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Sequencing-based assays (Page 7)
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GSE146867: RNA editing enzyme APOBEC3A promotes pro-inflammatory (M1) macrophage polarization
Macrophages acquire a pro-inflammatory M1 phenotype in response to microbial products or pro-inflamm...
GSE71800: Integrated analysis of MLL-AF9 AML patients and model leukemias highlights RET and other novel therapeutic targets (RNA-seq AML development)
Next generation DNA sequencing of acute myeloid leukemia (AML) patient samples has revealed novel re...
GSE67374: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type, 4L;C* and Isofagamine treated 4L;C* region specifics mouse brain Transcriptomes (RNA-Seq)
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular path...
GSE71304: Regulatory T cells from colonic lamina propria [RNA-Seq]
The colonic lamina propria contains a distinct population of Foxp3+ T regulatory cells (Tregs) that ...
GSE73317: Gene expression analysis of BRD4 knockdown in HT-29 and HCT116 cells
RNAseq is performed (50bp single end reads) on HT-29 and HCT-116 cell lines utilizing two independen...
GSE94438: A blood RNA signature for tuberculosis disease risk in household contact study - GC6 cohort.
Identification of blood biomarkers that prospectively predict progression of Mycobacterium tuberculo...
GSE100102: Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Cellular senescence is triggered by various distinct stresses and characterized by a permanent cell ...
GSE72603: mRNA-seq data from adipose tissues of the great roundleaf bat (Hipposideros armiger) and mouse
We performed transcriptomic profiling for two models of adipose browning, the classical mouse model ...
GSE71309: A mechanism for expansion of the regulatory T cell repertoire and its role in enforcing self-tolerance.
Thymic Treg cells, mature non-Treg CD4+ single positive thymocytes, peripheral (spleen) resting and ...
GSE74682: RNA-seq of Mesp1-induced cardiopharyngeal mesoderm derivatives from ES cells
We have developed a protocol to generate cardiopharyngeal mesoderm (CPM) in vitro by Mesp1 induction...
GSE76523: Methylomes and Transcriptomes of Human Pluripotent-to-Cardiomyocyte Differentiation [RNA-seq]
In this report, Tompkins et al describe the derivation, differentiation stage-specific purification,...
GSE67863: A lineage of myelolymphoblastic innate cells unmasked by inactivation of mTOR complex 1
Blockades in hematopoiesis deprive the host of vital blood cells and frequently cause leukemia. Her...
GSE123518: A novel target of EZH1/2 for treatment of mantle cell lymphoma
Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkins lymphoma, which is characterized by the...
GSE88956: CD74 role in transcription regulation [RNA-seq]
CD74 activation was previously shown to affect gene transcription. The goal of this study was to rea...
GSE75327: Aberrant downstream mechanisms following loss of KMT2C and KMT2D in Pancreatic Ductal Adenocarcinoma
Genes encoding the histone H3 lysine 4 (H3K4) methyltransferases KMT2C and KMT2D are subject to dele...
GSE75852: Cerebellar differentiation in Ataxia-Telangiectasia
Control (CRL2429 C11) and A-T (MC3/AT30) iPSC were differentiated according to Erceg et al to genera...
GSE76149: Gene expression profiling of sensory epithelium of cochleas and vestibules of the inner ears of wild-type C57Bl/6J mice at post-natal day 0 (P0)
The sensory epithelium of cochleas and vestibules of mice were compared. The two tissues are quite s...
GSE67889: Sequential Notch activation regulates ventricular chamber development
Ventricular chambers are essential for the rhythmic contraction and relaxation that occurs in every ...
GSE79095: Alternative splicing regulation by homologous Muscleblind proteins
We provide data showing alternative splicing regulation by Muscleblind proteins in MEFs. MEFs lackin...
GSE78128: RNA-sequencing of non-senescent and senescent mouse skin fibroblast
Mouse skin fibroblasts (MSFs) were obtained from a FASST (Fibroblasts Accelerate Stromal-Supported T...
GSE75291: RNA-seq analysis upon ARID1B overexpression
We transduced either an empty vector or ARID1B cDNA in IMR90 cells. Cells were selected with puromyc...
GSE92282: Early life antibiotic treatment enhances the pathogenicity of CD4+ T cells curing intestinal inflammation
Comparison between splenic nave CD4 T cells from antibiotic treated and non-treated C57BL/6 mice 8-1...
GSE88732: Systematic Identification and Characterization of Long Non-coding RNAs in Mouse Mature Sperm
Increasingly, studies have shown that mature spermatozoa contain many transcripts including mRNAs an...
GSE74230: Positively selected enhancer elements endow tumor cells with metastatic competence
Metastasis results from a complex set of traits acquired by tumor cells, distinct from those necessa...
