Explore curated data sets and assays

GSE82180: Genome-wide identification of transcription factor ATOH1 target genes in adult small intestine and colon.

We generated three mRNA expression profiles by RNA-Seq of (i) wild-type crypts, (ii) Atoh1 knockout ...

GSE103303: Fnip1 null kidney versus wildtype kidney RNAseq data

This RNAseq data was generated by comparing kidney tissue from Fnip1 null mice versus Wildtype Mice ...

GSE81251: RNA-seq analysis of Kdm6a deficient brains in mice

Kdm6a is an X-linked histone demethylase that activates gene expression via removal of the repressiv...

GSE91390: Distinct Brca1 mutations differentially reduce hematopoietic stem cell function

Mgbemena et al report that hematopoietic stem cells have an absolute requirement for Brca1 to surviv...

GSE79790: Mapping Gene Expression in Excitatory Neurons During Hippocampal Late-Phase Long-term Potentiation

The long-lasting changes in synaptic connectivity that underlie long-term memory require new RNA and...

GSE86826: Mitochondrial DNA background significantly alters transcriptional response to a various diets in mice

Mutations in the mitochondrial DNA (mtDNA) have been proposed to be essential for metabolic adaptati...

GSE80988: mRNA expression data from human parthenogenetic haploid ESCs (hPGES), normal ESCs (H9) and human fibroblast

Here we report the derivation of human haploid ESCs from parthenogenetic haploid embryos. We used RN...

GSE76123: Role of MPL expression in determining heterogeneity of leukemia-initiating capacity of chronic myelogenous leukemia stem cells

Using a CML mouse model, we identified differences in gene expression between leukemic compared with...

GSE81125: Whole transcriptome analysis of functionally distinct cell types of the jejunal intestinal epithelium of germfree and conventionalized mice [mRNA]

The highly characterized Sox9-EGFP transgenic mouse model, which permits the isolation and analysis ...

GSE83264: Small RNA and mRNA transcriptome profiling in wildtype mice at multiple stages of spermatogenesis, from whole testis at day 1 postpartum (pp), day 3 pp, and day 7 pp and purified leptotene/zygotene and pachytene spermatocytes.

MicroRNAs are essential for spermatogenesis. However, the stagespecific requirements for specific mi...

GSE119772: AP-induced hyperphagia is associated with a unique hypothalamic gene expression signature that is abrogated by adjuvant drug treatment

Antipsychotic-induced hyperphagia is associated with a unique hypothalamic gene expression signature...

GSE77262: RNA-seq of mouse P19 half-life samples upon loss of UPF3A

Gene duplication is a major evolutionary force driving adaptation and speciation, as it allows for t...

GSE98510: RNAseq in mast cells

GSE83315: Memory of inflammation in regulatory T cells

Transcriptome and epigenome of Treg and effector T cells in various activation states. SOURCE: Chris...

GSE83266: The -catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner

In pediatric glioma cell lines, treatment with ICG-001 had no inhibitory effect on canonical Wnt-tar...

GSE82177: Human liver RNA-seq data corresponding to uninfected non-malignant, HCV infected non-malignant, and HCV+ HCC tissue

We aimed to identify epigenetic regulators of transcription that may be involved in the development ...

GSE92572: Thyroid progenitors are robustly derived from embryonic stem cells through transient, developmental stage-specific overexpression of Nkx2-1

The clinical importance of anterior foregut endoderm (AFE) derivatives, such as thyrocytes, has led ...

GSE94263: ATR Mutations Promote the Growth of Melenama Tumor by Modulating the Immune Microenvironment [skin]

Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet the...

GSE80993: Mitochondrial retrograde signaling in mammals is mediated by the transcriptional cofactor GPS2 via direct mitochondria-to-nucleus translocation [RNA-seq]

As most of the mitochondrial proteome is encoded in the nucleus, mitochondrial functions critically ...

