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Sequencing-based assays page 102
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GSE146150: Dual function of hPSC-derived pericyte-like cells in vascularization and fibrosis-related cardiac tissue remodeling in vitro
In the heart, cardiomyocytes (CMs) are coupled to capillary endothelial cells (EC), mural cells (e.g...
GSE152247: Effects of FOXN1 or AFF4 deficiency on gene expression in the skin
Loss-of-function mutations in Foxn1 or Aff4 cause similar defects in skin morphology. To determine ...
GSE132926: Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells [RNA-Seq]
CD8+cytotoxic T cells play essential roles in anti-tumor immune responses. Here, we performed in viv...
GSE141339: Transcriptional profiling of neurons in the cerebral cortex of a Cbln1-TRAP (NIDA030) mouse line
TRAP translational profiling is a method that allows investigators to genetically characterize speci...
GSE149136: Single cell RNA sequencing of CD42+ and CD42- iHPC in RUNX1 haploinsufficiency
To gain insights into the global and local transcriptomic changes underlying defective production of...
GSE131425: The effects of Arginase 2 (Arg2) knockout on chronic hypoxia-induced pulmonary hypertension
Increased arginase 2 protein expression is associated with endothelial dysfunction and pulmonary hyp...
GSE145871: Maintenance of neural stem cell positional identity by Mixed-lineage leukemia 1
Neural stem cells (NSCs) in the developing and postnatal brain have distinct positional identities t...
GSE135046: RNA sequencing of PIK3CA-WT/WT and PIK3CA-WT/H1047R primary mouse embryonic fibroblasts
Gene targeting was carried out by Taconic Artemis (Cologne, Germany) to introduce a point mutation r...
GSE143844: Rapid and scalable profiling of nascent RNA with fastGRO
We developed a new method to profile nascent RNA in mammalian cells. The new methodology is based on...
GSE146243: Cellular Stress Response Links Nuclear Integrity to Type-I IFN response
RNA_seq analysis for neural progenitor cells (NPCs) SOURCE: Jihye Paik (Jep2025@med.cornell.edu) - ...
GSE149031 (mouse): Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in Multiple Myeloma
We have strong evidence on the essential role of Che-1 protein in promoting the proliferation of MM ...
GSE152342: Genes induced by PDGF-BB in cells lacking Signal Transducer and Activator of Transcription-1 (Stat1)
Comparison of gene expression between Stat1+/- and Stat1-/- dermal fibroblasts or vascular smooth mu...
GSE133230: Extraction of Distinct Cell Types from within a Genetically Continuous Population
The brain is composed of millions of diverse neurons that differ systematically in the genes that th...
GSE154849: The nuclear envelope protein Net39 is essential for nuclear integrity, chromatin organization, and muscle growth (RNA-Seq)
Lamins and transmembrane proteins within the nuclear envelope are regulators of nuclear structure an...
GSE142505: Ventral midbrain-type neural stem/precursor cells (VM-NSCs) derived from human midbrain organoids as a stable source for treating symptoms of Parkinsons disease
In this study, midbrain-like organoids were yielded from hPSCs to prepare cells used for PD therapy....
GSE135282: Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
Wolffs law and the Utah Paradigm of skeletal physiology state that bone architecture adapts to mecha...
GSE141323: A Tissue-Specific Tankyrase Inhibitor Drives Key Developmental and Oncogenic Pathways
Tissue-specific regulation of WNT and YAP/TAZ signaling is critical for optimal organismal growth, d...
GSE152345: Impact of chronic extracellular acidosis on gene expression in mammary and pancreatic cancer cell lines
The study aim was to determine whether the microenvironmental acidosis in solid tumors contributes t...
GSE141503: RUNX transciption factor mediated control of breast cancer stem cells
Cancer stem cells (CSC) are postulated to be capable of initiating tumor formation, growth, and are ...
GSE154921: Bulk RNA-seq of aorta intima resident macrophage from B6, and adventitia macrophages from ApoE-/- mice
Macrophages in atherosclerotic aorta are major population in lesion and contributes to lesion format...
