Nave Pluripotency and Execution of Mammalian Development (Ribo-seq)
In this study we identify Mettl3, an m6A RNA modification writer, as a critical regulator for termin...
GSE74966: Genome-wide maps of chromatin changes uppon contextual fear conditioning in mice (RNA-seq)
The ability to form memories is a prerequisite for an organisms behavioural adaptation to environmen...
GSE62659: A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation (RNA-seq)
The transcriptional activator MyoD serves as a master controller of myogenesis. Often in partnership...
GSE103790: Analysis of transcriptional regulation by Myt1 and Myt1l
We report the changes in gene expression in U87 glioblastoma cells with re-introduced Myt1 or Myt1l....
GSE66160: RNA-seq on mouse E11.5 ventral midbrain neurosphere cultures treated with the LXR agonist GW3965 and the GSK3beta inhibitor CT99021
We investigated mechanisms by which LXRs regulate midbrain dopaminergic neuron development. Using a ...
GSE60377: Setdb1 is required for persistence of H3K9me3 and repression of endogenous retroviruses in mouse primordial germ cells
Transcription of endogenous retroviruses (ERVs) is inhibited by de novo DNA methylation during gamet...
GSE63818: The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells
Germ cells are vital for transmitting genetic information from one generation to the next and for ma...
GSE62854: PER2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells
Implantation is dependent on synchronized interactions between the conceptus and surrounding decidua...
GSE63268: Effects of narciclasine treatment on major metabolic organs of C57BL/6 mice
To test the effects of narciclasine treatment on major metabolic organs of C57BL/6 mice, we first fe...
GSE66117: Transcriptome analysis in chronic lymphocytic leukemia cells using RNA sequencing (RNA-seq)
Chronic lymphocytic leukemia (CLL) is a biologically and clinically heterogeneous disease. The somat...
GSE142417: Interleukin-11 signaling drives vascular smooth muscle phenotypic switching and contributes to aortic remodelling
RNA sequencing of primary human aortic or arterial VSMCs after stimulation with transforming growth ...
GSE86110: Roquin suppresses PI3K-mTOR signaling to control T cell differentiation and Treg effector function
Roquin proteins are required to preclude spontaneous T cell activation and aberrant T follicular hel...
GSE60415: The G-protein Alpha Subunit Gs Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma [RNA-Seq]
Medulloblastoma, the most common malignant pediatric brain tumor, is highly heterogeneous with disti...
GSE66202: Intrinsic age-dependent changes and cell-cell contacts regulate nephron progenitor lifespan
Purpose: To use single-cell RNA-Seq analysis of nephron progenitors in order to determine transcrpti...
GSE60426 (mouse): mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues (sequencing)
MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational repression and mRNA ...
GSE63392: RNA-Seq of cKIT+ sorted cells from 53-137 day old fetal testes and ovaries and RNA-Seq of TRA-1-81+ H1 and UCLA1 hESCs.
We performed RNA-Seq analyses on 15 human fetal samples at 53-137 days of development, 9 female and ...
GSE63271: A Novel Neuron-specific Histone H4K20 Demethylase LSD1n Promotes Transcriptional Elongation and is Essential for Learning and Memory
LSD1n regulates transcriptional elongation by removing H4K20 methylation. SOURCE: Yuliang Tan (yut02...
GSE63863: Promoter hypermethylation of TERT is associated with hepatocellular carcinoma in the Han Chinese population
A recent study by Castelo-Branco, P., et al. Methylation of the TERT promoter and risk stratificatio...
GSE151956: RNA-seq analysis of mouse retinas from animals treated with 140mg/kg/day Vigabatrin
The goal of this study was to look at the effects of the anti epeleptic drug Vigabatrin on retinal t...
GSE64367: Epigenomic profiling reveals the key function of histone H3K9 methylation during tumor transformation process
To understand transcriptome and epigenome profilings alteration during breast cancer initiation and ...
GSE67478: RNA-seq expression profiling of murine inner-ear hair cells
Sensorineural hearing loss affects the majority of the elderly population. Mammalian hair cells (HC...
GSE72536: Gene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumours.
Purpose: Human papilloma virus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a ...
GSE60538: Sox5 and Sox6 direct a cardiac adaptive response to pressure overload
Rationale: We previously demonstrated that the transcription factor Sox6 regulates skeletal muscle b...
GSE128666: Gene expression analysis of primary mouse prostate organoid culture with overexpression of FOXA1
Gene expression analysis of primary mouse prostate organoid culture with overexpression of FOXA1 SOU...
GSE63348: Expression Analysis of Normal and Neoplastic Mouse Pancreatic Ductal Organoids
This study used Illumina strand-specific, paired-end RNA-sequencing to examine gene expression diffe...