GSE84480: PCGF6-PRC1 suppresses premature differentiation of embryonic stem cells by silencing germ cell-related genes [RNA-Seq]

Expression data of ES cells with or without Pcgf6, Ring1A/B, Max and Mga.; Expression data of ES cel...

GSE101628: Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin B in HCT116 cells treated with or without TNF-alpha

We have investigated the effects of CDK8/19 inhibitor Senexin B on NFB-mediated transcription, induc...

GSE81164: RNA Methyltransferase METTL14 Promotes Breast Cancer Growth and Progression

We investigated the role of RNA N6-adenosine methyltransferase protein METTL14 that supports breast ...

GSE105264: Uridilation by TUT4/7 restricts retrotransposition of human Line-1s

Purpose: the goal of this study was to test whether the amounts of genome-encoded Line-1s are influe...

GSE86962: Profiling of CD34+ hair follicle stem cells

RNA was isolated from fluorescence activated cell sorted (FACS) CD49f+/CD34+/GFP- hair follicle stem...

GSE91058: Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice

We sequenced strand-specific rRNA-depleted librairies performed from total RNAs isolated from subcut...

GSE77357: PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells [RNA-Seq]

Mutations in PROP1 are the most common cause of hypopituitarism in humans; therefore, unraveling its...

GSE81091: The global tissue-specific RNA transcription dysregulation effects in the third generation after embryonic exposure to the widely used herbicide atrazine are mediated via inherited histone trimethylation [RNA-Seq]

We report the effect of histone trimethylation on transgenerational inheritance. We exposed outbred ...

GSE113822: mRNA Seq of mouse tissues 9 weeks after RYGB or sham surgery [9 weeks]

In this study we sought to characterize the long tern response to RYGB surgery using diet induced ob...

GSE113764: Transcriptome of human white and brown adipose tissue biopsies

We analyzed coding transcript abundance in paired biopsies of white and brown adipose tissue obtaine...

GSE82000: Transcriptional analysis of rescue of Tfr-mediated B cell suppression with IL-21

Tfh and B cells were cultured together with or without Tfr cells and IL-21. After 4 days Tfh and B ...

GSE85251: Postnatal DNA demethylation and its role in tissue maturation

Development in mammals is accompanied by specific de novo and demethylation events that are thought ...

GSE90827: Transcriptome profiling of Dmrta2 KO neural progenitor cells derived from mouse embryonic stem cells (mESCs)

The goal of this study was to use RNAseq to identify genes that are differentially expressed by cort...

GSE134488: Transcriptomic analysis of the soleus muscle extracted from Dnm2 K562E point-mutant heterozygous mice

RNA sequencing was performed to evaluate the impact of Dnm2 K562E mutation in the soleus muscle. The...

GSE79586: Next generation sequencing facilitates quantitative analysis of changes in mRNA after knock-down of putative master regulators of the breast cancer metastasis transcriptome.

Purpose: To identify regulatory proteins that are potential drivers of a coordinated breast cancer ...

GSE120262: Transcriptome-wide mapping of host mRNA m6A modification to decipher the role of gut microbiome

A recently layer of gene expression regulation is N6-methyladenosine (m6A) mRNA modification. The ro...

GSE84526: RNAseq from Dp16 and control mice

RNA was sequenced from Normal and DP 16 mice to identify consistent changes in gene expression acros...

GSE90047: A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation

How the bi-potential hepatoblasts differentiate into hepatocytes and cholangiocytes remains unclear....

GSE85272: Comparison of the transcription of palmitoylcarnitine induced pluripotent stem cells, normal induced pluripotent stem cells and embryonic stem cells through RNA-seq

We sequenced mRNA from 2 clones of palmitoylcarnitine induced pluripotent stem cells, 2 clones of no...

GSE83314: Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription [RNA-Seq]

gene expression data from 3 pairs of cancer associated fibroblasts and normal fibroblasts from the s...

GSE104490: Clonally expanded CD4+ T cells with a unique gene signature contribute to persistence of the HIV-1 latent reservoir

Surface expression of the viral Envelope protein (Env) was used to enrich reactivated latent T cells...