GSE145265: Transcriptomic analysis of mouse brain microglia on aging-associated changes in response to cerebral ischemia
Senescence-associated alterations in microglia may have profound impact on cerebral homeostasis and ...
GSE72546: RNA sequencing of pancreatic islets and islet-derived macrophages and endothelial cells modulated by vascular endothelial growth factor-A signaling
Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular endothel...
GSE75219: Foxn1 choreographs both early and late events in thymic lympho-stromal cross-talk
Normal thymic T cell development is enabled by a stromal microenvironment most importantly composed ...
GSE73721: RNA-Seq of human astrocytes
Astrocytes were purified from fetal and adult human brain tissue using an immunopanning method with ...
GSE102533: Genome wide transcriptome analysis of Jak2 KD persistent murine E-Crlf2/Jak2R683G B-ALL cells
RNA-seq was performed to compare the transcriptional programmes of murine E-Crlf2/Jak2R683G-express...
GSE99112: A Upf3b-mutant mouse model with behavioral and neurogenesis defects
Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that a...
GSE79684: Loss of CREBBP results in gene expression repression in lymphoma cells
KD of CREBBP at lymphoma cell line, MD901, results in reduced expression SOURCE: Huimin Geng (huimin...
GSE107770: Alternative splicing of differentiated myeloid cell transcripts after infection by Anaplasma phagocytophilum impacts a selective group of cellular programs
Eukaryotic proteome diversity exceeds that encoded within individual genes, and results in part from...
GSE144274: RNA sequencing of healthy and diseased (idiopathic pulmonary hypertension) human pulmonary artery smooth muscle cells
We performed RNA-seq to analyze gene expression in human PASMCs (Pulmonary arterial smooth muscle ce...
GSE72627: Transcriptome profiles of moderate dysplasia in oral mucosa associated with malignant conversion
Oral malignancies are among the top most deadly cancers in the world. Early diagnosis of oral premal...
GSE72671: Gfi1 as a new predictive and therapeutical target of MDS/AML
MDS is characterized by a disturbed function of the myeloid lineage of the hematopoietic system that...
GSE75854: H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [Ring1a-1b_RNASeq]
The goal of this study is to understand the genome-wide alterations in chromatin landscapy induced b...
GSE83755: Dnmt3a Regulates T-cell Development and Suppresses T-ALL Transformation (RNA-seq)
Gene expression analysis of T-cell acute lymphoblastic leukemia blast cells from either control mice...
GSE75357: PS2APP whole tissue RNAseq
RNA was purified from intact cerebrocortical tissue of female PS2APP or non-transgenic mice, perfuse...
GSE79698: The effect of niclosamide on the growth and progression of endometriosis in an experimental mouse model
Because niclosamide inhibits growth and progression of endometriotic lesions, we performed RNA-seq i...
GSE73433: Redifferentiation of expanded human islet cells by inhibition of ARX
We applied RNA-seq analysis to human islet cells, received from 3 independent donors, treated with e...
GSE84374: Id3 Orchestrates Germinal Center B Cell Development
Previous studies have demonstrated that E-proteins induce AID expression in activated B cells. Here ...
GSE73853: Transcriptome analysis of diverse cell types infected with human cytomegalovirus [RNA-Seq]
Comprehensive RNA sequencing and splicing-sensitive microarray analysis of three diverse cell types ...
GSE73457: Genome-wide analysis of gene expression in MLL translocation transformed mouse leukemia cell lines
The purpose of this study is to investigate the transcriptional programs as it relates to disease la...
GSE74018: Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a (RNA-Seq)
Unlike clustered HOX genes, the role of non-clustered homeobox gene family members in hematopoiesis ...
GSE133079: Systematic identification of cell-cell communication networks in the developing brain
In the current study, we describe Brain-FACS, a method to simultaneously isolate neural, microglial,...
GSE68921: Parkin-mediated mitophagy evokes perinatal cardiac mitochondria maturation
Exclusion of Parkin from mitochondria of perinatal cardiomyocytes interrupts structural and molecula...
GSE69473: RAG Represents a Widespread Threat to the Lymphocyte Genome - (RNA-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is ...
GSE74397 (mouse): N6-methyladenosine-Mediated Nuclear Export of Messenger RNA
N6-methyladenosine (m6A) is the most common internal modification in eukaryotic messenger RNA (mRNA)...
GSE72369: Gene expression profiling of control cohesin knockdown LSK cells
We performed RNA-sequencing in LSK cells (Lin(neg)/c-Kit(+)/Sca-1(+)) from shRNA mice carrying an sh...
GSE75853: H3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [RNA_Chondroblastoma_H3K36M_H3WT]
The goal of this study is to understand the genome-wide alterations in chromatin landscapy induced b...