GSE132738: A Stromal Cell Niche Sustains ILC2-Mediated Type-2 Conditioning in Adipose Tissue
Group-2 innate lymphoid cells (ILC2), type-2 cytokines and eosinophils, have all been implicated in ...
GSE133291: Landscape of ribosome-engaged alternative transcript isoforms across neuronal cell classes
The goal of this project was to assess how alternative splicing programs are arrayed across neuronal...
GSE154773: Transcriptome profiling for hidradenitis suppurativa
Hidradenitis Suppurativa (HS) is a debilitating chronic inflammatory disease characterized by chroni...
GSE143995: Clonal Tracking Uncovers Barriers and Validate New Strategies to Enhance Gene Editing in Human Hematopoietic Stem Cells [RNA-seq]
By applying a barcoding strategy to clonal tracking of edited cells (BAR-seq), we show that p53 acti...
GSE145852: Comparative transcriptome analysis of a series of high stepper mutant mice to better understand mutational effect and Rorb function
To better understand the effects of high stepper (hstp) mutations on expression from the Rorb locus,...
GSE151447: Non-canonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen
Non-canonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen...
GSE136855: RNA-Seq transcriptome comparison of microglia and CD11c+ cells sorted from the ischemic brain tissue of parabiotic (female) mice
RNA-Seq transcriptome comparison of the following cell populations (n=3-4 independent samples per ce...
GSE144481: Runx1 negatively regulates inflammatory cytokine production by neutrophilsin response to Toll-like receptor signaling: PMN bulk RNA-seq
RUNX1 is frequently mutated in myeloid and lymphoid malignancies. It has been shown to negatively re...
GSE145797: Conversion of fibroblasts to functional Leydig like cells using defined small molecules
we report that fibroblasts can be efficiently and directly reprogrammed into Leydig-like cells by ex...
GSE139966: FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation
Germ-cell transcription factors control gene networks that regulate primordial follicle formation an...
GSE133074: TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development [RNA-Seq]
The GATA-type zinc-finger transcription factor TRPS1 has been implicated in breast cancer. However, ...
GSE143950: Transcriptome sequencing in patients with tongue cancer
Tongue cancer is one of the most common cancers, and its molecular etiology and pathogenesis remain ...
GSE141375: Quant-seq analysis of differential polyadenylation site usages in caused by different Pol II mutants with slow elongation rates in Flp-In-293 cells and dual inhibition of CDK12 and CDK13 by THZ531 HEK293T cells
We used 3' RNA-Seq to determine the effects of slow elongating Pol II on polyadenatltion site usages...
GSE131536: Lin28-mediated promotion of protein synthesis is critical for neural progenitor cell maintenance and brain development in mice
Neural progenitor cells (NPCs) undergo rapid proliferation during neurulation in early development. ...
GSE141385: Epstein-Barr virus positive gastric cancer involves enhancer activation through ATF3
ATF3 binding sites on the genome and histone modification arround the ATF3 binding sites were analiz...
GSE143860: Next Generation Sequencing of syncytializing first trimester human cytotrophoblasts.
Aim of this study was to monitor differentially expressed gene signatures of human first trimester v...
GSE144585: Transcriptome analysis in primary cell models of HIV latency and cells from HIV-infected ART-suppressed individuals
Comparison of total RNA-seq data from ex vivo unstimulated and stimulated (with anti-CD3/CD28) cells...
GSE145025: Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice [RNA-seq]
The emerging role of epigenetic mechanisms like DNA methylation executed by DNA methyltransferases (...
GSE128913: RNA-Seq of PRMT1 overexpression ECA109 cells
RNA-seq was performed on three biological replicates. Total RNA from ECA109 LV-GFP/LV-PRMT1.Differen...
GSE144010: Cardiac Mesenchymal Cells from Failing Hearts Limit Ventricular Dilation when Administered Late after Infarction
Donor source of cardiac mesenchymal cells influences their expression profile. SOURCE: Steven JonesJ...
GSE141401: Loss of tyrosine kinase receptor Ephb2 impairs proliferation and stem cell activity of spermatogonia in culture
In long-term in vitro culture, we report on gene expression in wild-type adult mouse SSCs compared t...