GSE82204: Genome-wide functional assessment of enhancer activities in the human genome

We illustrate that modifications to the previously published STARR-seq protocols are capable of ass...

GSE84820: Metabolic exhaustion of T cells in chronic infection is mediated by inhibitory receptor PD-1 and T cell receptor dependent transcription factor IRF4

During chronic stimulation T cells acquire an exhausted phenotype characterized by expression of mul...

GSE77691: miRNA regulatory networks in male and female mouse ESC-to-EpiSC differentiation [mRNA]

Early stem cell differentiation programmes are tightly controlled by coordinated pre- and post-trans...

GSE90874: Gene expression and 4sUDRB-seq for NF90/NF110 of human scramble and KD HeLa cells.

We have optimized the metabolic tagging of newly transcribed RNAs by 4-thiouridine (4sU) to identify...

GSE82282: MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

In this setup we have used RNA-seq to define which cAMP-induced genes are dependent on activity of t...

GSE113799: RNA-seq of PC3 prostate cancer cell line xenografts in mice administered the ghrelin receptor antagonist [D-Lys3]-GHRP-6 or PBS for two weeks

The ghrelin receptor antagonist [D-Lys3]-GHRP-6 (or PBS control) was administered for two weeks to N...

GSE84534: A multi-functional AAV-CRISPR-Cas9 and its host response

CRISPR-Cas9 delivery by AAV holds promise for gene therapy but faces critical barriers due to its po...

GSE93006: Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells (OT-I vs P14 RNA-seq)

T cell exhaustion is a progressive loss of effector function and memory potential due to persistent ...

GSE84538: Expression patterns in chronic thromboembolic pulmonary hypertension

We sequenced RNA from pulmonary arteries from CTEPH, IPAH or healthy, failed donors SOURCE: James We...

GSE81530: Development and differentiation of early innate lymphoid progenitors

Early innate lymphoid progenitors (EILP) have recently been identified in the mouse adult bone marro...

GSE84531: RNAseq from disomic and trisomic T cells and monocytes

RNA was sequenced from Disomic and Trisomic individuals for chromosome 21 to identify consistent cha...

GSE126998: Expression data from A2780 cells treated with DMSO, Olaparib(Ola), Palbociclib(PD), and their combination (Ola/PD)

Drug treatment-induced transcriptional changes in A2780 cells. SOURCE: Hailing Cheng (hailingcheng_d...

GSE108975: Von Hippel-Lindau protein is required for optimal alveolar macrophage terminal differentiation, self-renewal and function.

The rapid transit from hypoxia to normoxia in the lung that follows the first breath in newborn mice...

GSE83356: RNA-seq analysis of neonatal mouse cochlear supporting cells [NonTreated_JM]

This study examined transcripts that are enriched in neonatal mouse cochlear supporting cells at pos...

GSE83100: Epigenomic remodeling of the PAX8 cistrome in high grade serous ovarian cancer [RNA-Seq]

We report mapping of the PAX8 cistrome in three high grade serous ovarian cancer cell lines (KURAMOC...

GSE92308: Identification of imprinted gene Grb10 to associate with the pluripotency state in nuclear transfer embryonic stem cells using high throughput sequencing technology

We compared the exactly syngeneic ntESCs and iPSCs with same genomic insertion generated from adipoc...

GSE76748: The Histone Methyltransferases MLL1 and DOT1L Cooperate with Meningioma-1 to Induce AML [Mouse Dot1l ko RNA-seq]

Purpose: To characterize transcriptional changes associated with homozygous inactivation of Dot1l or...

GSE83796: Analysis of gene expression profiles in wild-type vs Ets1-/- follicular B cells

Ets1-/- mice have an increase in B cell differentiation to plasma cells and increased serum immunogl...

GSE129503: TBX5 Adult Knockout Atrial Gene Expression

TBX5 removed from adult mice with R26CreERt2, left and right atrial RNA extracted and sequenced. SOU...