GSE73561: Gene expression analysis to identify Mef2c/d target genes in B-cell progenitors
The sequential activation of distinct developmental gene networks governs the ultimate identity of a...
GSE74283: Epithelial cell RNA-seq in aged skin
Transcriptional analysis of hair follicle stem cells and epidermal cells in young and aged skin. SOU...
GSE99366: RNA-seq of subcellular fractions from nESC and EpiLC
We analysed lncRNA subcellular location by performing RNAseq with fractionated nESC and epiblast-lik...
GSE151116: Gene expression profiling of monocyte in response to Pf-iRBC stimulation from Pf-PCR negative Malian children and adults during dry season.
In malaria-nave individuals,P. falciparum(Pf) infection results in numerous Pf-infected red blood ce...
GSE72851: Intragenic DNA methylation prevents cryptic transcription initiations on gene bodies [ART-seq]
In mammals, DNA methylation occurs mainly at 5mC of CpG dinucleotides. The methylation on the promot...
GSE73653: Polysome-seq of YBX heterozygous testes
RNA sequence analysis of mRNP and polysome occupancy in single and compound Ybx2/3 heterozygotes rev...
GSE74235: Hydroxychloroquine inhibits responses to group A streptococcus in peripheral blood mononuclear cells
Immune responses to group A streptococcus in humans can lead to the development of acute rheumatic f...
GSE73325: 4sUDRB-seq of human PA1 cells, undifferentiated H9 cells and H9 differentiated FB neurons
We have optimized the metabolic tagging of newly transcribed RNAs by 4-thiouridine (4sU) to identify...
GSE76198: Cell type-specific alternative splicing of cytoskeletal domains governs cell fate in the developing cerebral cortex
Alternative splicing regulates over 90% of multiexon mammlian genes, but its role in specifying neur...
GSE79108: Identification of preoptic sleep-promoting neurons based on projection target
The preoptic area (POA) of the hypothalamus is known to be crucial for sleep generation, but the spa...
GSE74170: Comparative Systems Pharmacology of HIF Stabilization in the Prevention of Retinopathy of Prematurity
Retinopathy of prematurity (ROP) is the most common cause of childhood blindness worldwide and is ca...
GSE74429: Dclk1+ mouse pancreatic progenitor cells
Dclk1 (Doublecortin like kinase-1) labels a rare population of long-lived and largely quiescent cell...
GSE79739: Enhancer and transcriptomic changes in skeletal muscles in response to physical exercise
We address the transcriptomic changes in skeletal muscle after bouts of exercise SOURCE: Bin Fang (b...
GSE85089: Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs
We investigated the occupancy of RNA PolII and INTS11 during the stimulation of EGF and compared wit...
GSE104658: Polycomb Repressive Complex 2 methylates Elongin A to regulate transcripiton [BrU-RNA-seq]
Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 at lysine 27 (H3K27) and is required...
GSE76186: Sp7/Osterix is restricted to bone-forming vertebrates where it acts as a Dlx co-factor in osteoblast specification [RNA-Seq]
Sp7/Osterix is a master regulator of osteoblast specification. To identify transcripts profile in Sp...
GSE74369: Tumor-derived circulating endothelial cell clusters diagnostic for early colorectal cancer
Circulating tumor cells (CTCs) are the subject of several translational studies and clinical trials ...
GSE79112: Gene expression profile using RNA-seq in WC00060 or SR-0788 cells transfected with siRNA for KPC1 or control
Melanoma is a highly aggressive cancer with increasing incidence rates and a poor survival, particul...
GSE75832: RNAseq from neonatal mouse hindlimb muscles
During neonatal development, skeletal muscle grows dramatically by myonuclei accretion to existing f...
GSE70738: NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming [RNA-seq]
Changing the somatic cell transcriptome to a pluripotent state using exogenous reprogramming factors...
GSE74377: Overexpression of PHF8 promotes an EMT-related gene signature in MCF10A cells
PHF8 exerts distinct functions in different types of cancer. However, the mechanisms underlying its ...
GSE74456: PAPTRAP
We report the mRNAs bound to ribosomes in peripheral astrocyte processes, thus suggesting local tran...
GSE75491: Determination of a comprehensive alternative splicing regulatory network and the combinatorial regulation by key factors during Epithelial-to-Mesenchymal Transition [RBM47 KD]
RBM47 is a RNA binding protein that is known to regulate alternative splicing. To study the genome w...
GSE74064: Therapeutic targeting of myeloid leukemias with spliceosomal mutations through modulation of splicing catalysis
Mutations in spliceosomal genes are commonly found in patients with myelodysplastic syndromes (MDS) ...
GSE76877: RNA-Seq data for KRAS wild-type(WT) and two mutant forms G12V and Q61H over-expressed samples with green fluorescent protein control samples using human mammary epithelial cells
The goal was to capture the transcriptional activity due to over-expression of KRAS gene. Over-expre...