GSE146239: Glycyrrhizic acid improves cognitive levels of aging mice by regulating T/B cell proliferation
We implemented transcriptomic analyses of blood of 12M mice; These mice with the treatment of Glycyr...
GSE144587: A subpopulation of Periostin-expressing fibroblasts is required for cardiac muscle and neuronal maturation after birth
During the postnatal period in mammals, the cardiac muscle transitions from hyperplasic to hypertrop...
GSE144193: Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells
We report the effects of acute M2-like macrophage enrichment in a mouse closed head injury model of ...
GSE143189: Glioblastoma-derived extracellular vesicles facilitate transformation of astrocytes via reprogramming oncogenic metabolism
Background: Glioblastoma (GBM) may arise from brain astrocytes through a multistep process that occu...
GSE146252: Disrupting mitochondrial copper distribution inhibits leukemic stem cell self-renewal
Leukemic stem cells (LSC) rely on oxidative metabolism and are differentially sensitive to targeting...
GSE141376: Quant-seq analysis of differential gene expression and polyadenylation site usages in caused by inhibition of CDK12 and CDK13 using THZ531 in THP-1 cells (3 Quant-seq)
We used 3' RNA-Seq to determine effect of dual inhibition of CDK12 and CDK13 on gene expression and ...
GSE144996: Determining ribosome-associated mRNA in motor neurons after nerve crush [15NGS-001-rwb]
Determining ribosome-associated mRNA in motor neurons of wild-type adult mice 4 days after unilatera...
GSE144254: APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain.
The application of advanced sequencing technologies and improved mass-spectrometry platforms reveale...
GSE141446: Transcriptomic profiles of host epithelial cells in response to actin rearrangement induced by atypical enteropathogenic Escherichia coli
Atypical enteropathogenic Escherichia coli (aEPEC) is amongst the leading causes of diarrheal diseas...
GSE135482: Expression profiles of long noncoding RNAs and mRNAs in A549 cells infected by Influenza virus
Long noncoding RNAs (lncRNAs) participate in regulating many biological processes. However, their ro...
GSE141453: DLBCL-reminiscent MyD88- or CARD11-mutant aggressive B-cell lymphomas exhibit strong pro-senescent and immune-evasive phenotypes [part2]
Aberrant B-cell receptor (BCR)/NF-kB signaling activity is a prominent feature of diffuse large B-ce...
GSE141773: Wnt / Beta-Catenin signalling controls epiblast self-organization in naive and paused states of pluripotency
ES cells grown in growth factor depleted matrigel could recapitulate the morphogenesis of the epibla...
GSE144009: Single-Cell sequence profile in human cardiomyocytes differentiated from Wt and QKI mutant embryonic stem cells
Transcriptomic profiling of WT and QKI KO hESC derived cardiomyocyte on Day 6 and 15 via Single cell...
GSE142216: Global landscape of RNA editing in hematopoiesis
Adenosine-to-inosine (A-to-I) RNA editing plays a vital role in many biological processes. Our previ...
GSE145886: Engineering a Niche Supporting Hematopoietic Stem Cell Development Using Integrated Single Cell Transcriptomics
Hematopoietic stem cells (HSC) develop from hemogenic endothelium (HE) within embryonic arterial ves...
GSE143975: A novel non-canonical EZH2 function as a box C/D snoRNP assembly factor to facilitate FBL-NOP56 interaction [RNA-seq and Ribo-seq]
Overactivated ribosome biogenesis is a common feature of cancer. However, the underlying molecular m...
GSE141862: Single cell transcriptomics and chromatin accessibility in human fetal microglia
Microglia, the myeloid cells of the central nervous system (CNS), are heterogeneous and exhibit dist...
GSE142223: Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 [Mouse RNA-seq]
DNA methylation is a universal epigenetic mechanism involved in regulation of gene expression and ge...
GSE132886: Identification of IL17RB, CCL21, CXCL12 and CXCL14 as markers for endometrial cell aging.
Aging of uterine endometrium is a critical factor that affects reproductive success, but the mechani...