GSE85331: Genome-wide transcriptomic analysis of cardiomyocyte differentiation from human embryonic stem cells and iPS cells (RNA-seq)

In this study, time-course transcriptome profiling of caidiomyocyte differentiation derived from hum...

GSE87038: Single-Cell RNA-seq of Mouse Organogenesis

Using the modified smart-seq2 method for high-parallel single cell transcriptome sequencing on cells...

GSE85340: PNET animal model: new insights (II)

We studied our CNS-PNET animal model to get new insights on the onset of tumor formation SOURCE: Yin...

GSE121022: Gene Expression analysis in prostate cancer cell lines

The goal of the study is to profile the gene expression signatures in prosate cancer models. SOURCE:...

GSE76482: Pancreas lineage allocation and specifciation are regulated by sphingosine-1-phosphate signalling

Identifying the signals that regulate the survival, lineage allocation and specification of pancreas...

GSE84558: Discovery of Novel Determinants of Endothelial Lineage: Insights from Chimeric Heterokaryons

Our study provides a systematic and mechanistic approach for identifying key regulators in directed ...

GSE90869: Transcriptome-wide landscape of subcellular mRNA redistribution in cell stress

In cell stress, mRNA in the cytoplasm is sequestered to the insoluble ribonucleoprotein (RNP) compar...

GSE83132: Genes that mediate leptomeningeal metastasis from breast and lung solid tumor primaries

Little is understood about the gene expression changes that underlie cancer spread to the cerebrospi...

GSE77107: Single-cell RNA-seq of Ecad positive PyMT bulk tumor cells

In this study we studied the presence of tumor cells that underwent epithelial-to-mesenchymal transi...

GSE82073: Next Generation Sequencing of long-term hematopoietic cells (LT-HSCs) with or without mutations in JAK2 and Ezh2

Comparison of mRNA expression profiles of LT-HSCs with or without mutations in JAK2 and Ezh2 by RNA ...

GSE83084: alphaT-catenin in restricted brain cell types and its potential connection to autism

RNA-seq analysis was performed between WT and alphaT-cat KO mouse cerebella aiming to discover gene ...

GSE103362: 4sU-seq analysis for tethering hnRNPK to Xist lacking of XR-PID

Xist lacking of XR-PID (B-repeat and part of C-repeat) can't recruit the polycomb during X chromsom...

GSE82068: Negative allosteric modulation of mGluR5 partially corrects pathophysiology in a mouse model of Rett Syndrome

Rett syndrome is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MECP2), an e...

GSE92522: Transcriptional architecture of synaptic communication delineates cortical GABAergic neuron identity

We sequenced six types of interneurons from adult mouse frontal cortex across multiple library batch...

GSE78274: Transcriptome profiling in knock-in mouse models of Huntington's disease (striatum_mRNA).

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized ...

GSE83474: Biotin tagging of MeCP2 reveals contextual insights into the Rett syndrome transcriptome

Mutations in MECP2 cause Rett syndrome (RTT), a X-linked neurological disorder characterized by the ...

GSE83808: T cells from paroxysmal nocturnal hemoglobinuria patients show an altered TNFR signaling pathway

In order to identify aberrant molecular mechanisms involved in immune targeting of HSCs in bone marr...

GSE83476: Transcriptomic profiling of human coronary artery endothelial cells under laminar shear stress (LS), oscillatory shear stress (OS) and static culture (ST)

Aim: To survey the alteration of endothelial transcriptome under different types of shear stress and...

GSE76504: Transcriptome of IL-13 treated small intestinal tissue in Nod2-/- mice

We previously found that mice deficient in the CD susceptibility gene Nod2 develop small intestinal ...

GSE83809: An essential cell cycle regulator drives chromatin condensation in maturing erythroblasts

We report that Setd8 is essential for murine erythropoeisis. Setd8 null erythroblasts have severe de...

GSE105783: Transcriptional change of HTR8/Svneo cells over expressed with PLAC8-EGFP

The goal of this this project was to study the transcriptional change when PLAC8-EGFP was over expre...