GSE63091: Transcriptome-wide modulation of splicing by the exon junction complex
We report that knockdown of EJC core proteins, eIF4A3, Y14, Magoh, causes a transcript-wide changes ...
GSE63316: Whole-transcriptome analysis of endothelial-to-hematopoietic stem cell transition
Hematopoietic stem cells (HSCs) are generated via a natural transdifferentiation process known as en...
GSE63397: Ets homologous factor regulates pathways controlling response to injury in Calu-3 airway epithelial cells [RNA-seq]
Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell ...
GSE125500: Identifying Tumor Progression by Genome-Wide Characterization of Immature Myeloid Cells In the Peripheral Blood
characterize the molecular signature of PB-IMC in different stages of tumor development, thus possib...
GSE60556: From mouse to humans: detecting preventing vaccination targets associated to melanoma cancer stem cells. Gene-level analysis: B16
The efficacy of cancer treatments has improved constantly in the last decade. However, therapeutic r...
GSE131396: Systematic evaluation of RNA-Seq preparation protocol performance (RNASeq: SMARTer)
In this study, we present a comprehensive evaluation of four RNA-Seq library preparation methods. We...
GSE63234: Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (2)
DNA methylation is thought to induce a transcriptional silencing through the combination of two mech...
GSE60955 (mouse): The metabolome regulates the epigenetic landscape during naive to primed human embryonic stem cell transition
We performed mRNA-seq and small RNA-seq on the newly derived ELF human nave pluripotent stem cell li...
GSE81484: Gene expression profiling study by RNA-seq for identifying genes associated with epithelial-mesenchymal transition and acquired resistance to ALK inhibitors
Treatment with ALK tyrosine kinase inhibitors often elicits profound initial antitumor responses in ...
GSE126618: Whsc1 controls mesendodermal transcription factor expression
We report here chromatin related factor Whsc1 links pluripotency exit and mesendodermal differentiat...
GSE63887: RNA-sequencing of healthy human skeletal myocytes
Skeletal myocytes are metabolically active and susceptible to insulin resistance, thus implicated in...
GSE138487: AML5_DMSO vs UM171
UM171 effect on AML5 cell lines (kinetic) SOURCE: Guy Sauvageau Institute for Research in Immunology...
GSE61845: Cell cycle re-entry of newly born neurons in response to calcium influx
Once generated, neurons are thought to permanently exit the cell cycle and become irreversibly diffe...
GSE74981: Next generation sequencing to elucidate the novel function of RORC (RORgamma) in breast cancer
Exploring the novel role of RORC (RORgamma) in breast cancer, utilizing NEXTseq with genetic gain an...
GSE93554: The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help
Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone (DZ), a...
GSE63935: Human pluripotent stem cell-derived neural constructs for predictive neurotoxicity screening
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential t...
GSE58707: Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation, and platelet formation and function
Sp1 and Sp3 belong to the Specificity proteins (Sp)/Krppel-like transcription factor; family. They a...
GSE99437: AP4 regulates stem and Paneth cell homeostasis and promotes adenoma initiation in the intestine (adenoma)
AP4 is frequently expressed in primary CRCs. However, the in vivo relevance of AP4 for development o...
GSE64317: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma (RNA-Seq)
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated stra...
GSE72524: Effect of Hotair overexpression in human breast cancer cell lines
Study of the transcriptome changes upon Hotair overexpression in wt and Ezh2-/- Human breast cancer ...
GSE65705: Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction.
Recent technological advances have made transcriptome sequencing (RNA-seq) possible in cells with lo...
GSE64379: The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells
Selective genetic ablation of the SIRT1 deacetylase domain in skeletal muscle results in increased H...
GSE103003: Zeb2 regulates the output capacity of the neurogenic V-SVZ in the mouse forebrain.
Using RNA sequencing, this study aims to identify (1) downstream targets and (2) cellular processes ...
GSE66128: The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS
Purpose: Injuries to the adult central nervous system (CNS) often result in permanent disabilities b...
GSE67609: Runx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells
The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1...
GSE66390: The landscape of accessible chromatin in mammalian pre-implantation embryos
In mammals, extensive chromatin reorganization is essential for reprogramming terminally committed g...
GSE64428: Expression profiling of miR-294 and Mbd2 siRNA transfected Dgcr8-/- mESCs by high throughput sequencing
RNA-seq analysis on CTR, miR-294, and siMbd2 transfected Dgcr8-/- ESCs showed that Mbd2 is responsib...
GSE65747: Genome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation [RNA-Seq]
Purpose: The aim of this study is to identify genes that are under the transcriptional control of th...