GSE144760: RNA-seq analysis of WT and OGT KO female islets
We report our results from two runs of RNA-seq analysis on islets isolated from female C57Bl/6J mice...
GSE75949: RNA-seq analysis of the human fetal kidney.
Micro-dissection and FACS were used to isolate tissue and cells, respectively, for RNA-seq analyses ...
GSE76879: Expression profiling of p53-/- shPU.1 AML cells single cell clones
We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-d...
GSE70766: Distinct processes and transcriptional targets underlie CDX2 requirements in intestinal stem cells and differentiated villus cells
To define target genes of the intestine-restricted transcription factor (TF) CDX2 in intestinal stem...
GSE72910: Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution
In this study, using a murine model of Ph+ acute lymphoblastic leukemia (Ph+ ALL), a combined pharma...
GSE70210: An essential role for the Gai2 protein in Smoothened-stimulated mammary epithelial cell proliferation
Hedgehog (Hh) signaling is critical for organogenesis, tissue homeostasis, and stem cell maintenance...
GSE70440: Loss of EZH2 results in precocious mammary gland development and the activation of STAT5-dependent genes
Establishment and differentiation of mammary alveoli during pregnancy are controlled by prolactin th...
GSE125957: Transcriptional signatures of progressive neuropathology in tau and amyloid mouse models
Using highly-parallel RNA-sequencing on samples from rTg4510 and J20 mice (n = 121 mice), collected ...
GSE75431: Sorted cells_PS2APP brains_7/13mo
Mice of indicated ages and genotypes were perfused and their brains dissected and dissociated. Cells...
GSE137177: Adverse effect of folic acid supplementation on cilia
We report that fortified levels of folic acid adversely affect cilia structure and function. The dy...
GSE74973: Expression of human C9ORF72 hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice
Nuclear RNA foci are often associated with mis-regulation of RNA processing in repeat expansion dise...
GSE104152: Quantitative proteomic characterization and comparison of T helper 17 and iTreg cells
Using mass spectrometry-based label-free quantitative (LFQ) proteomics analysis of in vitro differen...
GSE73345: RNA-seq: weight cycling time series (eWAT)
Gene expression change on weight cycling mice eWAT SOURCE: Je Kyung Seong (snumouse@snu.ac.kr) - Se...
GSE81518: RNA-seq analysis of primary patient samples to characterize the CNS leukemia
We present a detailed genetic, transcriptional and physiological study of leukemic cells isolated fr...
GSE75907: Genome-wide landscape and functional necessity of heart enhancers
Analysis of the transcriptional changes in the heart resulting from the loss of cardiac enhancers.; ...
GSE124845: Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq 2]
RNA-seq analysis identifies transcripts regulated by HCF-1 expression SOURCE: John,G,Flanagan (flana...
GSE65267: Next Generation Sequencing identifies Cdh11 and Mrc1 as novel translational biomarkers of kidney fibrosis
Chronic kidney disease (CKD) is the gradual, asymptomatic loss of kidney function. Using a folic aci...
GSE75510: Impact of Prnp genetic ablation in the hippocampus transcriptome of congenic B6.129-PrnpZH1/ZH1 or coisogenic C57BL/6-PrnpZH3/ZH3 mice
To study the effect of Prnp genetic ablation on different aspects of RNA metabolism, we performed RN...
GSE90687: Functional Genomic Analyses of hepatic tissue after FTO knockout
To explore the molecular mechanism underlying glucose regulation by hepatic FTO, we analyzed transcr...
GSE75432: Muscle transcriptome analysis following Total Knee Arthroplasty with Tourniquet
Transcriptome profiling was performed on muscle biopsies from patients immediately before Total Knee...
GSE78178: Effect of BB608 on Gene Expression in HNSCC Cell Line
Study to determine the genome wide effects on transcripton in FaDu cells treated with BB608, a trans...
GSE122243: The hepatic integrated stress response to asparaginase corresponds with transcriptional signatures that differ with age.
Clinical reports describing increased liver toxicity in adult versus pediatric patients treated with...
GSE74583: Next Generation Sequencing Investigation of altered transcripts in presence of dominant-negative transcription factor
Purpose:The goals of this study was to determine alterations in expression levels of transcripts dow...
GSE122090: RNA sequence analysis to compare alteration in transcriptome upon Elf5 loss in C3-T+ tumors
The data generated here shows increased interferon gamma gene signatures in C3-T+ tumors with loss o...
GSE74998: Role of the histone demethylase Kdm6b/Jmjd3 in somatic cell reprogramming [RNA-Seq]
Somatic cells can be reprogrammed to pluripotent stem cells through the addition of just four transc...