GSE84138: miR-34a and miR-34b/c suppress intestinal tumorigenesis in ApcMin/+ Mice

miR-34a and miR-34b/c genes are frequently epigenetically silenced in primary CRCs. However, the in ...

GSE76776: Satb1 Overexpression Drives Tumor-Promoting Activities In Cancer-Associated Dendritic Cells

Special AT-rich sequence-binding protein-1 (Satb1) governs genome-wide transcriptional programs. Usi...

GSE83712: ILF2 Regulates RNA Splicing of DNA Damage Response Genes to Confer Poor Prognosis in 1q21-Amplified Multiple Myeloma

To understand whether ILF2 is required to ensure the alternative splicing and processing of specific...

GSE76824: DDX5-deficient affect cell fate decision by regulating lineage specific genes and polycomb repressive complexes [RNA-seq]

RNA-binding proteins (RBPs) are involved in a wide variety of regulatory pathways in mammalian cells...

GSE137349 (human): The transcriptomic landscape of MAIT cell development in the thymus (C006 RNAseq data set)

We report the transcriptomic landscape of MAIT cell development by examining thymic immature stage 1...

GSE86907: A novel requirement for Drosha in maintenance of mammalian CG methylation

Using a protein interaction screen, we identify the Microprocessor component Drosha as a novel Dnmt1...

GSE144765: Impact of dioxin exposure and high fat diet feeding on adult mouse islets

Purpose: to determine whether chronic low dose dioxin exposure in adult male and female mice impacts...

GSE86922: Activity of uncleaved caspase-8 controls anti-bacterial immune defense and TLR-induced cytokine production independent of cell death

Caspases regulate cell death programs in response to environmental stresses, including infection and...

GSE83855: Time-restricted feeding shifts the skin circadian clock and alters UVB-induced DNA damage

The epidermis is as a highly regenerative barrier protecting organisms from environmental insults, i...

GSE97101: Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntingtons disease

Huntingtons disease (HD) is an autosomal dominant neurodegenerative disease whose predominant neurop...

GSE86926: Dermal fibroblasts play a central role in skin model protection against C. albicans invasion

This study shows that, in the presence of CD4+ T cells, dermal fibroblasts shift towards an antimicr...

GSE84153: Tpl-2 small molecule project

Tpl-2 is a serine/threonine kinase that has been studied extensively in monocytes. Tpl-2 is believed...

GSE83218: Identification of Sin3B regulated genes in HSCs

We report differences in gene expression between WT and Sin3B KO HSCs. SOURCE: David Cantor (David.C...

GSE83483: RNA-Seq analysis of wild-type and Brpf1-null fetal liver LSK cells

To compare the impact of hematopoietic-specific Brpf1 gene inactivation, LSK (Lin-Sca1+cKit1+) cells...

GSE92488: Systems analysis of hepatic insulin resistance identifies RGS4 as a key mediator of metabolic adaptation

We profiled the transcriptomes of chow diet-fed and high-fat diet-fed mice across insulin stimulatio...

GSE116128: Precardiac Organoids Form Two Heart Fields via Bmp/Wnt Signaling

The discovery of the first heart field (FHF) and the second heart field (SHF) led us to understand h...

GSE84378: A Unique Twist-Dependent Progenitor Cell Contributes to Adult Skeletal Muscle [Tw2 vs Pax7]

Skeletal muscle possesses remarkable regenerative potential due to satellite cells, a stem cell popu...

GSE83226: The FUS protein participates in circRNA biogenesis

The RNA binding protein FUS exerts its function in several RNA biosynthetic processes; moreover, mut...

GSE85422: Gene expression analysis of CD122HI versus CD122LO V7+ murine small intestinal IEL at 14-17 days of age

Background: The neonatal (D14-17) murine small intestinal epithelium is enriched for V7+ IEL display...

GSE83243: Regionally distinct roles of ATXN1-CIC complex in ADHD and autism

We isolated RNAs from Otp-lineage cells in the mouse brain using translating ribosome affinity purif...