GSE141536: Transcriptome profile of Primary Human Lung Fibroblasts (Cystic Fibrosis vs. Non-Cystic Fibrosis) arranged in a 3D model of the connective airways tissue
The 3D model of the connective airways tissue was obtained by using a specific bottom up approach of...
GSE144020: Genomic alterations during the in situ to invasive ductal breast carcinoma transition shaped by the immune system
Genomic alterations during the in situ to invasive ductal breast carcinoma transition shaped by the ...
GSE81662: Nuclear Surveillance of long intervening noncoding RNA
Numerous long intervening non-coding RNA (lincRNA) are generated from the mammalian genome by RNA po...
GSE142232: GCGR Loss-of-Function Mutations Promote Amino Acid-Dependent Pancreatic Neuroendocrine Tumor Initiation from a Subpopulation of Alpha Cells [bulk RNA-seq]
Study gene expression changes in alpha cells and tumors from GCGR knockout mice SOURCE: Steffen Duri...
GSE141520: Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes.
Endogenous homeostatic mechanisms can restore normal neuronal function following cocaine-induced neu...
GSE143897: Integrated analysis of ovarian cancer samples to facilitate precision medicine
RNA-sequencing and metabolomic analysis reveal pathways important to drug response and associated wi...
GSE142250: Global evidence for programmed switching of gene expression from astrocytes to neurons in response to PTB depletion
RNA-seq data were generated on replicate samples of isolated astrocytes from mouse cortex or midbrai...
GSE142226 (mouse): Embryonic erythropoiesis and hemoglobin switching require transcriptional repressor ETO2 to modulate chromatin accessibility and looping (RNA-Seq)
ETO2 functions as a transcription repressor and is required for the embryonic erythropoiesis and the...
GSE132894: Genome-wide transcriptomic analysis of CRY2-KO and WT mouse articular cartilage
OBJECTIVES: Abnormal chondrocyte gene expression promotes osteoarthritis (OA) pathogenesis. RNA-sequ...
GSE132223: The expression profiles of GBC liver metastasis
In order to analyze the differential profile of RNAs from patients with liver metastasis. SOURCE: Hu...
GSE141569: Transcriptomes of lung adenocarcinomas
We performed RNA-seq using 19 human surgically-resected lung adenocarcinomas to investigate of diffe...
GSE142233: GCGR Loss-of-Function Mutations Promote Amino Acid-Dependent Pancreatic Neuroendocrine Tumor Initiation from a Subpopulation of Alpha Cells [single-cell RNA-seq]
Evaluating cell subpopulations in mouse pancreatic islets and pancreatic tumors SOURCE: Steffen Duri...
GSE143979: Skeletal muscle regeneration is compromised in advanced diabetic peripheral neuropathy
DPN muscle exhibits features of degeneration with attempted regeneration. In the most severely path...
GSE127001: Age-induced methylmalonic acid accumulation promotes tumor progression
From age 65 onwards, the risk of cancer incidence and associated mortality is substantially higher. ...
GSE142351: Whole blood leukocytes gene expression in human subjects exposed to printing shop particles
This study investigates differential expression in human blood leukocytes, from subjects who work in...
GSE137060: Hltf-deletion activates an IL33/ cell-CD8+T cell axis that triggers neonatal death
Epigenetic silencing of HLTF in human cells alters insulin secretion and is associated with diabete...
GSE143978: Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
We found different expression between glycolytic enzymes and TCA pathway in bone marrow neutrophils ...
GSE141891: Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling
Cell replacement therapies hold great therapeutic potential. Nevertheless, our knowledge of the mech...
GSE145067: SCA17 knock-in mice brain transcriptomes
To identify brain region specific proteins that contribute to brain region specific neurodegeneratio...
GSE128671: Replicational dilution of H3K27me3 in mammalian cells and the role of poised promoters
Differential effect of PRC2 loss on gene repression in intestinal stem cells, transit amplifying cel...
GSE144168: Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach
Background: Blood-retinal barrier cells are known to exhibit a massive phenotypic change during exp...
GSE132948: HyperTRIBE uncovers MSI2 increased RNA binding activity and differential regulation in leukemic stem cells [LSC and LSK]
Understanding RBPs molecular functions as well as their cell-type specific activity requires identif...
GSE141532: Macrophage-Tumor Cell Interaction Promotes ATRT Progression and Chemoresistance (GEMM)
Atypical teratoid/rhabdoid tumors (ATRT) are known for their heterogeneity concerning pathophysiolog...
GSE142064: Zinc-dependent gene expression in neurons upon glutamate stimulation
Zinc (Zn2+) has been increasingly recognized to function as an important neurotransmitter, although ...
GSE142042: Transcriptome analysis of hIPSCs differentiation towards the skeletal muscle and motor neurons lineages
We report the application of RNA sequencing technology for high-throughput expression profiling in h...
GSE136238: EBF1 and PAX5 control pro-B cell expansion via inverse regulation of the c-Myc gene.
EBF1 and PAX5 are two transcription factors targeted in human B-ALL. Their importance for normal B-c...
GSE143932: Gene expression profiles of atrial and ventriclular compartments in mouse embryonic hearts and induced heart organoids
We generated mouse heart organoids from mouse embryonic stem cells. The heart organoids showed both ...
GSE152221: Transcriptional changes during astrocyte maturation in vivo and in culture
Analysis of gene expression during astrocyte differentiation and maturation in vivo and in vitro in ...
GSE141422: Transcriptomic analysis of in-vitro plasma cell generation from follicular B cells lacking Xbp1 [Xbp1_PC_stim]
During plasma cell differentiation there is activation of UPR gene expression that has been termed t...
GSE144231: Next generation sequencing of the mammary gland and pituitary of WT and CXCR2 KO animals in SOPF or conventional conditions
We report the comparison of gene expression in the mammary gland and pituitary of WT Balb and CXCR2 ...
GSE145020: Molecular Mechanisms and Targets of the Cholehepatic Drug, NorUrsodeoxycholic Acid
RNA-seq has been applied to compare the liver gene differentiation between WT mice fed with Chow and...
GSE145746: Integrative omics analyses reveal epigenetic memory in diabetic cells regulating genes associated with kidney dysfunction. [sequencing]
We report novel epigenetic mechanisms of epigenetic memory and its role in regulation of transporter...
GSE134914: RNA-seq Analysis of GPCRs expressed in mouse inguinal white adipocytes (iWAT), epididymal white adipocytes (eWAT) and brown adipose tissues (BAT) after high fat diet treatment.
Purpose: The goals of this study are to identify GPCRs that are endogenously expressed by high fat d...
GSE141507: Maintaining iron homeostasis is the key role of lysosomal acidity for cell proliferation
Purpose: In previous work, we found that iron supplementation to cells rescues impairment of cell vi...
GSE141876: Gene expression comparison, WT and PDAP1-deficient primary B lymphocytes
Class switch recombination (CSR) and somatic hypermutation (SHM) are antibody gene diversification r...
GSE136284: RNAseq of C57BL/6J and C57BL6/J Sarm1-deficient mice to determine if genes surrounding the knockout locus are B6 or 129 sequence
The Toll/IL-1R domain-containing adaptor protein SARM1 is expressed primarily in the brain, where it...
GSE144236: Single Cell and Spatial Analysis of Human Squamous Cell Carcinoma [single-cell RNA-seq]
To define the cellular composition and spatial architecture of the tumor micoenvironment, we combine...
GSE151246: Single-cell analysis of mouse plasmacytoid dendritic cells (pDCs) unravels their activation trajectory and their molecular regulation in vivo during a viral infection [Ss2_pDC1]
The aim of the project is to characterize the heterogeneity of murine plasmacytoid dendritic cells (...
GSE127352: transcriptional profiling of H9 human embronic stem cells (hESC) and hESC derived retinal pigment epithelium (RPE)
RPE was derived from hESC based on the protocol described in Zhu et al. PlosOne. 2013. SOURCE: Seba ...
GSE142504: Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72
To provide further insight into the cellular function of the ALS-linked gene C9ORF72, we performed t...